Sabih A, Leslie SW. Complicated Urinary Tract Infections Treasure Island (FL), 2023.

U.S. Department of Health and Human Services Food and Drug Administration Center for Drug Evaluation and Research. Complicated urinary tract infections: developing drugs for treatment. Guidance for industry. Revision 1. FDA. Available online: https://www.fda.gov/media/71313/download

Committee for Human Medicinal Products (CHMP). Guideline on the evaluation of medicinal products indicated for treatment of bacterial infections, Rev. 3. (EMA/844951/2018 Rev. 3). European Medicines Agency. Available online: https://www.ema.europa.eu/en/documents/scientific-guideline/draft-guideline-evaluation-medicinal-products-indicated-treatment-bacterial-infections-revision-3_en.pdf

Simmering JE, Tang F, Cavanaugh JE, Polgreen LA, Polgreen PM. The increase in hospitalizations for urinary tract infections and the Associated costs in the United States, 1998–2011. Open Forum Infect Dis. 2017;4:ofw281. https://doi.org/10.1093/ofid/ofw281.

Article  PubMed  PubMed Central  Google Scholar 

Zilberberg MD, Nathanson BH, Sulham K, Shorr AF. Descriptive epidemiology and outcomes of hospitalizations with complicated urinary tract infections in the United States, 2018. Open Forum Infect Dis. 2022;9:ofab591. https://doi.org/10.1093/ofid/ofab591.

Article  PubMed  PubMed Central  Google Scholar 

Codelia-Anjum A, Lerner LB, Elterman D, Zorn KC, Bhojani N, Chughtai B. Enterococcal urinary tract infections: a review of the pathogenicity, epidemiology, and treatment. Antibiot (Basel). 2023;12. https://doi.org/10.3390/antibiotics12040778.

Chen Y-Y, Chen L-Y, Lin S-Y, Chou P, Liao S-Y, Wang F-D. Surveillance on secular trends of incidence and mortality for device-associated infection in the intensive care unit setting at a tertiary medical center in Taiwan, 2000–2008: a retrospective observational study. BMC Infect Dis. 2012;12. https://doi.org/10.1186/1471-2334-12-209.

Zilberberg MD, Nathanson BH, Sulham K, Shorr AF. Antimicrobial susceptibility and cross-resistance patterns among common complicated urinary tract infections in U.S. hospitals, 2013 to 2018. Antimicrob Agents Chemother. 2020;64. https://doi.org/10.1128/AAC.00346-20.

Soheili S, Ghafourian S, Sekawi Z, Neela V, Sadeghifard N, Ramli R, Hamat RA. Wide distribution of virulence genes among Enterococcus faecium and Enterococcus faecalis clinical isolates. ScientificWorldJournal 2014, 2014, 623174, https://doi.org/10.1155/2014/623174

Strateva T, Atanasova D, Savov E, Petrova G, Mitov I. Incidence of virulence determinants in clinical Enterococcus faecalis and Enterococcus faecium isolates collected in Bulgaria. Braz J Infect Dis. 2016;20:127–33. https://doi.org/10.1016/j.bjid.2015.11.011.

Article  PubMed  PubMed Central  Google Scholar 

Shigemura K, Tanaka K, Okada H, Nakano Y, Kinoshita S, Gotoh A, Arakawa S, Fujisawa M. Pathogen occurrence and antimicrobial susceptibility of urinary tract infection cases during a 20-year period (1983–2002) at a single institution in Japan. Jpn J Infect Dis. 2005;58:303–8.

Article  PubMed  Google Scholar 

Weiner-Lastinger LM, Abner S, Edwards JR, Kallen AJ, Karlsson M, Magill SS, Pollock D, See I, Soe MM, Walters MS, et al. Antimicrobial-resistant pathogens associated with adult healthcare-associated infections: Summary of data reported to the National Healthcare Safety Network, 2015–2017. Infect Control Hosp Epidemiol. 2020;41:1–18. https://doi.org/10.1017/ice.2019.296.

