Russell C, Baker P, Grimes C, Lindberg R, Lawrence MA (2022) Global trends in added sugars and non-nutritive sweetener use in the packaged food supply: drivers and implications for public health. Public Health Nutr 1–13. https://doi.org/10.1017/S1368980022001598
Martyn D, Darch M, Roberts A, Lee HY, Yaqiong Tian T, Kaburagi N, Belmar P (2018) Low-/No-Calorie sweeteners: A review of global intakes. Nutrients 10(3). https://doi.org/10.3390/nu10030357
Ashwell M, Gibson S, Bellisle F, Buttriss J, Drewnowski A, Fantino M, Gallagher AM, de Graaf K, Goscinny S, Hardman CA, Laviada-Molina H, Lopez-Garcia R, Magnuson B, Mellor D, Rogers PJ, Rowland I, Russell W, Sievenpiper JL, la Vecchia C (2020) Expert consensus on low-calorie sweeteners: facts, research gaps and suggested actions. Nutr Res Rev 33(1):145–154. https://doi.org/10.1017/S0954422419000283
Article PubMed PubMed Central Google Scholar
Rios-Leyvraz M, Montez J (2022) Health effects of the use of non-sugar sweeteners A systematic review and meta-analysis. World Health Organization, Geneva
Use of non-sugar sweeteners (2023) WHO Guidline. World Health Organization Geneva
Bundesinstitut für Risikobewertung (2014) Bewertung von Süßstoffen und Zuckeraustauschstoffen
Cyclamate (Cyclamlc Acid, Calcium Cyclamate, and Food and Drug Administration, Cyclamate S (1980) Commissioner’s Decision
Choudhary AK, Pretorius E (2017) Revisiting the safety of aspartame. Nutr Rev 75(9):718–730. https://doi.org/10.1093/nutrit/nux035
Landrigan PJ, Straif K (2021) Aspartame and cancer - new evidence for causation. Environ Health 20(1):42. https://doi.org/10.1186/s12940-021-00725-y
Article CAS PubMed PubMed Central Google Scholar
Riboli E, Beland FA, Lachenmeier DW, Marques MM, Phillips DH, Schernhammer E, Afghan A, Assunção R, Caderni G, Corton JC, De Aragão Umbuzeiro G, De Jong D, Deschasaux-Tanguy M, Hodge A, Ishihara J, Levy DD, Mandrioli D, McCullough ML, McNaughton SA, Morita T, Nugent AP, Ogawa K, Pandiri AR, Sergi CM, Touvier M, Zhang L, Benbrahim-Tallaa L, Chittiboyina S, Cuomo D, Debono NL, Debras C, De Conti A, El Ghissassi F, Fontvieille E, Harewood R, Kaldor J, Mattock H, Pasqual E, Rigutto G, Simba H, Suonio E, Viegas S, Wedekind R, Schubauer-Berigan MK, Madia F (2023) Carcinogenicity of aspartame, Methyleugenol, and isoeugenol. Lancet Oncol 24(8):848–850. https://doi.org/10.1016/s1470-2045(23)00341-8
Article CAS PubMed Google Scholar
Yin T, Li J, Wang Y, Liu K, Long T, Cheng L (2022) Artificially sweetened beverage consumption and cancer risk: A comprehensive Dose-Response Meta-Analysis of prospective studies. Nutrients 14(21). https://doi.org/10.3390/nu14214445
Pavanello S, Moretto A, La Vecchia C, Alicandro G (2023) Non-sugar sweeteners and cancer: toxicological and epidemiological evidence. Regul Toxicol Pharmacol 139:105369. https://doi.org/10.1016/j.yrtph.2023.105369
Article CAS PubMed Google Scholar
Debras C, Chazelas E, Sellem L, Porcher R, Druesne-Pecollo N, Esseddik Y, de Edelenyi FS, Agaesse C, De Sa A, Lutchia R, Fezeu LK, Julia C, Kesse-Guyot E, Alles B, Galan P, Hercberg S, Deschasaux-Tanguy M, Huybrechts I, Srour B, Touvier M (2022) Artificial sweeteners and risk of cardiovascular diseases: results from the prospective NutriNet-Sante cohort. BMJ 378:e071204. https://doi.org/10.1136/bmj-2022-071204
