Aarsland D, Creese B, Politis M, Chaudhuri KR, Ffytche DH, Weintraub D, Ballard C (2017) Cognitive decline in Parkinson disease. Nat Rev Neurol 13(4):217–231

Article  PubMed Central  PubMed  Google Scholar 

Abdullatef S, Farina C (2023) Publicly available ex vivo transcriptomics datasets to explore CNS physiology and neurodegeneration: state of the art and perspectives. Front Neurosci 17:1211079

Article  PubMed Central  PubMed  Google Scholar 

Biqing Z, Jae-Min P, Sarah C, Hsu IU, TuKiet TL, Pallavi PG, Stephen DG, Jiawei W, Chang S, Hongyu Z, David AH, Sreeganga SC, Le Z (2022). Single-cell transcriptomic and proteomic analysis of Parkinson’s disease Brains, vol 2014.480397. BioRxiv, US, pp 2022–2002

Google Scholar 

Bruchas MR, Schindler AG, Shankar H, Messinger DI, Miyatake M, Land BB, Lemos JC, Hagan CE, Neumaier JF, Quintana A, Palmiter RD, Chavkin C (2011) Selective p38α MAPK deletion in serotonergic neurons produces stress resilience in models of depression and addiction. Neuron 71(3):498–511

Article  CAS  PubMed Central  PubMed  Google Scholar 

Caviedes A, Lafourcade C, Soto C, Wyneken U (2017) BDNF/NF-κB signaling in the neurobiology of depression. Curr Pharm Des 23(21):3154–3163

Article  CAS  PubMed  Google Scholar 

Chamboredon S, Ciais D, Desroches-Castan A, Savi P, Bono F, Feige JJ, Cherradi N (2011) Hypoxia-inducible factor-1α mRNA: a new target for destabilization by tristetraprolin in endothelial cells. Mol Biol Cell 22(18):3366–3378

Article  CAS  PubMed Central  PubMed  Google Scholar 

Choudary PV, Molnar M, Evans SJ, Tomita H, Li JZ, Vawter MP, Myers RM, Bunney WE Jr, Akil H, Watson SJ, Jones EG (2005) Altered cortical glutamatergic and GABAergic signal transmission with glial involvement in depression. Proc Natl Acad Sci U S A 102(43):15653–15658

Article  ADS  CAS  PubMed Central  PubMed  Google Scholar 

Dai ZJ, Gao J, Ma XB, Yan K, Liu XX, Kang HF, Ji ZZ, Guan HT, Wang XJ (2012) Up-regulation of hypoxia inducible factor-1α by cobalt chloride correlates with proliferation and apoptosis in PC-2 cells. J Exp Clin Cancer Res 31(1):28

Article  CAS  PubMed Central  PubMed  Google Scholar 

Durkee C, Kofuji P, Navarrete M, Araque A (2021) Astrocyte and neuron cooperation in long-term depression. Trends Neurosci 44(10):837–848

Article  CAS  PubMed Central  PubMed  Google Scholar 

Eskow Jaunarajs KL, Angoa-Perez M, Kuhn DM, Bishop C (2011) Potential mechanisms underlying anxiety and depression in Parkinson’s disease: consequences of l-DOPA treatment. Neurosci Biobehav Rev 35(3):556–564

Article  CAS  PubMed  Google Scholar 

Janelidze S, Lindqvist D, Francardo V, Hall S, Zetterberg H, Blennow K, Adler CH, Beach TG, Serrano GE, van Westen D, Londos E, Cenci MA, Hansson O (2015) Increased CSF biomarkers of angiogenesis in Parkinson disease. Neurology 85(21):1834–1842

Article  CAS  PubMed Central  PubMed  Google Scholar 

Jellinger KA (2022) The pathobiological basis of depression in Parkinson disease: challenges and outlooks. J Neural Transm (vienna) 129(12):1397–1418

Article  PubMed  Google Scholar 

Jungke P, Ostrow G, Li JL, Norton S, Nieber K, Kelber O, Butterweck V (2011) Profiling of hypothalamic and hippocampal gene expression in chronically stressed rats treated with St. John’s wort extract (STW 3-VI) and fluoxetine. Psychopharmacology 213(4):757–772

Article  CAS  PubMed  Google Scholar 

Larsen JP, Dalen I, Pedersen KF, Tysnes OB (2017) The natural history of depressive symptoms in patients with incident Parkinson’s disease: a prospective cohort study. J Neurol 264(12):2401–2408

Article  PubMed  Google Scholar 

Lee Y, Oh JS, Chung SJ, Lee JJ, Chung SJ, Moon H, Lee PH, Kim JS, Sohn YH (2018) The presence of depression in de novo Parkinson’s disease reflects poor motor compensation. PLoS ONE 13(9):e0203303

Article  PubMed Central  PubMed  Google Scholar 

Liu B, He J, Zhong L, Huang L, Gong B, Hu J, Qian H, Yang Z (2022) Single-cell transcriptome reveals diversity of Müller cells with different metabolic-mitochondrial signatures in normal and degenerated macula. Front Neurosci 16:1079498

Article  PubMed Central  PubMed  Google Scholar 

McKenna MC, Stridh MH, McNair LF, Sonnewald U, Waagepetersen HS, Schousboe A (2016) Glutamate oxidation in astrocytes: roles of glutamate dehydrogenase and aminotransferases. J Neurosci Res 94(12):1561–1571

