World Health Organization. World Population Ageing (2019) https://www.un.org/en/development/desa/population/publications/pdf/ageing/WorldPopulationAgeing2019-Report.pdf. Accessed April 4 2024
Iburg KM, Charalampous P, Allebeck P et al (2023) Burden of disease among older adults in Europe-trends in mortality and disability, 1990–2019. Eur J Public Health 33(1):121–126. https://doi.org/10.1093/eurpub/ckac160
Polidori CM (2021) Physiology of aging as a basis of complexity in Aging Medicine and Geriatrics. Springer EBooks, pp 3824–3829. https://doi.org/10.1007/978-3-030-22009-9_548
Singh P (2013) Andropause: current concepts. Indian J Endocrinol Metab 17(9):621. https://doi.org/10.4103/2230-8210.123552
Khera M (2020) Controversies with testosterone therapy. Can J Urol 27(S3):20–23
Snyder PJ, Bhasin S, Cunningham GR et al (2018) Lessons from the testosterone trials. Endocr Rev 39(3):369–386. https://doi.org/10.1210/er.2017-00234
Article PubMed PubMed Central Google Scholar
Lincoff AM, Bhasin S, Flevaris P et al (2023) Cardiovascular Safety of testosterone-replacement therapy. N Engl J Med 389(2):107–111. https://doi.org/10.1056/nejmoa2215025
Article CAS PubMed Google Scholar
Oduwole OO, Huhtaniemi IT, Misrahi M (2021) The roles of luteinizing hormone, follicle-stimulating hormone and testosterone in spermatogenesis and folliculogenesis revisited. Int J Mol Sci 22(23):12735. https://doi.org/10.3390/ijms222312735
Article CAS PubMed PubMed Central Google Scholar
Dunn JF, Nisula BC, Rodbard D (1981) Transport of Steroid hormones: binding of 21 endogenous steroids to both testosterone-binding globulin and corticosteroid-binding globulin in human plasma. J Clin Endocrinol Metab 53(1):58–68. https://doi.org/10.1210/jcem-53-1-58
Article CAS PubMed Google Scholar
Schlich C, Romanelli F (2016) Issues surrounding testosterone replacement therapy. Hosp Pharm 51(9):712–720. https://doi.org/10.1310/hpj5109-712
Article CAS PubMed PubMed Central Google Scholar
Swerdloff RS, Dudley RE, Page ST et al (2017) Dihydrotestosterone: Biochemistry, Physiology, and clinical implications of elevated blood levels. Endocr Rev 38(3):220–254. https://doi.org/10.1210/er.2016-1067
Article PubMed PubMed Central Google Scholar
Jin Y, Penning TM (2001) Steroid 5α-reductases and 3α-hydroxysteroid dehydrogenases: key enzymes in androgen metabolism. Best Pract Res Clin Endocrinol Metab 15(1):79–94. https://doi.org/10.1053/beem.2001.0120
Article CAS PubMed Google Scholar
Finkelstein JS, Lee H, Burnett-Bowie S-AM et al (2013) Gonadal steroids and body composition, strength, and sexual function in men. N Engl J Med 369(11):1011–1022. https://doi.org/10.1056/nejmoa1206168
Article CAS PubMed PubMed Central Google Scholar
Ketchem JM, Bowman EJ, Isales CM (2023) Male sex hormones, aging, and inflammation. Biogerontology 24(1):1–25. https://doi.org/10.1007/s10522-022-10002-1
Article CAS PubMed PubMed Central Google Scholar
Li C, Ford ES, Li B, Giles WH, Liu S (2010) Association of Testosterone and Sex hormone-binding globulin with metabolic syndrome and insulin resistance in men. Diabetes Care 33(7):1618–1624. https://doi.org/10.2337/dc09-1788
Article CAS PubMed PubMed Central Google Scholar
Johannsson G, Gibney J, Wolthers T et al (2005) Independent and Combined effects of Testosterone and Growth hormone on Extracellular Water in Hypopituitary Men. J Clin Endocrinol Metab 90(7):3989–3994. https://doi.org/10.1210/jc.2005-0553
Article CAS PubMed Google Scholar
