Stratton IM, Adler AI, Neil HA, Matthews DR, Cull CA, Hadden D, et al. Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study. BMJ. 2000;321(7258):405–12. https://doi.org/10.1136/bmj.321.7258.405.

Article  CAS  PubMed  PubMed Central  Google Scholar 

ElSayed NA, Aleppo G, Aroda VR, Bannuru RR, Brown FM, Bruemmer D, et al. Pharmacologic approaches to glycemic treatment: Standards of Care in Diabetes—2023. Diabetes Care. 2023;46(Suppl 1):S140–57. https://doi.org/10.2337/dc23-S009.

Article  CAS  PubMed  Google Scholar 

Seino Y, Kuwata H, Yabe D. Incretin-based drugs for type 2 diabetes: focus on East Asian perspective. J Diabetes Investig. 2016;7(Suppl 1):102–9. https://doi.org/10.1111/jdi.12490.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yagi N, Komiya I, Arai K, Oishi M, Fukumoto Y, Shirabe S, et al. Current status of oral antidiabetic drug prescribing patterns based on the body mass index for Japanese type 2 diabetes mellitus patients and yearly changes in diabetologists’ prescribing patterns from 2002 to 2019 (JDDM61). J Diabetes Investig. 2022;13(1):65–73. https://doi.org/10.1111/jdi.13621.

Article  CAS  PubMed  Google Scholar 

Kim YG, Hahn S, Oh TJ, Kwak SH, Park KS, Cho YM. Differences in the glucose-lowering efficacy of dipeptidyl peptidase-4 inhibitors between Asians and non-Asians: a systematic review and meta-analysis. Diabetologia. 2013;56(4):696–708. https://doi.org/10.1007/s00125-012-2827-3.

Article  CAS  PubMed  Google Scholar 

Suzuki K, Akiyama M, Ishigaki K, Kanai M, Hosoe J, Shojima N, et al. Identification of 28 new susceptibility loci for type 2 diabetes in the Japanese population. Nat Genet. 2019;51(3):379–86. https://doi.org/10.1038/s41588-018-0332-4.

Article  CAS  PubMed  Google Scholar 

Nazare JA, Smith JD, Borel AL, Haffner SM, Balkau B, Ross R, et al. Ethnic influences on the relations between abdominal subcutaneous and visceral adiposity, liver fat, and cardiometabolic risk profile: the International Study of Prediction of Intra-Abdominal Adiposity and its relationship with Cardiometabolic Risk/Intra-Abdominal Adiposity. Am J Clin Nutr. 2012;96(4):714–26. https://doi.org/10.3945/ajcn.112.035758.

Article  CAS  PubMed  Google Scholar 

Miyazawa I, Kadota A, Miura K, Okamoto M, Nakamura T, Ikai T, et al. Twelve-year trends of increasing overweight and obesity in patients with diabetes: the Shiga Diabetes Clinical Survey. Endocr J. 2018;65(5):527–36. https://doi.org/10.1507/endocrj.EJ17-0415.

Article  CAS  PubMed  Google Scholar 

Kato K, Takamura T, Takeshita Y, Ryu Y, Misu H, Ota T, et al. Ectopic fat accumulation and distant organ-specific insulin resistance in Japanese people with nonalcoholic fatty liver disease. PLoS One. 2014;9(3):e92170. https://doi.org/10.1371/journal.pone.0092170.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sugimoto D, Tamura Y, Takeno K, Kaga H, Someya Y, Kakehi S, et al. Clinical features of nonobese, apparently healthy, japanese men with reduced adipose tissue insulin sensitivity. J Clin Endocrinol Metab. 2019;104(6):2325–33. https://doi.org/10.1210/jc.2018-02190.

Article  PubMed  Google Scholar 

Gabery S, Salinas CG, Paulsen AJ, Ahnefelt-Ronne J, Alanentalo T, Baquero AF, et al. Semaglutide lower body weight in rodents via distributed neural pathways. JCI insight. 2020;5(6):e133429. https://doi.org/10.1172/jci.insight.133429.

Article  PubMed  PubMed Central  Google Scholar 

Nevola R, Epifani R, Imbriani S, Tortorella G, Aprea C, Galiero R, et al. GLP-1 receptor agonists in non-alcoholic fatty liver disease: current evidence and future perspectives. Int J Mol Sci. 2023;24(2):1703. https://doi.org/10.3390/ijms24021703.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Coskun T, Sloop KW, Loghin C, Alsina-Fernandez J, Urva S, Bokvist KB, et al. LY3298176, a novel dual GIP and GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus: from discovery to clinical proof of concept. Mol Metab. 2018;18:3–14. https://doi.org/10.1016/j.molmet.2018.09.009.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Taminato T, Seino Y, Goto Y, Inoue Y, Kadowaki S. Synthetic gastric inhibitory polypeptide. Stimulatory effect on insulin and glucagon secretion in the rat. Diabetes. 1977;26:480–4. https://doi.org/10.2337/diab.26.5.480.