Article  CAS  PubMed  Google Scholar 

Miguel-Hidalgo JJ, Baucom C, Dilley G, Overholser JC, Meltzer HY, Stockmeier CA, Rajkowska G (2000) Glial fibrillary acidic protein immunoreactivity in the prefrontal cortex distinguishes younger from older adults in major depressive disorder. Biol Psychiatry 48(8):861–873

Article  CAS  PubMed  Google Scholar 

Mikulska J, Juszczyk G, Gawrońska-Grzywacz M, Herbet M (2021) HPA Axis in the Pathomechanism of Depression and Schizophrenia: New Therapeutic Strategies Based on Its Participation. Brain Sci 11(10):1298

Article  PubMed Central  PubMed  Google Scholar 

Mojsilovic-Petrovic J, Callaghan D, Cui H, Dean C, Stanimirovic DB, Zhang W (2007) Hypoxia-inducible factor-1 (HIF-1) is involved in the regulation of hypoxia-stimulated expression of monocyte chemoattractant protein-1 (MCP-1/CCL2) and MCP-5 (Ccl12) in astrocytes. J Neuroinflammation 4:12

Article  PubMed Central  PubMed  Google Scholar 

Pellerin L, Magistretti PJ (1994) Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization. Proc Natl Acad Sci U S A 91(22):10625–10629

Article  ADS  CAS  PubMed Central  PubMed  Google Scholar 

Perelman A, Wachtel C, Cohen M, Haupt S, Shapiro H, Tzur A (2012) JC-1: alternative excitation wavelengths facilitate mitochondrial membrane potential cytometry. Cell Death Dis 3(11):e430

Article  CAS  PubMed Central  PubMed  Google Scholar 

Prange S, Klinger H, Laurencin C, Danaila T, Thobois S (2022) Depression in patients with Parkinson’s disease: current understanding of its neurobiology and implications for treatment. Drugs Aging 39(6):417–439

Article  CAS  PubMed Central  PubMed  Google Scholar 

Rose J, Brian C, Pappa A, Panayiotidis MI, Franco R (2020) Mitochondrial metabolism in astrocytes regulates brain bioenergetics, neurotransmission and redox balance. Front Neurosci 14:536682

Article  PubMed Central  PubMed  Google Scholar 

Ruiz Barrio I, Miki Y, Jaunmuktane ZT, Warner T, De Pablo-Fernandez E (2023) Association between orthostatic hypotension and dementia in patients with Parkinson disease and multiple system atrophy. Neurology 100(10):e998–e1008

Article  CAS  PubMed Central  PubMed  Google Scholar 

Schousboe A, Bak LK, Waagepetersen HS (2013) Astrocytic control of biosynthesis and turnover of the neurotransmitters glutamate and GABA. Front Endocrinol (lausanne) 4:102

Article  PubMed  Google Scholar 

Smajić S, Prada-Medina CA, Landoulsi Z, Ghelfi J, Delcambre S, Dietrich C, Jarazo J, Henck J, Balachandran S, Pachchek S, Morris CM, Antony P, Timmermann B, Sauer S, Pereira SL, Schwamborn JC, May P, Grünewald A, Spielmann M (2022) Single-cell sequencing of human midbrain reveals glial activation and a Parkinson-specific neuronal state. Brain 145(3):964–978

Article  PubMed  Google Scholar 

Starkstein SE, Brockman S (2017) Management of depression in Parkinson’s disease: a systematic review. Mov Disord Clin Pract 4(4):470–477

Article  PubMed Central  PubMed  Google Scholar 

Storch A, Ebersbach G, Fuchs G, Jost WH, Odin P, Reifschneider G, Bauer M (2008) Depression in Parkinson’s disease. Part 1: epidemiology, signs and symptoms, pathophysiology and diagnosis. Fortschr Neurol Psychiatr 76(12):715–724

Article  CAS  PubMed  Google Scholar 

Stuart T, Butler A, Hoffman P, Hafemeister C, Papalexi E, Mauck WM 3rd, Hao Y, Stoeckius M, Smibert P, Satija R (2019) Comprehensive integration of single-cell data. Cell 177(7):1888-1902.e1821

Article  CAS  PubMed Central  PubMed  Google Scholar 

Supplie LM, Düking T, Campbell G, Diaz F, Moraes CT, Götz M, Hamprecht B, Boretius S, Mahad D, Nave KA (2017) Respiration-deficient astrocytes survive as glycolytic cells in vivo. J Neurosci 37(16):4231–4242

Article  CAS  PubMed Central  PubMed  Google Scholar 

Webster MJ, Knable MB, Johnston-Wilson N, Nagata K, Inagaki M, Yolken RH (2001) Immunohistochemical localization of phosphorylated glial fibrillary acidic protein in the prefrontal cortex and hippocampus from patients with schizophrenia, bipolar disorder, and depression. Brain Behav Immun 15(4):388–400

Article  CAS  PubMed  Google Scholar 

Weintraub D, Mamikonyan E (2019) The neuropsychiatry of Parkinson disease: a perfect storm. Am J Geriatr Psychiatry 27(9):998–1018

Article  PubMed Central  PubMed  Google Scholar 

Whitehouse LM, Manzon RG (2019) Hypoxia alters the expression of hif-1a mRNA and downstream HIF-1 response genes in embryonic and larval lake whitefish (Coregonus clupeaformis). Comp Biochem Physiol A Mol Integr Physiol 230:81–90

Article