Albert V, Svensson K, Shimobayashi M, Colombi M, Muñoz S, Jimenez V et al (2016) mTORC2 sustains thermogenesis via Akt-induced glucose uptake and glycolysis in brown adipose tissue. EMBO Mol Med 8(3):232–246. https://doi.org/10.15252/emmm.201505610

Article  CAS  PubMed  PubMed Central  Google Scholar 

Blaha C, Ramakrishnan G, Jeon S, Nogueira V, Rho H, Kang S et al (2022) A non-catalytic scaffolding activity of hexokinase 2 contributes to EMT and metastasis. Nat Commun 13(1):899. https://doi.org/10.1038/s41467-022-28440-3

Article  CAS  PubMed  PubMed Central  ADS  Google Scholar 

Cao J, Huo P, Cui K, Wei H, Cao J, Wang J et al (2022) Follicular fluid-derived exosomal miR-143–3p/miR-155–5p regulate follicular dysplasia by modulating glycolysis in granulosa cells in polycystic ovary syndrome. Cell Commun Signal CCS 20(1):61. https://doi.org/10.1186/s12964-022-00876-6

Article  CAS  PubMed  Google Scholar 

Chen X, Lv Y, Sun Y, Zhang H, Xie W, Zhong L et al (2019) PGC1β regulates breast tumor growth and metastasis by SREBP1-mediated HKDC1 expression. Front Oncol 9:290. https://doi.org/10.3389/fonc.2019.00290

Article  PubMed  PubMed Central  ADS  Google Scholar 

Chen Z, Lei L, Wen D, Yang L (2019) Melatonin attenuates palmitic acid-induced mouse granulosa cells apoptosis via endoplasmic reticulum stress. J Ovarian Res 12(1):43. https://doi.org/10.1186/s13048-019-0519-z

Article  PubMed  PubMed Central  Google Scholar 

Deng Y, Li H, Song Y, Cen J, Zhang Y, Sui Y et al (2022) Whole genome transcriptomic analysis of ovary granulosa cells revealed an anti-apoptosis regulatory gene DLGAP5 in polycystic ovary syndrome. Front Endocrinol 13:781149. https://doi.org/10.3389/fendo.2022.781149

Article  Google Scholar 

Ding Y, Jiang Z, Xia B, Zhang L, Zhang C, Leng J (2019) Mitochondria-targeted antioxidant therapy for an animal model of PCOS-IR. Int J Mol Med 43(1):316–324. https://doi.org/10.3892/ijmm.2018.3977

Article  CAS  PubMed  Google Scholar 

Ding Y, Jiang Z, Xia B, Zhang L, Zhang C, Leng J (2019) Mitochondria-targeted antioxidant therapy for an animal model of PCOS-IR. Int J Mol Med. 43(1):316–324. https://doi.org/10.3892/ijmm.2018.3977

Article  CAS  PubMed  Google Scholar 

Fuhr L, El-Athman R, Scrima R, Cela O, Carbone A, Knoop H et al (2018) The circadian clock regulates metabolic phenotype rewiring via HKDC1 and modulates tumor progression and drug response in colorectal cancer. EBioMed 33:105–121. https://doi.org/10.1016/j.ebiom.2018.07.002

Article  Google Scholar 

Greenwood E, Pasch L, Cedars M, Legro R, Huddleston H (2018) Association among depression, symptom experience, and quality of life in polycystic ovary syndrome. Am J Obstet Gynecol 219(3):279.e271-279.e277. https://doi.org/10.1016/j.ajog.2018.06.017

Article  Google Scholar 

Guastella E, Longo R, Carmina E (2010) Clinical and endocrine characteristics of the main polycystic ovary syndrome phenotypes. Fertil Steril 94(6):2197–2201. https://doi.org/10.1016/j.fertnstert.2010.02.014

Article  CAS  PubMed  Google Scholar 

Guo J, Ye F, Xie W, Zhang X, Zeng R, Sheng W et al (2022) The HOXC-AS2/miR-876–5p/HKDC1 axis regulates endometrial cancer progression in a high glucose-related tumor microenvironment. Cancer Sci 113(7):2297–2310. https://doi.org/10.1111/cas.15384

Article  CAS  PubMed  PubMed Central  Google Scholar 

Han Y, Zhang W, Liu J, Song Y, Liu T, Li Z et al (2020) Metabolomic and lipidomic profiling of preoperative CSF in elderly hip fracture patients with postoperative delirium. Front Aging Neurosci 12:570210. https://doi.org/10.3389/fnagi.2020.570210

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hayes M, Urbanek M, Hivert M, Armstrong L, Morrison J, Guo C et al (2013) Identification of HKDC1 and BACE2 as genes influencing glycemic traits during pregnancy through genome-wide association studies. Diabetes 62(9):3282–3291. https://doi.org/10.2337/db12-1692

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hu M, Zhang Y, Ma S, Li J, Wang X, Liang M et al (2021) Suppression of uterine and placental ferroptosis by N-acetylcysteine in a rat model of polycystic ovary syndrome. Mol Human Reprod. https://doi.org/10.1093/molehr/gaab067

Article  Google Scholar 

Huang J, Duan C, Jin S, Sheng C, Wang Y, Yue Z et al (2022) HB-EGF induces mitochondrial dysfunction via estrogen hypersecretion in granulosa cells dependent on cAMP-PKA-JNK/ERK-Ca-FOXO1 pathway. Int J Biol Sci 18(5):2047–2059. https://doi.org/10.7150/ijbs.69343

