Anger F, Camara M, Ellinger E, Germer CT, Schlegel N, Otto C, Klein I (2019) Human mesenchymal stromal cell-derived extracellular vesicles improve liver regeneration after ischemia reperfusion injury in mice. Stem Cells Dev 28:1451–1462

Article  CAS  PubMed  Google Scholar 

Börger V, Bremer M, Ferrer-Tur R, Gockeln L, Stambouli O, Becic A, Giebel B (2017) Mesenchymal stem/stromal cell-derived extracellular vesicles and their potential as novel immunomodulatory therapeutic agents. Int J Mol Sci 18:1450

Article  PubMed  PubMed Central  Google Scholar 

Cao Y, Ji C, Lu L (2020) Mesenchymal stem cell therapy for liver fibrosis/cirrhosis. Ann Transl Med 8:562

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cao XF, Jin SZ, Sun L, Zhan YB, Lin F, Li Y, Zhou YL, Wang XM, Gao L, Zhang B (2017) Therapeutic effects of hepatocyte growth factor-overexpressing dental pulp stem cells on liver cirrhosis in a rat model. Sci Rep 7:15812

Article  ADS  PubMed  PubMed Central  Google Scholar 

Cao T, Xiao D, Ji P, Zhang Z, Cai WX, Han C, Li W, Tao K (2022) Effects of exosomes from hepatocyte growth factor-modified human adipose mesenchymal stem cells on full-thickness skin defect in diabetic mice. Zhonghua Shao Shang Za Zhi 38:1004–1013

CAS  Google Scholar 

Choi SS, Sicklick JK, Ma Q, Yang L, Huang J, Qi Y, Chen W, Li YX, Goldschmidt-Clermont PJ, Diehl AM (2006) Sustained activation of Rac1 in hepatic stellate cells promotes liver injury and fibrosis in mice. Hepatology 44:1267–1277

Article  CAS  PubMed  Google Scholar 

D’Amico G, Morabito A, D’Amico M, Pasta L, Malizia G, Rebora P, Valsecchi MG (2018) Clinical states of cirrhosis and competing risks. J Hepatol 68:563–576

Article  PubMed  Google Scholar 

Deng L, Liu G, Wu X, Wang Y, Tong M, Liu B, Wang K, Peng Y, Kong X (2014) Adipose derived mesenchymal stem cells efficiently rescue carbon tetrachloride-induced acute liver failure in mouse. ScientificWorldJournal 2014:103643

Article  PubMed  PubMed Central  Google Scholar 

Driscoll J, Patel T (2019) The mesenchymal stem cell secretome as an acellular regenerative therapy for liver disease. J Gastroenterol 54:763–773

Article  PubMed  PubMed Central  Google Scholar 

Ge J, Burnier L, Adamopoulou M, Kwa MQ, Schaks M, Rottner K, Brakebusch C (2018) RhoA, Rac1, and Cdc42 differentially regulate αSMA and collagen I expression in mesenchymal stem cells. J Biol Chem 293:9358–9369

Article  CAS  PubMed  PubMed Central  Google Scholar 

Goodman ZD (2007) Grading and staging systems for inflammation and fibrosis in chronic liver diseases. J Hepatol 47:598–607

Article  PubMed  Google Scholar 

He Y, Guo X, Lan T, Xia J, Wang J, Li B, Peng C, Chen Y, Hu X, Meng Z (2021) Human umbilical cord-derived mesenchymal stem cells improve the function of liver in rats with acute-on-chronic liver failure via downregulating Notch and Stat1/Stat3 signaling. Stem Cell Res Ther 12:396

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hennenberg M, Trebicka J, Stark C, Kohistani AZ, Heller J, Sauerbruch T (2009) Sorafenib targets dysregulated rho kinase expression and portal Hypertension in rats with secondary biliary cirrhosis. Br J Pharmacol 157:258–270

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hu C, Wu Z, Li L (2020) Mesenchymal stromal cells promote liver regeneration through regulation of immune cells. Int J Biol Sci 16:893–903

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hu C, Zhao L, Duan J, Li L (2019) Strategies to improve the efficiency of mesenchymal stem cell transplantation for reversal of liver fibrosis. J Cell Mol Med 23:1657–1670

Article  PubMed  PubMed Central  Google Scholar 

Hu C, Zhao L, Zhang L, Bao Q, Li L (2020) Mesenchymal stem cell-based cell-free strategies: safe and effective treatments for liver injury. Stem Cell Res Ther 11:377

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang YW, Hu JT, Yang SS (2010) Complications of alcoholic liver cirrhosis: active assessment by endoscopy and sonography. Hepatology 52:1864–1865

Article  PubMed  Google Scholar 

Keating A (2012) Mesenchymal stromal cells: new directions. Cell Stem Cell 10:709–716

