Singh A, et al. Aging and Inflammation. Cold Spring Harbor Perspect Med. 2024;14(6):a041197.

Article  Google Scholar 

Fulop T, et al. Immunology of Aging: the Birth of Inflammaging. Clin Rev Allergy Immunol. 2023;64(2):109–22.

Article  CAS  PubMed  Google Scholar 

Tilstra JS, et al. NF-κB in Aging and Disease. Aging Dis. 2011;2(6):449–65.

PubMed  PubMed Central  Google Scholar 

Widjaja AA, et al. Inhibition of IL-11 signalling extends mammalian healthspan and lifespan. Nature. 2024;632(8023):157–65.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tyshkovskiy A, et al. Identification and Application of Gene Expression Signatures Associated with Lifespan Extension. Cell Metab. 2019;30(3):573-593.e8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tyshkovskiy A, et al. Distinct longevity mechanisms across and within species and their association with aging. Cell. 2023;186(13):2929-2949.e20.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li X, et al. Muscle-dependent regulation of adipose tissue function in long-lived growth hormone-mutant mice. Aging (Albany NY). 2020;12(10):8766–89.

Article  CAS  PubMed  Google Scholar 

Jayarathne HSM, et al. Neuroprotective effects of Canagliflozin: Lessons from aged genetically diverse UM-HET3 mice. Aging Cell. 2022;21(7):e13653.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang J, et al. Caloric restriction favorably impacts metabolic and immune/inflammatory profiles in obese mice but curcumin/piperine consumption adds no further benefit. Nutr Metab. 2013;10(1):29.

Article  Google Scholar 

Liu Y, et al. Rapamycin: a bacteria-derived immunosuppressant that has anti-atherosclerotic effects and its clinical application. Front Pharmacol. 2019;9:1520.

Article  PubMed  PubMed Central  Google Scholar 

Dumont FJ, Su Q. Mechanism of action of the immunosuppressant rapamycin. Life Sci. 1996;58(5):373–95.

Article  CAS  PubMed  Google Scholar 

Varghese Z, et al. Effects of sirolimus on mesangial cell cholesterol homeostasis: a novel mechanism for its action against lipid-mediated injury in renal allografts. Am J Physiol Renal Physiol. 2005;289(1):F43–8.

Article  CAS  PubMed  Google Scholar 

Ge C, et al. Rapamycin suppresses inflammation and increases the interaction between p65 and IκBα in rapamycin-induced fatty livers. PLoS ONE. 2023;18(3):e0281888.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wink L, Miller RA, Garcia GG. Rapamycin, Acarbose and 17α-estradiol share common mechanisms regulating the MAPK pathways involved in intracellular signaling and inflammation. Immun Ageing. 2022;19(1):8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lawrence T. The nuclear factor NF-kappaB pathway in inflammation. Cold Spring Harb Perspect Biol. 2009;1(6):a001651.

Article  PubMed  PubMed Central  Google Scholar 

Liu T, et al. NF-κB signaling in inflammation. Signal Transduct Target Ther. 2017;2(1):17023.

Article  PubMed  PubMed Central  Google Scholar 

Yu Y, Wan Y, Huang C. The biological functions of NF-kappaB1 (p50) and its potential as an anti-cancer target. Curr Cancer Drug Targets. 2009;9(4):566–71.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Buss H, et al. Cyclin-dependent kinase 6 phosphorylates NF-κB P65 at serine 536 and contributes to the regulation of inflammatory gene expression. PLoS ONE. 2012;7(12): e51847.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ke B, et al. Inactivation of NF-κB p65 (RelA) in Liver Improves Insulin Sensitivity and Inhibits cAMP/PKA Pathway. Diabetes. 2015;64(10):3355–62.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li P, et al. NCoR repression of LXRs restricts macrophage biosynthesis of insulin-sensitizing omega 3 fatty acids. Cell. 2013;155(1):200–14.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wilkaniec A, et al. Inhibition of cyclin-dependent kinase 5 affects early neuroinflammatory signalling in murine model of amyloid beta toxicity. J Neuroinflammation. 2018;15(1):1.

Article  PubMed  PubMed Central  Google Scholar 

Abe Y, et al. RANK ligand converts the NCoR/HDAC3 co-repressor to a PGC1β- and RNA-dependent co-activator of osteoclast gene expression. Mol Cell. 2023;83(19):3421-3437.e11.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Elmansi AM, Miller RA. Coordinated transcriptional upregulation of oxidative metabolism proteins in long-lived endocrine mutant mice. Geroscience. 2023;45(5):2967–81.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Armour SM, et al. An HDAC3-PROX1 corepressor module acts on HNF4α to control hepatic triglycerides. Nat Commun. 2017;8(1):549–549.

Article  PubMed  PubMed Central  Google Scholar 

Sun Z, et al. Deacetylase-independent function of HDAC3 in transcription and metabolism requires nuclear receptor corepressor. Mol Cell. 2013;52(6):769–82.

Article  CAS  PubMed  Google Scholar 

Pérez-Schindler J, et al. The corepressor NCoR1 antagonizes PGC-1α and estrogen-related receptor α in the regulation of skeletal muscle function and oxidative metabolism. Mol Cell Biol. 2012;32(24):4913–24.

Article  PubMed  PubMed Central  Google Scholar 

Yamamoto H, et al. NCoR1 is a conserved physiological modulator of muscle mass and oxidative function. Cell. 2011;147(4):827–39.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sen K, et al. NCoR1 controls immune tolerance in conventional dendritic cells by fine-tuning glycolysis and fatty acid oxidation. Redox Biol. 2023;59:102575–102575.

Article  CAS  PubMed  Google Scholar 

Shao S, et al. Macrophage Nuclear Receptor Corepressor 1 Deficiency Protects Against Ischemic Stroke in Mice. J Cardiovasc Transl Res. 2022;15(4):816–27.

Article  PubMed  Google Scholar 

Ehle C, et al. Downregulation of HNF4A enables transcriptomic reprogramming during the hepatic acute-phase response. Communications Biology. 2024;7(1):589.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Babeu JP, Boudreau F. Hepatocyte nuclear factor 4-alpha involvement in liver and intestinal inflammatory networks. World J Gastroenterol. 2014;20(1):22–30.

Article  CAS  PubMed