The transradial approach (TRA) had globally replaced the TFA as the primary access for CAG and PCI since decades. However, the TFA may be preferred in certain clinical situations such as in patient with previous CABG surgery or patient with failed TRA. Bleeding is the most common complication of the TFA and can manifest as hematoma, uncontrolled bleeding, pseudoaneurysm or retroperitoneal hemorrhage [4]. The incidence of major bleeding complications after PCI ranges from 2 to 6% [4, 5]. While inguinal hematoma is common, scrotal hematoma is very rare and only few cases reported in the studies. Few cases of scrotal/penoscrotal hematoma were reported with failed vascular closure device (VCD) [1, 2]. A scrotal hematoma occurs when the femoral puncture is at or very close to the inguinal ligament, with blood tracking along the spermatic cord into the scrotum [3]. Bleeding above the inguinal ligament such as retroperitoneal hemorrhage and bleeding from the inferior epigastric vessel through the pre-peritoneal space both may dissect down into the spermatic cord and the inguinal canal, causing groin and scrotal hematoma [6,7,8].

The risk of access site bleeding is higher in female sex, older age, obese patient, renal impairment, interventional procedures as compared to diagnostic procedures, use of anticoagulation, increased sheath size and use of glycoprotein IIb/IIIa antagonists.

To reduce access site bleeding complications, several approaches can be adopted. In our case, the left TRA may be a good option to avoid the TFA with additional benefit, which is easier engagement of the left internal mammary artery in comparison with TFA.

When choosing TFA, puncturing the femoral artery at the proper site will greatly reduce access site complications. This should be at the mid common femoral artery (CFA) above its bifurcation into the deep femoral artery and the superficial femoral artery. Using the inguinal ligament as a landmark, the femoral artery should be punctured at the area of maximal pulsation, 2–3 cm below the mid inguinal ligament. At this course, the femoral artery lies in front of the middle third of the head of the femur and can be easily compressed against the bone to achieve hemostasis after sheath removal. High femoral puncture above the inguinal ligament is associated with higher risk of retroperitoneal hemorrhage, while very low puncture increases the risk of pseudoaneurysm or arteriovenous (A-V) fistula.

Fluoroscopic or ultrasound-guided femoral access might help in localizing the proper site for femoral artery cannulation and reduce bleeding complications. Fluoroscopic-guided TFA uses the femoral head as a reference with the aim to do the skin prick over the inferior border of the middle third of femoral head. Ultrasound-guided femoral puncture can precisely localize the CFA and therefore avoid high or low femoral access. A recent randomized clinical trial (The UNIVERSAL Trial) “Routine Ultrasonography Guidance for Femoral Vascular Access for Cardiac Procedures” compared ultrasonography-guided approach on top of fluoroscopy versus fluoroscopy without ultrasonography for TFA. This trial showed that routine use of ultrasonography did not reduce the primary events of bleeding or vascular complications, but ultrasonography did reduce the risk of venipuncture and number of attempts [9].

Various types of vascular closure devices (VCD) had been used to achieve hemostasis and to replace manual or mechanical compression, e.g., AngioSeal (St. Jude Medical), Prostar XL (Abbott Vascular), Perclose ProGlide (Abbott Vascular). These devices allowed early ambulation of the patients and faster discharge, but did not reduce access site bleeding complications [1, 3, 10].

After finishing the procedure, performing angiography through the sidearm of the arterial sheath will identify any dissection, perforation or retroperitoneal hematoma and allowing the operator to intervene immediately.

The management of scrotal hematoma is usually conservative with painkillers, IV fluid, blood transfusion (when the blood loss is significant leading to drop in patient’s hemoglobin or hemodynamic instability), bed rest, elevation of the scrotum and observation. Surgery is only indicated when there is active bleeding due to vascular injury, enlarging hematoma or the blood supply to the testes is compromised [1].