Khoury JD, Solary E, Abla O, Akkari Y, Alaggio R, Apperley JF et al (2022) The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: myeloid and Histiocytic/Dendritic neoplasms. Leukemia 36(7):1703–1719. https://doi.org/10.1038/s41375-022-01613-1Epub 2022 Jun 22

Article  PubMed  PubMed Central  Google Scholar 

Iacobucci I, Mullighan CG (2017) Genetic basis of acute lymphoblastic leukemia. J Clin Oncol 35:975–983. https://doi.org/10.1200/JCO.2016.70.7836

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kuiper RP, Schoenmakers EF, van Reijmersdal SV, Hehir-Kwa JY, van Kessel AG, van Leeuwen FN, Hoogerbrugge PM (2007) High-resolution genomic profiling of childhood ALL reveals novel recurrent genetic lesions affecting pathways involved in lymphocyte differentiation and cell cycle progression. Leukemia 21:1258–1266. https://doi.org/10.1038/sj.leu.2404691

Article  CAS  PubMed  Google Scholar 

Mullighan CG, Goorha S, Radtke I, Miller CB, Coustan-Smith E, Dalton JD et al (2007) Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia. Nature 446(7137):758–764. https://doi.org/10.1038/nature05690

Article  CAS  PubMed  Google Scholar 

Arber DA, Orazi A, Hasserjian RP et al (2022) International Consensus classification of myeloid neoplasms and Acute Leukemias: integrating morphologic, clinical, and genomic data. Blood 140(11):1200–1228

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hunger SP, Mullighan CG (2015) Acute lymphoblastic leukemia in children. N Engl J Med 373:1541–1552

Article  CAS  PubMed  Google Scholar 

Frey NV, Luger SM (2015) How I treat adults with relapsed or refractory Philadelphia chromosome-negative acute lymphoblastic leukemia. Blood 126:589–596

Article  CAS  PubMed  Google Scholar 

Das N, Banavali S, Bakhshi S, Trehan A, Radhakrishnan V, Seth R et al (2022) Protocol for ICiCLe-ALL-14 (InPOG-ALL-15-01): a prospective, risk stratified, randomised, multicentre, open label, controlled therapeutic trial for newly diagnosed childhood acute lymphoblastic leukaemia in India. Trials 23(1). https://doi.org/10.1186/s13063-022-06033-1

Siraj AK, Kamat S, Gutiérrez MI et al (2003) Frequencies of the major subgroups of precursor B-cell acute lymphoblastic leukemia in Indian children differ from the West. Leukemia 17(6):1192–1193

Article  CAS  PubMed  Google Scholar 

Sazawal S, Bhatia K, Gutierrez MI, Saxena R, Arya LS, Bhargava M (2004) Paucity of TEL-AML 1 translocation, by multiplex RT-PCR, in B-lineage acute lymphoblastic leukemia (ALL) in Indian patients. Am J Hematol 76(1):80–82

Article  CAS  PubMed  Google Scholar 

Gupta SK, Bakhshi S, Kumar L, Kamal VK, Kumar R (2017) Gene copy number alteration profile and its clinical correlation in B-cell acute lymphoblastic leukemia. Leuk Lymphoma 58(2):333–342

Article  PubMed  Google Scholar 

Holmfeldt L, Wei L, Diaz-Flores E, Walsh M, Zhang J, Ding L, Payne-Turner D, Churchman M, Andersson A, Chen SC et al (2013) The genomic landscape of hypodiploid acute lymphoblastic leukemia. Nat Genet 45:242–252

Article  CAS  PubMed  PubMed Central  Google Scholar 

Comeaux EQ, Mullighan CG (2017) TP53 mutations in hypodiploid acute lymphoblastic leukemia. Cold Spring Harb Perspect Med 7(3):a026286

Article  PubMed  PubMed Central  Google Scholar 

Amare PSK, Jain H, Kabre S, Deshpande Y, Pawar P, Banavali S et al (2016) Cytogenetic Profile in 7209 Indian patients with de novo acute leukemia: a single centre study from India. J Cancer Ther 07(07):530–544

Article  Google Scholar 

Carroll AJ, Shago M, Mikhail FM et al (2019) Masked hypodiploidy: hypodiploid acute lymphoblastic leukemia (ALL) mimicking hyper-diploid ALL in children: a report from the Children’s Oncology Group. Cancer Genet 238:62–68

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tembhare P, Badrinath Y, Ghogale S, Patkar N, Dhole N, Dalavi P et al (2016) A novel and easy FxCycle™ violet based flow cytometric method for simultaneous assessment of DNA ploidy and six-color immunophenotyping. Cytometry 89:281–291

