Siegel RL, Miller KD, Wagle NS, Jemal A. Cancer statistics, 2023. Cancer J Clin. 2023;73(1):17–48.

Article  Google Scholar 

Arnold M, Sierra MS, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global patterns and trends in colorectal cancer incidence and mortality. Gut. 2017;66(4):683–91.

Article  PubMed  Google Scholar 

Kim HJ, Lee S, Chun KH, Jeon JY, Han SJ, Kim DJ, et al. Metformin reduces the risk of cancer in patients with type 2 diabetes: An analysis based on the Korean National Diabetes Program Cohort. Medicine. 2018;97(8):36.

Article  Google Scholar 

Nayan M, Finelli A, Jewett MA, Juurlink DN, Austin PC, Kulkarni GS, et al. Metformin use and kidney cancer outcomes in patients 140 Actions and mechanisms of metformin as an anti-cancer agent with diabetes: a propensity score analysis. Clin Genitourin Cancer. 2017;15:300–5.

Article  PubMed  Google Scholar 

Chen CB, Eurich DT, Majumdar SR, Johnson JA. Metformin and the risk of prostate cancer across racial/ethnic groups: a population-based cohort study. Prostate Cancer Prostatic Dis. 2017;20:122–6.

Article  CAS  PubMed  Google Scholar 

Ko EM, Sturmer T, Hong JL, Castillo WC, Bae-Jump V, Funk MJ. Metformin and the risk of endometrial cancer: a population-based cohort study. Gynecol Oncol. 2015;136:341–7.

Article  CAS  PubMed  Google Scholar 

Drzewoski J, Hanefeld M. The current and potential therapeutic use of metformin—the good old drug. Pharmaceuticals. 2021;14(2):122.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wu Z, Zhang C, Najafi M. Targeting of the tumor immune microenvironment by metformin. J Cell Commun Signal. 2022;16(3):333–48.

Article  CAS  PubMed  Google Scholar 

De A, Kuppusamy G. Metformin in breast cancer: preclinical and clinical evidence. Curr Probl Cancer. 2020;44(1): 100488.

Article  PubMed  Google Scholar 

Yu X, Mao W, Zhai Y, Tong C, Liu M, Ma L, et al. Anti-tumor activity of metformin: from metabolic and epigenetic perspectives. Oncotarget. 2017;8(3):5619.

Article  PubMed  Google Scholar 

Malaekeh-Nikouei A, Shokri-Naei S, Karbasforoushan S, Bahari H, Rahimi VB, Heidari R, et al. Metformin beyond an anti-diabetic agent: a comprehensive and mechanistic review on its effects against natural and chemical toxins. Biomed Pharmacother. 2023;165: 115263.

Article  CAS  PubMed  Google Scholar 

Mu W, Jiang Y, Liang G, Feng Y, Qu F. Metformin: a promising antidiabetic medication for cancer treatment. Curr Drug Targets. 2023;24(1):41–54.

Article  CAS  PubMed  Google Scholar 

Hua Y, Zheng Y, Yao Y, Jia R, Ge S, Zhuang A. Metformin and cancer hallmarks: shedding new lights on therapeutic repurposing. J Transl Med. 2023;21(1):403.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kabir MI, Kumar R, Bugata LSP, Raina K. Anti-cancer efficacy of metformin: recent updates on breast and other cancers. Curr Pharmacol Rep. 2023;1:1–45.

Google Scholar 

Wu XY, Xu WW, Huan XK, Wu GN, Li G, Zhou YH, et al. Mechanisms of cancer cell killing by metformin: a review on different cell death pathways. Mol Cell Biochem. 2023;478(1):197–214.

Article  CAS  PubMed  Google Scholar 

Saini N, Yang X. Metformin as an anti-cancer agent: actions and mechanisms targeting cancer stem cells. Acta Biochim Biophys Sin. 2018;50(2):133–43.

Article  CAS  PubMed  Google Scholar 

Stuart CH, Singh R, Smith TL, D’Agostino R, Caudell D, Balaji KC, et al. Prostate-specific membrane antigen-targeted liposomes specifically deliver the Zn2+ chelator TPEN inducing oxidative stress in prostate cancer cells. Nanomedicine. 2016;11(10):1207–22.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shukla SK, Kulkarni NS, Chan A, Parvathaneni V, Farrales P, et al. Metformin-encapsulated liposome delivery system: an effective treatment approach against breast cancer. Pharmaceutics. 2016;11(11):559.

Article  Google Scholar 

Hernández-Velázquez ED, Alba-Betancourt C, Alonso-Castro ÁJ, Ortiz-Alvarado R, López JA, Meza-Carmen V, et al. Metformin, a biological and synthetic overview. Bioorg Med Chem Lett. 2023;86:129241.

Article  PubMed  Google Scholar 

Bailey CJ. Metformin: historical overview. Diabetologia. 2017;60:1566–76.

Article  CAS  PubMed  Google Scholar 

Johnson J, Rychahou P, Sviripa VM, Weiss HL, Liu C, et al. Induction of AMPK activation by N, N0-diarylurea FND-4b decreases growth and increases apoptosis in triple negative and estrogen-receptor positive breast cancers. PLoS ONE. 2019;14: e0209392.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Buczyńska A, Sidorkiewicz I, Krętowski AJ, Zbucka-Krętowska M, Adamska A. Metformin intervention—a panacea for cancer treatment? Cancers. 2022;14(5):1336.

Article  PubMed  PubMed Central  Google Scholar 

Lv Z, Guo Y. Metformin and its benefits for various diseases. Front Endocrinol. 2020;11:191.

Article  Google Scholar 

Zi F, ZiH., Li Y, He J, Shi Q,Cai Z. Metformin and cancer: An existing drug for cancer prevention and therapy. Oncol. Lett. 2018;15: 683–690

Kashkooli FM, Soltani M, Souri M. Controlled anti-cancer drug release through advanced nano-drug delivery systems: static and dynamic targeting strategies. J Control Release. 2020;327:316–49.

Article  Google Scholar 

Lee JY, Shin DH, Kim JS. Anticancer effect of metformin in herceptin-conjugated liposome for breast cancer. Pharmaceutics. 2019;12(1):11.

Article  PubMed  PubMed Central  Google Scholar 

Vaidya B, Parvathaneni V, Kulkarni NS, Shukla SK, Damon JK, Sarode A, et al. Cyclodextrin modified erlotinib loaded PLGA nanoparticles for improved therapeutic efficacy against non-small cell lung cancer. Int J Biol Macromol. 2019;122:338–47.

Article  CAS  PubMed  Google Scholar 

Farajzadeh R, Pilehvar-Soltanahmadi Y, Dadashpour M, Javidfar S, Lotfi-Attari J, Sadeghzadeh H, et al. Nano-encapsulated metformin-curcumin in PLGA/PEG inhibits synergistically growth and hTERT gene expression in human breast cancer cells. Artif Cells Nanomed Biotechnol. 2018;46:917–25.

Article  CAS  PubMed  Google Scholar 

Pendhari J, Savla H, Bethala D, Vaidya S, Shinde U, Menon M. Mitochondria targeted liposomes of metformin for improved anticancer activity: preparation and evaluation. J Drug Deliv Sci Technol. 2022;76: 103795.

Article  CAS  Google Scholar 

Heckman-Stoddard BM, DeCensi A, Sahasrabuddhe VV, Ford LG. Repurposing metformin for the prevention of cancer and cancer recurrence. Diabetologia. 2017;60(9):1639–47.

Article  CAS  PubMed  PubMed Central  Google Scholar