Wörz R, Horlemann J, Müller-Schwefe GHH. Auswirkungen chronifizierung, epidemiologie, zeitgemäße. Diagnostik Schmerzmed. 2022;38(4):46–50. https://doi.org/10.1007/s00940-022-3350-3. (Epub 2022 Jul 19).

Article  Google Scholar 

Cohen SP, Vase L, Hooten WM. Chronic pain: an update on burden, best practices, and new advances. Lancet. 2021;397(10289):2082–97.

Article  PubMed  Google Scholar 

Zimmer Z, Fraser K, Grol-Prokopczyk H, Zajacova A. A global study of pain prevalence across 52 countries: examining the role of country-level contextual factors. Pain. 2022;163(9):1740–50.

Article  PubMed  Google Scholar 

Raja SN, Carr DB, Cohen M, Finnerup NB, Flor H, Gibson S, et al. The revised International Association for the Study of Pain definition of pain: concepts, challenges, and compromises. Pain. 2020;161(9):1976–82.

Article  PubMed  PubMed Central  Google Scholar 

Granger DN, Kvietys PR. Reperfusion injury and reactive oxygen species: the evolution of a concept. Redox Biol. 2015;6:524–51.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mittal M, Siddiqui MR, Tran K, Reddy SP, Malik AB. Reactive oxygen species in inflammation and tissue injury. Antioxid Redox Signal. 2014;20(7):1126–67.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liou GY, Storz P. Reactive oxygen species in cancer. Free Radic Res. 2010;44(5):479–96.

Article  CAS  PubMed  Google Scholar 

Nakamura H, Takada K. Reactive oxygen species in cancer: current findings and future directions. Cancer Sci. 2021;112(10):3945–52.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Makrantonaki E, Wlaschek M, Scharffetter-Kochanek K. Pathogenesis of wound healing disorders in the elderly. J Dtsch Dermatol Ges. 2017;15(3):255–75.

PubMed  Google Scholar 

Dos Santos JM, Rodrigues Lacerda AC, Ribeiro VGC, Scheidt Figueiredo PH, Fonseca SF, da Silva Lage VK, et al. Oxidative stress biomarkers and quality of life are contributing factors of muscle pain and lean body mass in patients with fibromyalgia. Biology (Basel). 2022;11(6):935.

PubMed  PubMed Central  Google Scholar 

Assavarittirong C, Samborski W, Grygiel-Górniak B. Oxidative stress in fibromyalgia: from pathology to treatment. Oxid Med Cell Longev. 2022;2022:1582432.

Article  PubMed  PubMed Central  Google Scholar 

Hendrix J, Nijs J, Ickmans K, Godderis L, Ghosh M, Polli A. The interplay between oxidative stress, exercise, and pain in health and disease: potential role of autonomic regulation and epigenetic mechanisms. Antioxidants (Basel). 2020;9(11):1166.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fernández-Araque A, Verde Z, Torres-Ortega C, Sainz-Gil M, Velasco-Gonzalez V, González-Bernal JJ, et al. Effects of antioxidants on pain perception in patients with fibromyalgia—a systematic review. J Clin Med. 2022;11(9):2462.

Article  PubMed  PubMed Central  Google Scholar 

Carr AC, Maggini S. Vitamin C and immune function. Nutrients. 2017;9(11):1211.

Article  PubMed  PubMed Central  Google Scholar 

Lunec J, Blake DR. The determination of dehydroascorbic acid and ascorbic acid in the serum and synovial fluid of patients with rheumatoid arthritis (RA). Free Radic Res Commun. 1985;1(1):31–9.

Article  CAS  PubMed  Google Scholar 

Carr AC, Cook J. Intravenous vitamin C for cancer therapy—identifying the current gaps in our knowledge. Front Physiol. 2018;9:1182.

Article  PubMed  PubMed Central  Google Scholar 

Travica N, Ried K, Hudson I, Scholey A, Pipingas A, Sali A. The effects of surgery on plasma/serum vitamin C concentrations: a systematic review and meta-analysis. Br J Nutr. 2022;127(2):233–47.

Article  CAS  PubMed  Google Scholar 

Dionne CE, Laurin D, Desrosiers T, Abdous B, Le Sage N, Frenette J, et al. Serum vitamin C and spinal pain: a nationwide study. Pain. 2016;157(11):2527–35.

Article  CAS  PubMed  Google Scholar 

Suzen M, Zengin M, Ciftci B, Uckan S. Does the vitamin C level affect postoperative analgesia in patients who undergo orthognathic surgery? Int J Oral Maxillofac Surg. 2023;52(2):205–10.

Article  CAS  PubMed  Google Scholar 

Frei B, England L, Ames BN. Ascorbate is an outstanding antioxidant in human blood plasma. Proc Natl Acad Sci USA. 1989;86(16):6377–81.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gęgotek A, Skrzydlewska E. Antioxidative and anti-inflammatory activity of ascorbic acid. Antioxidants (Basel). 2022;11(10):1993.

Article  PubMed  Google Scholar 

Vollbracht C, Kraft K. Oxidative stress and hyper-inflammation as major drivers of severe COVID-19 and long COVID: implications for the benefit of high-dose intravenous vitamin C. Front Pharmacol. 2022;13: 899198.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Carr AC, McCall C. The role of vitamin C in the treatment of pain: new insights. J Transl Med. 2017;15(1):77.

Article  PubMed  PubMed Central  Google Scholar 

Thaler R, Khani F, Sturmlechner I, Dehghani SS, Denbeigh JM, Zhou X, et al. Vitamin C epigenetically controls osteogenesis and bone mineralization. Nat Commun. 2022;13(1):5883.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hong JY, Davaa G, Yoo H, Hong K, Hyun JK. Ascorbic acid promotes functional restoration after spinal cord injury partly by epigenetic modulation. Cells. 2020;9(5):1310.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Morris-Blanco KC, Chokkalla AK, Kim T, Bhatula S, Bertogliat MJ, Gaillard AB, et al. High-dose vitamin C prevents secondary brain damage after stroke via epigenetic reprogramming of neuroprotective genes. Transl Stroke Res. 2022;13:1017–36.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Padayatty SJ, Sun H, Wang Y, Riordan HD, Hewitt SM, Katz A, et al. Vitamin C pharmacokinetics: implications for oral and intravenous use. Ann Intern Med. 2004;140(7):533–7.

Article  CAS  PubMed  Google Scholar 

Hung KC, Lin YT, Chen KH, Wang LK, Chen JY, Chang YJ, et al. The effect of perioperative vitamin C on postoperative analgesic consumption: a meta-analysis of randomized controlled trials. Nutrients. 2020;12(10):3109.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen S, Roffey DM, Dion CA, Arab A, Wai EK. Effect of perioperative vitamin C supplementation on postoperative pain and the incidence of chronic regional pain syndrome: a systematic review and meta-analysis. Clin J Pain. 2016;32(2):179–85.

Article  PubMed  Google Scholar 

Seth I, Bulloch G, Seth N, Siu A, Clayton S, Lower K, et al. Effect of perioperative vitamin C on the incidence of complex regional pain syndrome: a systematic review and meta-analysis. J Foot Ankle Surg. 2021;61:748–54.

Article  PubMed  Google Scholar 

Alimian M, Sobhani Eraghi A, Chavoshizadeh SA, Mohseni M, Mousavi E, Movassaghi S. Regional vitamin C in Bier block reduces the incidence of CRPS-1 following distal radius fracture surgery. Eur J Orthop Surg Traumatol. 2021;31(4):689–93.