Interstitial Lung Abnormalities (ILA) and Pulmonary Fibrosis

Hatabu H, Hunninghake GM, Lynch DA. Interstitial lung abnormality: recognition and perspectives. Radiology. 2019;291(1):1–3.

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•• Hatabu H, Hunninghake GM, Richeldi L, Brown KK, Wells AU, Remy-Jardin M, et al. Interstitial lung abnormalities detected incidentally on CT: a Position Paper from the Fleischner Society. Lancet Respir Med. 2020;8(7):726–37. This Position Paper by the Fleischner Society addressed important issues regarding ILA, including standardization of the definition and terminology, predisposing risk factors, clinical outcomes, management, and future research needs.

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•• Hata A, Schiebler ML, Lynch DA, Hatabu H. Interstitial lung abnormalities: state of the art. Radiology. 2021;301(1):19–34. This article reviewed the latest knowledge about ILA and explained the role of the radiologist in the management of ILA, including how ILA are described in radiologic reports.

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Putman RK, Rosas IO, Hunninghake GM. Genetics and early detection in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 2014;189(7):770–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

• Hino T, Lee KS, Han J, Hata A, Ishigami K, Hatabu H,. Spectrum of pulmonary fibrosis from interstitial lung abnormality to usual interstitial pneumonia: importance of identification and quantification of traction bronchiectasis in patient management. Korean J Radiol. 2021;22(5):811–28. This article described the spectrum of pulmonary fibrosis from ILA to UIP based on the radiological and pathological features of UIP, NSIP, and ILA, and special focus was given to traction bronchiectasis/bronchiolectasis on HRCT.

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• Hino T, Lee KS, Yoo H, Han J, Franks TJ, Hatabu H. Interstitial lung abnormality (ILA) and nonspecific interstitial pneumonia (NSIP). Eur J Radiol Open. 2021;8:100336. This article described the spectrum of pulmonary fibrosis from ILA to UIP based on the radiological and pathological features of UIP, NSIP, and ILA, and special focus was given to traction bronchiectasis/bronchiolectasis on HRCT.

Article  PubMed  PubMed Central  Google Scholar 

Tomassetti S, Poletti V, Ravaglia C, Sverzellati N, Piciucchi S, Cozzi D, et al. Incidental discovery of interstitial lung disease: diagnostic approach, surveillance and perspectives. Eur Respir Rev. 2022;31(164): 210206.

Article  PubMed  PubMed Central  Google Scholar 

Lee KS, Han J, Wada N, Hata A, Lee HY, Yi C, et al. Imaging of pulmonary fibrosis: an update, from the AJR Special Series on Imaging of Fibrosis. AJR Am J Roentgenol. 2023. https://doi.org/10.2214/AJR.23.29119.(publishedonline).

Article  PubMed  Google Scholar 

• Hata A, Hino T, Yanagawa M, Nishino M, Hida T, Hunninghake GM, et al. Interstitial lung abnormalities at CT: subtypes, clinical significance, and associations with lung cancer. Radiographics. 2022;42(7):1925–39. This article addressed the association between ILA and lung cancer in detail as well as an overview of ILA.

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Washko GR, Lynch DA, Matsuoka S, Ross JC, Umeoka S, Diaz A, et al. Identification of early interstitial lung disease in smokers from the COPDGene study. Acad Radiol. 2010;17(1):48–53.

Article  PubMed  Google Scholar 

Washko GR, Hunninghake GM, Fernandez IE, Nishino M, Okajima Y, Yamashiro T, et al. Lung volumes and emphysema in smokers with interstitial lung abnormalities. N Engl J Med. 2011;364(10):897–906.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hunninghake GM, Hatabu H, Okajima Y, Gao W, Dupuis J, Latourelle JC, et al. MUC5B promoter polymorphism and interstitial lung abnormalities. N Engl J Med. 2013;368(23):2192–200.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jin GY, Lynch D, Chawla A, Garg K, Tammemagi MC, Sahin H, et al. Interstitial lung abnormalities in a CT lung cancer screening population: prevalence and progression rate. Radiology. 2013;268(2):563–71.

Article  PubMed  PubMed Central  Google Scholar 

Araki T, Putman RK, Hatabu H, Gao W, Dupuis J, Latourelle JC, et al. Development and progression of interstitial lung abnormalities in the Framingham Heart study. Am J Respir Crit Care Med. 2016;194(12):1514–22.

Article  PubMed  PubMed Central  Google Scholar 

Putman RK, Hatabu H, Araki T, Gudmundsson G, Gao W, Nishino M, et al. Association between interstitial lung abnormalities and all-cause mortality. JAMA. 2016;315(7):672–81.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang Y, Wan H, Richeldi L, Zhu M, Huang Y, Xiong X, et al. Reticulation is a risk factor of progressive subpleural nonfibrotic interstitial lung abnormalities. Am J Respir Crit Care Med. 2022;206(2):178–85.

Article  PubMed  Google Scholar 

• Lee JE, Chae KJ, Suh YJ, Jeong WG, Lee T, Kim YH, et al. Prevalence and long-term outcomes of CT interstitial lung abnormalities in a health screening cohort. Radiology. 2023;306(2):e221172. This study showed that the prevalence of ILA in an Asian health screening cohort was approximately 3% and that fibrotic ILA was associated with imaging progression, lung cancer development, and mortality within 10-year follow-up.

