PABPC1 silencing inhibits pancreatic cancer cell proliferation and EMT, and induces apoptosis via PI3K/AKT pathway

Andersson R, Haglund C, Seppanen H, Ansari D (2022) Pancreatic cancer-the past, the present, and the future. Scand J Gastroenterol 57:1169–1177. https://doi.org/10.1080/00365521.2022.2067786

Article  CAS  PubMed  Google Scholar 

Chen H, Zhou L, Wu X, Li R, Wen J, Sha J, Wen X (2016) The PI3K/AKT pathway in the pathogenesis of prostate cancer. Front Biosci (Landmark Ed) 21:1084–1091. https://doi.org/10.2741/4443

Article  CAS  PubMed  Google Scholar 

Di Martino M, El Boghdady M (2023) Pancreatic cancer surgery. BMC Surg 23:196. https://doi.org/10.1186/s12893-023-02091-7

Article  PubMed  PubMed Central  Google Scholar 

Feng C, Han YH, Qi N, Li J, Sheng QH, Liu Y, Yang LL (2021) Functional implications of PABPC1 in the development of ovarian cancer. Open Med 16:805–815. https://doi.org/10.1515/med-2021-0278

Article  CAS  Google Scholar 

Gadgeel SM, Wozniak A (2013) Preclinical rationale for PI3K/Akt/mTOR pathway inhibitors as therapy for epidermal growth factor receptor inhibitor-resistant non-small-cell lung cancer. Clin Lung Cancer 14:322–332. https://doi.org/10.1016/j.cllc.2012.12.001

Article  CAS  PubMed  Google Scholar 

Gugenheim J, Crovetto A, Petrucciani N (2022) Neoadjuvant therapy for pancreatic cancer. Updates Surg 74:35–42. https://doi.org/10.1007/s13304-021-01186-1

Article  PubMed  Google Scholar 

Guven E (2022) Gene expression characteristics of tumor and adjacent non-tumor tissues of pancreatic ductal adenocarcinoma (PDAC) in-silico. Iran J Biotechnol 20:e3092. https://doi.org/10.30498/ijb.2021.292558.3092

Article  PubMed  PubMed Central  Google Scholar 

Hronek JW, Reed M (2015) Nursing implications of chemotherapy agents and their associated side effects in patients with pancreatic cancer. Clin J Oncol Nurs 19:751–757. https://doi.org/10.1188/15.CJON.751-757

Article  PubMed  Google Scholar 

Hu Y, Jing J, Shi Y, Zhang P, Dong D, Wu Y, Dong X, Li E, Fan Y (2021) Apatinib inhibits pancreatic cancer growth, migration and invasion through the PI3K/AKT and ERK1/2/MAPK pathways. Trans Cancer Res 10:3306–3316. https://doi.org/10.21037/tcr-21-207

Article  CAS  Google Scholar 

Jie Zhu HD, Wang X, Lu Q (2015) PABPC1 exerts carcinogenesis in gastric carcinoma by targeting miR-34c. Int J Clin Exp Pathol 8:3794–3802

PubMed  PubMed Central  Google Scholar 

Klein AP (2021) Pancreatic cancer epidemiology: understanding the role of lifestyle and inherited risk factors. Nat Rev Gastroenterol Hepatol 18:493–502. https://doi.org/10.1038/s41575-021-00457-x

Article  PubMed  PubMed Central  Google Scholar 

Kumar P, Nagarajan A, Uchil PD (2018) Analysis of cell viability by the MTT assay. Cold Spring Harbor Protoc. https://doi.org/10.1101/pdb.prot095505

Article  Google Scholar 

Kyung-Hee Chun JWKI, Shihua Sun JM, Pezzuto R, Lotan WK, Lee HH-Y (2003) Effects of deguelin on the phosphatidylinositol 3-Kinase/Akt pathway and apoptosis in Premalignant Human bronchial epithelial cells. J Natl Cancer Inst 95:291–302. https://doi.org/10.1093/jnci/95.4.291

Article  PubMed  Google Scholar 

Lei Y, Liu B, Su L, Xie X, Kuang M, Chen M, Lan H, Zhao H, Lin M (2020) Perioperative nursing of patients with pancreatic cancer treated with a nanoknife. J Nanosci Nanotechnol 20:6584–6590. https://doi.org/10.1166/jnn.2020.18603

Article  CAS  PubMed  Google Scholar 

Li J, Pei M, Xiao W, Liu X, Hong L, Yu Z, Peng Y, Zhang J, Yang P, Lin J, Wu X, Lin Z, Tang W, Zhi F, Li G, Xiang L, Li A, Liu S, Chen Y, Wang J (2023) The HOXD9-mediated PAXIP1-AS1 regulates gastric cancer progression through PABPC1/PAK1 modulation. Cell Death Dis 14:341. https://doi.org/10.1038/s41419-023-05862-5

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu X, Wen L, Gao C (2022) Effect of evidence-based nursing on quality of life and nursing satisfaction of patients with severe pancreatic cancer. Minerva Gastroenterol 68:495–497. https://doi.org/10.23736/S2724-5985.22.03241-7

Article  Google Scholar 

Luo W, Tao J, Zheng L, Zhang T (2020) Current epidemiology of pancreatic cancer: challenges and opportunities. Chin J Cancer Res 32:705–19

