IL-1β induced down-regulation of miR-146a-5p promoted pyroptosis and apoptosis of corneal epithelial cell in dry eye disease through targeting STAT3

Ræder S, Klyve P, Utheim TP. (2019). [Dry eye disease– diagnosis and treatment]. Tidsskrift for den Norske laegeforening: tidsskrift for praktisk medicin, ny raekke 139(11).

Markoulli M, Chandramohan N, Papas EB. (2021). Photobiomodulation (low-level light therapy) and dry eye disease. Clin Exp Optom 1–6.

Matsuda Y, Machida M, Nakagami Y, Nakajima T, Azuma M. NFE2L2 activator RS9 protects against corneal epithelial cell damage in dry eye models. PLoS ONE. 2020;15(4):e0229421.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen H, Gan X, Li Y, Gu J, Liu Y, Deng Y, Wang X, Hong Y, Hu Y, Su L, Chi W. NLRP12- and NLRC4-mediated corneal epithelial pyroptosis is driven by GSDMD cleavage accompanied by IL-33 processing in dry eye. Ocul Surf. 2020;18(4):783–94.

Article  PubMed  Google Scholar 

Fakih D, Zhao Z, Nicolle P, Reboussin E, Joubert F, Luzu J, Labbé A, Rostène W, Baudouin C, Mélik Parsadaniantz S, Réaux-Le Goazigo A. Chronic dry eye induced corneal hypersensitivity, neuroinflammatory responses, and synaptic plasticity in the mouse trigeminal brainstem. J Neuroinflamm. 2019;16(1):268.

Article  CAS  Google Scholar 

Zhao H, Li Q, Ye M, Yu J. Tear Luminex Analysis in Dry Eye patients. Med Sci Monitor: Int Med J Experimental Clin Res. 2018;24:7595–602.

Article  CAS  Google Scholar 

Akpek EK, Wu HY, Karakus S, Zhang Q, Masli S. Differential diagnosis of Sjögren Versus Non-Sjögren Dry Eye through tear Film biomarkers. Cornea. 2020;39(8):991–7.

Article  PubMed  Google Scholar 

Grosskreutz CL, Hockey HU, Serra D, Dryja TP. (2015). Dry Eye signs and symptoms persist during systemic neutralization of IL-1β by Canakinumab or IL-17A by Secukinumab. Cornea. 34(12):1551–6.

Chen Y, Zhang X, Yang L, Li M, Li B, Wang W, Sheng M. Decreased PPAR-γ expression in the conjunctiva and increased expression of TNF-α and IL-1β in the conjunctiva and tear fluid of dry eye mice. Mol Med Rep. 2014;9(5):2015–23.

Article  CAS  PubMed  Google Scholar 

Chen L, Heikkinen L, Wang C, Yang Y, Sun H, Wong G. Trends in the development of miRNA bioinformatics tools. Brief Bioinform. 2019;20(5):1836–52.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rassi DM, De Paiva CS, Dias LC, Módulo CM, Adriano L, Fantucci MZ, Rocha EM. Review: MicroRNAS in ocular surface and dry eye diseases. Ocul Surf. 2017;15(4):660–9.

Article  PubMed  Google Scholar 

Xu WD, Lu MM, Pan HF, Ye D. Q.(2012). Association of MicroRNA-146a with autoimmune diseases. Inflammation. 35(4):1525–9.

Yang B, Ni J, Long H, Huang J, Yang C, Huang X. IL-1β-induced miR-34a up-regulation inhibits Cyr61 to modulate osteoarthritis chondrocyte proliferation through ADAMTS-4. J Cell Biochem. 2018;119(10):7959–70.

Article  CAS  PubMed  Google Scholar 

Sun Y, Zhou S, Shi Y, Zhou Y, Zhang Y, Liu K, Zhu Y, Han X. Inhibition of miR-153, an IL-1β-responsive miRNA, prevents beta cell failure and inflammation-associated diabetes. Metab Clin Exp. 2020;111:154335.

