EASL clinical practice guidelines. management of hepatocellular carcinoma. J Hepatol. 2018;69(1):182–236.
Xu J. Trends in liver cancer mortality among adults aged 25 and over in the United States, 2000–2016. NCHS Data Brief. 2018;314:1–8.
Schobert IT, Savic LJ, Chapiro J, Bousabarah K, Chen E, Laage-Gaupp F, Tefera J, Nezami N, Lin M, Pollak J, Schlachter T. Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios as predictors of tumor response in hepatocellular carcinoma after DEB-TACE. Eur Radiol. 2020;30(10):5663–73.
Article PubMed PubMed Central Google Scholar
Heimbach JK, Kulik LM, Finn RS, Sirlin CB, Abecassis MM, Roberts LR, Zhu AX, Murad MH, Marrero JA. AASLD guidelines for the treatment of hepatocellular carcinoma. Hepatology. 2018;67(1):358–80.
Chen B, Wu JX, Cheng SH, Wang LM, Rong WQ, Wu F, Wang SL, Jin J, Liu YP, Song YW, Ren H, Fang H, Tang Y, Li N, Li YX, Wang WH. Phase 2 study of adjuvant radiotherapy following narrow-margin hepatectomy in patients with HCC. Hepatology. 2021;74(5):2595–604.
Olsen SK, Brown RS, Siegel AB. Hepatocellular carcinoma: review of current treatment with a focus on targeted molecular therapies. Therap Adv Gastroenterol. 2010;3(1):55–66.
Article PubMed PubMed Central Google Scholar
Chen YD, Zhang L, Zhou ZP, Lin B, Jiang ZJ, Tang C, Dang YW, Xia YW, Song B, Long LL. Radiomics and nomogram of magnetic resonance imaging for preoperative prediction of microvascular invasion in small hepatocellular carcinoma. World J Gastroenterol. 2022;28(31):4399–416.
Article PubMed PubMed Central Google Scholar
Cao Y, Ke R, Wang S, Zhu X, Chen J, Huang C, Jiang Y, Lv L. DNA topoisomerase IIα and Ki67 are prognostic factors in patients with hepatocellular carcinoma. Oncol Lett. 2017;13(6):4109–16.
Article PubMed PubMed Central Google Scholar
Scholzen T, Gerdes J. The Ki-67 protein: from the known and the unknown. J Cell Physiol. 2000;182(3):311–22.
Fleming GF, Pagani O, Regan MM, Walley BA, Francis PA. Adjuvant abemaciclib combined with endocrine therapy for high-risk early breast cancer: updated efficacy and Ki-67 analysis from the monarchE study. Ann Oncol. 2022;33(6):658.
Li Z, Li F, Pan C, He Z, Pan X, Zhu Q, Wu W, Chen L. Tumor cell proliferation (Ki-67) expression and its prognostic significance in histological subtypes of lung adenocarcinoma. Lung cancer (Amsterdam, Netherlands). 2021;154:69–75.
Ye Z, Jiang H, Chen J, Liu X, Wei Y, Xia C, Duan T, Cao L, Zhang Z, Song B. Texture analysis on gadoxetic acid enhanced-MRI for predicting Ki-67 status in hepatocellular carcinoma: a prospective study. Chin J Cancer Res. 2019;31(5):806–17.
Article PubMed PubMed Central Google Scholar
Zhang X, Wu Z, Peng Y, Li D, Jiang Y, Pan F, Li Y, Lai Y, Cui Z, Zhang K. Correlationship between Ki67, VEGF, and p53 and hepatocellular carcinoma recurrence in liver transplant patients. Biomed Res Int. 2021;2021:6651397.
PubMed PubMed Central Google Scholar
Li Y, Yan C, Weng S, Shi Z, Sun H, Chen J, Xu X, Ye R, Hong J. Texture analysis of multi-phase MRI images to detect expression of Ki67 in hepatocellular carcinoma. Clin Radiol. 2019;74(10):813.e19-813.e27.
Fan Y, Yu Y, Wang X, Hu M, Hu C. Radiomic analysis of Gd-EOB-DTPA-enhanced MRI predicts Ki-67 expression in hepatocellular carcinoma. BMC Med Imaging. 2021;21(1):100.
Article PubMed PubMed Central Google Scholar
Chen Y, Qin X, Long L, Zhang L, Huang Z, Jiang Z, Li C. Diagnostic value of Gd-EOB-DTPA-enhanced MRI for the expression of Ki67 and microvascular density in hepatocellular carcinoma. J Magn Reson Imaging. 2020;51(6):1755–63.
