Testosterone therapy for functional hypogonadism in middle-aged and elderly males: current evidence and future perspectives

World Health Organization. World Population Ageing (2019) https://www.un.org/en/development/desa/population/publications/pdf/ageing/WorldPopulationAgeing2019-Report.pdf. Accessed April 4 2024

Iburg KM, Charalampous P, Allebeck P et al (2023) Burden of disease among older adults in Europe-trends in mortality and disability, 1990–2019. Eur J Public Health 33(1):121–126. https://doi.org/10.1093/eurpub/ckac160

Article  PubMed  Google Scholar 

Polidori CM (2021) Physiology of aging as a basis of complexity in Aging Medicine and Geriatrics. Springer EBooks, pp 3824–3829. https://doi.org/10.1007/978-3-030-22009-9_548

Singh P (2013) Andropause: current concepts. Indian J Endocrinol Metab 17(9):621. https://doi.org/10.4103/2230-8210.123552

Article  CAS  Google Scholar 

Khera M (2020) Controversies with testosterone therapy. Can J Urol 27(S3):20–23

PubMed  Google Scholar 

Snyder PJ, Bhasin S, Cunningham GR et al (2018) Lessons from the testosterone trials. Endocr Rev 39(3):369–386. https://doi.org/10.1210/er.2017-00234

Article  PubMed  PubMed Central  Google Scholar 

Lincoff AM, Bhasin S, Flevaris P et al (2023) Cardiovascular Safety of testosterone-replacement therapy. N Engl J Med 389(2):107–111. https://doi.org/10.1056/nejmoa2215025

Article  CAS  PubMed  Google Scholar 

Oduwole OO, Huhtaniemi IT, Misrahi M (2021) The roles of luteinizing hormone, follicle-stimulating hormone and testosterone in spermatogenesis and folliculogenesis revisited. Int J Mol Sci 22(23):12735. https://doi.org/10.3390/ijms222312735

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dunn JF, Nisula BC, Rodbard D (1981) Transport of Steroid hormones: binding of 21 endogenous steroids to both testosterone-binding globulin and corticosteroid-binding globulin in human plasma. J Clin Endocrinol Metab 53(1):58–68. https://doi.org/10.1210/jcem-53-1-58

Article  CAS  PubMed  Google Scholar 

Schlich C, Romanelli F (2016) Issues surrounding testosterone replacement therapy. Hosp Pharm 51(9):712–720. https://doi.org/10.1310/hpj5109-712

Article  CAS  PubMed  PubMed Central  Google Scholar 

Swerdloff RS, Dudley RE, Page ST et al (2017) Dihydrotestosterone: Biochemistry, Physiology, and clinical implications of elevated blood levels. Endocr Rev 38(3):220–254. https://doi.org/10.1210/er.2016-1067

Article  PubMed  PubMed Central  Google Scholar 

Jin Y, Penning TM (2001) Steroid 5α-reductases and 3α-hydroxysteroid dehydrogenases: key enzymes in androgen metabolism. Best Pract Res Clin Endocrinol Metab 15(1):79–94. https://doi.org/10.1053/beem.2001.0120

Article  CAS  PubMed  Google Scholar 

Finkelstein JS, Lee H, Burnett-Bowie S-AM et al (2013) Gonadal steroids and body composition, strength, and sexual function in men. N Engl J Med 369(11):1011–1022. https://doi.org/10.1056/nejmoa1206168

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ketchem JM, Bowman EJ, Isales CM (2023) Male sex hormones, aging, and inflammation. Biogerontology 24(1):1–25. https://doi.org/10.1007/s10522-022-10002-1

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li C, Ford ES, Li B, Giles WH, Liu S (2010) Association of Testosterone and Sex hormone-binding globulin with metabolic syndrome and insulin resistance in men. Diabetes Care 33(7):1618–1624. https://doi.org/10.2337/dc09-1788

Article  CAS  PubMed  PubMed Central  Google Scholar 

Johannsson G, Gibney J, Wolthers T et al (2005) Independent and Combined effects of Testosterone and Growth hormone on Extracellular Water in Hypopituitary Men. J Clin Endocrinol Metab 90(7):3989–3994. https://doi.org/10.1210/jc.2005-0553

