Gulati M, Levy PD, Mukherjee D, Amsterdam E, Bhatt DL, Birtcher KK, et al. 2021 AHA/ACC/ASE/CHEST/SAEM/SCCT/SCMR guideline for the evaluation and diagnosis of chest pain: A report of the American College of Cardiology/American Heart Association Joint Committee on clinical practice guidelines. Circulation. 2021;144:e368–454.

PubMed  Google Scholar 

Azadani PN, Miller RJH, Sharir T, Diniz MA, Hu L-H, Otaki Y, et al. JACC Cardiovasc Imaging. 2021;14:644–53.

Article  PubMed  Google Scholar 

Hachamovitch R, Hayes SW, Friedman JD, Cohen I, Berman DS. Comparison of the short-term survival benefit associated with revascularization compared with medical therapy in patients with no prior coronary artery disease undergoing stress myocardial perfusion single photon emission computed tomography. Circulation. 2003;107:2900–7.

Article  PubMed  Google Scholar 

Patel KK, Spertus JA, Chan PS, Sperry BW, Thompson RC, Al Badarin F, et al. Extent of myocardial ischemia on positron emission tomography and survival benefit with early revascularization. N Engl J Med. 2019;74:1645–54.

CAS  Google Scholar 

Maron DJ, Hochman JS, Reynolds HR, Bangalore S, O’Brien SM, Boden WE, et al. Initial invasive or conservative strategy for stable coronary disease. N Engl J Med. 2020;382:1395–407.

Article  PubMed  PubMed Central  Google Scholar 

Boden WE, O’Rourke RA, Teo KK, Hartigan PM, Maron DJ, Kostuk WJ, et al. Optimal medical therapy with or without PCI for stable coronary disease. N Engl J Med. 2007;356:1503–16.

Article  CAS  PubMed  Google Scholar 

BARI 2D study group. A randomized trial of therapies for type 2 diabetes and coronary artery disease. N Engl J Med. 2009;360(24):2503–15. https://doi.org/10.1056/NEJMoa0805796

Mark DB, Spertus JA, Bigelow R, Anderson S, Daniels MR, Anstrom KJ, et al. Comprehensive quality-of-life outcomes with invasive versus conservative management of chronic coronary disease in ISCHEMIA. Circulation. 2022;145:1294–307.

Article  PubMed  PubMed Central  Google Scholar 

Hochman JS, Anthopolos R, Reynolds HR, Bangalore S, Xu Y, O’Brien SM, et al. Survival after invasive or conservative management of stable coronary disease. Circulation. 2023;147:8–19.

Article  PubMed  Google Scholar 

Navarese EP, Lansky AJ, Kereiakes DJ, Kubica J, Gurbel PA, Gorog DA, et al. Cardiac mortality in patients randomised to elective coronary revascularisation plus medical therapy or medical therapy alone: A systematic review and meta-analysis. Eur Heart J. 2021;42:4638–51.

Article  PubMed  PubMed Central  Google Scholar 

Bolognese L, Reccia MR, Sabini A. Long-term follow-up after invasive or conservative management of stable coronary disease: The ISCHEMIA-EXTEND study. Eur Heart J Suppl. 2023;25:B34–B6.

Article  PubMed  PubMed Central  Google Scholar 

Sharir T, Hollander I, Hemo B, Tsamir J, Yefremov N, Bojko A, et al. Survival benefit of coronary revascularization after myocardial perfusion SPECT: The role of ischemia. J Nucl Cardiol. 2021;28:1676–87.

Article  PubMed  Google Scholar 

Rozanski A, Miller RJH, Gransar H, Han D, Slomka P, Dey D, et al. Benefit of early revascularization based on inducible ischemia and left ventricular ejection fraction. J Am Coll Cardiol. 2022;80:202–15.

Article  PubMed  Google Scholar 

Al-Mallah MH, Ahmed AI, Nabi F, Chang SM, Kleiman NS, Chamsi-Pasha MA, et al. Outcomes of patients with moderate-to-severe Ischemia excluded from the ischemia trial. J Nucl Cardiol. 2022;29:1100–5.

Article  PubMed  Google Scholar 

Alderman EL, Fisher LD, Litwin P, Kaiser GC, Myers WO, Maynard C, et al. Results of coronary artery surgery in patients with poor left ventricular function (CASS). Circulation. 1983;68:785–95.

Article  CAS  PubMed  Google Scholar 

Reynolds HR, Shaw LJ, Min JK, Page CB, Berman DS, Chaitman BR, et al. Outcomes in the ISCHEMIA trial based on coronary artery disease and ischemia severity. Circulation. 2021;144:1024–38.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Budoff MJ. ISCHEMIA trial - Failed intervention or failed stratification? J Cardiovasc Comput Tomogr. 2021;15:110–1. https://doi.org/10.1016/j.jcct.2020.08.010.