Article PubMed PubMed Central Google Scholar
Debras C, Deschasaux-Tanguy M, Chazelas E, Sellem L, Druesne-Pecollo N, Esseddik Y, Szabo de Edelenyi F, Agaesse C, De Sa A, Lutchia R, Julia C, Kesse-Guyot E, Alles B, Galan P, Hercberg S, Huybrechts I, Cosson E, Tatulashvili S, Srour B, Touvier M (2023) Artificial sweeteners and risk of type 2 diabetes in the prospective NutriNet-Sante cohort. Diabetes Care 46(9):1681–1690. https://doi.org/10.2337/dc23-0206
Article CAS PubMed PubMed Central Google Scholar
Diaz C, Rezende LFM, Sabag A, Lee DH, Ferrari G, Giovannucci EL, Rey-Lopez JP (2023) Artificially sweetened beverages and health outcomes: an umbrella review. Adv Nutr 14(4):710–717. https://doi.org/10.1016/j.advnut.2023.05.010
Article CAS PubMed PubMed Central Google Scholar
Espinosa A, Mendoza K, Laviada-Molina H, Rangel-Mendez JA, Molina-Segui F, Sun Q, Tobias DK, Willett WC, Mattei J (2023) Effects of non-nutritive sweeteners on the BMI of children and adolescents: a systematic review and meta-analysis of randomised controlled trials and prospective cohort studies. Lancet Glob Health 11(Suppl 1):S8. https://doi.org/10.1016/S2214-109X(23)00093-1
Tobiassen PA, Koster-Rasmussen R (2023) Substitution of sugar-sweetened beverages with non-caloric alternatives and weight change: A systematic review of randomized trials and meta-analysis. Obes Rev:e13652. https://doi.org/10.1111/obr.13652
Higgins KA, Mattes RD (2019) A randomized controlled trial contrasting the effects of 4 low-calorie sweeteners and sucrose on body weight in adults with overweight or obesity. Am J Clin Nutr 109(5):1288–1301. https://doi.org/10.1093/ajcn/nqy381
Steffen BT, Jacobs DR, Yi SY, Lees SJ, Shikany JM, Terry JG, Lewis CE, Carr JJ, Zhou X, Steffen LM (2023) Long-term aspartame and saccharin intakes are related to greater volumes of visceral, intermuscular, and subcutaneous adipose tissue: the CARDIA study. Int J Obes (Lond) 47(10):939–947. https://doi.org/10.1038/s41366-023-01336-y
Article CAS PubMed Google Scholar
Buso MEC, Brouwer-Brolsma EM, Naomi ND, Ngo J, Soedamah-Muthu SS, Mavrogianni C, Harrold JA, Halford JCG, Raben A, Geleijnse JM, Manios Y, Serra-Majem L, Feskens EJM (2023) Sugar and low/no-calorie-sweetened beverage consumption and associations with body weight and waist circumference changes in five European cohort studies: the SWEET project. Eur J Nutr 62(7):2905–2918. https://doi.org/10.1007/s00394-023-03192-y
Article CAS PubMed PubMed Central Google Scholar
Turner A, Veysey M, Keely S, Scarlett CJ, Lucock M, Beckett EL (2020) Intense sweeteners, taste receptors and the gut microbiome: A metabolic health perspective. Int J Environ Res Public Health 17(11). https://doi.org/10.3390/ijerph17114094
Chometton S, Tsan L, Hayes AMR, Kanoski SE, Schier LA (2023) Early-Life influences of Low-Calorie sweetener consumption on sugar taste. Physiol Behav 114133. https://doi.org/10.1016/j.physbeh.2023.114133
Shum B, Georgia S (2021) The effects of Non-Nutritive sweetener consumption in the pediatric populations: what we know, what we don’t, and what we need to learn. Front Endocrinol (Lausanne) 12:625415. https://doi.org/10.3389/fendo.2021.625415