Harada N, Hamasaki A, Yamane S, Muraoka A, Joo E, Fujita K, et al. Plasma gastric inhibitory polypeptide and glucagon-like peptide-1 levels after glucose loading are associated with different factors in Japanese subjects. J Diabetes Investig. 2011;2:193–9. https://doi.org/10.1111/j.2040-1124.2010.00078.x.

Article  CAS  PubMed  Google Scholar 

Nauck MA, eMeier JJ. GIP and GLP-1: Stepsiblings rather than monozygotic twins within the incretin family. Diabetes. 2019;68(5):897–900. https://doi.org/10.2337/dbi19-0005.

Visboll T, Krarup T, Madsbad S, Holst JJ. Defective amplification of the late phase insulin response to glucose by GIP in obese Type II diabetic patients. Diabetologia. 2002;2002(45):1111–9. https://doi.org/10.1007/s00125-002-0878-6.

Article  CAS  Google Scholar 

Lynn FC, Thompson SA, Pospisilik JA, Ehses JA, Hinke S, Pamir N, et al. A novel pathway for regulation of glucose-dependent insulinotropic polypeptide (GIP) receptor expression in beta cells. FASEB J. 2003;17:91–3. https://doi.org/10.1096/fj.02-0243fje.

Article  CAS  PubMed  Google Scholar 

Zang Q, Delessa CT, Augustin R, Bakhti M, Collden G, Drucker D, et al. The glucose-dependent insulinotropic polypeptide (GIP) regulates body weight and food intake via CNS-GIPR signaling. Cell Metab. 2021;33(4):833–44. https://doi.org/10.1016/j.cmet.2021.01.015.

Article  CAS  Google Scholar 

Inagaki N, Takeuchi M, Oura T, Imaoka T, Seino Y. Efficacy and safety of tirzepatide monotherapy compared with dulaglutide in Japanese patients with type 2 diabetes (SURPASS J-mono): a double-blind, multicentre, randomised, phase 3 trial. Lancet Diabetes Endocrinol. 2022;10(9):623–33. https://doi.org/10.1016/S2213-8587(22)00188-7.

Article  CAS  PubMed  Google Scholar 

Kanda Y. Investigation of the freely-available easy-to-use software “EZR” (Easy R) for medical statistics. Bone Marrow Transplant. 2013;48:452–8.

Article  CAS  PubMed  Google Scholar 

Onishi Y, Oura T, Nishiyama H, Ohyama S, Takeuchi M, Iwamoto N. Subgroup analysis of phase 3 studies of dulaglutide in Japanese patients with type 2 diabetes. Endocr J. 2016;63(3):263–73. https://doi.org/10.1507/endocrj.EJ15-0518.

Article  CAS  PubMed  Google Scholar 

Yabe D, kawamori D, Seino Y, Oura T, Takeuchi M. Change in pharmacodynamic variable following once-weekly tirzepatide treatment versus dulaglutide in Japanese patients with type 2 diabetes (SURPASS J-mono substudy). Diabetes Obes Metab. 2023;25(2):398–406. https://doi.org/10.1111/dom.14882.

Samms RJ, Christe ME, Collins KA, Pirro V, Droz BA, Holland AK, et al. GIPR abonism mediates weight-independent insulin sensitization by tirzepatide in obese mice. J Clin Invest. 2021;131(12): e146353. https://doi.org/10.1172/JCI146353.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Goto A, Arsh OA, Goto M, Terauchi Y, Noda M. Severe hypoglycemia and cardiovascular disease: systematic review and meta-analysis with bias analysis. BMJ. 2013;347:f4533. https://doi.org/10.1136/bmj.f4533.

Article  PubMed  Google Scholar 

Hanefeld M, Frier BM, Pistrosch F. Hypoglycemia and cardiovascular risk: is there a major link? Diabetes Care. 2016;39(Suppl 2):S205–9. https://doi.org/10.2337/dcS15-3014.

Article  CAS  PubMed  Google Scholar 

Mattishent K, Loke YK. Bi-directional interaction between hypoglycemia and cognitive impairment in elderly patients treated with glucose-lowering agents: a systematic review and meta-analysis. Diabetes Obes Metab. 2016;18(2):135–41. https://doi.org/10.1111/dom.12587.

Article  CAS  PubMed  Google Scholar 

Komorita Y, Minami M, Maeda Y, Yoshioka R, Ohkuma T, Kitazono T. Prevalence of bone fracture and its association with severe hypoglycemia in Japanese patients with type 1 diabetes. BMJ Open Diabetes Res Care. 2021;9(1):e002099. https://doi.org/10.1136/bmjdrc-2020-002099.

Article  PubMed  PubMed Central  Google Scholar 

Bhaskaran K, Dos-Santos-Silva I, Leon DA, Douglas IJ, Smeeth L. Association of BMI with overall and cause-specific mortality: a population-based cohort study of 3·6 million adults in the UK. Lancet Diabetes Endocriol. 2018;6(12):944–53.