A systematic review on the culture methods and applications of 3D tumoroids for cancer research and personalized medicine

K. Ronaldson-Bouchard, I. Baldassarri, D.N. Tavakol, P.L. Graney, M. Samaritano, E. Cimetta et al., Engineering complexity in human tissue models of cancer. Adv. Drug Deliv. Rev. 184, 114181 (2022). https://doi.org/10.1016/j.addr.2022.114181

Article  CAS  PubMed  PubMed Central  Google Scholar 

H. Sajjad, S. Imtiaz, T. Noor, Y.H. Siddiqui, A. Sajjad, M. Zia, Cancer models in preclinical research: a chronicle review of advancement in effective cancer research. Anim. Model. Exp. Med. 4, 87–103 (2021). https://doi.org/10.1002/ame2.12165

Article  Google Scholar 

K. Duval, H. Grover, L.-H. Han, Y. Mou, A.F. Pegoraro, J. Fredberg et al., Modeling physiological events in 2D vs. 3D cell culture. Physiol. (Bethesda). 32, 266–277 (2017). https://doi.org/10.1152/physiol.00036.2016

Article  CAS  Google Scholar 

M. Kapałczyńska, T. Kolenda, W. Przybyła, M. Zajączkowska, A. Teresiak, V. Filas et al., 2D and 3D cell cultures– a comparison of different types of cancer cell cultures. Arch. Med. Sci. 14, 910–919 (2018). https://doi.org/10.5114/aoms.2016.63743

Article  CAS  PubMed  Google Scholar 

J.-P. Gillet, A.M. Calcagno, S. Varma, M. Marino, L.J. Green, M.I. Vora et al., Redefining the relevance of established cancer cell lines to the study of mechanisms of clinical anti-cancer drug resistance. Proc Natl Acad Sci. 108, 18708–13 (2011). https://doi.org/10.1073/pnas.1111840108

L. Trastulla, J. Noorbakhsh, F. Vazquez, J. McFarland, F. Iorio, Computational estimation of quality and clinical relevance of cancer cell lines. Mol. Syst. Biol. 18, e11017 (2022). https://doi.org/10.15252/msb.202211017

Article  PubMed  PubMed Central  Google Scholar 

S. Abdolahi, Z. Ghazvinian, S. Muhammadnejad, M. Saleh, H. Asadzadeh Aghdaei, K. Baghaei, Patient-derived xenograft (PDX) models, applications and challenges in cancer research. J. Transl Med. 20, 206 (2022). https://doi.org/10.1186/s12967-022-03405-8

Article  PubMed  PubMed Central  Google Scholar 

K.F. Idrisova, H.-U. Simon, M.O. Gomzikova, Role of patient-derived models of cancer in translational oncology. Cancers. 15, 139 (2023). https://doi.org/10.3390/cancers15010139

Article  CAS  Google Scholar 

K.H. Griffin, S.W. Fok, J. Kent Leach, Strategies to capitalize on cell spheroid therapeutic potential for tissue repair and disease modeling. Npj Regen Med. 7, 1–13 (2022). https://doi.org/10.1038/s41536-022-00266-z

Article  Google Scholar 

M.A. Lancaster, M. Huch, Disease modelling in human organoids. Dis. Model. Mech. 12, dmm039347 (2019). https://doi.org/10.1242/dmm.039347

Article  CAS  PubMed  PubMed Central  Google Scholar 

T. Sato, D.E. Stange, M. Ferrante, R.G.J. Vries, Van J.H. Es, Van den S. Brink et al., Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett’s epithelium. Gastroenterology. 141, 1762–1772 (2011). https://doi.org/10.1053/j.gastro.2011.07.050

Article  CAS  PubMed  Google Scholar 

M. Huch, B.-K. Koo, Modeling mouse and human development using organoid cultures. Development. 142, 3113–3125 (2015). https://doi.org/10.1242/dev.118570

Article  CAS  PubMed  Google Scholar 

X. Li, L. Nadauld, A. Ootani, D.C. Corney, R.K. Pai, O. Gevaert et al., Oncogenic transformation of diverse gastrointestinal tissues in primary organoid culture. Nat. Med. 20, 769–777 (2014). https://doi.org/10.1038/nm.3585

Article  CAS  PubMed  PubMed Central  Google Scholar 

T. Sato, R.G. Vries, H.J. Snippert, van de M. Wetering, N. Barker, D.E. Stange et al., Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature. 459, 262–265 (2009). https://doi.org/10.1038/nature07935

Article  CAS  PubMed  Google Scholar 

C. Corrò, L. Novellasdemunt, V.S.W. Li, A brief history of organoids. Am. J. Physiology-Cell Physiol. 319, C151–C165 (2020). https://doi.org/10.1152/ajpcell.00120.2020

Article  CAS  Google Scholar 

S. Yang, H. Hu, H. Kung, R. Zou, Y. Dai, Y. Hu et al., Organoids: The current status and biomedical applications. MedComm (2020) 2023;4:e274. https://doi.org/10.1002/mco2.274

