Matthay MA, Zemans RL, Zimmerman GA et al (2019) Acute respiratory distress syndrome. Nat Rev Dis Primers 5:18

Article  PubMed  PubMed Central  Google Scholar 

Wang D, Hu B, Hu C et al (2020) Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA: 323(11):1061–1069. https://doi.org/10.1001/jama.2020.1585

Channappanavar R, Perlman S (2017) Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology. Semin Immunopathol 39:529–539

Article  CAS  PubMed  PubMed Central  Google Scholar 

Calfee CS, Delucchi KL, Sinha P et al (2018) Acute respiratory distress syndrome subphenotypes and differential response to simvastatin: secondary analysis of a randomised controlled trial. Lancet Respir Med 6:691–698

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sinha P, Delucchi KL, Thompson BT, McAuley DF, Matthay MA, Calfee CS (2018) Latent class analysis of ARDS subphenotypes: a secondary analysis of the statins for acutely injured lungs from sepsis (SAILS) study. Intensive Care Med 44:1859–1869

Article  CAS  PubMed  PubMed Central  Google Scholar 

Calfee CS, Delucchi K, Parsons PE, Thompson BT, Ware LB, Matthay MA (2014) Subphenotypes in acute respiratory distress syndrome: latent class analysis of data from two randomised controlled trials. Lancet Respir Med 2:611–620

Article  PubMed  PubMed Central  Google Scholar 

Chow CW, Herrera Abreu MT, Suzuki T, Downey GP (2003) Oxidative stress and acute lung injury. Am J Respir Cell Mol Biol 29:427–431

Article  CAS  PubMed  Google Scholar 

Kellner M, Noonepalle S, Lu Q, Srivastava A, Zemskov E, Black SM (2017) ROS signaling in the pathogenesis of Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS). Adv Exp Med Biol 967:105–137

Article  CAS  PubMed  PubMed Central  Google Scholar 

Taher A, Lashgari M, Sedighi L, Rahimi-Bashar F, Poorolajal J, Mehrpooya M (2021) A pilot study on intravenous N-Acetylcysteine treatment in patients with mild-to-moderate COVID19-associated acute respiratory distress syndrome. Pharmacol Rep 73:1650–1659

Article  CAS  PubMed  PubMed Central  Google Scholar 

Obi J, Pastores SM, Ramanathan LV, Yang J, Halpern NA (2020) Treating sepsis with vitamin C, thiamine, and hydrocortisone: exploring the quest for the magic elixir. J Crit Care 57:231–239

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bernard GR, Wheeler AP, Arons MM et al (1997) A trial of antioxidants N-acetylcysteine and procysteine in ARDS. The antioxidant in ARDS study group. Chest 112:164–172

Article  CAS  PubMed  Google Scholar 

Dushianthan A, Cusack R, Burgess VA, Grocott MP, Calder PC (2019) Immunonutrition for acute respiratory distress syndrome (ARDS) in adults. Cochrane Database Syst Rev 1:Cd012041

PubMed  Google Scholar 

Fowler AA 3rd, Truwit JD, Hite RD et al (2019) Effect of vitamin C infusion on organ failure and biomarkers of inflammation and vascular injury in patients with sepsis and severe acute respiratory failure: the CITRIS-ALI randomized clinical trial. JAMA 322:1261–1270

Article  PubMed  PubMed Central  Google Scholar 

Langlois PL, D’Aragon F, Hardy G, Manzanares W (2019) Omega-3 polyunsaturated fatty acids in critically ill patients with acute respiratory distress syndrome: a systematic review and meta-analysis. Nutrition 61:84–92

Article  CAS  PubMed  Google Scholar 

Mahmoodpoor A, Hamishehkar H, Shadvar K et al (2019) The effect of intravenous selenium on oxidative stress in critically ill patients with acute respiratory distress syndrome. Immunol Invest 48:147–159

Article  PubMed  Google Scholar 

Alonso de Vega JM, Díaz J, Serrano E, Carbonell LF (2002) Oxidative stress in critically ill patients with systemic inflammatory response syndrome. Crit Care Med 30:1782–1786

