PDL-1 and insulin resistance in obesity: a possible pathway for macrovascular disease

El-Arabey AA, Abdalla M. GATA3 as an immunomodulator in obesity-related metabolic dysfunction associated with fatty liver disease, insulin resistance, and type 2 diabetes. Chem Biol Interact. 2022;366: 110141.

Article  CAS  PubMed  Google Scholar 

Jiang S-Y, Yang X, Yang Z, Li J-W, Xu M-Q, Qu Y-X, et al. Discovery of an insulin-induced gene binding compound that ameliorates nonalcoholic steatohepatitis by inhibiting sterol regulatory element-binding protein-mediated lipogenesis. Hepatology. 2022;76:1466–81.

Article  CAS  PubMed  Google Scholar 

Ou H-X, Guo B-B, Liu Q, Li Y-K, Yang Z, Feng W-J, et al. Regulatory T cells as a new therapeutic target for atherosclerosis. Acta Pharmacol Sin. 2018;39:1249–58.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tysoe O. PDL1 reduces adipose inflammation in obesity. Nat Rev Endocrinol. 2022;18:334–334.

Article  PubMed  Google Scholar 

Lin J-D, Nishi H, Poles J, Niu X, Mccauley C, Rahman K, et al. Single-cell analysis of fate-mapped macrophages reveals heterogeneity, including stem-like properties, during atherosclerosis progression and regression. JCI Insight. 2019;4.

Grievink HW, Smit V, Verwilligen RAF, Bernabé Kleijn MNA, Smeets D, Binder CJ, et al. Stimulation of the PD-1 pathway decreases atherosclerotic lesion development in Ldlr deficient mice. Front Cardiovasc Med. 2021;8: 740531.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tabas I, Lichtman AH. Monocyte-macrophages and T cells in atherosclerosis. Immunity. 2017;47:621–34.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Couturier J, Nuotio-Antar AM, Agarwal N, Wilkerson GK, Saha P, Kulkarni V, et al. Lymphocytes upregulate CD36 in adipose tissue and liver. Adipocyte. 2019;8:154–63.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Silverstein RL. Type 2 scavenger receptor CD36 in platelet activation: the role of hyperlipemia and oxidative stress. Clin Lipidol. 2009;4:767.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nishimura S, Manabe I, Nagasaki M, Eto K, Yamashita H, Ohsugi M, et al. CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. Nat Med. 2009;15:914–20.

Article  CAS  PubMed  Google Scholar 

留言 (0)

沒有登入
gif