Afsar B, Turkmen K, Covic A, Kanbay M (2014) An update on coronary artery disease and chronic kidney disease. Int J Nephrol 2014:767424

Article  PubMed  PubMed Central  Google Scholar 

Budanov AV, Karin M (2008) p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling. Cell 134:451–460

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cao Q, Du H, Fu X, Duan N, Liu C, Li X (2020) Artemisinin attenuated atherosclerosis in high-fat diet-fed ApoE−/− mice by promoting macrophage autophagy through the AMPK/mTOR/ULK1 pathway. J Cardiovasc Pharmacol 75:321–332

Article  CAS  PubMed  Google Scholar 

Che J, Liang B, Zhang Y, Wang Y, Tang J, Shi G (2017) Kaempferol alleviates ox-LDL-induced apoptosis by up-regulation of autophagy via inhibiting PI3K/Akt/mTOR pathway in human endothelial cells. Cardiovasc Pathol 31:57–62

Article  CAS  PubMed  Google Scholar 

Choi AM, Ryter SW, Levine B (2013) Autophagy in human health and disease. N Engl J Med 368:651–662

Article  CAS  PubMed  Google Scholar 

Cordani M, Butera G, Dando I et al (2018) Mutant p53 blocks SESN1/AMPK/PGC-1alpha/UCP2 axis increasing mitochondrial O2− production in cancer cells. Br J Cancer 119:994–1008

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ding Z, Liu S, Wang X, Khaidakov M, Dai Y, Mehta JL (2013) Oxidant stress in mitochondrial DNA damage, autophagy and inflammation in atherosclerosis. Sci Rep 3:1077

Article  PubMed  PubMed Central  Google Scholar 

Fan X, Wang J, Hou J et al (2015) Berberine alleviates ox-LDL induced inflammatory factors by up-regulation of autophagy via AMPK/mTOR signaling pathway. J Transl Med 13:92

Article  PubMed  PubMed Central  Google Scholar 

Frostegård J (2013) Immunity, atherosclerosis and cardiovascular disease. BMC Med 11:117

Article  PubMed  PubMed Central  Google Scholar 

Fu XC, Wang MW, Li SP, Wang HL (2006) Anti-apoptotic effect and the mechanism of orientin on ischaemic/reperfused myocardium. J Asian Nat Prod Res 8:265–272

Article  CAS  PubMed  Google Scholar 

Fukai T, Ushio-Fukai M (2011) Superoxide dismutases: role in redox signaling, vascular function, and diseases. Antioxid Redox Signal 15:1583–1606

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gao S, Liu J (2017) Association between circulating oxidized low-density lipoprotein and atherosclerotic cardiovascular disease. Chronic Dis Transl Med 3:89–94

PubMed  PubMed Central  Google Scholar 

Gawel S, Wardas M, Niedworok E, Wardas P (2004) Malondialdehyde (MDA) as a lipid peroxidation marker. Wiad Lek 57:453–455

PubMed  Google Scholar 

Hamasaki M, Shibutani ST, Yoshimori T (2013) Up-to-date membrane biogenesis in the autophagosome formation. Curr Opin Cell Biol 25:455–460

Article  CAS  PubMed  Google Scholar 

He D, Xu L, Wu Y et al (2020) Rac3, but not Rac1, promotes ox-LDL induced endothelial dysfunction by downregulating autophagy. J Cell Physiol 235:1531–1542

Article  CAS  PubMed  Google Scholar 

Jensen HA, Mehta JL (2016) Endothelial cell dysfunction as a novel therapeutic target in atherosclerosis. Expert Rev Cardiovasc Ther 14:1021–1033

Article  CAS  PubMed  Google Scholar 

Kang H, Yu H, Fan J, Cao G (2021) Rotigotine protects against oxidized low-density lipoprotein(ox-LDL)-induced damages in human umbilical vein endothelial cells(HUVECs). Bioengineered 12:10568–10579

Article  CAS  PubMed  PubMed Central  Google Scholar 

Keping Y, Yunfeng S, Pengzhuo X, Liang L, Chenhong X, Jinghua M (2020) Sestrin1 inhibits oxidized low-density lipoprotein-induced activation of NLRP3 inflammasome in macrophages in a murine atherosclerosis model. Eur J Immunol 50:1154–1166