Article  PubMed  Google Scholar 

Hochman JS, Reynolds HR, Bangalore S, O’Brien SM, Alexander KP, Senior R, et al. Baseline characteristics and risk profiles of participants in the ISCHEMIA randomized clinical trial. JAMA Cardiol. 2019;4:273–86.

Article  PubMed  PubMed Central  Google Scholar 

Dorbala S, Hachamovitch R, Curillova Z, Thomas D, Vangala D, Kwong RY, et al. Incremental prognostic value of gated Rb-82 positron emission tomography myocardial perfusion imaging over clinical variables and rest LVEF. JACC Cardiovasc Imaging. 2009;2:846–54.

Article  PubMed  PubMed Central  Google Scholar 

Ziadi MC, Dekemp RA, Williams K, Guo A, Renaud JM, Chow BJ, et al. Does quantification of myocardial flow reserve using rubidium-82 positron emission tomography facilitate detection of multivessel coronary artery disease? J Nucl Cardiol. 2012;19:670–80.

Article  PubMed  Google Scholar 

Ahmed AI, Al Rifai M, Alahdab F, Saad JM, Han Y, Alfawara MS, et al. Incremental prognostic value of digital positron emission tomography derived myocardial flow reserve: A prospective cohort study. Int J Cardiol. 2023;371:465–71.

Article  PubMed  Google Scholar 

Parker MW, Iskandar A, Limone B, Perugini A, Kim H, Jones C, et al. Diagnostic accuracy of cardiac positron emission tomography versus single photon emission computed tomography for coronary artery disease: A bivariate meta-analysis. Circ Cardiovasc Imaging. 2012;5:700–7.

Article  PubMed  Google Scholar 

Huang JY, Huang CK, Yen RF, Chien KL, Wu YW. Diagnostic effect of attenuation correction in myocardial perfusion imaging in different coronary arteries: A systematic review and meta-analysis. Front Cardiovasc Med. 2021;8:756060.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Danad I, Raijmakers PG, Driessen RS, Leipsic J, Raju R, Naoum C, et al. Comparison of coronary CT angiography, SPECT, PET, and hybrid imaging for diagnosis of ischemic heart disease determined by fractional flow reserve. JAMA Cardiol. 2017;2:1100–7.

Article  PubMed  PubMed Central  Google Scholar 

Mc Ardle BA, Dowsley TF, deKemp RA, Wells GA, Beanlands RS. Does rubidium-82 PET have superior accuracy to SPECT perfusion imaging for the diagnosis of obstructive coronary disease?: A systematic review and meta-analysis. J Am Coll Cardiol. 2012;60:1828–37.

Article  PubMed  Google Scholar 

Di Carli MF. PET perfusion and flow assessment: Tomorrows’ technology today. Semin Nucl Med. 2020;50:227–37.

Article  PubMed  Google Scholar 

Le VT, Knight S, Min DB, McCubrey RO, Horne BD, Jensen KR, et al. Absence of coronary artery calcium during positron emission tomography stress testing in patients without known coronary artery disease identifies individuals with very low risk of cardiac events. Circulation Cardiovascular Imaging. 2020;13:e009907.

Article  PubMed  Google Scholar 

Engbers EM, Timmer JR, Ottervanger JP, Mouden M, Knollema S, Jager PL. Prognostic value of coronary artery calcium scoring in addition to single-photon emission computed tomographic myocardial perfusion imaging in symptomatic patients. Circ Cardiovasc Imaging. 2016;9:e003966.

Article  PubMed  Google Scholar 

Chang SM, Nabi F, Xu J, Peterson LE, Achari A, Pratt CM, et al. The coronary artery calcium score and stress myocardial perfusion imaging provide independent and complementary prediction of cardiac risk. J Am Coll Cardiol. 2009;54:1872–82.

Article  PubMed  Google Scholar 

Rifai MA, Ahmed AI, Alahdab F, Nabi F, Mahmarian JJ, Soliman A, et al. Prognostic value of myocardial flow reserve by body mass index. J Am Coll Cardiol. 2023;81:1501. https://doi.org/10.1016/S0735-1097(23)01945-9.

Article  Google Scholar 

Aljizeeri A, Ahmed AI, Alfaris MA, Ahmed D, Farea J, Elneama A, et al. Myocardial flow reserve and coronary calcification in prognosis of patients with suspected coronary artery disease. JACC Cardiovasc Imaging. 2021;14:2443–52.

Article  PubMed  Google Scholar 

Al Rifai M, Ahmed AI, Saad JM, Alahdab F, Nabi F, Al-Mallah MH. Prognostic value of global myocardial flow reserve in patients with history of coronary artery bypass grafting. Eur Heart J Cardiovasc Imaging. 2023;24:1470–7.

Article  PubMed  Google Scholar 

Bairey Merz CN, Pepine CJ, Walsh MN, Fleg JL. Ischemia and no obstructive coronary artery disease (INOCA): Developing evidence-based therapies and research agenda for the next decade. Circulation. 2017;135:1075–92.

Article