Brancatella A, Marcocci C (2020) TSH suppressive therapy and bone. Endocr Connect 9:R158–R172. https://doi.org/10.1530/EC-20-0167
Article CAS PubMed PubMed Central Google Scholar
Adlin EV, Maurer AH, Marks AD, Channick BJ (1991) Bone mineral density in postmenopausal women treated with L-thyroxine. Am J Med 90:360–366. https://doi.org/10.1016/0002-9343(91)90577-K
Article CAS PubMed Google Scholar
Ma R, Morshed S, Latif R et al (2011) The Influence of Thyroid-Stimulating Hormone and Thyroid-Stimulating Hormone Receptor Antibodies on Osteoclastogenesis. Thyroid 21:897–906. https://doi.org/10.1089/thy.2010.0457
Article CAS PubMed PubMed Central Google Scholar
Yoon B-H, Lee Y, Oh HJ et al (2019) Influence of thyroid-stimulating hormone suppression therapy on bone mineral density in patients with differentiated thyroid cancer: a meta-analysis. J Bone Metab 26:51. https://doi.org/10.11005/jbm.2019.26.1.51
Article PubMed PubMed Central Google Scholar
Wang M-Y, Han Z-Q, Gong X-W et al (2020) TSH-suppressive therapy can reduce bone mineral density in patients with differentiated thyroid carcinoma: a meta-analysis. Eur Rev Med Pharmacol Sci 24:922–929. https://doi.org/10.26355/eurrev_202001_20077
Blum MR, Bauer DC, Collet T-H et al (2015) Subclinical Thyroid Dysfunction and Fracture Risk. JAMA 313:2055. https://doi.org/10.1001/jama.2015.5161
Article PubMed PubMed Central Google Scholar
Ku EJ, Yoo WS, Lee EK et al (2021) Effect of TSH suppression therapy on bone mineral density in differentiated thyroid cancer: a systematic review and meta-analysis. J Clin Endocrinol Metab. https://doi.org/10.1210/clinem/dgab539
Bonczar M, Ostrowski P, D’Antoni AV et al (2022) How to write an Umbrella Review? A step-by-step tutorial with tips and tricks. Folia Morphol (Warsz) 82:1–6. https://doi.org/10.5603/FM.a2022.0104
Shea BJ, Reeves BC, Wells G et al (2017) AMSTAR 2: a critical appraisal tool for systematic reviews that include randomised or non-randomised studies of healthcare interventions, or both. BMJ 358:j4008. https://doi.org/10.1136/bmj.j4008
Whiting P, Savović J, Higgins JPT et al (2016) ROBIS: A new tool to assess risk of bias in systematic reviews was developed. J Clin Epidemiol 69:225–234. https://doi.org/10.1016/j.jclinepi.2015.06.005
Article PubMed PubMed Central Google Scholar
Guyatt G, Oxman AD, Akl EA et al (2011) GRADE guidelines: 1. Introduction—GRADE evidence profiles and summary of findings tables. J Clin Epidemiol 64:383–394. https://doi.org/10.1016/j.jclinepi.2010.04.026
Higgins JPT, Thomas J, Chandler J et al (2019) Cochrane Handbook for Systematic Reviews of Interventions. Wiley
Uzzan B, Campos J, Cucherat M et al (1996) Effects on bone mass of long term treatment with thyroid hormones: a meta-analysis. J Clin Endocrinol Metab 81:4278–4289. https://doi.org/10.1210/jcem.81.12.8954028
Article CAS PubMed Google Scholar
Segna D, Bauer DC, Feller M et al (2018) Association between subclinical thyroid dysfunction and change in bone mineral density in prospective cohorts. J Intern Med 283:56–72. https://doi.org/10.1111/joim.12688
Article CAS PubMed Google Scholar
Sdano MT, Falciglia M, Welge JA, Steward DL (2005) Efficacy of thyroid hormone suppression for benign thyroid nodules: meta-analysis of randomized trials. Otolaryngol-Head and Neck Surgery 133:391–396. https://doi.org/10.1016/j.otohns.2005.06.007
Faber J, Galløe AM (1994) Changes in bone mass during prolonged subclinical hyperthyroidism due to l-thyroxine treatment: a meta-analysis. Eur J Endocrinol 130:350–356. https://doi.org/10.1530/eje.0.1300350
Article CAS PubMed Google Scholar
Heemstra KA, Hamdy NAT, Romijn JA, Smit JWA (2006) The effects of thyrotropin-suppressive therapy on bone metabolism in patients with well-differentiated thyroid carcinoma. Thyroid 16:583–591. https://doi.org/10.1089/thy.2006.16.583
Article CAS PubMed Google Scholar
Kwak D, Ha J, Won Y et al (2021) Effects of thyroid-stimulating hormone suppression after thyroidectomy for thyroid cancer on bone mineral density in postmenopausal women: a systematic review and meta-analysis. BMJ Open 11:e043007. https://doi.org/10.1136/bmjopen-2020-043007
Article PubMed PubMed Central Google Scholar
