Cassar GE, Youssef GJ, Knowles S, Moulding R, Austin DW. Health-related quality of life in irritable bowel syndrome: A systematic review and meta-analysis. Gastroenterol Nurs 2020, 43: E102–E122.
Price DD, Zhou Q, Moshiree B, Robinson ME, Verne GN. Peripheral and central contributions to hyperalgesia in irritable bowel syndrome. J Pain 2006, 7: 529–535.
Lv MD, Wei YX, Chen JP, Cao MY, Wang QL, Hu S. Melatonin attenuated chronic visceral pain by reducing Nav1.8 expression and nociceptive neuronal sensitization. Mol Pain 2023, 19: 17448069231170072.
Article PubMed PubMed Central CAS Google Scholar
Romeo RD, Mueller A, Sisti HM, Ogawa S, McEwen BS, Brake WG. Anxiety and fear behaviors in adult male and female C57BL/6 mice are modulated by maternal separation. Horm Behav 2003, 43: 561–567.
Millstein RA, Holmes A. Effects of repeated maternal separation on anxiety- and depression-related phenotypes in different mouse strains. Neurosci Biobehav Rev 2007, 31: 3–17.
Hu S, Sun Q, Du WJ, Song J, Li X, Zhang PA. Adult stress promotes purinergic signaling to induce visceral pain in rats with neonatal maternal deprivation. Neurosci Bull 2020, 36: 1271–1280.
Article PubMed PubMed Central CAS Google Scholar
Dos Santos Júnior ED, Da Silva AV, Da Silva KRT, Haemmerle CAS, Batagello DS, Da Silva JM, et al. The centrally projecting Edinger-Westphal nucleus—I: Efferents in the rat brain. J Chem Neuroanat 2015, 68: 22–38.
Ramanathan KR, Jin J, Giustino TF, Payne MR, Maren S. Prefrontal projections to the thalamic nucleus reuniens mediate fear extinction. Nat Commun 2018, 9: 4527.
Article PubMed PubMed Central Google Scholar
Kafetzopoulos V, Kokras N, Sotiropoulos I, Oliveira JF, Leite-Almeida H, Vasalou A, et al. The nucleus reuniens: A key node in the neurocircuitry of stress and depression. Mol Psychiatry 2018, 23: 579–586.
Article PubMed CAS Google Scholar
Bushnell MC, Ceko M, Low LA. Cognitive and emotional control of pain and its disruption in chronic pain. Nat Rev Neurosci 2013, 14: 502–511.
Article PubMed PubMed Central CAS Google Scholar
Xiao X, Ding M, Zhang YQ. Role of the anterior cingulate cortex in translational pain research. Neurosci Bull 2021, 37: 405–422.
Article PubMed PubMed Central Google Scholar
Krout KE, Belzer RE, Loewy AD. Brainstem projections to midline and intralaminar thalamic nuclei of the rat. J Comp Neurol 2002, 448: 53–101.
Vertes RP, Linley SB, Hoover WB. Pattern of distribution of serotonergic fibers to the thalamus of the rat. Brain Struct Funct 2010, 215: 1–28.
Article PubMed CAS Google Scholar
Hoover WB, Vertes RP. Anatomical analysis of afferent projections to the medial prefrontal cortex in the rat. Brain Struct Funct 2007, 212: 149–179.
Scheel N, Wulff P, de Mooij-van Malsen JG. Afferent connections of the thalamic nucleus reuniens in the mouse. J Comp Neurol 2020, 528: 1189–1202.
Zhou W, Jin Y, Meng Q, Zhu X, Bai T, Tian Y, et al. A neural circuit for comorbid depressive symptoms in chronic pain. Nat Neurosci 2019, 22: 1649–1658.
Article PubMed CAS Google Scholar
Hao S, Shi W, Liu W, Chen QY, Zhuo M. Multiple modulatory roles of serotonin in chronic pain and injury-related anxiety. Front Synaptic Neurosci 2023, 15: 1122381.
Article PubMed PubMed Central CAS Google Scholar
Sharp T, Barnes NM. Central 5-HT receptors and their function; present and future. Neuropharmacology 2020, 177: 108155.