Article  CAS  PubMed  Google Scholar 

Bommannan K, Arumugam JR, Koshy T, Radhakrishnan V, Sagar TG, Sundersingh S (2021) Blast size-specific flowcytometric ploidy assessment using FxCycleTM Violet dye and its correlation with conventional cytogenetic ploidy in pediatric precursor B-lineage acute lymphoblastic leukemia patients. Int J Lab Hematol 43(4):760–770. https://doi.org/10.1111/ijlh.13436

Article  PubMed  Google Scholar 

Gupta SK, Singh M, Chandrashekar PH, Bakhshi S, Trehan A, Gupta R et al (2022) Clinical and prognostic impact of Copy Number alterations and Associated Risk profiles in a cohort of Pediatric B-cell Precursor Acute lymphoblastic leukemia cases treated under ICiCLe protocol. Hemasphere 6(10):e782

Article  CAS  PubMed  PubMed Central  Google Scholar 

Paulsson K, Lilljebjörn H, Biloglav A, Olsson L, Rissler M, Castor A, Barbany G, Fogelstrand L, Nordgren A, Sjogren H et al (2015) The genomic landscape of high hyperdiploid childhood acute lymphoblastic leukemia. Nat Genet 47:672–676

Article  CAS  PubMed  Google Scholar 

Burmeister T, Schwartz S, Taubald A, Jost E, Lipp T, Schneller F et al (2007) Atypical BCR-ABL mRNA transcripts in adult acute lymphoblastic leukemia. Haematologica 92(12):1699–1702. https://doi.org/10.3324/haematol.11737

Article  CAS  PubMed  Google Scholar 

Gupta DG, Varma N, Sharma P et al (2023) Hematological, clinical, immunophenotypic characterization, and treatment outcomes of prognostically significant genetic subtypes of B-lineage acute lymphoblastic leukemia: a report of 1021 patients from India. Cancer 129(21):3390–3404. https://doi.org/10.1002/cncr.34957

Article  CAS  PubMed  Google Scholar 

Mullighan CG, Miller CB, Radtke I, Phillips LA, Dalton J, Ma J, White D, Hughes TP, Le Beau MM, Pui CH et al (2008) BCR-ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros. Nature 453:110–114

Article  CAS  PubMed  Google Scholar 

Nakase K, Kita K, Miwa H et al (2007) Clinical and prognostic significance of cytokine receptor expression in adult acute lymphoblastic leukemia: interleukin-2 receptor alpha-chain predicts a poor prognosis. Leukemia 21(2):326–332

Article  CAS  PubMed  Google Scholar 

Corrente F, Bellesi S, Metafuni E et al (2018) Role of flow-cytometric immunophenotyping in prediction of BCR/ABL1 gene rearrangement in adult B-cell acute lymphoblastic leukemia. Cytometry B Clin Cytom 94(3):468–476

Article  CAS  PubMed  Google Scholar 

Foà R, Bassan R, Vitale A et al (2020) Dasatinib-blinatumomab for Ph-positive acute lymphoblastic leukemia in adults. N Engi J Med 383(17):1613–1623 PMID 33085860

Article  Google Scholar 

Winters AC, Bernt KM (2017) MLL-rearranged leukemias-an update on science and clinical approaches. Front Pediatr 5:4

Article  PubMed  PubMed Central  Google Scholar 

Krivtsov AV, Evans K, Gadrey JY, Eschle BK, Hatton C, Uckelmann HJ, Ross KN, Perner F, Olsen SN, Pritchard T et al (2019) A Menin-MLL inhibitor induces specific chromatin changes and eradicates Disease in models of MLL-Rearranged leukemia. Cancer Cell 36:660–673e11

Article  CAS  PubMed  PubMed Central  Google Scholar 

Stein EM, Garcia-Manero G, Rizzieri DA, Tibes R, Berdeja JG, Savona MR, Jongen-Lavrenic M, Altman JK, Thomson B, Blakemore SJ et al (2018) The DOT1L inhibitor pinometostat reduces H3K79 methylation and has modest clinical activity in adult acute leukemia. Blood 131:2661–2669

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dworzak MN, Buldini B, Gaipa G et al (2018) AIEOP-BFM consensus guidelines 2016 for flow cytometric immunophenotyping of pediatric acute lymphoblastic leukemia. Cytometry B Clin Cytom 94(1):82–93

Article  PubMed  Google Scholar 

Inukai T, Hirose K, Inaba T et al (2007) Hypercalcemia in childhood acute lymphoblastic leukemia: frequent implication of parathyroid hormone-related peptide and E2A-HLF from translocation 17;19. Leukemia 21(2):288–296

Article  CAS