Androgen deficiency in hypopituitary women: its consequences and management

Fleseriu M, Hashim IA, Karavitaki N, et al. Hormonal replacement in hypopituitarism in adults: an endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2016;101(11):3888–921. https://doi.org/10.1210/jc.2016-2118.

Article  CAS  PubMed  Google Scholar 

Esposito D, Olsson DS, Ragnarsson O, et al. Non-functioning pituitary adenomas: indications for pituitary surgery and post-surgical management. Pituitary. 2019;22(4):422–34. https://doi.org/10.1007/s11102-019-00960-0.

Article  PubMed  PubMed Central  Google Scholar 

Olivius C, Landin-Wilhelmsen K, Olsson DS, et al. Prevalence and treatment of central hypogonadism and hypoandrogenism in women with hypopituitarism. Pituitary. 2018;21(5):445–53. https://doi.org/10.1007/s11102-018-0895-1.

Article  PubMed  Google Scholar 

van Bunderen CC, Olsson DS. Meta-analysis of mortality in adults with growth hormone deficiency: does growth hormone replacement therapy really improve mortality rates? Best Pract Res Clin Endocrinol Metab. 2023;37(6):101835. https://doi.org/10.1016/j.beem.2023.101835.

Article  CAS  PubMed  Google Scholar 

Pappachan JM, Raskauskiene D, Kutty VR, et al. Excess mortality associated with hypopituitarism in adults: a meta-analysis of observational studies. J Clin Endocrinol Metab. 2015;100(4):1405–11. https://doi.org/10.1210/jc.2014-3787.

Article  CAS  PubMed  Google Scholar 

Rosén T, Bengtsson BA. Premature mortality due to cardiovascular disease in hypopituitarism. Lancet. 1990;336(8710):285–8. https://doi.org/10.1016/0140-6736(90)91812-o.

Article  PubMed  Google Scholar 

Sherlock M, Ayuk J, Tomlinson JW, et al. Mortality in patients with pituitary disease. Endocr Rev. 2010;31(3):301–42. https://doi.org/10.1210/er.2009-0033.

Article  PubMed  Google Scholar 

Olsson DS, Bryngelsson IL, Ragnarsson O. Higher incidence of morbidity in women than men with non-functioning pituitary adenoma: a Swedish nationwide study. Eur J Endocrinol. 2016;175(1):55–61. https://doi.org/10.1530/EJE-16-0173.

Article  CAS  PubMed  Google Scholar 

Shah T, Palaskas N, Ahmed A. An update on gender disparities in coronary heart disease care. Curr Atheroscler Rep. 2016;18(5):28. https://doi.org/10.1007/s11883-016-0574-5.

Article  CAS  PubMed  Google Scholar 

Arnetz L, Ekberg NR, Alvarsson M. Sex differences in type 2 diabetes: focus on disease course and outcomes. Diabetes Metab Syndr Obes. 2014;7:409–20. https://doi.org/10.2147/DMSO.S51301.

Article  PubMed  PubMed Central  Google Scholar 

Esposito D, Ragnarsson O, Johannsson G, et al. Prolonged diagnostic delay in acromegaly is associated with increased morbidity and mortality. Eur J Endocrinol. 2020;182(6):523–31. https://doi.org/10.1530/EJE-20-0019.

Article  CAS  PubMed  Google Scholar 

Nunes E, Gallardo E, Morgado-Nunes S, et al. Steroid hormone levels in postmenopausal hysterectomised women with and without ovarian conservation: the continuous endocrine function of the ovaries. J Obstet Gynaecol. 2023;43(1):2141618. https://doi.org/10.1080/01443615.2022.2141618.

Article  CAS  PubMed  Google Scholar 

Wierman ME, Kiseljak-Vassiliades K. Should dehydroepiandrosterone be administered to women? J Clin Endocrinol Metab. 2022;107(6):1679–85. https://doi.org/10.1210/clinem/dgac130.

