Andrzejewska A, Lukomska B, Janowski M (2019) Concise review: mesenchymal stem cells: from roots to boost. Stem Cells (Dayton, Ohio) 37:855–864. https://doi.org/10.1002/stem.3016
Cabalzar-Wondberg D, Turina M, Biedermann L et al (2021) Allogeneic expanded adipose-derived mesenchymal stem cell therapy for perianal fistulas in Crohn’s disease: a case series. Colorectal Dis Off J Assoc Coloproctol Great Br Irel 23:1444–1450. https://doi.org/10.1111/codi.15587
Cheng W, Su J, Hu Y et al (2017) Interleukin-25 primed mesenchymal stem cells achieve better therapeutic effects on dextran sulfate sodium-induced colitis via inhibiting Th17 immune response and inducing T regulatory cell phenotype. Am J Transl Res 9:4149–4160
CAS PubMed PubMed Central Google Scholar
Danese S, Solitano V, Jairath V et al (2022) The future of drug development for inflammatory bowel disease: the need to ACT (advanced combination treatment). Gut 71:2380–2387. https://doi.org/10.1136/gutjnl-2022-327025
Article CAS PubMed Google Scholar
De Souza HS, Fiocchi C (2016) Immunopathogenesis of IBD: current state of the art. Nat Rev Gastroenterol Hepatol 13:13–27. https://doi.org/10.1038/nrgastro.2015.186
Article CAS PubMed Google Scholar
Fan H, Zhao G, Liu L et al (2012) Pre-treatment with IL-1beta enhances the efficacy of MSC transplantation in DSS-induced colitis. Cell Mol Immunol 9:81–473. https://doi.org/10.1038/cmi.2012.40
Filipescu IE, Leonardi L, Menchetti L et al (2018) Preventive effects of bovine colostrum supplementation in TNBS-induced colitis in mice. PLoS One 13:e0202929. https://doi.org/10.1371/journal.pone.0202929
Article CAS PubMed PubMed Central Google Scholar
Forbes GM, Sturm MJ, Leong RW et al (2014) A phase 2 study of allogeneic mesenchymal stromal cells for luminal Crohn’s disease refractory to biologic therapy. Clin Gastroenterol Hepatol 12:64–71. https://doi.org/10.1016/j.cgh.2013.06.021
García-olmo D, García-arranz M, Herreros D et al (2005) A phase I clinical trial of the treatment of Crohn’s fistula by adipose mesenchymal stem cell transplantation. Dis Colon Rectum 48:1416–1423. https://doi.org/10.1007/s10350-005-0052-6
Gergely M, Prado E, Deepak P (2022) Management of refractory inflammatory bowel disease. Curr Opin Gastroenterol 38:347–357. https://doi.org/10.1097/MOG.0000000000000849
Article CAS PubMed Google Scholar
Gills JJ, Dennis PA (2009) Perifosine: update on a novel Akt inhibitor. Curr Oncol Rep 11:102–110. https://doi.org/10.1007/s11912-009-0016-4
Article CAS PubMed PubMed Central Google Scholar
Gubser PM, Bantug GR, Razik L et al (2013) Rapid effector function of memory CD8+ T cells requires an immediate-early glycolytic switch. Nat Immunol 14:72–1064. https://doi.org/10.1038/ni.2687
He J, Zhang N, Zhu Y et al (2021) MSC spheroids-loaded collagen hydrogels simultaneously promote neuronal differentiation and suppress inflammatory reaction through PI3K-Akt signaling pathway. Biomaterials 265:120448. https://doi.org/10.1016/j.biomaterials.2020.120448
Article CAS PubMed Google Scholar
Hu X, Xu Q, Wan H et al (2020) PI3K-Akt-mTOR/PFKFB3 pathway mediated lung fibroblast aerobic glycolysis and collagen synthesis in lipopolysaccharide-induced pulmonary fibrosis. Lab Investig J Tech Methods Pathol 100:801–811. https://doi.org/10.1038/s41374-020-0404-9
Huldani H, Margiana R, Ahmad F et al (2022) Immunotherapy of inflammatory bowel disease (IBD) through mesenchymal stem cells. Int Immunopharmacol 107:108698. https://doi.org/10.1016/j.intimp.2022.108698
Article CAS PubMed Google Scholar
Huynh DL, Ngau TH, Nguyen NH et al (2020) Potential therapeutic and pharmacological effects of Wogonin: an updated review. Mol Biol Rep 47:9779–9789. https://doi.org/10.1007/s11033-020-05972-9
Article CAS PubMed Google Scholar
Jones N, Vincent EE, Cronin JG et al (2019) Akt and STAT5 mediate naive human CD4+ T-cell early metabolic response to TCR stimulation. Nat Commun 10:2042. https://doi.org/10.1038/s41467-019-10023-4
Article CAS PubMed PubMed Central Google Scholar
Killer MC, Nold P, Henkenius K et al (2017) Immunosuppressive capacity of mesenchymal stem cells correlates with metabolic activity and can be enhanced by valproic acid. Stem Cell Res Ther 8:100. https://doi.org/10.1186/s13287-017-0553-y