Article  PubMed  Google Scholar 

Esparcia A, Artero A, Eiros JM, Balaguer M, Madrazo M, Alberola J, Nogueira JM. Influence of inadequate antimicrobial therapy on prognosis in elderly patients with severe urinary tract infections. Eur J Intern Med. 2014;25:523–7. https://doi.org/10.1016/j.ejim.2014.04.009.

Article  PubMed  Google Scholar 

Arias CA, Murray BE. The rise of the Enterococcus: beyond Vancomycin resistance. Nat Rev Microbiol. 2012;10:266–78. https://doi.org/10.1038/nrmicro2761.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jindal J, Meelu A, Kaur S, Chahal HS, Makkar V, Garg V. Clinical Profile and Outcome in patients of complicated urinary tract infections: a single-center prospective observational study. Int J Appl Basic Med Res. 2022;12:167–70. https://doi.org/10.4103/ijabmr.ijabmr_50_22.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Eliakim-Raz N, Babitch T, Shaw E, Addy I, Wiegand I, Vank C, Torre-Vallejo L, Joan-Miquel V, Steve M, Grier S, et al. Risk factors for treatment failure and mortality among hospitalized patients with complicated urinary tract infection: a Multicenter Retrospective Cohort Study (RESCUING Study Group). Clin Infect Dis. 2019;68:29–36. https://doi.org/10.1093/cid/ciy418.

Article  PubMed  Google Scholar 

Karve S, Ryan K, Peeters P, Baelen E, Rojas-Farreras S, Potter D, Rodríguez-Baño J. The impact of initial antibiotic treatment failure: real-world insights in patients with complicated urinary tract infection. J Infect. 2018;76:121–31. https://doi.org/10.1016/j.jinf.2017.11.001.

Article  PubMed  Google Scholar 

Righolt CH, Lagace-Wiens P, Mahmud SM. Prevalence, predictors, and consequences of inappropriate empiric antimicrobial therapy for complicated urinary tract and intra-abdominal infections in Winnipeg hospitals. Diagn Microbiol Infect Dis. 2020;96:114891. https://doi.org/10.1016/j.diagmicrobio.2019.114891.

Article  PubMed  Google Scholar 

Zhu H, Chen Y, Hang Y, Luo H, Fang X, Xiao Y, Cao X, Zou S, Hu X, Hu L, et al. Impact of inappropriate empirical antibiotic treatment on clinical outcomes of urinary tract infections caused by Escherichia coli: a retrospective cohort study. J Global Antimicrob Resist. 2021;26:148–53. https://doi.org/10.1016/j.jgar.2021.05.016.

Article  CAS  Google Scholar 

Elm E. The strengthening the reporting of Observational studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. J Clin Epidemiol. 2008;61:344–9. https://doi.org/10.1016/j.jclinepi.2007.11.008. AltmanD.G.Egger, M.; Pocock, S.J.; Gøtzsche, P.C.; Vandenbroucke, J.P.

Article  Google Scholar 

Álvarez-Artero E, Campo-Nuñez A, García-García I, García-Bravo M, Cores-Calvo O, Galindo-Pérez I, Pendones-Ulerio J, López-Bernus A, Belhassen-García M, Pardo-Lledías J. Urinary tract infection caused by Enterococcus spp.: risk factors and mortality. An observational study. Rev Clin Esp (Barc). 2021;221:375–83. https://doi.org/10.1016/j.rceng.2020.09.004.

Article  PubMed  Google Scholar 

Madrazo M, Esparcia A, Alberola J, Ferrer A, Eiros JM, Nogueira JM, Artero A. Predictive factors for Enterococcus faecalis in complicated community-acquired urinary tract infections in older patients. Geriatr Gerontol Int. 2020;20:183–6. https://doi.org/10.1111/ggi.13856.

Article  PubMed  Google Scholar 

Turjeman A, Babich T, Pujol M, Carratalà J, Shaw E, Gomila-Grange A, Vuong C, Addy I, Wiegand I, Grier S, et al. Risk factors for enterococcal urinary tract infections: a multinational, retrospective cohort study. Eur J Clin Microbiol Infect Dis. 2021;40:2005–10. https://doi.org/10.1007/s10096-021-04207-4.