E. Driehuis, K. Kretzschmar, H. Clevers, Establishment of patient-derived cancer organoids for drug-screening applications. Nat. Protoc. 15, 3380–3409 (2020). https://doi.org/10.1038/s41596-020-0379-4

Article  CAS  PubMed  Google Scholar 

J. Drost, W.R. Karthaus, D. Gao, E. Driehuis, C.L. Sawyers, Y. Chen et al., Organoid culture systems for prostate epithelial tissue and prostate cancer tissue. Nat. Protoc. 11, 347–358 (2016). https://doi.org/10.1038/nprot.2016.006

Article  CAS  PubMed  PubMed Central  Google Scholar 

S. Nuciforo, I. Fofana, M.S. Matter, T. Blumer, D. Calabrese, T. Boldanova et al., Organoid models of Human Liver cancers derived from Tumor needle biopsies. Cell. Rep. 24, 1363–1376 (2018). https://doi.org/10.1016/j.celrep.2018.07.001

Article  CAS  PubMed  PubMed Central  Google Scholar 

C.J. Phifer, K.N. Bergdorf, M.E. Bechard, A. Vilgelm, N. Baregamian, O.G. McDonald et al., Obtaining patient-derived cancer organoid cultures via fine-needle aspiration. STAR. Protocols. 2, 100220 (2021). https://doi.org/10.1016/j.xpro.2020.100220

Article  CAS  PubMed  Google Scholar 

A.E. Vilgelm, K. Bergdorf, M. Wolf, V. Bharti, R. Shattuck-Brandt, A. Blevins et al., Fine-needle aspiration-based patient-derived cancer organoids. iScience. 23, 101408 (2020). https://doi.org/10.1016/j.isci.2020.101408

F. Schutgens, M.B. Rookmaaker, T. Margaritis, A. Rios, C. Ammerlaan, J. Jansen et al., Tubuloids derived from human adult kidney and urine for personalized disease modeling. Nat. Biotechnol. 37, 303–313 (2019). https://doi.org/10.1038/s41587-019-0048-8

Article  CAS  PubMed  Google Scholar 

O. Kopper, de C.J. Witte, K. Lõhmussaar, J.E. Valle-Inclan, N. Hami, L. Kester et al., An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity. Nat. Med. 25, 838–849 (2019). https://doi.org/10.1038/s41591-019-0422-6

Article  CAS  PubMed  Google Scholar 

N. Sachs, A. Papaspyropoulos, D.D. Zomer-van Ommen, I. Heo, L. Böttinger, D. Klay et al., Long-term expanding human airway organoids for disease modeling. EMBO J. 38, e100300 (2019). https://doi.org/10.15252/embj.2018100300

Article  CAS  PubMed  PubMed Central  Google Scholar 

K. Kinoshita, Y. Tsukamoto, Y. Hirashita, T. Fuchino, S. Kurogi, T. Uchida et al., Efficient establishment of bile-derived organoids from biliary cancer patients. Lab. Invest. 103, 100105 (2023). https://doi.org/10.1016/j.labinv.2023.100105

Article  PubMed  Google Scholar 

D. Gao, I. Vela, A. Sboner, P.J. Iaquinta, W.R. Karthaus, A. Gopalan et al., Organoid cultures derived from patients with advanced prostate cancer. Cell. 159, 176–187 (2014). https://doi.org/10.1016/j.cell.2014.08.016

Article  CAS  PubMed  PubMed Central  Google Scholar 

H.K. Kleinman, G.R. Martin, matrigel, basement membrane matrix with biological activity. Sem. Cancer Biol. 15, 378–386 (2005). https://doi.org/10.1016/j.semcancer.2005.05.004

Z. Gan, X. Qin, H. Liu, J. Liu, J. Qin, Recent advances in defined hydrogels in organoid research. Bioactive Mater. 28, 386 (2023). https://doi.org/10.1016/j.bioactmat.2023.06.004

Article  CAS  Google Scholar 

M. Fujii, M. Matano, K. Nanki, T. Sato, Efficient genetic engineering of human intestinal organoids using electroporation. Nat. Protoc. 10, 1474–1485 (2015). https://doi.org/10.1038/nprot.2015.088

Article  CAS  PubMed  Google Scholar 

J.F. Dekkers, van E.J. Vliet, N. Sachs, J.M. Rosenbluth, O. Kopper, H.G. Rebel et al., Long-term culture, genetic manipulation and xenotransplantation of human normal and breast cancer organoids. Nat. Protoc. 16, 1936–1965 (2021). https://doi.org/10.1038/s41596-020-00474-1

Article  CAS  PubMed  PubMed Central  Google Scholar 

J. Clinton, P. McWilliams-Koeppen, Initiation, expansion, and cryopreservation of human primary tissue-derived normal and diseased organoids in embedded three-dimensional culture. Curr. Protocols Cell. Biol. 82, e66 (2019). https://doi.org/10.1002/cpcb.66

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