Putman RK, Gudmundsson G, Axelsson GT, Hida T, Honda O, Araki T, et al. Imaging patterns are associated with interstitial lung abnormality progression and mortality. Am J Respir Crit Care Med. 2019;200(2):175–83.

Article  PubMed  PubMed Central  Google Scholar 

Bowman WS, Echt GA, Oldham JM. Biomarkers in progressive fibrosing interstitial lung disease: optimizing diagnosis, prognosis, and treatment response. Front Med (Lausanne). 2021;8:680997.

Article  PubMed  Google Scholar 

Raghu G, Remy-Jardin M, Richeldi L, Thomson CC, Inoue Y, Johkoh T, et al. Idiopathic pulmonary fibrosis (an update) and progressive pulmonary fibrosis in adults: an official ATS/ERS/JRS/ALAT clinical practice guideline. Am J Respir Crit Care Med. 2022;205(9):e18–47.

Article  PubMed  PubMed Central  Google Scholar 

Travis WD, Costabel U, Hansell DM, King TE Jr, Lynch DA, Nicholson AG, et al. An official American Thoracic Society/European Respiratory Society statement: update of the international multidisciplinary classification of the idiopathic interstitial pneumonias. Am J Respir Crit Care Med. 2013;188(6):733–48.

Article  PubMed  PubMed Central  Google Scholar 

Wijsenbeek M, Cottin V. Spectrum of fibrotic lung diseases. N Engl J Med. 2020;383(10):958–68.

Article  CAS  PubMed  Google Scholar 

Flaherty KR, Wells AU, Cottin V, Devaraj A, Walsh SLF, Inoue Y, et al. Nintedanib in progressive fibrosing interstitial lung diseases. N Engl J Med. 2019;381(18):1718–27.

Article  CAS  PubMed  Google Scholar 

Wells AU, Brown KK, Flaherty KR, Kolb M, Thannickal VJ, Group IPFCW. What’s in a name? That which we call IPF, by any other name would act the same. Eur Respir J. 2018;51(5):1800692.

Article  PubMed  Google Scholar 

Martinez FJ, Collard HR, Pardo A, Raghu G, Richeldi L, Selman M, et al. Idiopathic pulmonary fibrosis. Nat Rev Dis Primers. 2017;3:17074.

Article  PubMed  Google Scholar 

Lederer DJ, Martinez FJ. Idiopathic pulmonary fibrosis. N Engl J Med. 2018;378(19):1811–23.

Article  CAS  PubMed  Google Scholar 

Sverzellati N, Guerci L, Randi G, Calabro E, La Vecchia C, Marchiano A, et al. Interstitial lung diseases in a lung cancer screening trial. Eur Respir J. 2011;38(2):392–400.

Article  CAS  PubMed  Google Scholar 

Tsushima K, Sone S, Yoshikawa S, Yokoyama T, Suzuki T, Kubo K. The radiological patterns of interstitial change at an early phase: over a 4-year follow-up. Respir Med. 2010;104(11):1712–21.

Article  PubMed  Google Scholar 

Richeldi L, Collard HR, Jones MG. Idiopathic pulmonary fibrosis. Lancet. 2017;389(10082):1941–52.

Article  PubMed  Google Scholar 

Hoyer N, Wille MMW, Thomsen LH, Wilcke T, Dirksen A, Pedersen JH, et al. Interstitial lung abnormalities are associated with increased mortality in smokers. Respir Med. 2018;136:77–82.

Article  PubMed  Google Scholar 

Ash SY, Harmouche R, Putman RK, Ross JC, Diaz AA, Hunninghake GM, et al. Clinical and genetic associations of objectively identified interstitial changes in smokers. Chest. 2017;152(4):780–91.

Article  PubMed  PubMed Central  Google Scholar 

Putman RK, Hunninghake GM, Dieffenbach PB, Barragan-Bradford D, Serhan K, Adams U, et al. Interstitial lung abnormalities are associated with acute respiratory distress syndrome. Am J Respir Crit Care Med. 2017;195(1):138–41.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Marchioni A, Tonelli R, Ball L, Fantini R, Castaniere I, Cerri S, et al. Acute exacerbation of idiopathic pulmonary fibrosis: lessons learned from acute respiratory distress syndrome? Crit Care. 2018;22(1):80.

Article  PubMed  PubMed Central  Google Scholar 

Axelsson GT, Putman RK, Aspelund T, Gudmundsson EF, Hida T, Araki T, et al. The associations of interstitial lung abnormalities with cancer diagnoses and mortality. Eur Respir J. 2020;56(6):1902154.

Article  PubMed  PubMed Central  Google Scholar 

Whittaker Brown SA, Padilla M, Mhango G, Powell C, Salvatore M, Henschke C, et al. Interstitial lung abnormalities and lung cancer risk in the National Lung Screening Trial. Chest. 2019;156(6):1195–203.

Article  PubMed  Google Scholar 

Hoyer N, Thomsen LH, Wille MMW, Wilcke T, Dirksen A, Pedersen JH, et al. Increased respiratory morbidity in individuals with interstitial lung abnormalities. BMC Pulm Med. 2020;20(1):67.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Park J, Kim DS, Shim TS, Lim CM, Koh Y, Lee SD, et al. Lung cancer in patients with idiopathic pulmonary fibrosis. Eur Respir J. 2001;17(6):1216–9.

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