aAGE Research Group, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University

bNIHR Newcastle Biomedical Research Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust, Cumbria, Northumberland, Tyne and Wear NHS Foundation Trust and Newcastle University, Newcastle upon Tyne, UK

Correspondence to Antoneta Granic, Newcastle University, Newcastle upon Tyne, NE4 5PL UK. E-mail: [email protected]