Photon-counting CT: technical features and clinical impact on abdominal imaging

Zeman RK, Fox SH, Silverman PM, et al. Helical (spiral) CT of the abdomen. AJR Am J Roentgenol. 1993 Apr;160(4):719-25.

Article  CAS  PubMed  Google Scholar 

Agrawal MD, Pinho DF, Kulkarni NM, Hahn PF, Guimaraes AR, Sahani DV. Oncologic applications of dual-energy CT in the abdomen. Radiographics. 2014 May-Jun;34(3):589–612.

Elbanna KY, Mansoori B, Mileto A, Rogalla P, S Guimarães L. Dual-energy CT in diffuse liver disease: is there a role? Abdom Radiol (NY). 2020 Nov;45(11):3413–3424.

Wildberger JE, Prokop M. Hounsfield’s Legacy. Investig Radiol 2020; 55:556–558.

Article  Google Scholar 

Hsieh J, Flohr T. Computed tomography recent history and future perspectives. J Med Imaging 2021; 8:052109

Article  Google Scholar 

Murakami T, Kim T, Hori M, Federle MP. Double arterial phase multi-detector row helical CT for detection of hypervascular hepatocellular carcinoma. Radiology. 2003 Dec;229(3):931-2.

Article  PubMed  Google Scholar 

Nino-Murcia M, Tamm EP, Charnsangavej C, Jeffrey RB Jr. Multidetector-row helical CT and advanced postprocessing techniques for the evaluation of pancreatic neoplasms. Abdom Imaging. 2003 May-Jun;28(3):366–77.

Hyodo T, Yada N, Hori M, et al. Multimaterial Decomposition Algorithm for the Quantification of Liver Fat Content by Using Fast-Kilovolt-Peak Switching Dual-Energy CT: Clinical Evaluation. Radiology. 2017 Apr;283(1):108-118.

Article  PubMed  Google Scholar 

Okada M, Kim T, Murakami T. Hepatocellular nodules in liver cirrhosis: state of the art CT evaluation (perfusion CT/volume helical shuttle scan/dual-energy CT, etc.). Abdom Imaging. 2011 Jun;36(3):273–81.

Douek PC, Boccalini S, Oei EHG, et al. Clinical Applications of Photon-counting CT: A Review of Pioneer Studies and a Glimpse into the Future. Radiology 2023; 309(1):e222432

Article  PubMed  Google Scholar 

Willemink MJ, Persson M, Pourmorteza A, et al. Photon-counting CT: technical principles and clinical prospects. Radiology. 2018;289:293–312.

Article  PubMed  Google Scholar 

DanielssonM, Persson M, Sjölin M. Photon-counting x-ray detectors for CT. Phys Med Biol. 2021;66:03tr1.

Flohr T, Petersilka M, Henning A, Ulzheimer S, Ferda J, Schmidt B. Photon-Counting CT review. Phys Med 2020; 79: S1120–1797(20)30273–8:126–36:

Pourmorteza A, Symons R, Reich DS, et al. Photon-Counting CT of the Brain: In Vivo Human Results and Image-Quality Assessment. AJNR Am J Neuroradiol. 2017 Dec;38(12):2257–2263.

Symons R, Reich DS, Bagheri M, et al. Photon-Counting Computed Tomography for Vascular Imaging of the Head and Neck: First In Vivo Human Results. Invest Radiol. 2018 Mar;53(3):135-142.

Article  PubMed  PubMed Central  Google Scholar 

McCollough, C.H., Rajendran, K., Leng, S. et al. The technical development of photon-counting detector CT. Eur Radiol 33, 5321–5330 (2023).

Article  PubMed  PubMed Central  Google Scholar 

Wrazidlo R, Walder L, Estler A, et al. Radiation Dose Reduction in Contrast-Enhanced Abdominal CT: Comparison of Photon-Counting Detector CT with 2nd Generation Dual-Source Dual-Energy CT in an oncologic cohort. Acad Radiol. 2023 May;30(5):855-862.

Article  PubMed  Google Scholar 

Decker JA, Bette S, Lubina N, et al. Low-dose CT of the abdomen: Initial experience on a novel photon-counting detector CT and comparison with energy-integrating detector CT. Eur J Radiol. 2022 Mar;148:110181.

Article  PubMed  Google Scholar 

Schwartz FR, Samei E, Marin D. Exploiting the Potential of Photon-Counting CT in Abdominal Imaging. Invest Radiol. 2023 Jul 1;58(7):488-498.

Article  PubMed  Google Scholar 

Hagen F, Hofmann J, Wrazidlo R, et al. Image quality and dose exposure of contrast-enhanced abdominal CT on a 1st generation clinical dual-source photon-counting detector CT in obese patients vs. a 2nd generation dual-source dual energy integrating detector CT. Eur J Radiol. 2022 Jun;151:110325.

Sawall S, Klein L, Amato C, et al. Iodine contrast-to-noise ratio improvement at unit dose and contrast media volume reduction in whole-body photon-counting CT. Eur J Radiol. 2020 May;126:108909.

Article  CAS  PubMed  Google Scholar 

Hagen F, Estler A, Hofmann J, et al. Reduced versus standard dose contrast volume for contrast-enhanced abdominal CT in overweight and obese patients using photon counting detector technology vs. second-generation dual-source energy integrating detector CT. Eur J Radiol. 2023 Dec;169:111153.

Sartoretti T, Landsmann A, Nakhostin D, et al. Quantum Iterative Reconstruction for Abdominal Photon-counting Detector CT Improves Image Quality. Radiology. 2022 May;303(2):339-348.

