Brun P, Giron MC, Qesari M et al (2013) Toll-like receptor 2 regulates intestinal inflammation by controlling integrity of the enteric nervous system. Gastroenterology 145:1323–1333

Article  CAS  PubMed  Google Scholar 

Bush TG, Savidge TC, Freeman TC et al (1998) Fulminant jejuno-ileitis following ablation of enteric glia in adult transgenic mice. Cell 93:189–201

Article  CAS  PubMed  Google Scholar 

Cader MZ, Kaser A (2013) Recent advances in inflammatory bowel disease: mucosal immune cells in intestinal inflammation. Gut 62:1653–1664

Article  CAS  PubMed  Google Scholar 

Capaldo CT (2023) Claudin barriers on the brink: how conflicting tissue and cellular priorities drive IBD pathogenesis. Int J Mol Sci 24:8562

Article  CAS  PubMed  PubMed Central  Google Scholar 

Coelho-Aguiar Jde M, Bon-Frauches AC, Gomes AL et al (2015) The enteric glia: identity and functions. Glia 63:921–935

Article  PubMed  Google Scholar 

Cornet A, Savidge TC, Cabarrocas J et al (2001) Enterocolitis induced by autoimmune targeting of enteric glial cells: a possible mechanism in Crohn’s disease? Proc Natl Acad Sci U S A 98:13306–13311

Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

Dharmasiri S, Garrido-Martin EM (2021) Human intestinal macrophages are involved in the pathology of both ulcerative colitis and Crohn disease. Inflamm Bowel Dis 27:1641–1652

Article  PubMed  PubMed Central  Google Scholar 

Fuenzalida P, Kurte M, Fernández-O’ryan C et al (2016) Toll-like receptor 3 pre-conditioning increases the therapeutic efficacy of umbilical cord mesenchymal stromal cells in a dextran sulfate sodium-induced colitis model. Cytotherapy 18:630–641

Article  CAS  PubMed  Google Scholar 

Holland AM, Bon-Frauches AC (2021) The enteric nervous system in gastrointestinal disease etiology. Cell Mol Life Sci 78:4713–4733

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hunter MM, Wang A, Parhar KS et al (2010) In vitro-derived alternatively activated macrophages reduce colonic inflammation in mice. Gastroenterology 138:1395–1405

Article  CAS  PubMed  Google Scholar 

Isidro RA, Appleyard CB (2016) Colonic macrophage polarization in homeostasis, inflammation, and cancer. Am J Physiol Gastrointest Liver Physiol 311:G59–73

Article  PubMed  PubMed Central  Google Scholar 

Li X, Cudaback E, Breyer RM et al (2012) Eicosanoid receptor subtype-mediated opposing regulation of TLR-stimulated expression of astrocyte glial-derived neurotrophic factor. Faseb j 26:3075–3083

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li H, Fan C, Lu H et al (2020) Protective role of berberine on ulcerative colitis through modulating enteric glial cells-intestinal epithelial cells-immune cells interactions. Acta Pharm Sin B 10:447–461

Article  CAS  PubMed  Google Scholar 

Martini E, Krug SM, Siegmund B, Neurath MF, Becker C (2017) Mend your fences: the epithelial barrier and its relationship with mucosal immunity in inflammatory bowel disease. Cell Mol Gastroenterol Hepatol 4:33–46

Article  PubMed  PubMed Central  Google Scholar 

Meir M, Kannapin F, Diefenbacher M (2021) Intestinal epithelial barrier maturation by enteric glial cells is GDNF-dependent. Int J Mol Sci 22:1887

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pan LN, Zhu W, Li C et al (2012) Toll-like receptor 3 agonist poly I:C protects against simulated cerebral ischemia in vitro and in vivo. Acta Pharmacol Sin 33:1246–1253

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pochard C, Coquenlorge S, Jaulin J et al (2016) Defects in 15-HETE production and control of epithelial permeability by human enteric glial cells from patients with Crohn’s disease. Gastroenterology 150:168–180