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ma W, Zhang L, Wang C, Xu X (2022) Effect of multidisciplinary team collaborative nursing model combined with mind mapping teaching method on postoperative complications and mental health of patients with advanced pancreatic cancer. Iran J Public Health 51:535–543. https://doi.org/10.18502/ijph.v51i3.8929

Article  PubMed  PubMed Central  Google Scholar 

Meng X, Xiao W, Sun J, Li W, Yuan H, Yu T, Zhang X, Dong W (2023) CircPTK2/PABPC1/SETDB1 axis promotes EMT-mediated tumor metastasis and gemcitabine resistance in bladder cancer. Cancer Lett 554:216023. https://doi.org/10.1016/j.canlet.2022.216023

Article  CAS  PubMed  Google Scholar 

Mortazavi M, Moosavi F, Martini M, Giovannetti E, Firuzi O (2022) Prospects of targeting PI3K/AKT/mTOR pathway in pancreatic cancer. Crit Rev Oncol/Hematol 176:103749. https://doi.org/10.1016/j.critrevonc.2022.103749

Article  PubMed  Google Scholar 

Mukherji R, Debnath D, Hartley ML, Noel MS (2022) The role of immunotherapy in pancreatic cancer. Curr Oncol 29:6864–6892. https://doi.org/10.3390/curroncol29100541

Article  PubMed  PubMed Central  Google Scholar 

Ozturk S, Uysal F (2017) Poly(A)-binding proteins are required for translational regulation in vertebrate oocytes and early embryos. Reprod Fertil Dev 29:1890–1901. https://doi.org/10.1071/RD16283

Article  CAS  PubMed  Google Scholar 

Ozturk S, Uysal F (2018) Potential roles of the poly(A)-binding proteins in translational regulation during spermatogenesis. J Reprod Dev 64:289–296. https://doi.org/10.1262/jrd.2018-026

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shao Q, Zhang Z, Cao R, Zang H, Pei W, Sun T (2020) CPA4 promotes EMT in pancreatic cancer via stimulating PI3K-AKT-mTOR signaling. OncoTargets Therapy 13:8567–8580. https://doi.org/10.2147/OTT.S257057

Article  CAS  PubMed  PubMed Central  Google Scholar 

Spross JA, Manolatos A, Thorpe M (1988) Pancreatic cancer: nursing challenges. Semin Oncol Nurs 4:274–284. https://doi.org/10.1016/0749-2081(88)90079-4

Article  CAS  PubMed  Google Scholar 

Stoffel EM, Brand RE, Goggins M (2023) Pancreatic cancer: changing epidemiology and new approaches to risk assessment, early detection, and prevention. Gastroenterology 164:752–765. https://doi.org/10.1053/j.gastro.2023.02.012

Article  PubMed  Google Scholar 

Tailai An LD, Wang Y, Yang Z, Chai C, Ouyang J, Lu X, Zhang C (2021) The prognostic impacts of PABPC1 expression on gastric cancer patients. FutureOncol 17:4471–4479

Google Scholar 

Vincent A, Herman J, Schulick R, Hruban RH, Goggins M (2011) Pancreatic cancer. Lancet 378:607–620. https://doi.org/10.1016/s0140-6736(10)62307-0

Article  PubMed  PubMed Central  Google Scholar 

Wen X, Shao Z, Chen S, Wang W, Wang Y, Jiang J, Ma Q, Zhang L (2020) Construction of an RNA-binding protein-related prognostic model for pancreatic adenocarcinoma based on TCGA and GTEx databases. Front Genet 11:610350. https://doi.org/10.3389/fgene.2020.610350

Article  CAS  PubMed  Google Scholar 

Wood LD, Canto MI, Jaffee EM, Simeone DM (2022) Pancreatic cancer: pathogenesis, screening, diagnosis, and treatment. Gastroenterology 163:386–402. https://doi.org/10.1053/j.gastro.2022.03.056

Article  PubMed  Google Scholar 

Wu YQ, Ju CL, Wang BJ, Wang RG (2019) PABPC1L depletion inhibits proliferation and migration via blockage of AKT pathway in human colorectal cancer cells. Oncol Lett 17:3439–3445. https://doi.org/10.3892/ol.2019.9999

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yao W, Yao Y, He W, Zhao C, Liu D, Wang G, Wang Z (2023) PABPC1 promotes cell proliferation and metastasis in pancreatic adenocarcinoma by regulating COL12A1 expression. Immun Inflamm Dis 11:e919. https://doi.org/10.1002/iid3.919

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yu L, Wei J, Liu P (2022) Attacking the PI3K/Akt/mTOR signaling pathway for targeted therapeutic treatment in human cancer. Sem Cancer Biol 85:69–94. https://doi.org/10.1016/j.semcancer.2021.06.019

Article  CAS  Google Scholar 

Zhang Y, Chen C, Liu Z, Guo H, Lu W, Hu W, Lin Z (2022) PABPC1-induced stabilization of IFI27 mRNA promotes angiogenesis and malignant progression in esophageal squamous cell carcinoma through exosomal miRNA-21-5p. J Exp Clin Cancer Res 41:111. https://doi.org/10.1186/s13046-022-02339-9

Article  CAS  PubMed  PubMed Central  Google Scholar 

留言 (0)

沒有登入
gif