Hypothermic machine perfusion reduces donation after circulatory death liver ischemia–reperfusion injury through the SERPINA3-mediated PI3Kδ/Akt pathway

Zarrinpar A, Busuttil RW. Liver transplantation: past, present and future. Nat Rev Gastroenterol Hepatol. 2013;10:434–40.

Article  CAS  PubMed  Google Scholar 

Ravaioli M, De Pace V, Angeletti A, et al. Hypothermic oxygenated new machine perfusion system in liver and kidney transplantation of extended criteria donors: first Italian clinical trial. Sci Rep. 2020;10:6063.

Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

Giraud S, Steichen C, Allain G, et al. Dynamic transcriptomic analysis of Ischemic Injury in a porcine pre-clinical model mimicking donors deceased after circulatory death. Sci Rep. 2018;8:5986.

Article  ADS  PubMed  PubMed Central  Google Scholar 

Ertugrul IA, van Suylen V, Damman K, et al. Donor heart preservation with hydrogen sulfide: a systematic review and meta-analysis. Int J Mol Sci. 2021;22:5737.

Article  CAS  PubMed  PubMed Central  Google Scholar 

de Vries RJ, Tessier SN, Banik PD, et al. Subzero non-frozen preservation of human livers in the supercooled state. Nat Protoc. 2020;15:2024–40.

Article  PubMed  PubMed Central  Google Scholar 

van Rijn R, Schurink IJ, de Vries Y, et al. Hypothermic machine perfusion in liver transplantation—a randomized trial. N Engl J Med. 2021;384:1391–401.

Article  PubMed  Google Scholar 

He W, Ye S, Zeng C, et al. Hypothermic oxygenated perfusion (HOPE) attenuates ischemia/reperfusion injury in the liver through inhibition of the TXNIP/NLRP3 inflammasome pathway in a rat model of donation after cardiac death. FASEB J. 2018.

Zhou W, Zhong Z, Lin D, et al. Hypothermic oxygenated perfusion inhibits HECTD3-mediated TRAF3 polyubiquitination to alleviate DCD liver ischemia–reperfusion injury. Cell Death Dis. 2021;12:211.

Article  PubMed  PubMed Central  Google Scholar 

Zeng C, Hu X, He W, et al. Hypothermic machine perfusion ameliorates inflammation during ischemiareperfusion injury via sirtuin1mediated deacetylation of nuclear factorkappaB p65 in rat livers donated after circulatory death. Mol Med Rep. 2017;16:8649–56.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Monbaliu D, Brassil J. Machine perfusion of the liver: past, present and future. Curr Opin Organ Transplant. 2010;15:160–6.

Article  PubMed  Google Scholar 

Bae C, Henry SD, Guarrera JV. Is extracorporeal hypothermic machine perfusion of the liver better than the “good old icebox”? Curr Opin Organ Transplant. 2012;17:137–42.

Article  PubMed  Google Scholar 

Clarke G, Mergental H, Hann A, et al. How machine perfusion ameliorates hepatic ischaemia reperfusion injury. Int J Mol Sci. 2021;22:7523.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zeng C, Hu X, Wang Y, et al. A novel hypothermic machine perfusion system using a LifePort kidney transporter for the preservation of rat liver. Exp Ther Med. 2018;15:1410–6.

CAS  PubMed  Google Scholar 

Zhang B, Ma JX. SERPINA3K prevents oxidative stress induced necrotic cell death by inhibiting calcium overload. PLoS ONE. 2008;3:e4077.

Article  ADS  PubMed  PubMed Central  Google Scholar 

Yiu WH, Wong DW, Wu HJ, et al. Kallistatin protects against diabetic nephropathy in db/db mice by suppressing AGE-RAGE-induced oxidative stress. Kidney Int. 2016;89:386–98.

Article  CAS  PubMed  Google Scholar 

Murohara T, Guo JP, Lefer AM. Cardioprotection by a novel recombinant serine protease inhibitor in myocardial ischemia and reperfusion injury. J Pharmacol Exp Ther. 1995;274:1246–53.

CAS  PubMed  Google Scholar 

Sandford AJ, Chagani T, Weir TD, et al. Alpha 1-antichymotrypsin mutations in patients with chronic obstructive pulmonary disease. Dis Markers. 1998;13:257–60.

Article  CAS  PubMed  Google Scholar 

Kamboh MI, Minster RL, Kenney M, et al. Alpha-1-antichymotrypsin (ACT or SERPINA3) polymorphism may affect age-at-onset and disease duration of Alzheimer’s disease. Neurobiol Aging. 2006;27:1435–9.