Article  PubMed  Google Scholar 

Friedman ND, Kaye KS, Stout JE, McGarry SA, Trivette SL, Briggs JP, Lamm W, Clark C, MacFarquhar J, Walton AL, et al. Health care–associated bloodstream infections in adults: a reason to change the accepted definition of community-acquired infections. Ann Intern Med. 2002;137:791–7. https://doi.org/10.7326/0003-4819-137-10-200211190-00007.

Article  PubMed  Google Scholar 

Bannay A, Chaignot C, Blotière P-O, Basson M, Weill A, Ricordeau P, Alla F. The best use of the Charlson Comorbidity Index with Electronic Health Care Database to Predict Mortality. Med Care. 2016;54:188–94. https://doi.org/10.1097/MLR.0000000000000471.

Article  PubMed  Google Scholar 

García-Solache M, Rice LB. The Enterococcus: a model of adaptability to its environment. Clin Microbiol Rev. 2019;32. https://doi.org/10.1128/CMR.00058-18.

Kafil HS, Mobarez AM. Assessment of biofilm formation by enterococci isolates from urinary tract infections with different virulence profiles. J King Saud Univ - Sci. 2015;27:312–7. https://doi.org/10.1016/j.jksus.2014.12.007.

Article  Google Scholar 

Miller WR, Munita JM, Arias CA. Mechanisms of antibiotic resistance in enterococci. Expert Rev Anti Infect Ther. 2014;12:1221–36. https://doi.org/10.1586/14787210.2014.956092.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zilberberg MD, Nathanson BH, Sulham K, Shorr AF. Multiple antimicrobial resistance and outcomes among hospitalized patients with complicated urinary tract infections in the US, 2013–2018: a retrospective cohort study. BMC Infect Dis. 2021;21:159. https://doi.org/10.1186/s12879-021-05842-0.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Moses V, Jerobin J, Nair A, Sathyendara S, Balaji V, George IA, Peter JV. Enterococcal Bacteremia is Associated with prolonged stay in the Medical Intensive Care Unit. J Glob Infect Dis. 2012;4:26–30. https://doi.org/10.4103/0974-777X.93758.

Article  PubMed  PubMed Central  Google Scholar 

Maeda M, Hasegawa T, Noma H, Ota E. Efficacy of carbapenems versus alternative antimicrobials for treating complicated urinary tract infections caused by antimicrobial-resistant Gram-negative bacteria: protocol for a systematic review and meta-analysis. BMJ Open. 2023;13:e069166. https://doi.org/10.1136/bmjopen-2022-069166.

Article  PubMed  PubMed Central  Google Scholar 

Portsmouth S, van Veenhuyzen D, Echols R, Machida M, Ferreira J.C.A., Ariyasu M, Tenke P., Nagata Tden. Cefiderocol versus imipenem-cilastatin for the treatment of complicated urinary tract infections caused by Gram-negative uropathogens: a phase 2, randomised, double-blind, non-inferiority trial. Lancet Infect Dis. 2018;18:1319–28. https://doi.org/10.1016/S1473-3099(18)30554-1.

Khalil MA, Alorabi JA, Al-Otaibi LM, Ali SS, Elsilk SE. Antibiotic Resistance and biofilm formation in Enterococcus spp. Isolated from urinary tract infections. Pathogens. 2022;12. https://doi.org/10.3390/pathogens12010034.

Asmarawati TP, Djojodimedjo T, Andhika DP, Rusli M, Qibtiyah M, Mahdi BA, Novendrianto D, Martani OS, Paraton H, Wertheim H, et al. The use of antibiotic prophylaxis in patients undergoing urologic procedures in an academic hospital surabaya: a retrospective study. J Infect Dev Ctries. 2023;17:874–80. https://doi.org/10.3855/jidc.17180.

Article  PubMed  Google Scholar 

Bilsen MP, Conroy SP, Schneeberger C, Platteel TN, van Nieuwkoop C, Mody L, Caterino JM, Geerlings SE, Köves B, Wagenlehner F, et al. A reference standard for urinary tract infection research: a multidisciplinary Delphi consensus study. Lancet Infect Dis. 2024;24:e513–21. https://doi.org/10.1016/S1473-3099(23)00778-8.