Regal M, Páramo C, Sierra SM, Garcia-Mayor RV. Prevalence and incidence of hypopituitarism in an adult Caucasian population in northwestern Spain. Clin Endocrinol (Oxf). 2001;55(6):735–40. https://doi.org/10.1046/j.1365-2265.2001.01406.x.

Article  CAS  PubMed  Google Scholar 

Pappachan JM, Raskauskiene D, Kutty VR, Clayton RN. Excess mortality associated with hypopituitarism in adults: a meta-analysis of observational studies. J Clin Endocrinol Metab. 2015;100(4):1405–11. https://doi.org/10.1210/jc.2014-3787.

Article  CAS  PubMed  Google Scholar 

Singh S, Bajorek B. Defining “elderly” in clinical practice guidelines for pharmacotherapy. Pharm Pract (Granada). 2014;12(4):489. https://doi.org/10.4321/s1886-36552014000400007.

Article  PubMed  Google Scholar 

Tanriverdi F, Dokmetas HS, Kebapcı N, Kilicli F, Atmaca H, Yarman S, Ertorer ME, Erturk E, Bayram F, Tugrul A, Culha C, Cakir M, Mert M, Aydin H, Taskale M, Ersoz N, Canturk Z, Anaforoglu I, Ozkaya M, Oruk G, Hekimsoy Z, Kelestimur F, Erbas T. Etiology of hypopituitarism in tertiary care institutions in Turkish population: analysis of 773 patients from Pituitary Study Group database. Endocrine. 2014;47(1):198–205. https://doi.org/10.1007/s12020-013-0127-4.

Article  CAS  PubMed  Google Scholar 

Karaca Z, Laway BA, Dokmetas HS, Atmaca H, Kelestimur F. Sheehan syndrome Nat Rev Dis Primers. 2016;2:16092. https://doi.org/10.1038/nrdp.2016.92.

Article  PubMed  Google Scholar 

Villar-Taibo R, Díaz-Ortega C, Sifontes-Dubon M, Fernández-Pombo A, Serramito-García R, Martínez-Capoccioni G, Bernabeu I. Pituitary surgery in elderly patients: a safe and effective procedure. Endocrine. 2021;72(3):814–22. https://doi.org/10.1007/s12020-021-02665-6.

Article  CAS  PubMed  Google Scholar 

Nomikos P, Ladar C, Fahlbusch R, Buchfelder M. Impact of primary surgery on pituitary function in patients with non-functioning pituitary adenomas – a study on 721 patients. Acta Neurochir (Wien). 2004;146(1):27–35. https://doi.org/10.1007/s00701-003-0174-3.

Article  CAS  PubMed  Google Scholar 

Jahangiri A, Wagner JR, Han SW, Tran MT, Miller LM, Chen R, Tom MW, Ostling LR, Kunwar S, Blevins L, Aghi MK. Improved versus worsened endocrine function after transsphenoidal surgery for nonfunctional pituitary adenomas: rate, time course, and radiological analysis. J Neurosurg. 2016;124(3):589–95. https://doi.org/10.3171/2015.1.Jns141543.

Article  CAS  PubMed  Google Scholar 

Cohen-Inbar O, Ramesh A, Xu Z, Vance ML, Schlesinger D, Sheehan JP. Gamma knife radiosurgery in patients with persistent acromegaly or Cushing’s disease: long-term risk of hypopituitarism. Clin Endocrinol (Oxf). 2016;84(4):524–31. https://doi.org/10.1111/cen.12938.

Article  PubMed  Google Scholar 

Klose M, Juul A, Struck J, Morgenthaler NG, Kosteljanetz M, Feldt-Rasmussen U. Acute and long-term pituitary insufficiency in traumatic brain injury: a prospective single-centre study. Clin Endocrinol (Oxf). 2007;67(4):598–606. https://doi.org/10.1111/j.1365-2265.2007.02931.x.

Article  CAS  PubMed  Google Scholar 

Schneider HJ, Schneider M, Saller B, Petersenn S, Uhr M, Husemann B, von Rosen F, Stalla GK. Prevalence of anterior pituitary insufficiency 3 and 12 months after traumatic brain injury. Eur J Endocrinol. 2006;154(2):259–65. https://doi.org/10.1530/eje.1.02071.

Article  CAS  PubMed  Google Scholar 

Schneider HJ, Kreitschmann-Andermahr I, Ghigo E, Stalla GK, Agha A. Hypothalamopituitary dysfunction following traumatic brain injury and aneurysmal subarachnoid hemorrhage: a systematic review. JAMA. 2007;298(12):1429–38. https://doi.org/10.1001/jama.298.12.1429.

Article  CAS  PubMed  Google Scholar 

Bondanelli M, Ambrosio MR, Carli A, Bergonzoni A, Bertocchi A, Zatelli MC, Ceruti S, Valle D, Basaglia N, degli Uberti EC. Predictors of pituitary dysfunction in patients surviving ischemic stroke. J Clin Endocrinol Metab. 2010;95(10):4660–8. https://doi.org/10.1210/jc.2010-0611.

