Cryo-Fluorescence Tomography as a Tool for Visualizing Whole-Body Inflammation Using Perfluorocarbon Nanoemulsion Tracers

Ahrens ET, Bulte JWM (2013) Tracking immune cells in vivo using magnetic resonance imaging. Nat Rev Immunol 13:755–763

Article  CAS  PubMed  Google Scholar 

Roy D, Steyer GJ, Gargesha M, Stone ME, Wilson DL (2009) 3D cryo-imaging: a very high-resolution view of the whole mouse. Anat Rec (Hoboken) 292:342–351

Article  PubMed  Google Scholar 

Wang C, Adams SR, Ahrens ET (2021) Emergent Fluorous Molecules and Their Uses in Molecular Imaging. Acc Chem Res 54:3060–3070

Article  CAS  PubMed  Google Scholar 

Steyer GJ, Roy D, Salvado O, Stone ME, Wilson DL (2009) Cryo-imaging of fluorescently-labeled single cells in a mouse. Proc SPIE Int Soc Opt Eng 7262:72620W-72620W72628

Khurana A, Chapelin F, Xu H et al (2018) Visualization of macrophage recruitment in head and neck carcinoma model using fluorine-19 magnetic resonance imaging. Magn Reson Med 79:1972–1980

Article  CAS  PubMed  Google Scholar 

Zhong J, Narsinh K, Morel PA, Xu H, Ahrens ET (2015) In vivo quantification of inflammation in experimental autoimmune encephalomyelitis rats using fluorine-19 magnetic resonance imaging reveals immune cell recruitment outside the nervous system. PLoS ONE 10:e0140238

Article  PubMed  PubMed Central  Google Scholar 

Ahrens ET, Zhong J (2013) In vivo MRI cell tracking using perfluorocarbon probes and fluorine-19 detection. NMR Biomed 26:860–871

Article  CAS  PubMed  PubMed Central  Google Scholar 

Janjic JM, Ahrens ET (2009) Fluorine-containing nanoemulsions for MRI cell tracking. Wiley Interdiscip Rev Nanomed Nanobiotechnol 1:492–501

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ahrens ET, Flores R, Xu H, Morel PA (2005) In vivo imaging platform for tracking immunotherapeutic cells. Nat Biotechnol 23:983–987

Article  CAS  PubMed  Google Scholar 

Wang C, Leach BI, Lister D et al (2021) Metallofluorocarbon nanoemulsion for inflammatory macrophage detection via PET and MRI. J Nucl Med 62:1146–1153

Article  CAS  PubMed  Google Scholar 

Balducci A, Wen Y, Zhang Y et al (2013) A novel probe for the non-invasive detection of tumor-associated inflammation. OncoImmunology 2:e23034

Article  PubMed  PubMed Central  Google Scholar 

Janjic JM, Srinivas M, Kadayakkara DK, Ahrens ET (2008) Self-delivering nanoemulsions for dual fluorine-19 MRI and fluorescence detection. J Am Chem Soc 130:2832–2841

Article  CAS  PubMed  Google Scholar 

Patrick MJ, Janjic JM, Teng H et al (2013) Intracellular pH measurements using perfluorocarbon nanoemulsions. J Am Chem Soc 135:18445–18457

Article  CAS  PubMed  PubMed Central  Google Scholar 

Krafft MP, Chittofrati A, Riess JG (2003) Emulsions and microemulsions with a fluorocarbon phase. Curr Opin Colloid Interface Sci 8:251–258

Article  CAS  Google Scholar 

Squires JE (2002) Artificial blood. Science 295:1002–1005

Article  CAS  PubMed  Google Scholar 

Perez AS, Zhou J, Leach B, et al (2021) Click-Ready Perfluorocarbon Nanoemulsion for 19F MRI and Multimodal Cellular Detection. ACS Nanoscience Au

Posadas I, Bucci M, Roviezzo F et al (2004) Carrageenan-induced mouse paw oedema is biphasic, age-weight dependent and displays differential nitric oxide cyclooxygenase-2 expression. Brit J Pharmacol 142:331–338