Article  PubMed  PubMed Central  Google Scholar 

van Winden LJ, Vermeulen RFM, van den Noort V, et al. Changes in sex steroids and relation with menopausal complaints in women undergoing risk-reducing salpingo-oophorectomy. J Endocr Soc. 2022;6(6):bvac069. https://doi.org/10.1210/jendso/bvac069.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Alemany M. The roles of androgens in humans: Biology, metabolic regulation and health. Int J Mol Sci. 2022;23(19):11952. https://doi.org/10.3390/ijms231911952.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shiffer L, Barnard L, Baranowski E, et al. Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: a comprehensive review. J Steroid Biochem Mol Biol. 2019;194:105439. https://doi.org/10.1016/j.jsbmb.2019.105439.

Article  CAS  Google Scholar 

Handelsman DJ. Free testosterone: pumping up the tires or ending the free ride? Endocr Rev. 2017;38(4):297–301. https://doi.org/10.1210/er.2017-00171.

Article  PubMed  Google Scholar 

Goldman AL, Bhasin S, Wu FCW, et al. A reappraisal of testosterone’s binding in circulation: physiological and clinical implications. Endocr Rev. 2017;38(4):302–24. https://doi.org/10.1210/er.2017-00025.

Article  PubMed  PubMed Central  Google Scholar 

Labrie F, Luu-The V, Labrie C, et al. Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone. Endocr Rev. 2003;24(2):152–82. https://doi.org/10.1210/er.2001-0031.

Article  CAS  PubMed  Google Scholar 

Mezzullo M, Gambineri A, Di Dalmazi G, et al. Steroid reference intervals in women: influence of menopause, age and metabolism. Eur J Endocrinol. 2021;184(3):395–407. https://doi.org/10.1530/EJE-20-1147.

Article  PubMed  Google Scholar 

Rothman MS, Carlson NE, Xu M, et al. Reexamination of testosterone, dihydrotestosterone, estradiol and estrone levels across the menstrual cycle and in postmenopausal women measured by liquid chromatography-tandem mass spectrometry. Steroids. 2011;76(1–2):177–82. https://doi.org/10.1016/j.steroids.2010.10.010.

Article  CAS  PubMed  Google Scholar 

Wierman ME, Arlt W, Basson R, et al. Androgen therapy in women: a reappraisal: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2014;99(10):3489–510. https://doi.org/10.1210/jc.2014-2260.

Article  CAS  PubMed  Google Scholar 

Labrie F, Martel C, Bélanger A, et al. Androgens in women are essentially made from DHEA in each peripheral tissue according to intracrinology. J Steroid Biochem Mol Biol. 2017;168:9–18. https://doi.org/10.1016/j.jsbmb.2016.12.007.

Article  CAS  PubMed  Google Scholar 

Storbeck KH, O’Reilly MW. The clinical and biochemical significance of 11-oxygenated androgens in human health and disease. Eur J Endocrinol. 2023;188(4):R98–109. https://doi.org/10.1093/ejendo/lvad047.

Article  PubMed  Google Scholar 

Hsing AW, Stanczyk FZ, Bélanger A, et al. Reproducibility of serum sex steroid assays in men by RIA and mass spectrometry. Cancer Epidemiol Biomarkers Prev. 2007;16(5):1004–8. https://doi.org/10.1158/1055-9965.EPI-06-0792.

Article  CAS  PubMed  Google Scholar 

Ohlsson C, Nilsson ME, Tivesten A, et al. Comparisons of immunoassay and mass spectrometry measurements of serum estradiol levels and their influence on clinical association studies in men. J Clin Endocrinol Metab. 2013;98(6):E1097–102. https://doi.org/10.1210/jc.2012-3861.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Handelsman DJ, Wartofsky L. Requirement for mass spectrometry sex steroid assays in the Journal of Clinical Endocrinology and Metabolism. J Clin Endocrinol Metab. 2013;98(10):3971–3. https://doi.org/10.1210/jc.2013-3375.

Article  CAS  PubMed  Google Scholar 

Miller KK, Sesmilo G, Schiller A, et al. Androgen deficiency in women with hypopituitarism. J Clin Endocrinol Metab. 2001;86(2):561–7. https://doi.org/10.1210/jcem.86.2.7246.

Article  CAS  PubMed 

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