Waring AC, Harrison S, Fink HA et al (2013) A prospective study of thyroid function, bone loss, and fractures in older men: The MrOS study. J Bone Miner Res 28:472–479. https://doi.org/10.1002/jbmr.1774
Article CAS PubMed Google Scholar
Walsh JP, Bremner AP, Bulsara MK et al (2005) Subclinical Thyroid Dysfunction as a Risk Factor for Cardiovascular Disease. Arch Intern Med 165:2467. https://doi.org/10.1001/archinte.165.21.2467
van der Deure WM, Uitterlinden AG, Hofman A et al (2007) Effects of serum TSH and FT4 levels and the TSHR-Asp727Glu polymorphism on bone: the Rotterdam Study. Clin Endocrinol (Oxf) 68:175–181. https://doi.org/10.1111/j.1365-2265.2007.03016.x
Article CAS PubMed Google Scholar
Tournis S, Antoniou JD, Liakou CG et al (2015) Volumetric bone mineral density and bone geometry assessed by peripheral quantitative computed tomography in women with differentiated thyroid cancer under TSH suppression. Clin Endocrinol (Oxf) 82:197–204. https://doi.org/10.1111/cen.12560
Toivonen J, Tahtela R, Laitinen K et al (1998) Markers of bone turnover in patients with differentiated thyroid cancer with and following withdrawal of thyroxine suppressive therapy. Eur J Endocrinol 138:667–673. https://doi.org/10.1530/eje.0.1380667
Article CAS PubMed Google Scholar
Svare A, Nilsen TIL, Åsvold BO et al (2013) Does thyroid function influence fracture risk? Prospective data from the HUNT2 study, Norway. Eur J Endocrinol 169:845–852. https://doi.org/10.1530/EJE-13-0546
Article CAS PubMed Google Scholar
Štěpán JJ, Límanová Z (1992) Biochemical assessment of bone loss in patients on long-term thyroid hormone treatment. Bone Miner 17:377–388. https://doi.org/10.1016/0169-6009(92)90787-E
Stall GM (1990) Accelerated Bone Loss in Hypothyroid Patients Overtreated with L-Thyroxine. Ann Intern Med 113:265. https://doi.org/10.7326/0003-4819-113-4-265
Article CAS PubMed Google Scholar
Schneider R, Schneider M, Reiners C, Schneider P (2012) Effects of levothyroxine on bone mineral density, muscle force, and bone turnover markers: a cohort study. J Clin Endocrinol Metab 97:3926–3934. https://doi.org/10.1210/jc.2012-2570
Article CAS PubMed Google Scholar
Schneider DL, Barrett-Connor EL, Morton DJ (1994) Thyroid hormone use and bone mineral density in elderly women. Effects of estrogen JAMA 271:1245–1249
Schneider P, Berger P, Kruse K, Börner W (1991) Effect of calcitonin deficiency on bone density and bone turnover in totally thyroidectomized patients. J Endocrinol Invest 14:935–942. https://doi.org/10.1007/BF03347119
Article CAS PubMed Google Scholar
Sajjinanont T, Rajchadara S, Sriassawaamorn N, Panichkul S (2005) The comparative study of bone mineral density between premenopausal women receiving long term suppressive doses of levothyroxine for well-differentiated thyroid cancer with healthy premenopausal women. J Med Assoc Thai 88(Suppl 3):S71–S76
Ross DS, Neer RM, Chester Ridgway E, Daniels GH (1987) Subclinical Hyperthyroidism and reduced bone density as a possible result of prolonged suppression of the pituitary-thyroid axis with L-Thyroxine. Am J Med 82:1167–1170. https://doi.org/10.1016/0002-9343(87)90219-1
Article CAS PubMed Google Scholar
Rodondi N, Newman AB, Vittinghoff E et al (2005) Subclinical hypothyroidism and the risk of heart failure, other cardiovascular events, and death. Arch Intern Med 165:2460. https://doi.org/10.1001/archinte.165.21.2460
Reverter JL, Holgado S, Alonso N et al (2005) Lack of deleterious effect on bone mineral density of long-term thyroxine suppressive therapy for differentiated thyroid carcinoma. Endocr Relat Cancer 12:973–981. https://doi.org/10.1677/erc.1.01072
Article CAS PubMed Google Scholar
Radetti G, Castellan C, Tatò L, et al (1993) Bone mineral density in children and adolescent females treated with high doses of L-thyroxine. Horm Res 39:127–131. https://doi.org/10.1159/000182712
Article CAS PubMed Google Scholar
Notsu M, Yamauchi M, Morita M et al (2020) Papillary thyroid carcinoma is a risk factor for severe osteoporosis. J Bone Miner Metab 38:264–270. https://doi.org/10.1007/s00774-019-01053-5
Article CAS PubMed Google Scholar
Nanchen D, Gussekloo J, Westendorp RGJ et al (2012) Subclinical thyroid dysfunction and the risk of heart failure in older persons at high cardiovascular risk. J Clin Endocrinol Metab 97:852–861. https://doi.org/10.1210/jc.2011-1978
Comments (0)