Plows JF, Aris IM, Rifas-Shiman SL, Goran MI, Oken E (2022) Associations of maternal non-nutritive sweetener intake during pregnancy with offspring body mass index and body fat from birth to adolescence. Int J Obes (Lond) 46(1):186–193. https://doi.org/10.1038/s41366-021-00897-0
Li G, Wang R, Zhang C, Li L, Zhang J, Sun G (2022) Consumption of Non-Nutritive sweetener during pregnancy and weight gain in offspring: evidence from human studies. Nutrients 14(23). https://doi.org/10.3390/nu14235098
Chiang YF, Chen HY, Lai YH, Ali M, Chen YC, Hsia SM (2022) Consumption of artificial sweetener acesulfame potassium increases preterm risk and uterine contraction with calcium influx increased via myosin light chain Kinase-Myosin light chain 20 related signaling pathway. Mol Nutr Food Res 66(20):e2200298. https://doi.org/10.1002/mnfr.202200298
Article CAS PubMed Google Scholar
Lobach AR, Roberts A, Rowland IR (2019) Assessing the in vivo data on low/no-calorie sweeteners and the gut microbiota. Food Chem Toxicol 124:385–399. https://doi.org/10.1016/j.fct.2018.12.005
Article CAS PubMed Google Scholar
Schiffman SS, Nagle HT (2019) Revisited: assessing the in vivo data on low/no-calorie sweeteners and the gut microbiota. Food Chem Toxicol 132:110692. https://doi.org/10.1016/j.fct.2019.110692
Article CAS PubMed Google Scholar
Roberts A, Lobach AR (2019) Response to the Letter to the Editor by S. Schiffman and H. Nagle: Revisiting the data and information that has collectively established the safety of low/no-calorie sweeteners, including sucralose. Food Chem Toxicol 132:110691. https://doi.org/10.1016/j.fct.2019.110691
Conz A, Salmona M, Diomede L (2023) Effect of Non-Nutritive sweeteners on the gut microbiota. Nutrients 15(8). https://doi.org/10.3390/nu15081869
Gauthier E, Milagro FI, Navas-Carretero S (2023) Effect of low-and non-calorie sweeteners on the gut microbiota: A review of clinical trials and cross-sectional studies. Nutrition 117:112237. https://doi.org/10.1016/j.nut.2023.112237
Article CAS PubMed Google Scholar
Suez J, Cohen Y, Valdes-Mas R, Mor U, Dori-Bachash M, Federici S, Zmora N, Leshem A, Heinemann M, Linevsky R, Zur M, Ben-Zeev Brik R, Bukimer A, Eliyahu-Miller S, Metz A, Fischbein R, Sharov O, Malitsky S, Itkin M, Stettner N, Harmelin A, Shapiro H, Stein-Thoeringer CK, Segal E, Elinav E (2022) Personalized microbiome-driven effects of non-nutritive sweeteners on human glucose tolerance. Cell 185(18):3307–3328e3319. https://doi.org/10.1016/j.cell.2022.07.016
Article CAS PubMed Google Scholar
Green CH, Syn WK (2019) Non-nutritive sweeteners and their association with the metabolic syndrome and non-alcoholic fatty liver disease: a review of the literature. Eur J Nutr 58(5):1785–1800. https://doi.org/10.1007/s00394-019-01996-5
Khan TA, Lee JJ, Ayoub-Charette S, Noronha JC, McGlynn N, Chiavaroli L, Sievenpiper JL (2023) WHO guideline on the use of non-sugar sweeteners: a need for reconsideration. Eur J Clin Nutr 77(11):1009–1013. https://doi.org/10.1038/s41430-023-01314-7
Article PubMed PubMed Central Google Scholar
Hedrick VE, Nieto C, Grilo MF, Sylvetsky AC (2023) Non-sugar sweeteners: helpful or harmful? The challenge of developing intake recommendations with the available research. BMJ 383:e075293. https://doi.org/10.1136/bmj-2023-075293
Comments (0)