Article  PubMed  Google Scholar 

Higashigaito K, Euler A, Eberhard M, Flohr TG, Schmidt B, Alkadhi H. Contrast-Enhanced Abdominal CT with Clinical Photon-Counting Detector CT: Assessment of Image Quality and Comparison with Energy-Integrating Detector CT. Acad Radiol. 2022 May;29(5):689-697.

Article  PubMed  Google Scholar 

Graafen D, Müller L, Halfmann MC, et al. Soft Reconstruction Kernels Improve HCC Imaging on a Photon-Counting Detector CT. Acad Radiol. 2023 Sep;30 Suppl 1:S143-S154.

Article  PubMed  Google Scholar 

Bette S, Decker JA, Braun FM, et al. Optimal Conspicuity of Liver Metastases in Virtual Monochromatic Imaging Reconstructions on a Novel Photon-Counting Detector CT-Effect of keV Settings and BMI. Diagnostics (Basel). 2022;12(5):1231.

Article  PubMed  PubMed Central  Google Scholar 

Graafen D, Müller L, Halfmann M, Düber C, Hahn F, Yang Y, Emrich T, Kloeckner R. Photon-counting detector CT improves quality of arterial phase abdominal scans: A head-to-head comparison with energy-integrating CT. Eur J Radiol. 2022;156:110514.

Article  CAS  PubMed  Google Scholar 

McCollough CH, Leng S,Yu L, et al. Dual- andmulti-energy CT: principles, technical approaches, and clinical applications. Radiology. 2015;276:637–653.

Article  PubMed  Google Scholar 

Booij R, van der Werf NR, Dijkshoorn ML, van der Lugt A, van Straten M. Assessment of Iodine Contrast-To-Noise Ratio in Virtual Monoenergetic Images Reconstructed from Dual-Source Energy-Integrating CT and Photon-Counting CT Data. Diagnostics (Basel). 2022;12(6):1467.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Marcus RP, Fletcher JG, Ferrero A, et al. Detection and Characterization of Renal Stones by Using Photon-Counting-based CT. Radiology. 2018;289(2):436-442.

Article  PubMed  Google Scholar 

Sawall S, Klein L, Wehrse E, Rotkopf LT, Amato C, Maier J, Schlemmer HP, Ziener CH, Heinze S, Kachelrieß M. Threshold-dependent iodine imaging and spectral separation in a whole-body photon-counting CT system. Eur Radiol. 2021 Sep;31(9):6631-6639.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Racine D, Mergen V, Viry A, Frauenfelder T, Alkadhi H, Vitzthum V, Euler A. Photon-Counting Detector CT for Liver Lesion Detection-Optimal Virtual Monoenergetic Energy for Different Simulated Patient Sizes and Radiation Doses. Invest Radiol. 2024 Jan 9.

McCollough CH, Rajendran K, Baffour FI, et al. Clinical applications of photon counting detector CT. Eur Radiol. 2023 Aug;33(8):5309-5320.

Article  PubMed  PubMed Central  Google Scholar 

Sartoretti T, Mergen V, Higashigaito K, Eberhard M, Alkadhi H, Euler A. Virtual Noncontrast Imaging of the Liver Using Photon-Counting Detector Computed Tomography: A Systematic Phantom and Patient Study. Invest Radiol. 2022 Jul 1;57(7):488-493.

Article  CAS  PubMed  Google Scholar 

Mergen V, Racine D, Jungblut L, et al. Virtual Noncontrast Abdominal Imaging with Photon-counting Detector CT. Radiology. 2022 Oct;305(1):107-115.

Article  PubMed  Google Scholar 

Burkhart RA, Pawlik TM. Staging and Prognostic Models for Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma. Cancer Control. 2017 Jul-Sep;24(3):1073274817729235.

Brown ZJ, Tsilimigras DI, Ruff SM, et al. Management of Hepatocellular Carcinoma: A Review. JAMA Surg. 2023 Apr 1;158(4):410-420.

Article  PubMed  Google Scholar 

Onishi H, Kim T, Imai Y, et al. Hypervascular hepatocellular carcinomas: detection with gadoxetate disodium-enhanced MR imaging and multiphasic multidetector CT. Eur Radiol. 2012 Apr;22(4):845-54.

Article  PubMed  Google Scholar 

Kuchay MS, Choudhary NS, Mishra SK. Pathophysiological mechanisms underlying MAFLD. Diabetes Metab Syndr. 2020 Nov-Dec;14(6):1875–1887.

Hyodo T, Hori M, Lamb P, et al. Multimaterial Decomposition Algorithm for the Quantification of Liver Fat Content by Using Fast-Kilovolt-Peak Switching Dual-Energy CT: Experimental Validation. Radiology. 2017;282(2):381-389.

Article  PubMed  Google Scholar 

Niehoff JH, Woeltjen MM, Saeed S, et al. Assessment of hepatic steatosis based on virtual non-contrast computed tomography: Initial experiences with a photon counting scanner approved for clinical use. Eur J Radiol. 2022 Apr;149:110185.

Article  PubMed  Google Scholar 

Hollý S, Chmelík M, Suchá S, et al. Photon-counting CT using multi-material decomposition algorithm enables fat quantification in the presence of iron deposits. Phys Med. 2024 Feb;118:103210.

Article  PubMed  Google Scholar 

Cai J, Chen H, Lu M, et al. Advances in the epidemiology of pancreatic cancer: Trends, risk factors, screening, and prognosis. Cancer Lett. 2021 Nov 1;520:1-11.

Article  Google Scholar 

Gandhi NS, Feldman MK, Le O, et al. Imaging mimics of pancreatic ductal adenocarcinoma. Abdom Radiol (NY). 2018;43:273–284.

Article  PubMed 

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