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang L, Liang A, Li T, Lei X, Chen X, Liao B et al (2022) Mogroside V improves follicular development and ovulation in young-adult PCOS rats induced by letrozole and high-fat diet through promoting glycolysis. Front Endocrinol 13:838204. https://doi.org/10.3389/fendo.2022.838204

Article  Google Scholar 

Huang X, Hong L, Wu Y, Chen M, Kong P, Ruan J et al (2021) Raman spectrum of follicular fluid: a potential biomarker for oocyte developmental competence in polycystic ovary syndrome. Front Cell Dev Biol 9:777224. https://doi.org/10.3389/fcell.2021.777224

Article  PubMed  PubMed Central  Google Scholar 

Khan M, Priyadarshini M, Cordoba-Chacon J, Becker T, Layden B (1865) (2019) Hepatic hexokinase domain containing 1 (HKDC1) improves whole body glucose tolerance and insulin sensitivity in pregnant mice. Biochimica et Biophysica acta Mol Basis Dis 3:678–687. https://doi.org/10.1016/j.bbadis.2018.11.022

Article  CAS  Google Scholar 

Khan M, Terry A, Priyadarshini M, Ilievski V, Farooq Z, Guzman G et al (2022) The hexokinase “HKDC1” interaction with the mitochondria is essential for liver cancer progression. Cell Death Dis 13(7):660. https://doi.org/10.1038/s41419-022-04999-z

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ludvik A, Pusec C, Priyadarshini M, Angueira A, Guo C, Lo A et al (2016) HKDC1 is a novel hexokinase involved in whole-body glucose use. Endocrinology 157(9):3452–3461. https://doi.org/10.1210/en.2016-1288

Article  CAS  PubMed  PubMed Central  Google Scholar 

Massey V, Parrish A, Argemi J, Moreno M, Mello A, García-Rocha M et al (2021) Integrated multiomics reveals glucose use reprogramming and identifies a novel hexokinase in alcoholic hepatitis. Gastroenterology 160(5):1725-1740.e1722. https://doi.org/10.1053/j.gastro.2020.12.008

Article  CAS  PubMed  Google Scholar 

Pang X, Zhao Y, Wang J, Li W, Xiang Q, Zhang Z et al (2019) Competing endogenous RNA and coexpression network analysis for identification of potential biomarkers and therapeutics in association with metastasis risk and progression of prostate cancer. Oxid Med Cell Longev 2019:8265958. https://doi.org/10.1155/2019/8265958

Article  CAS  PubMed  PubMed Central  Google Scholar 

Peng Y, Guo L, Gu A, Shi B, Ren Y, Cong J et al (2020) Electroacupuncture alleviates polycystic ovary syndrome-like symptoms through improving insulin resistance, mitochondrial dysfunction, and endoplasmic reticulum stress via enhancing autophagy in rats. Mol Med 26(1):73. https://doi.org/10.1186/s10020-020-00198-8. (Cambridge, Mass.)

Article  CAS  PubMed  PubMed Central  Google Scholar 

Peng Y, Yang X, Luo X, Liu C, Cao X, Wang H et al (2020) Novel mechanisms underlying anti-polycystic ovary like syndrome effects of electroacupuncture in rats: suppressing SREBP1 to mitigate insulin resistance, mitochondrial dysfunction and oxidative stress. Biol Res 53(1):50. https://doi.org/10.1186/s40659-020-00317-z

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pusec C, De Jesus A, Khan M, Terry A, Ludvik A, Xu K et al (2019) Hepatic HKDC1 expression contributes to liver metabolism. Endocrinology 160(2):313–330. https://doi.org/10.11210/en.2018-00887

Article  CAS  PubMed  Google Scholar 

Qi X, Yun C, Sun L, Xia J, Wu Q, Wang Y et al (2019) Gut microbiota-bile acid-interleukin-22 axis orchestrates polycystic ovary syndrome. Nat Med 25(8):1225–1233. https://doi.org/10.11038/s41591-019-0509-0

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sadeghi HM, Adeli I, Calina D, Docea AO, Mousavi T, Daniali M et al (2022) Polycystic ovary syndrome: a comprehensive review of pathogenesis, management, and drug repurposing. Int J Mol Sci. https://doi.org/10.3390/ijms23020583

Article  PubMed  PubMed Central  Google Scholar 

Sreerangaraja Urs DB, Wu WH, Komrskova K, Postlerova P, Lin YF, Tzeng CR et al (2020) Mitochondrial function in modulating human granulosa cell steroidogenesis and female fertility. Int J Mol Sci. https://doi.org/10.3390/ijms21103592

Article  PubMed  PubMed Central  Google Scholar 

Szczuko M, Kikut J, Szczuko U, Szydłowska I, Nawrocka-Rutkowska J, Ziętek M et al (2021) Nutrition strategy and life style in polycystic ovary syndrome-narrative review. Nutrients. https://doi.org/10.3390/nu13072452

Article  PubMed  PubMed Central  Google Scholar 

Torchen L, Legro R, Dunaif A (2019) Distinctive reproductive phenotypes in peripubertal girls at risk for polycystic ovary syndrome. J Clin Endocrinol Metabol 104(8):3355–3361. https://doi.org/10.11210/jc.2018-02313

Article  Google Scholar 

van der Kooij M, Rojas-Charry L, Givehchi M, Wolf C, Bueno D, Arndt S et al (2022) Chronic social stress disrupts the intracellular redistribution of brain hexokinase 3 induced by shifts in peripheral glucose levels. J Mol Med 100(10):1441–1453. https://doi.org/10.11007/s00109-022-02235-x. (Berlin Germany)

Article  PubMed