aSouthampton Children's Hospital, University Hospital Southampton NHS Foundation Trust

bUniversity of Southampton

cNIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust and University of Southampton, Southampton, UK

Correspondence to R. Mark Beattie, Children's Hospital, University Hospital Southampton NHS Foundation Trust, Tremona Road, Southampton SO16 6YD, UK. Tel: +2380777222; e-mail: [email protected]