Article PubMed CAS Google Scholar
Lambe EK, Aghajanian GK. Electrophysiology of 5-HT2A receptors and relevance for hallucinogen and atypical antipsychotic drug actions. Serotonin Recept 2006, 403-417.
Marek GJ (2010) Electrophysiology of serotonin receptors. Handbook of Behavioral Neuroscience, Elsevier, Amsterdam, pp 163–182.
Aira Z, Buesa I, García Del Caño G, Bilbao J, Doñate F, Zimmermann M, et al. Transient, 5-HT2B receptor-mediated facilitation in neuropathic pain: Up-regulation of PKCγ and engagement of the NMDA receptor in dorsal horn neurons. Pain 2013, 154: 1865–1877.
Article PubMed CAS Google Scholar
Borman RA, Burleigh DE. 5-HT1D and 5-HT2B receptors mediate contraction of smooth muscle in human small intestine. Ann N Y Acad Sci 1997, 812: 222–223.
Article PubMed CAS Google Scholar
Xu QY, Zhang HL, Du H, Li YC, Ji FH, Li R, et al. Identification of a glutamatergic claustrum-anterior cingulate cortex circuit for visceral pain processing. J Neurosci 2022, 42: 8154–8168.
Article PubMed PubMed Central CAS Google Scholar
Li YC, Wang Q, Li MG, Hu SF, Xu GY. A paraventricular hypothalamic nucleus input to ventral of lateral septal nucleus controls chronic visceral pain. Pain 2023, 164: 625–637.
Article PubMed CAS Google Scholar
Wang HJ, Xu X, Zhang PA, Li M, Zhou YL, Xu YC, et al. Epigenetic upregulation of acid-sensing ion channel 1 contributes to gastric hypersensitivity in adult offspring rats with prenatal maternal stress. Pain 2020, 161: 989–1004.
Article PubMed CAS Google Scholar
Wu YY, Zhang HL, Lu X, Du H, Li YC, Zhang PA, et al. Targeting GATA1 and p2x7r locus binding in spinal astrocytes suppresses chronic visceral pain by promoting DNA demethylation. Neurosci Bull 2022, 38: 359–372.
Article PubMed CAS Google Scholar
Huang ST, Chen BB, Song ZJ, Tang HL, Hua R, Zhang YM. Unraveling the role of Epac1-SOCS3 signaling in the development of neonatal-CRD-induced visceral hypersensitivity in rats. CNS Neurosci Ther 2022, 28: 1393–1408.
Article PubMed PubMed Central CAS Google Scholar
Wang D, Wang X, Liu P, Jing S, Du H, Zhang L, et al. Serotonergic afferents from the dorsal raphe decrease the excitability of pyramidal neurons in the anterior piriform cortex. Proc Natl Acad Sci U S A 2020, 117: 3239–3247.
Article PubMed PubMed Central CAS Google Scholar
Li X, Xu YC, Tian YQ, Zhang PA, Hu SF, Wang LH, et al. Downregulation of GRK6 in arcuate nucleus promotes chronic visceral hypersensitivity via NF-κB upregulation in adult rats with neonatal maternal deprivation. Mol Pain 2020, 16: 1744806920930858.
Article PubMed PubMed Central CAS Google Scholar
Zhang PA, Zhu HY, Xu QY, Du WJ, Hu S, Xu GY. Sensitization of P2X3 receptors in insular cortex contributes to visceral pain of adult rats with neonatal maternal deprivation. Mol Pain 2018, 14: 1744806918764731.
Article PubMed PubMed Central CAS Google Scholar
Zhang PA, Xu QY, Xue L, Zheng H, Yan J, Xiao Y, et al. Neonatal maternal deprivation enhances presynaptic P2X7 receptor transmission in insular cortex in an adult rat model of visceral hypersensitivity. CNS Neurosci Ther 2017, 23: 145–154.
Article PubMed CAS Google Scholar
Xiao Y, Chen X, Zhang PA, Xu Q, Zheng H, Xu GY. TRPV1-mediated presynaptic transmission in basolateral amygdala contributes to visceral hypersensitivity in adult rats with neonatal maternal deprivation. Sci Rep 2016, 6: 29026.
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