Article  PubMed  Google Scholar 

Kim M, Kowalsky AH, Lee JH (2021) Sestrins in physiological stress responses. Annu Rev Physiol 83:381–403

Article  CAS  PubMed  Google Scholar 

Kregel KC, Zhang HJ (2007) An integrated view of oxidative stress in aging: basic mechanisms, functional effects, and pathological considerations. Am J Physiol Regul Integr Comp Physiol 292:R18-36

Article  CAS  PubMed  Google Scholar 

Ku SK, Kwak S, Bae JS (2014) Orientin inhibits high glucose-induced vascular inflammation in vitro and in vivo. Inflammation 37:2164–2173

Article  CAS  PubMed  Google Scholar 

Lawal AO, Davids LM, Marnewick JL (2016) Diesel exhaust particles and endothelial cells dysfunction: An update. Toxicol In Vitro 32:92–104

Article  CAS  PubMed  Google Scholar 

Lee JH, Cho US, Karin M (2016) Sestrin regulation of TORC1: Is Sestrin a leucine sensor? Sci Signal 9:re5

Article  PubMed  PubMed Central  Google Scholar 

Li F, Zong J, Zhang H et al (2017) Orientin reduces myocardial infarction size via eNOS/NO signaling and thus mitigates adverse cardiac remodeling. Front Pharmacol 8:926

Article  PubMed  PubMed Central  Google Scholar 

Li W, Li Y, Zhao Y, Ren L (2020a) The protective effects of aloperine against ox-LDL-induced endothelial dysfunction and inflammation in HUVECs. Artif Cells Nanomed Biotechnol 48:107–115

Article  PubMed  Google Scholar 

Li C, Cai C, Zheng X, Sun J, Ye L (2020b) Orientin suppresses oxidized low-density lipoproteins induced inflammation and oxidative stress of macrophages in atherosclerosis. Biosci Biotechnol Biochem 84:774–779

Article  CAS  PubMed  Google Scholar 

Li X, Zhou J, Dou Y et al (2020c) The protective effects of angelica organic acid against ox-LDL-induced autophagy dysfunction of HUVECs. BMC Complement Med Ther 20:164

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li L, Chen Y, Shi C (2022d) Nintedanib ameliorates oxidized low-density lipoprotein -induced inflammation and cellular senescence in vascular endothelial cells. Bioengineered 13:6196–6207

Article  CAS  PubMed  PubMed Central  Google Scholar 

Libby P, Buring JE, Badimon L et al (2019) Atherosclerosis. Nat Rev Dis Primers 5:56

Article  PubMed  Google Scholar 

Lin HH (2015) In vitro and in vivo atheroprotective effects of gossypetin against endothelial cell injury by induction of autophagy. Chem Res Toxicol 28:202–215

Article  CAS  PubMed  Google Scholar 

Liu L, Wu Y, Huang X (2016) Orientin protects myocardial cells against hypoxia-reoxygenation injury through induction of autophagy. Eur J Pharmacol 776:90–98

Article  CAS  PubMed  Google Scholar 

Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25:402–408

Article  CAS  PubMed  Google Scholar 

Martinet W, De Meyer GR (2009) Autophagy in atherosclerosis: a cell survival and death phenomenon with therapeutic potential. Circ Res 104:304–317

Article  CAS  PubMed  Google Scholar 

Mizushima N, Komatsu M (2011) Autophagy: renovation of cells and tissues. Cell 147:728–741

Article  CAS  PubMed  Google Scholar 

Mizushima N, Levine B, Cuervo AM, Klionsky DJ (2008) Autophagy fights disease through cellular self-digestion. Nature 451:1069–1075

Article  CAS  PubMed  PubMed Central  Google Scholar 

Monteiro JP, Bennett M, Rodor J, Caudrillier A, Ulitsky I, Baker AH (2019) Endothelial function and dysfunction in the cardiovascular system: the long non-coding road. Cardiovasc Res 115:1692–1704

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pennathur S, Heinecke JW (2007) Oxidative stress and endothelial dysfunction in vascular disease. Curr Diab Rep 7:257–264

Article  CAS  PubMed  Google Scholar 

Su Q, Sun Y, Ye Z, Yang H, Kong B, Li L (2018) Pinocembrin protects endothelial cells from oxidized LDL-induced injury. Cytokine 111:475–480

Article