Recent Advances in Treatment of Systemic Sclerosis and Morphea

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Khanna D, et al. New composite endpoint in early diffuse cutaneous SSc: revisiting the provisional American College of Rheumatology Composite Response Index in SSc. Ann Rheum Dis. 2021;80(5):641–50.

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Sullivan KM, et al. Myeloablative autologous stem-cell transplantation for severe scleroderma. N Engl J Med. 2018;378(1):35–47.

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Khanna D, et al. Safety and efficacy of subcutaneous tocilizumab in adults with SSc (faSScinate): a phase 2, randomised, controlled trial. Lancet. 2016;387(10038):2630–40.

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Khanna D, et al. Tocilizumab in SSc: a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet Respir Med. 2020;8(10):963–74.

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Allanore Y, et al. A randomised, double-blind, placebo-controlled, 24-week, phase II, proof-of-concept study of romilkimab (SAR156597) in early diffuse cutaneous SSc. Ann Rheum Dis. 2020;79(12):1600–7.

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Khanna D, et al. A 24-week, phase IIa, randomized, double-blind, placebo-controlled study of ziritaxestat in early diffuse cutaneous SSc. Arthritis Rheumatol. 2023;75(8):1434–44.

Rice LM, et al. Fresolimumab treatment decreases biomarkers and improves clinical symptoms in SSc patients. J Clin Invest. 2015;125(7):2795–807.

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Fukasawa T, et al. Interleukin-17 pathway inhibition with brodalumab in early SSc: analysis of a single-arm, open-label, phase 1 trial. J Am Acad Dermatol. 2023;89(2):366–9.

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