Hu XX, Yang ZX, Liang HY, Ding Y, Grimm R, Fu CX, Liu H, Yan X, Ji Y, Zeng MS, Rao SX. Whole-tumor MRI histogram analyses of hepatocellular carcinoma: correlations with Ki-67 labeling index. J Magn Reson Imaging. 2017;46(2):383–92.
Liu Z, Yang S, Chen X, Luo C, Feng J, Chen H, Ouyang F, Zhang R, Li X, Liu W, Guo B, Hu Q. Nomogram development and validation to predict Ki-67 expression of hepatocellular carcinoma derived from Gd-EOB-DTPA-enhanced MRI combined with T1 mapping. Front Oncol. 2022;12:954445.
Article PubMed PubMed Central Google Scholar
Wu C, Chen J, Fan Y, Zhao M, He X, Wei Y, Ge W, Liu Y. Nomogram based on CT radiomics features combined with clinical factors to predict Ki-67 expression in hepatocellular carcinoma. Front Oncol. 2022;12:943942.
Article PubMed PubMed Central Google Scholar
Yerushalmi R, Woods R, Ravdin PM, Hayes MM, Gelmon KA. Ki67 in breast cancer: prognostic and predictive potential. Lancet Oncol. 2010;11(2):174–83.
Klöppel G, La Rosa S. Ki67 labeling index: assessment and prognostic role in gastroenteropancreatic neuroendocrine neoplasms. Virchows Arch. 2018;472(3):341–9.
Tu Y, Jiang P, Zhang J, Jiang S, Yi Q, Yuan R. The positive threshold of the immunohistochemical parameter Ki67 for predicting the recurrence of cervical cancer. Int J Gynaecol Obstet. 2022;158(2):330–7.
Zhang YF, Guo RP, Zou RH, Shen JX, Wei W, Li SH, OuYang HY, Zhu HB, Xu L, Lao XM, Shi M. Efficacy and safety of preoperative chemoembolization for resectable hepatocellular carcinoma with portal vein invasion: a prospective comparative study. Eur Radiol. 2016;26(7):2078–88.
Yang C, Zhang J, Ding M, Xu K, Li L, Mao L, Zheng J. Ki67 targeted strategies for cancer therapy. Clin Transl Oncol. 2018;20(5):570–5.
Hu X, Zhou J, Li Y, Wang Y, Guo J, Sack I, Chen W, Yan F, Li R, Wang C. Added value of viscoelasticity for MRI-based prediction of Ki-67 expression of hepatocellular carcinoma using a deep learning combined radiomics (DLCR) model. Cancers (Basel). 2022;14(11):2575.
Wen L, Weng S, Yan C, Ye R, Zhu Y, Zhou L, Gao L, Li Y. A radiomics nomogram for preoperative prediction of early recurrence of small hepatocellular carcinoma after surgical resection or radiofrequency ablation. Front Oncol. 2021;11:657039.
Article PubMed PubMed Central Google Scholar
Aktas S, Karakayali H, Moray G, Ozdemir H, Haberal M. Effects of risk factors and Ki-67 on rates of recurrence on patients who have undergone liver transplant for hepatocellular carcinoma. Transplant Proc. 2011;43(10):3807–12.
Ahmed AA, Elmohr MM, Fuentes D, Habra MA, Fisher SB, Perrier ND, Zhang M, Elsayes KM. Radiomic mapping model for prediction of Ki-67 expression in adrenocortical carcinoma. Clin Radiol. 2020;75(6):479.e17-479.e22.
Wang Q, Li B, Liu Z, Shang H, Jing H, Shao H, Chen K, Liang X, Cheng W. Prediction model of axillary lymph node status using automated breast ultrasound (ABUS) and ki-67 status in early-stage breast cancer. BMC Cancer. 2022;22(1):929.
Article PubMed PubMed Central Google Scholar
Zhang S, Duan C, Zhou X, Liu F, Wang X, Shao Q, Gao Y, Duan F, Zhao R, Wang G. Radiomics nomogram for prediction of microvascular invasion in hepatocellular carcinoma based on MR imaging with Gd-EOB-DTPA. Front Oncol. 2022;12:1034519.
Article PubMed PubMed Central Google Scholar
Park SJ, Jang JY, Jeong SW, Cho YK, Lee SH, Kim SG, Cha SW, Kim YS, Cho YD, Kim HS, Kim BS, Park S, Bang HI. Usefulness of AFP, AFP-L3, and PIVKA-II, and their combinations in diagnosing hepatocellular carcinoma. Medicine (Baltimore). 2017;96(11):e5811.
Kumada T, Toyoda H, Kiriyama S, Tanikawa M, Hisanaga Y, Kanamori A, Tada T, Tanaka J, Yoshizawa H. Predictive value of tumor markers for hepatocarcinogenesis in patients with hepatitis C virus. J Gastroenterol. 2011;46(4):536–44.
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