Article  CAS  Google Scholar 

Okayasu I, Hatakeyama S, Yamada M, Ohkusa T, Inagaki Y, Nakaya R (1990) A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice. Gastroenterology 98:694–702

Article  CAS  PubMed  Google Scholar 

Schindelin J, Arganda-Carreras I, Frise E et al (2012) Fiji: an open-source platform for biological-image analysis. Nat Methods 9:676–682

Article  CAS  PubMed  Google Scholar 

Ahrens ET, Young W-B, Xu H, Pusateri LK (2011) Rapid quantification of inflammation in tissue samples using perfluorocarbon emulsion and fluorine-19 nuclear magnetic resonance. Biotechniques 50:229–234

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sandell JL, Zhu TC (2011) A review of in-vivo optical properties of human tissues and its impact on PDT. J Biophotonics 4:773–787

Article  PubMed  PubMed Central  Google Scholar 

Jacques SL (2013) Optical properties of biological tissues: a review. Phys Med Biol 58:R37-61

Article  PubMed  Google Scholar 

Schaeffter T (2005) Imaging modalities: principles and information content. Prog Drug Res 62:15–81

PubMed  Google Scholar 

Kadayakkara DK, Ranganathan S, Young WB, Ahrens ET (2012) Assaying macrophage activity in a murine model of inflammatory bowel disease using fluorine-19 MRI. Lab Invest 92:636–645

Article  CAS  PubMed  PubMed Central  Google Scholar 

Makela AV, Foster PJ (2018) Imaging macrophage distribution and density in mammary tumors and lung metastases using fluorine-19 MRI cell tracking. Magn Reson Med 80:1138–1147

Article  CAS  PubMed  Google Scholar 

Geyer RP (1973) Fluorocarbon-polyol artificial blood substitutes. N Engl J Med 289:1077–1082

Article  CAS  PubMed  Google Scholar 

Spahn DR (1999) Blood substitutes. Artificial oxygen carriers: perfluorocarbon emulsions. Crit Care 3:R93-97

Article  CAS  PubMed  PubMed Central  Google Scholar 

Flögel U, Ding Z, Hardung H et al (2008) In vivo monitoring of inflammation after cardiac and cerebral ischemia by fluorine magnetic resonance imaging. Circulation 118:140–148

Article  PubMed  PubMed Central  Google Scholar 

Hitchens TK, Ye Q, Eytan DF, Janjic JM, Ahrens ET, Ho C (2011) 19F MRI detection of acute allograft rejection with in vivo perfluorocarbon labeling of immune cells. Magn Reson Med 65:1144–1153

Article  PubMed  PubMed Central  Google Scholar 

Shin SH, Kadayakkara DK, Bulte JW (2017) In vivo 19F MR imaging cell tracking of inflammatory macrophages and site-specific development of colitis-associated dysplasia. Radiology 282:194–201

Article  PubMed  Google Scholar 

Vindegaard N, Muñoz-Briones C, El Ali HH et al (2017) T-cells and macrophages peak weeks after experimental stroke: Spatial and temporal characteristics. Neuropathology 37:407–414

Article  CAS  PubMed  Google Scholar 

Hertlein T, Sturm V, Kircher S et al (2011) Visualization of abscess formation in a murine thigh infection model of staphylococcus aureus by F-19-magnetic resonance imaging (MRI). PLoS ONE 6(3):e18246

Article  CAS  PubMed  PubMed Central  Google Scholar 

Weise G, Basse-Luesebrink TC, Wessig C, Jakob PM, Stoll G (2011) In vivo imaging of inflammation in the peripheral nervous system by F-19 MRI. Exp Neurol 229:494–501

Article  CAS  PubMed  Google Scholar 

Makela AV, Gaudet JM, Foster PJ (2017) Quantifying tumor associated macrophages in breast cancer: a comparison of iron and fluo

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