Article  CAS  PubMed  Google Scholar 

Hoffmann DC, Textoris C, Oehme F, et al. Pivotal role for alpha1-antichymotrypsin in skin repair. J Biol Chem. 2011;286:28889–901.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhu H, Liu Q, Tang J, et al. Alpha1-ACT functions as a tumour suppressor in hepatocellular carcinoma by inhibiting the PI3K/AKT/mTOR Signalling pathway via activation of PTEN. Cell Physiol Biochem. 2017;41:2289–306.

Article  CAS  PubMed  Google Scholar 

Zhou ML, Chen FS, Mao H. Clinical significance and role of up-regulation of SERPINA3 expression in endometrial cancer. World J Clin Cases. 2019;7:1996–2002.

Article  PubMed  PubMed Central  Google Scholar 

Sanchez-Navarro A, Mejia-Vilet JM, Perez-Villalva R, et al. SerpinA3 in the early recognition of acute kidney injury to chronic kidney disease (CKD) transition in the rat and its potentiality in the recognition of patients with CKD. Sci Rep. 2019;9:10350.

Article  ADS  PubMed  PubMed Central  Google Scholar 

Sanchez-Navarro A, Murillo-de-Ozores AR, Perez-Villalva R, et al. Transient response of serpinA3 during cellular stress. FASEB J. 2022;36: e22190.

Article  CAS  PubMed  Google Scholar 

Ko E, Kim JS, Bae JW, et al. SERPINA3 is a key modulator of HNRNP-K transcriptional activity against oxidative stress in HCC. Redox Biol. 2019;24: 101217.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ko E, Seo HW, Jung ES, et al. PI3Kdelta Is a therapeutic target in hepatocellular carcinoma. Hepatology. 2018;68:2285–300.

Article  CAS  PubMed  Google Scholar 

Vivanco I, Sawyers CL. The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat Rev Cancer. 2002;2:489–501.

Article  CAS  PubMed  Google Scholar 

Uehara M, McGrath MM, Ohori S, et al. Regulation of T cell alloimmunity by PI3Kgamma and PI3Kdelta. Nat Commun. 2017;8:951.

Article  ADS  PubMed  PubMed Central  Google Scholar 

Ghareghomi S, Ahmadian S, Zarghami N, et al. Fundamental insights into the interaction between telomerase/TERT and intracellular signaling pathways. Biochimie. 2021;181:12–24.

Article  CAS  PubMed  Google Scholar 

Chinese Society of Organ Transplantation CMA. National guidelines for donation after cardiac death in China. Hepatobiliary Pancreat Dis Int. 2013;12:234–8.

Article  Google Scholar 

Huang J, Millis JM, Mao Y, et al. A pilot programme of organ donation after cardiac death in China. Lancet. 2012;379:862–5.

Article  PubMed  Google Scholar 

Durand CM, Chattergoon MA. Bypassing the bottleneck: intentional hepatitis C transmission with organ transplant. J Clin Invest. 2019;129:3038–40.

Article  PubMed  PubMed Central  Google Scholar 

Hrydziuszko O, Perera MT, Laing R, et al. Mass Spectrometry based metabolomics comparison of liver grafts from donors after circulatory death (DCD) and donors after brain death (DBD) used in human orthotopic liver transplantation. PLoS ONE. 2016;11:e0165884.

Article  PubMed  PubMed Central  Google Scholar 

Zeng X, Wang S, Li S, et al. Hypothermic oxygenated machine perfusion alleviates liver injury in donation after circulatory death through activating autophagy in mice. Artif Organs. 2019;43:E320–32.

Article  CAS  PubMed  Google Scholar 

Hu X, Wang W, Zeng C, et al. Appropriate timing for hypothermic machine perfusion to preserve livers donated after circulatory death. Mol Med Rep. 2020;22:2003–11.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhou W, Peng S, Du P, et al. Hypothermic oxygenated perfusion combined with TJ-M2010-5 alleviates hepatic ischemia–reperfusion injury in donation after circulatory death. Int Immunopharmacol. 2022;105: 108541.

Article  CAS  PubMed  Google Scholar 

Decker K. Eicosanoids, signal molecules of liver cells. Semin Liver Dis. 1985;5:175–90.

Article  CAS  PubMed  Google Scholar 

Dar WA, Sullivan E, Bynon JS, et al. Ischaemia reperfusion injury in liver transplantation: cellular and molecular mechanisms. Liver Int. 2019;39:788–801.

Article  PubMed  PubMed Central  Google Scholar 

Zhou T, Zong R, Zhang Z, et al. SERPINA3K protects against oxidative stress via modulating ROS generation/degradation and KEAP1-NRF2 pathway in the corneal epithelium. Invest Ophthalmol Vis Sci. 2012;53:5033–43.

Article 

留言 (0)

沒有登入
gif