Article  CAS  PubMed  Google Scholar 

Tanriverdi F, Schneider HJ, Aimaretti G, Masel BE, Casanueva FF, Kelestimur F. Pituitary dysfunction after traumatic brain injury: a clinical and pathophysiological approach. Endocr Rev. 2015;36(3):305–42. https://doi.org/10.1210/er.2014-1065.

Article  CAS  PubMed  Google Scholar 

Torino F, Corsello SM, Salvatori R. Endocrinological side-effects of immune checkpoint inhibitors. Curr Opin Oncol. 2016;28(4):278–87. https://doi.org/10.1097/cco.0000000000000293.

Article  CAS  PubMed  Google Scholar 

Caturegli P, Di Dalmazi G, Lombardi M, Grosso F, Larman HB, Larman T, Taverna G, Cosottini M, Lupi I. Hypophysitis secondary to cytotoxic T-lymphocyte-associated protein 4 blockade: Insights into pathogenesis from an autopsy series. Am J Pathol. 2016;186(12):3225–35. https://doi.org/10.1016/j.ajpath.2016.08.020.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Barnabei A, Strigari L, Corsello A, Paragliola RM, Falzone L, Salvatori R, Corsello SM, Torino F. Immune checkpoint inhibitor-induced central diabetes insipidus: Looking for the needle in the haystack or a very rare side-effect to promptly diagnose? Front Oncol. 2022;12:798517. https://doi.org/10.3389/fonc.2022.798517.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Türe U, De Bellis A, Harput MV, Bellastella G, Topcuoglu M, Yaltirik CK, Cirillo P, Yola RN, Sav A, Kelestimur F. Hypothalamitis: a novel autoimmune endocrine disease. A literature review and case report. J Clin Endocrinol Metabol. 2020;106(2):e415–29. https://doi.org/10.1210/clinem/dgaa771.

Article  Google Scholar 

Biondi B. The normal TSH reference range: What has changed in the last decade? J Clin Endocrinol Metab. 2013;98(9):3584–7. https://doi.org/10.1210/jc.2013-2760.

Article  CAS  PubMed  Google Scholar 

Hollowell JG, Staehling NW, Flanders WD, Hannon WH, Gunter EW, Spencer CA, Braverman LE. Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III). J Clin Endocrinol Metab. 2002;87(2):489–99. https://doi.org/10.1210/jcem.87.2.8182.

Article  CAS  PubMed  Google Scholar 

Kahapola-Arachchige KM, Hadlow N, Wardrop R, Lim EM, Walsh JP. Age-specific TSH reference ranges have minimal impact on the diagnosis of thyroid dysfunction. Clin Endocrinol (Oxf). 2012;77(5):773–9. https://doi.org/10.1111/j.1365-2265.2012.04463.x.

Article  CAS  PubMed  Google Scholar 

Vadiveloo T, Donnan PT, Murphy MJ, Leese GP. Age- and gender-specific TSH reference intervals in people with no obvious thyroid disease in Tayside, Scotland: the Thyroid Epidemiology, Audit, and Research Study (TEARS). J Clin Endocrinol Metab. 2013;98(3):1147–53. https://doi.org/10.1210/jc.2012-3191.

Article  CAS  PubMed  Google Scholar 

Corsonello A, Montesanto A, Berardelli M, De Rango F, Dato S, Mari V, Mazzei B, Lattanzio F, Passarino G. A cross-section analysis of FT3 age-related changes in a group of old and oldest-old subjects, including centenarians’ relatives, shows that a down-regulated thyroid function has a familial component and is related to longevity. Age Ageing. 2010;39(6):723–7. https://doi.org/10.1093/ageing/afq116.

Article  PubMed  PubMed Central  Google Scholar 

Donda A, Lemarchand-Beraud T. Aging alters the activity of 5’-deiodinase in the adenohypophysis, thyroid gland, and liver of the male rat. Endocrinology. 1989;124(3):1305–9. https://doi.org/10.1210/endo-124-3-1305.

Article  CAS  PubMed  Google Scholar 

Bremner AP, Feddema P, Leedman PJ, Brown SJ, Beilby JP, Lim EM, Wilson SG, O’Leary PC, Walsh JP. Age-related changes in thyroid function: a longitudinal study of a community-based cohort. J Clin Endocrinol Metab. 2012;97(5):1554–62. https://doi.org/10.1210/jc.2011-3020.

Article  CAS  PubMed  Google Scholar 

Fleseriu M, Hashim IA, Karavitaki N, Melmed S, Murad MH, Salvatori R, Samuels MH. Hormonal Replacement in Hypopituitarism in Adults: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2016;101(11):3888–921. https://doi.org/10.1210/jc.2016-2118.

Article  CAS  PubMed