Article  PubMed  Google Scholar 

Forman HJ, Zhang H (2021) Targeting oxidative stress in disease: promise and limitations of antioxidant therapy. Nat Rev Drug Discovery 20:689–709

Article  CAS  PubMed  Google Scholar 

Dikalov S, Fink B, Skatchkov M, Bassenge E (1999) Comparison of glyceryl trinitrate-induced with pentaerythrityl tetranitrate-induced in vivo formation of superoxide radicals: effect of vitamin C. Free Radic Biol Med 27:170–176

Article  CAS  PubMed  Google Scholar 

Dikalov SI, Dikalova AE, Morozov DA, Kirilyuk IA (2018) Cellular accumulation and antioxidant activity of acetoxymethoxycarbonyl pyrrolidine nitroxides. Free Radic Res 52:339–350

Article  CAS  PubMed  Google Scholar 

Carlsson LM, Jonsson J, Edlund T, Marklund SL (1995) Mice lacking extracellular superoxide dismutase are more sensitive to hyperoxia. Proc Natl Acad Sci U S A 92:6264–6268

Article  CAS  PubMed  PubMed Central  Google Scholar 

Folz RJ, Abushamaa AM, Suliman HB (1999) Extracellular superoxide dismutase in the airways of transgenic mice reduces inflammation and attenuates lung toxicity following hyperoxia. J Clin Invest 103:1055–1066

Article  CAS  PubMed  PubMed Central  Google Scholar 

Elajaili HB, Dee N, Woodcock L et al (2022) Developing EPR Tools for Preclinical Interrogation of Redox Regulation Mechanisms Contributing to Acute Lung Injury. In B50 Diffuse Lung Disease and Acute Lung Injury. American Thoracic Society, pp. A3018-A3018

Fink B, Dikalov S, Bassenge E (2000) A new approach for extracellular spin trapping of nitroglycerin-induced superoxide radicals both in vitro and in vivo. Free Radical Biol Med 28:121–128

Article  CAS  Google Scholar 

Ahmed MN, Zhang Y, Codipilly C et al (2012) Extracellular superoxide dismutase overexpression can reverse the course of hypoxia-induced pulmonary hypertension. Mol Med 18:38–46

Article  CAS  PubMed  Google Scholar 

Auten RL, O’Reilly MA, Oury TD, Nozik-Grayck E, Whorton MH (2006) Transgenic extracellular superoxide dismutase protects postnatal alveolar epithelial proliferation and development during hyperoxia. Am J Physiol Lung Cell Mol Physiol 290:L32-40

Article  CAS  PubMed  Google Scholar 

Kang SK, Rabbani ZN, Folz RJ et al (2003) Overexpression of extracellular superoxide dismutase protects mice from radiation-induced lung injury. Int J Radiat Oncol Biol Phys 57:1056–1066

Article  CAS  PubMed  Google Scholar 

Nozik-Grayck E, Suliman HB, Majka S et al (2008) Lung EC-SOD overexpression attenuates hypoxic induction of Egr-1 and chronic hypoxic pulmonary vascular remodeling. Am J Physiol Lung Cell Mol Physiol 295:L422-430

Article  CAS  PubMed  PubMed Central  Google Scholar 

Perveen S, Patel H, Arif A, Younis S, Codipilly CN, Ahmed M (2012) Role of EC-SOD overexpression in preserving pulmonary angiogenesis inhibited by oxidative stress. PLoS One 7:e51945

Article  PubMed  PubMed Central  Google Scholar 

Rabbani ZN, Anscher MS, Folz RJ et al (2005) Overexpression of extracellular superoxide dismutase reduces acute radiation induced lung toxicity. BMC Cancer 5:59

Article  PubMed  PubMed Central  Google Scholar 

Suliman HB, Ryan LK, Bishop L, Folz RJ (2001) Prevention of influenza-induced lung injury in mice overexpressing extracellular superoxide dismutase. Am J Physiol Lung Cell Mol Physiol 280:L69-78

Article  CAS  PubMed  Google Scholar 

Zaghloul N, Nasim M, Patel H et al (2012) Overexpression of extracellular superoxide dismutase has a protective role against hyperoxia-induced brain injury in neonatal mice. FEBS J 279:871–881

Article  CAS  PubMed