Santosa S, Bush NC, Jensen MD (2017) Acute Testosterone Deficiency alters adipose tissue fatty acid storage. J Clin Endocrinol Metab 102(8):3056–3064. https://doi.org/10.1210/jc.2017-00757
Article PubMed PubMed Central Google Scholar
Carmina E, Dreno B, Lucky WA et al (2022) Female adult acne and androgen excess: a Report from the multidisciplinary androgen excess and PCOS Committee. J Endocr Soc 6(3):bvad003. https://doi.org/10.1210/jendso/bvac003
Arora MK, Yadav A, Saini V (2011) Role of hormones in acne vulgaris. Clin Biochem 44(13):1035–1040. https://doi.org/10.1016/j.clinbiochem.2011.06.984
Article CAS PubMed Google Scholar
Chegeni R, Pallesen S, McVeigh J, Sagoe D (2021) Anabolic-androgenic steroid administration increases self-reported aggression in healthy males: a systematic review and meta-analysis of experimental studies. Psychopharmacology 238(7):1911–1922. https://doi.org/10.1007/s00213-021-05818-7
Article CAS PubMed PubMed Central Google Scholar
Wilson CM, McPhaul MJ (1996) A and B forms of the androgen receptor are expressed in a variety of human tissues. Mol Cell Endocrinol 120(1):51–57. https://doi.org/10.1016/0303-7207(96)03819-1
Article CAS PubMed Google Scholar
Alves JV, da Costa RM, Pereira CA et al (2020) Supraphysiological levels of Testosterone Induce Vascular Dysfunction via activation of the NLRP3 inflammasome. Front Immunol 11:1647. https://doi.org/10.3389/fimmu.2020.01647
Article CAS PubMed PubMed Central Google Scholar
Wu FCW, Tajar A, Pye SR et al (2008) Hypothalamic-pituitary-testicular Axis disruptions in older men are differentially linked to age and modifiable risk factors: the European Male Aging Study. J Clin Endocrinol Metab 93(7):2737–2745. https://doi.org/10.1210/jc.2007-1972
Article CAS PubMed Google Scholar
Handelsman DJ, Yeap BB, Flicker L et al (2015) Age-specific population centiles for androgen status in men. Eur J Endocrinol 173(6):809–817. https://doi.org/10.1530/eje-15-0380
Article CAS PubMed Google Scholar
Travison TG, Araujo AB, Kupelian V et al (2007) The relative contributions of aging, Health, and lifestyle factors to serum testosterone decline in men. J Clin Endocrinol Metab 92(2):549–555. https://doi.org/10.1210/jc.2006-1859
Article CAS PubMed Google Scholar
Feldman HA, Longcope C, Derby CA et al (2002) Age trends in the level of serum testosterone and other hormones in Middle-aged men: longitudinal results from the Massachusetts Male Aging Study. J Clin Endocrinol Metab 87(2):589–598. https://doi.org/10.1210/jcem.87.2.8201
Article CAS PubMed Google Scholar
Harman SM, Metter EJ, Tobin JD et al (2001) Longitudinal effects of Aging on serum total and free testosterone levels in healthy men. J Clin Endocrinol Metab 86(2):724–731. https://doi.org/10.1210/jcem.86.2.7219
Article CAS PubMed Google Scholar
Xia F, Wang N, Han B et al (2016) Hypothalamic-pituitary-gonadal Axis in Aging men and women: increasing total testosterone in Aging men. Neuroendocrinology 104(3):291–301. https://doi.org/10.1159/000446656
Article CAS PubMed Google Scholar
Nieschlag E (2019) Late-onset hypogonadism: a concept comes of age. Androl 8(6):1506–1511. https://doi.org/10.1111/andr.12719
Tajar A, Forti G, O’Neill TW et al (2010) Characteristics of secondary, primary, and compensated hypogonadism in Aging men: evidence from the Eur Male Ageing Study. J Clin Endocrinol Metab 95(4):1810–1818. https://doi.org/10.1210/jc.2009-1796
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