Article  CAS  PubMed  Google Scholar 

Santosa S, Bush NC, Jensen MD (2017) Acute Testosterone Deficiency alters adipose tissue fatty acid storage. J Clin Endocrinol Metab 102(8):3056–3064. https://doi.org/10.1210/jc.2017-00757

Article  PubMed  PubMed Central  Google Scholar 

Carmina E, Dreno B, Lucky WA et al (2022) Female adult acne and androgen excess: a Report from the multidisciplinary androgen excess and PCOS Committee. J Endocr Soc 6(3):bvad003. https://doi.org/10.1210/jendso/bvac003

Article  CAS  Google Scholar 

Arora MK, Yadav A, Saini V (2011) Role of hormones in acne vulgaris. Clin Biochem 44(13):1035–1040. https://doi.org/10.1016/j.clinbiochem.2011.06.984

Article  CAS  PubMed  Google Scholar 

Chegeni R, Pallesen S, McVeigh J, Sagoe D (2021) Anabolic-androgenic steroid administration increases self-reported aggression in healthy males: a systematic review and meta-analysis of experimental studies. Psychopharmacology 238(7):1911–1922. https://doi.org/10.1007/s00213-021-05818-7

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wilson CM, McPhaul MJ (1996) A and B forms of the androgen receptor are expressed in a variety of human tissues. Mol Cell Endocrinol 120(1):51–57. https://doi.org/10.1016/0303-7207(96)03819-1

Article  CAS  PubMed  Google Scholar 

Alves JV, da Costa RM, Pereira CA et al (2020) Supraphysiological levels of Testosterone Induce Vascular Dysfunction via activation of the NLRP3 inflammasome. Front Immunol 11:1647. https://doi.org/10.3389/fimmu.2020.01647

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wu FCW, Tajar A, Pye SR et al (2008) Hypothalamic-pituitary-testicular Axis disruptions in older men are differentially linked to age and modifiable risk factors: the European Male Aging Study. J Clin Endocrinol Metab 93(7):2737–2745. https://doi.org/10.1210/jc.2007-1972

Article  CAS  PubMed  Google Scholar 

Handelsman DJ, Yeap BB, Flicker L et al (2015) Age-specific population centiles for androgen status in men. Eur J Endocrinol 173(6):809–817. https://doi.org/10.1530/eje-15-0380

Article  CAS  PubMed  Google Scholar 

Travison TG, Araujo AB, Kupelian V et al (2007) The relative contributions of aging, Health, and lifestyle factors to serum testosterone decline in men. J Clin Endocrinol Metab 92(2):549–555. https://doi.org/10.1210/jc.2006-1859

Article  CAS  PubMed  Google Scholar 

Feldman HA, Longcope C, Derby CA et al (2002) Age trends in the level of serum testosterone and other hormones in Middle-aged men: longitudinal results from the Massachusetts Male Aging Study. J Clin Endocrinol Metab 87(2):589–598. https://doi.org/10.1210/jcem.87.2.8201

Article  CAS  PubMed  Google Scholar 

Harman SM, Metter EJ, Tobin JD et al (2001) Longitudinal effects of Aging on serum total and free testosterone levels in healthy men. J Clin Endocrinol Metab 86(2):724–731. https://doi.org/10.1210/jcem.86.2.7219

Article  CAS  PubMed  Google Scholar 

Xia F, Wang N, Han B et al (2016) Hypothalamic-pituitary-gonadal Axis in Aging men and women: increasing total testosterone in Aging men. Neuroendocrinology 104(3):291–301. https://doi.org/10.1159/000446656

Article  CAS  PubMed  Google Scholar 

Nieschlag E (2019) Late-onset hypogonadism: a concept comes of age. Androl 8(6):1506–1511. https://doi.org/10.1111/andr.12719

Article  Google Scholar 

Tajar A, Forti G, O’Neill TW et al (2010) Characteristics of secondary, primary, and compensated hypogonadism in Aging men: evidence from the Eur Male Ageing Study. J Clin Endocrinol Metab 95(4):1810–1818. https://doi.org/10.1210/jc.2009-1796

Article 

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