Article  CAS  PubMed  Google Scholar 

Kim MD, Kim SS, Cha HY, Jang SH, Chang DY, Kim W, Suh-Kim H, Lee JH (2014) Therapeutic effect of hepatocyte growth factor-secreting mesenchymal stem cells in a rat model of liver fibrosis. Exp Mol Med 46:e110

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kisseleva T, Gigante E, Brenner DA (2010) Recent advances in liver stem cell therapy. Curr Opin Gastroenterol 26:395–402

Article  PubMed  Google Scholar 

Li L, Wang JY, Yang CQ, Jiang W (2012) Effect of RhoA on transforming growth factor β1-induced rat hepatic stellate cell migration. Liver Int 32:1093–1102

Article  PubMed  Google Scholar 

Lou G, Chen Z, Zheng M, Liu Y (2017) Mesenchymal stem cell-derived exosomes as a new therapeutic strategy for liver diseases. Exp Mol Med 49:e346

Article  PubMed  PubMed Central  Google Scholar 

Lurie Y, Webb M, Cytter-Kuint R, Shteingart S, Lederkremer GZ (2015) Non-invasive diagnosis of liver fibrosis and Cirrhosis. World J Gastroenterol 21:11567–11583

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ma L, Wei J, Zeng Y, Liu J, Xiao E, Kang Y, Kang Y (2022) Mesenchymal stem cell-originated exosomal circDIDO1 suppresses hepatic stellate cell activation by miR-141-3p/PTEN/AKT pathway in human liver fibrosis. Drug Deliv 29:440–453

Article  CAS  PubMed  PubMed Central  Google Scholar 

Piscaglia AC, Campanale M, Gasbarrini A, Gasbarrini G (2010) Stem cell-based therapies for liver diseases: state of the art and new perspectives. Stem Cells Int 2010:259461

Article  PubMed  PubMed Central  Google Scholar 

Qiao H, Zhou Y, Qin X, Cheng J, He Y, Jiang Y (2018) NADPH oxidase signaling pathway mediates mesenchymal stem cell-induced inhibition of hepatic stellate cell activation. Stem Cells Int 2018:1239143

Article  PubMed  PubMed Central  Google Scholar 

Qin S, Jiang H, Su S, Wang D, Liang Z, Zhang J, Yang W (2012) Inhibition of hepatic stellate cell proliferation by bone marrow mesenchymal stem cells via regulation of the cell cycle in rat. Exp Ther Med 4:375–380

Article  CAS  PubMed  PubMed Central  Google Scholar 

Qu Y, Zhang Q, Cai X, Li F, Ma Z, Xu M, Lu L (2017) Exosomes derived from mir-181-5p-modified adipose-derived mesenchymal stem cells prevent liver fibrosis via autophagy activation. J Cell Mol Med 21:2491–2502

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ren X, Meng T, Ren X, Li X, Lu L (2021) Fasudil alleviates acetaminophen-induced liver injury via targeting Rhoa/ROCK signal pathway. J Toxicol Sci 46:255–262

Article  CAS  PubMed  Google Scholar 

Roehlen N, Crouchet E, Baumert TF (2020) Liver fibrosis: mechanistic concepts and therapeutic perspectives. Cells 9:875

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rong X, Liu J, Yao X, Jiang T, Wang Y, Xie F (2019) Human bone marrow mesenchymal stem cells-derived exosomes alleviate liver fibrosis through the Wnt/β-catenin pathway. Stem Cell Res Ther 10:98

Article  CAS  PubMed  PubMed Central  Google Scholar 

Seki A, Sakai Y, Komura T, Nasti A, Yoshida K, Higashimoto M, Honda M, Usui S, Takamura M, Takamura T, Ochiya T, Furuichi K, Wada T, Kaneko S (2013) Adipose tissue-derived stem cells as a regenerative therapy for a mouse steatohepatitis-induced cirrhosis model. Hepatology 58:1133–1142

Article  CAS  PubMed  Google Scholar 

Seo KW, Sohn SY, Bhang DH, Nam MJ, Lee HW, Youn HY (2014) Therapeutic effects of hepatocyte growth factor-overexpressing human umbilical cord blood-derived mesenchymal stem cells on liver fibrosis in rats. Cell Biol Int 38:106–116

Article  CAS  PubMed  Google Scholar 

Shiels MS, Chernyavskiy P, Anderson WF, Best AF, Haozous EA, Hartge P, Rosenberg PS, Thomas D, Freedman ND, Berrington A, de Gonzalez, (2017) Trends in premature mortality in the USA by sex, race, and ethnicity from 1999 to 2014: an analysis of death certificate data. Lancet 389:1043–1054

Article  PubMed  PubMed Central  Google Scholar 

Silveira MG, Brunt EM, Heathcote J, Gores GJ, Lindor KD, Mayo MJ (2010) American association for the study of liver diseases endpoints conference: design and endpoints for clinical trials in primary biliary cirrhosis. Hepatology 52:349–359

Article  PubMed