Assessment of Cardiac, Hepatic and Pancreatic Iron Overload in Transfusion Dependent Thalassemia Patients Using T2* Magnetic Resonance Imaging

Rund D, Rachmilewitz E, Beta-thalassemia (2005) N Engl J Med 353:1135–1146

Article  CAS  PubMed  Google Scholar 

Hershko C, Link G, Konijn AM et al (2005) Objectives and mechanism of iron chelation therapy. Ann N Y AcadSci 1054:124–135

Article  CAS  Google Scholar 

Gabutti V, Piga A, Sacchetti L et al (1989) Quality of life and life expectancy in thalassemic patients with complications. Prog ClinBiol Res 309:35–41

CAS  Google Scholar 

Porter JB, Davis BA (2002) Monitoring chelation therapy to achieve optimal outcome in the treatment of Thalassaemia. Best Pract Res Clin Haematol 15:329–368

Article  PubMed  Google Scholar 

Gandon Y, Olivie D, Guyader D et al (2004) Non-invasive assessment of hepatic iron stores by MRI. Lancet 363:357–362

Article  CAS  PubMed  Google Scholar 

Pennell DJT (2005) 2* magnetic resonance and myocardial iron in Thalassemia. Ann N Y AcadSci 1054:373–378

Article  CAS  Google Scholar 

Rashid merchant, Ahmed J (april, 2012) Pradeep Krishnan and Bhavin Jankharia; efficacy and safety of deferasirox for reducing total body and cardiac iron in Thalassemia. Indian Pediatr Volume 49:281–285

Kaltwasser JP, Gottschalk R, Schalk KP et al (1990) Noninvasive quantitation of liver iron-overload by magnetic resonance imaging. Br J Haematol 74:360–363

Article  CAS  PubMed  Google Scholar 

Chezmar JL, Nelson RC, Malko JA et al (1990) Hepatic iron overload: diagnosis and quantification by noninvasive imaging. Gastrointest Radiol 15:27–31

Article  CAS  PubMed  Google Scholar 

Garbowski MW, Carpenter JP, Smith G, Roughton M, Alam MH, He T et al (2014) Biopsy-based calibration of T2* magnetic resonance for estimation of Liver Iron Concentration and Comparison with R2 Ferriscan. J Cardiovasc Magn Reson 16:40

Article  PubMed  PubMed Central  Google Scholar 

Carpenter J-P, He T, Kirk P, Roughton M, Anderson LJ, de Noronha SV et al (2011) On T2* magnetic resonance and cardiac iron. Circulation 123(14):1519–1528

Article  PubMed  PubMed Central  Google Scholar 

de Valke B, Marx MDJJM (1999) MD PhD; iron, atherosclerosis & ischemic heart disease; arch intern med. ; 159;1542–1548

Shahram Akhlaghpoor1, Hoseini M, Jafarisepehr A (2010) Association of iron overload based quantitative T2* MRI technique and carotid intima-media thickness in patients with beta-thalassemia: a cross-sectional study. BMC Cardiovasc Disord 10:62

Article  Google Scholar 

Hossain MS, Raheem E, Sultana TA, ferdous, et al (2017) Thalassemia in South Asia: clinical lessons learnt from Bangladesh. Orphanet J Rare Dis 12(1):93. https://doi.org/10.1186/s13023-017-0643-z

Article  PubMed  PubMed Central  Google Scholar 

Karakus V, Kurtoğlu A, Soysal DE, Dere Y, Bozkurt S, Kurtoğlu E (2017) Evaluation of Iron overload in the heart and liver tissue by Magnetic Resonance Imaging and its relation to Serum Ferritin and hepcidin concentrations in patients with thalassemia syndromes. Indian J Hematol Blood Transfus 33(3):389–395 Epub 2016 Oct 7. PMID: 28824242; PMCID: PMC5544633

Article  PubMed  Google Scholar 

Majd Z, Haghpanah S, Ajami GH, Matin S, Namazi H, Bardestani M, Karimi M (2015) Serum ferritin levels correlation with heart and liver MRI and LIC in patients with transfusion-dependent thalassemia. Iran Red Crescent Med J 17(4):e24959. https://doi.org/10.5812/ircmj.17(4)2015.24959 PMID: 26023341; PMCID: PMC4443302

Article  PubMed  PubMed Central  Google Scholar 

Eghbali A, Taherahmadi H, Shahbazi M, Bagheri B, Ebrahimi L (2014) Association between serum ferritin level, cardiac and hepatic T2-star MRI in patients with major β-thalassemia. Iran J Ped Hematol Oncol 4(1):17–21 Epub 2014 Feb 20. PMID: 24734159; PMCID: PMC3980017

CAS  PubMed  PubMed Central  Google Scholar 

Khaled A, Ezzat D, Salem H, Seif H, Rabea H (2019) Effective method of evaluating myocardial iron concentration in pediatric patients with Thalassemia major. J Blood Med Volume 10. https://doi.org/10.2147/JBM.S204848

Yang G, Liu R, Peng P, Long L, Zhang X, Yang W, Tan S, Pan H, Long X, He T, Anderson L, Lai Y (2014) How early can myocardial iron overload occur in beta thalassemia major? PLoS ONE 9(1):e85379. https://doi.org/10.1371/journal.pone.0085379 PMID: 24465548; PMCID: PMC3899006

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wahidiyat PA, Liauw F, Sekarsari D, Putriasih SA, Berdoukas V, Pennell DJ (2017) Evaluation of cardiac and hepatic iron overload in Thalassemia major patients with T2* magnetic resonance imaging. Hematology 22(8):501–507 Epub 2017 Feb 20. PMID: 28218005

CAS  PubMed  Google Scholar 

Wood JC, Tyszka JM, Carson S, Nelson MD, Coates TD (2004) Myocardial iron loading in transfusion-dependent thalassemia and sickle cell disease. Blood. 103(5):1934-6. https://doi.org/10.1182/blood-2003-06-1919. Epub 2003 Nov 20. PMID: 14630822

Marsella M, Borgna-Pignatti C, Meloni A, Caldarelli V, Dell’Amico MC, Spasiano A, Pitrolo L, Cracolici E, Valeri G, Positano V, Lombardi M, Pepe A (2011) Cardiac iron and cardiac disease in males and females with transfusion-dependent thalassemia major: a T2* magnetic resonance imaging study. Haematologica 96(4):515–520 Epub 2011 Jan 12. PMID: 21228034; PMCID: PMC3069227

Article  PubMed  PubMed Central  Google Scholar 

Bayraktaroǧlu S, Aydinok Y, Yildiz D, Uluer H, Savaş R, Alper H, T86 (2011) Diagn Interv Radiol 17(4):346–351. https://doi.org/10.4261/1305-3825.DIR.3933-10.2

Article  PubMed  Google Scholar 

Anderson LJ, Holden S, Davis B et al (2001) Cardiovascular T2-star (T2*) magnetic resonance for the early diagnosis of myocardial iron overload. Eur Heart J 22(23):2171–2179. https://doi.org/10.1053/euhj.2001.2822

Article  CAS  PubMed  Google Scholar 

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