Lees KR, et al. Time to treatment with intravenous alteplase and outcome in stroke: an updated pooled analysis of ECASS, ATLANTIS, NINDS, and EPITHET trials. Lancet. 2010;375(9727):1695–703.

Article  CAS  PubMed  Google Scholar 

Bhatia R, et al. Low rates of acute recanalization with intravenous recombinant tissue plasminogen activator in ischemic stroke: real-world experience and a call for action. Stroke. 2010;41(10):2254–8.

Article  CAS  PubMed  Google Scholar 

Whiteley WN, et al. Risk of intracerebral haemorrhage with alteplase after acute ischaemic stroke: a secondary analysis of an individual patient data meta-analysis. Lancet Neurol. 2016;15(9):925–33.

Article  PubMed  Google Scholar 

Wang Y, et al. Clopidogrel with aspirin in acute minor stroke or transient ischemic attack. N Engl J Med. 2013;369(1):11–9.

Article  CAS  PubMed  Google Scholar 

Johnston SC, et al. Clopidogrel and aspirin in acute ischemic stroke and high-risk TIA. N Engl J Med. 2018;379(3):215–25.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Demel SL, et al. Sex differences in endovascular therapy for ischemic stroke: results from the Get with the Guidelines—Stroke Registry. Stroke. 2022;53(10):3099–106.

Article  CAS  PubMed  Google Scholar 

Uchida K, et al. Sex differences in management and outcomes of acute ischemic stroke with large vessel occlusion. Stroke. 2019;50(7):1915–8.

Article  PubMed  Google Scholar 

Spaander FH, et al. Sex differences and functional outcome after intravenous thrombolysis. Stroke. 2017;48(3):699–703.

Article  PubMed  Google Scholar 

Liu M, et al. The influence of sex in stroke thrombolysis: a systematic review and meta-analysis. J Clin Neurol. 2018;14(2):141–52.

Article  PubMed  PubMed Central  Google Scholar 

Chen HS, et al. Dual antiplatelet therapy vs alteplase for patients with minor nondisabling acute ischemic stroke: the ARAMIS randomized clinical trial. JAMA. 2023;329(24):2135–44.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pan Y, et al. Risks and benefits of clopidogrel-aspirin in minor stroke or TIA: time course analysis of CHANCE. Neurology. 2017;88(20):1906–11.

Article  CAS  PubMed  Google Scholar 

Huang X, et al. Alteplase versus tenecteplase for thrombolysis after ischaemic stroke (ATTEST): a phase 2, randomised, open-label, blinded endpoint study. Lancet Neurol. 2015;14(4):368–76.

Article  CAS  PubMed  Google Scholar 

Logallo N, et al. Tenecteplase versus alteplase for management of acute ischaemic stroke (NOR-TEST): a phase 3, randomised, open-label, blinded endpoint trial. Lancet Neurol. 2017;16(10):781–8.

Article  CAS  PubMed  Google Scholar 

Tong X, et al. Thrombectomy versus combined thrombolysis and thrombectomy in patients with acute stroke: a matched-control study. Stroke. 2021;52(5):1589–600.

Article  PubMed  Google Scholar 

Zhou H, et al. Effect of sex differences on prognosis of intravenous thrombolysis: data from the Thrombolysis Implementation and Monitor of Acute Ischemic Stroke in China (TIMS-China). Stroke Vasc Neurol. 2021;6(1):10–5.

Article  PubMed  Google Scholar 

Bushnell CD, et al. Sex differences in stroke: challenges and opportunities. J Cereb Blood Flow Metab. 2018;38(12):2179–91.

Article  PubMed  PubMed Central  Google Scholar 

Glader EL, et al. Sex differences in management and outcome after stroke: a Swedish national perspective. Stroke. 2003;34(8):1970–5.

Article  PubMed  Google Scholar 

Di Carlo A, et al. Sex differences in the clinical presentation, resource use, and 3-month outcome of acute stroke in Europe: data from a multicenter multinational hospital-based registry. Stroke. 2003;34(5):1114–9.

Article  PubMed  Google Scholar 

Mandelzweig L, et al. Perceptual, social, and behavioral factors associated with delays in seeking medical care in patients with symptoms of acute stroke. Stroke. 2006;37(5):1248–53.

Article  PubMed  Google Scholar 

The LN. Sex differences and stroke prevention. Lancet Neurol. 2014;13(4):339.

Article  Google Scholar 

Hurn PD, Brass LM. Estrogen and stroke: a balanced analysis. Stroke. 2003;34(2):338–41.

Article  PubMed  Google Scholar 

Qu HL, et al. Efficacy of remote ischemic conditioning does not differ between men and women: a secondary analysis of the RICAMIS study. Eur J Neurol. 2023;30(7):2022–30.

Article  PubMed  Google Scholar 

Martinez-Sanchez P, et al. Female gender is a factor of worse outcome in acute stroke even after thrombolytic treatment. Int J Stroke. 2011;6(4):371–2.

Article  PubMed  Google Scholar 

Elkind MS, et al. Sex as a predictor of outcomes in patients treated with thrombolysis for acute stroke. Neurology. 2007;68(11):842–8.

Article  CAS  PubMed  Google Scholar 

Ribo M, et al. Admission fibrinolytic profile predicts clot lysis resistance in stroke patients treated with tissue plasminogen activator. Thromb Haemost. 2004;91(6):1146–51.

Article  CAS  PubMed  Google Scholar 

Carcel C, et al. Sex differences in treatment and outcome after stroke: pooled analysis including 19,000 participants. Neurology. 2019;93(24):e2170–80.

Article  PubMed  Google Scholar 

Bousser MG. Stroke in women: the 1997 Paul Dudley White International Lecture. Circulation. 1999;99(4):463–7.

Article  CAS  PubMed  Google Scholar 

Kapral MK, et al. Sex differences in stroke care and outcomes: results from the Registry of the Canadian Stroke Network. Stroke. 2005;36(4):809–14.

Article  PubMed  Google Scholar 

Niewada M, et al. Influence of gender on baseline features and clinical outcomes among 17,370 patients with confirmed ischaemic stroke in the international stroke trial. Neuroepidemiology. 2005;24(3):123–8.

Article  PubMed  Google Scholar 

Hill MD, et al. Sex-based differences in the effect of intra-arterial treatment of stroke: analysis of the PROACT-2 study. Stroke. 2006;37(9):2322–5.

Article  CAS  PubMed  Google Scholar 

Niessen F, et al. Differences in clot preparation determine outcome of recombinant tissue plasminogen activator treatment in experimental thromboembolic stroke. Stroke. 2003;34(8):2019–24.

Article  CAS  PubMed  Google Scholar 

Zivin JA, et al. Tissue plasminogen activator reduces neurological damage after cerebral embolism. Science. 1985;230(4731):1289–92.

Article  CAS  PubMed  Google Scholar 

Perry A, et al. The relationship between cardiometabolic and hemostatic variables: influence of race. Metabolism. 2008;57(2):200–6.

Article  CAS  PubMed  Google Scholar 

Gebara OC, et al. Association between increased estrogen status and increased fibrinolytic potential in the Framingham Offspring Study. Circulation. 1995;91(7):1952–8.