Article CAS PubMed PubMed Central Google Scholar
Li M, Zhang YX, Zhang Z et al (2015) Endomicroscopy will track injected mesenchymal stem cells in rat colitis models. Inflamm Bowel Dis 21:77–2068. https://doi.org/10.1097/MIB.0000000000000458
Lin H, Li C, Qian S et al (2022) Evaluation of the biological properties of human umbilical cord mesenchymal stem cells in difffferent passages. J Histochem Cytochem 31:341–350. https://doi.org/10.16705/j.cnki.1004-1850.2022.04.003
Liu W, Yu M, Xie D et al (2020) Melatonin-stimulated MSC-derived exosomes improve diabetic wound healing through regulating macrophage M1 and M2 polarization by targeting the PTEN/AKT pathway. Stem Cell Res Ther 11:259. https://doi.org/10.1186/s13287-020-01756-x
Article CAS PubMed PubMed Central Google Scholar
Lügering A, Schmidt M, Lügering N et al (2001) Infliximab induces apoptosis in monocytes from patients with chronic active Crohn’s disease by using a caspase-dependent pathway. Gastroenterology 121(5):1145–1157. https://doi.org/10.1053/gast.2001.28702
Manning BD, Toker A (2017) AKT/PKB signaling: navigating the network. Cell 169:381–405. https://doi.org/10.1016/j.cell.2017.04.001
Article CAS PubMed PubMed Central Google Scholar
Markov A, Thangavelu L, Aravindhan S et al (2021) Mesenchymal stem/stromal cells as a valuable source for the treatment of immune-mediated disorders. Stem Cell Res Ther 12:192. https://doi.org/10.1186/s13287-021-02265-1
Article CAS PubMed PubMed Central Google Scholar
Menk AV, Scharping NE, Moreci RS et al (2018) Early TCR signaling induces rapid aerobic glycolysis enabling distinct acute T cell effector functions. Cell Rep 22:1509–1521. https://doi.org/10.1016/j.celrep.2018.01.040
Article CAS PubMed PubMed Central Google Scholar
Molendijk I, Bonsing BA, Roelofs H et al (2015) Allogeneic bone marrow-derived mesenchymal stromal cells promote healing of refractory perianal fistulas in patients with Crohn’s disease. Gastroenterology 149:918–27.e6. https://doi.org/10.1053/j.gastro.2015.06.014
Mrahleh MA, Matar S, Jafar H et al (2021) Human Wharton’s Jelly-derived mesenchymal stromal cells primed by tumor necrosis factor-α and interferon-γ modulate the innate and adaptive immune cells of type 1 diabetic patients. Front Immunol 12:732549. https://doi.org/10.3389/fimmu.2021.732549
Article CAS PubMed PubMed Central Google Scholar
Pan T, Sun S, Chen Y et al (2022) Immune effects of PI3K/Akt/HIF-1alpha-regulated glycolysis in polymorphonuclear neutrophils during sepsis. Crit Care (Lond, Engl) 26:29. https://doi.org/10.1186/s13054-022-0389
Ren W, Chai M, Jiang M et al (2022) High glucose mediates apoptosis and osteogenesis of MSCs via downregulation of AKT-Sirt1-TWIST. Mol Biol Rep 49:2723–2733. https://doi.org/10.1007/s11033-021-07082-6
Article CAS PubMed Google Scholar
Ryu DB, Lim JY, Lee SE et al (2016) Induction of Indoleamine 2,3-dioxygenase by pre-treatment with Poly(I:C) may enhance the efficacy of MSC treatment in DSS-induced colitis. Immune Netw 16:358–365. https://doi.org/10.4110/in.2016.16.6.358
Article PubMed PubMed Central Google Scholar
Strober W, Fuss IJ (2011) Proinflammatory cytokines in the pathogenesis of inflammatory bowel diseases. Gastroenterology 140(6):1756–1767. https://doi.org/10.1053/j.gastro.2011.02.016
Article CAS PubMed Google Scholar
Wang W, Xia T, Yu X (2015) Wogonin suppresses inflammatory response and maintains intestinal barrier function via TLR4-MyD88-TAK1-mediated NF-kappaB pathway in vitro. Inflamm Res Off J Eur Histamine Res Soc 64:31–423. https://doi.org/10.1007/s00011-015-0822-0
Wu Q, Xie S, Zhu Y et al (2021) Wogonin strengthens the therapeutic effects of mesenchymal stem cells in dss-induced colitis via promoting IL-10 production. Oxid Med Cell Longev 2021:5527935. https://doi.org/10.1155/2021/5527935
Article CAS PubMed PubMed Central Google Scholar
Xu C, Feng C, Huang P et al (2022) TNFalpha and IFNgamma rapidly activate PI3K-AKT signaling to drive glycolysis that confers mesenchymal stem cells enhanced anti-inflammatory property. Stem Cell Res Ther 13:491. https://doi.org/10.1186/s13287-022-03178-3
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