Article  CAS  PubMed  Google Scholar 

Wierzbicki PM, Klacz J, Kotulak-Chrzaszcz A, Wronska A, Stanislawowski M, Rybarczyk A, Ludziejewska A, Kmiec Z, Matuszewski M. Prognostic significance of VHL, HIF1A, HIF2A, VEGFA and p53 expression in patients with clear–cell renal cell carcinoma treated with sunitinib as first–line treatment. Int J Oncol. 2019;55(2):371–90.

CAS  PubMed  PubMed Central  Google Scholar 

Fang JQ, Ou Q, Pan J, Fang J, Zhang DY, Qiu MQ, Li YQ, Wang XH, Yang XY, Chi Z, Gao W, Guo JP, Miethke T. Pan J. P.(2021). TcpC inhibits toll-like receptor signaling pathway by serving as an E3 ubiquitin ligase that promotes degradation of myeloid differentiation factor 88. PLoS pathogens 17(3):e1009481.

Luo Q, Yang J, Xu H, Shi J, Liang Z, Zhang R, Lu P, Pu G, Zhao N, Zhang J. Sorafenib-loaded nanostructured lipid carriers for topical ocular therapy of corneal neovascularization: development, in-vitro and in vivo study. Drug Delivery. 2022;29(1):837–55.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Choi H, Kwon J, Cho MS, Sun Y, Zheng X, Wang J, Bouker KB, Casey JL, Atkins MB, Toretsky J, Han C. Targeting DDX3X triggers Antitumor Immunity via a dsRNA-Mediated tumor-intrinsic type I Interferon Response. Cancer Res. 2021;81(13):3607–20.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Craig J, Nichols K, Akpek E, Caffery B, Dua H, Joo C, Liu Z, Nelson J, Nichols J, Tsubota K, Stapleton F. (2017). TFOS DEWS II definition and classification report. Ocul Surf.15(3):276–83.

Yamaguchi T. Inflammatory response in Dry Eye. Investig Ophthalmol Vis Sci. 2018;59(14):Des192–9.

Article  CAS  Google Scholar 

Nelson J, Farris R. Sodium hyaluronate and polyvinyl alcohol artificial tear preparations. A comparison in patients with keratoconjunctivitis sicca. Archives Ophthalmol (Chicago Ill: 1960). 1988;106(4):484–7.

Article  CAS  Google Scholar 

López-Cano J, González-Cela-Casamayor M, Andrés-Guerrero V, Herrero-Vanrell R, Benítez-Del-Castillo J, Molina-Martínez I. Combined hyperosmolarity and inflammatory conditions in stressed human corneal epithelial cells and macrophages to evaluate osmoprotective agents as potential DED treatments. Exp Eye Res. 2021;211:108723.

Article  PubMed  Google Scholar 

You H, Wang L, Meng H, Huang C, Fang G, Li J. Pyroptosis: shedding light on the mechanisms and links with cancers. Front Immunol. 2023;14:1290885.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lopez-Castejon G, Brough D. Understanding the mechanism of IL-1β secretion. Cytokine Growth Factor Rev. 2011;22(4):189–95.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kovacs SB, Miao EA. Gasdermins: effectors of Pyroptosis. Trends Cell Biol. 2017;27(9):673–84.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xu YJ, Zheng L, Hu YW, Wang Q. Pyroptosis and its relationship to atherosclerosis. Clin Chim Acta. 2018;476:28–37.

Article  CAS  PubMed  Google Scholar 

Roda M, Corazza I, Bacchi Reggiani ML, Pellegrini M, Taroni L, Giannaccare G, Versura P. (2020). Dry Eye Disease and Tear Cytokine Levels-A Meta-Analysis. Int J Mol Sci. 21(9).

Dai Y, Zhang J, Xiang J, Li Y, Wu D, Xu J. Calcitriol inhibits ROS-NLRP3-IL-1β signaling axis via activation of Nrf2-antioxidant signaling in hyperosmotic stress stimulated human corneal epithelial cells. Redox Biol. 2019;21:101093.