Article  CAS  PubMed  Google Scholar 

Qiu Y, Guo J, Mao R et al (2017) TLR3 preconditioning enhances the therapeutic efficacy of umbilical cord mesenchymal stem cells in TNBS-induced colitis via the TLR3-Jagged-1-Notch-1 pathway. Mucosal Immunol 10:727–742

Article  CAS  PubMed  Google Scholar 

Rocha SM, Cristovão AC, Campos FL, Fonseca CP, Baltazar G (2012) Astrocyte-derived GDNF is a potent inhibitor of microglial activation. Neurobiol Dis 47:407–415

Article  CAS  PubMed  Google Scholar 

Savidge TC, Newman P, Pothoulakis C et al (2007) Enteric glia regulate intestinal barrier function and inflammation via release of S-nitrosoglutathione. Gastroenterology 132:1344–1358

Article  CAS  PubMed  Google Scholar 

Sica A, Mantovani A (2012) Macrophage plasticity and polarization: in vivo veritas. J Clin Invest 122:787–795

Article  CAS  PubMed  PubMed Central  Google Scholar 

Souza RF, Evangelinellis MM, Mendes CE et al (2020) P2X7 receptor antagonist recovers ileum myenteric neurons after experimental ulcerative colitis. World J Gastrointest Pathophysiol 11:84–103

Article  PubMed  PubMed Central  Google Scholar 

Stakenborg M, Abdurahiman S, De Simone V et al (2022) Enteric glial cells favor accumulation of anti-inflammatory macrophages during the resolution of muscularis inflammation. Mucosal Immunol 15:1296–1308

Article  CAS  PubMed  PubMed Central  Google Scholar 

Turco F, Sarnelli G, Cirillo C et al (2014) Enteroglial-derived S100B protein integrates bacteria-induced toll-like receptor signalling in human enteric glial cells. Gut 63:105–115

Article  CAS  PubMed  Google Scholar 

Vijay-Kumar M, Wu H, Aitken J et al (2007) Activation of toll-like receptor 3 protects against DSS-induced acute colitis. Inflamm Bowel Dis 13:856–864

Article  PubMed  Google Scholar 

von Boyen GB, Steinkamp M, Geerling I et al (2006) Proinflammatory cytokines induce neurotrophic factor expression in enteric glia: a key to the regulation of epithelial apoptosis in Crohn’s disease. Inflamm Bowel Dis 12:346–354

Article  Google Scholar 

Walldorf J, Porzner M, Neumann M et al (2022) The selective 5-HT1A agonist SR57746A protects intestinal epithelial cells and enteric glia cells and promotes mucosal recovery in experimental colitis. Inflamm Bowel Dis 28:423–433

Article  PubMed  Google Scholar 

Wang S, Ding Y, Jiang W (2022) CSE/H(2)S ameliorates colitis in mice via protection of enteric glial cells and inhibition of the RhoA/ROCK pathway. Front Immunol 13:966881

Article  CAS  PubMed  PubMed Central  Google Scholar 

Weisser SB, Brugger HK, Voglmaier NS et al (2011) SHIP-deficient, alternatively activated macrophages protect mice during DSS-induced colitis. J Leukoc Biol 90:483–492

Article  CAS  PubMed  Google Scholar 

Wirtz S, Popp V, Kindermann M et al (2017) Chemically induced mouse models of acute and chronic intestinal inflammation. Nat Protoc 12:1295–1309

Article  CAS  PubMed  Google Scholar 

Zeng J, Yu H, Gan HT (2021) Glial cell line-derived neurotrophic factor ameliorates dextran sulfate sodium-induced colitis in mice via a macrophage-mediated pathway. Int Immunopharmacol 100:108143

Article  CAS  PubMed  Google Scholar 

Zhao HW, Yue YH, Han H et al (2017) Effect of toll-like receptor 3 agonist poly I:C on intestinal mucosa and epithelial barrier function in mouse models of acute colitis. World J Gastroenterol 23:999–1009

Article  CAS  PubMed  PubMed Central  Google Scholar