Article  CAS  PubMed  Google Scholar 

Li J, Yang K, Pan X, Peng H, Hou C, Xiao J, Wang Q. Long noncoding RNA MIAT regulates hyperosmotic stress-Induced corneal epithelial cell Injury via inhibiting the caspase-1-Dependent pyroptosis and apoptosis in Dry Eye Disease. J Inflamm Res. 2022;15:3269–83.

Article  PubMed  PubMed Central  Google Scholar 

Iacona JR, Lutz CS. miR-146a-5p: expression, regulation, and functions in cancer.Wiley. Interdisciplinary Reviews RNA. 2019;10(4):e1533.

Article  PubMed  Google Scholar 

Li X, Liao J, Su X, Li W, Bi Z, Wang J, Su Q, Huang H, Wei Y, Gao Y, Li J, Liu L, Wang C. Human urine-derived stem cells protect against renal ischemia/reperfusion injury in a rat model via exosomal miR-146a-5p which targets IRAK1. Theranostics. 2020;10(21):9561–78.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang HL, Li L, Cheng CJ, Sun XC. Expression of miR-146a-5p in patients with intracranial aneurysms and its association with prognosis. Eur Rev Med Pharmacol Sci. 2018;22(3):726–30.

PubMed  Google Scholar 

Sun HY, Lv AK, Yao H. (2017). Relationship of miRNA-146a to primary Sjögren’s syndrome and to systemic lupus erythematosus: a meta-analysis. Rheumatology International. 37(8):1311–6.

Wang X, Xin S, Wang Y, Ju D, Wu Q, Qiu Y, Niu X, Liu W, Li J, Ji P. (2021). MicroRNA-146a-5p enhances T helper 17 cell differentiation via decreasing a disintegrin and metalloprotease 17 level in primary sjögren’s syndrome. Bioengineered 12(1):310–24.

Jiang Z, Yin X, Wang M, Wang Y, Li F, Gao Y, Han G, Gao Z, Wang Z. β-Hydroxybutyrate alleviates pyroptosis in MPP/MPTP-induced Parkinson’s disease models via inhibiting STAT3/NLRP3/GSDMD pathway. Int Immunopharmacol. 2022;113:109451.

Article  CAS  PubMed  Google Scholar 

Jiang Z, Yin X, Wang M, Wang Y, Li F, Gao Y, Han G, Gao Z, Wang Z. (2022). β-Hydroxybutyrate alleviates pyroptosis in MPP+/MPTP-induced Parkinson’s disease models via inhibiting STAT3/NLRP3/GSDMD pathway. International Immunopharmacology 113(Pt B):109451.

Yao R, Chen Y, Hao H, Guo Z, Cheng X, Ma Y, Ji Q, Yang X, Wang Y, Li X, Wang Z. Pathogenic effects of inhibition of mTORC1/STAT3 axis facilitates Staphylococcus aureus-induced pyroptosis in human macrophages. Cell Communication Signaling: CCS. 2020;18(1):187.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Okuma A, Hoshino K, Ohba T, Fukushi S, Aiba S, Akira S, Ono M, Kaisho T, Muta T. Enhanced apoptosis by disruption of the STAT3-IκB-ζ signaling pathway in epithelial cells induces Sjögren’s syndrome-like. Autoimmune Disease Immun. 2013;38(3):450–60.

CAS  Google Scholar 

Wang X, Zhang S, Dong M, Li Y, Zhou Q, Yang L. The proinflammatory cytokines IL-1β and TNF-α modulate corneal epithelial wound healing through p16(Ink4a) suppressing STAT3 activity. J Cell Physiol. 2020;235(12):10081–93.

Article  CAS  PubMed  Google Scholar 

Qu M, Qi X, Wang Q, Wan L, Li J, Li W, Li Y, Zhou Q. Therapeutic effects of STAT3 inhibition on experimental murine Dry Eye. Investig Ophthalmol Vis Sci. 2019;60(12):3776–85.

Article  CAS  Google Scholar 

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