Timmis A, Vardas P, Townsend N, Torbica A, Katus H, De Smedt D, Gale CP, Maggioni AP, Petersen SE, Huculeci R, et al. European Society of Cardiology: cardiovascular disease statistics 2021. Eur Heart J. 2022;43(8):716–99.

Article  PubMed  Google Scholar 

Ormazabal V, Nair S, Elfeky O, Aguayo C, Salomon C, Zuniga FA. Association between insulin resistance and the development of cardiovascular disease. Cardiovasc Diabetol. 2018;17(1):122.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hill MA, Yang Y, Zhang L, Sun Z, Jia G, Parrish AR, Sowers JR. Insulin resistance, cardiovascular stiffening and cardiovascular disease. Metabolism. 2021;119:154766.

Article  CAS  PubMed  Google Scholar 

Unger G, Benozzi SF, Perruzza F, Pennacchiotti GL. Triglycerides and glucose index: a useful indicator of insulin resistance. Endocrinol Nutr. 2014;61(10):533–40.

Article  PubMed  Google Scholar 

Hong S, Han K, Park CY. The triglyceride glucose index is a simple and low-cost marker associated with atherosclerotic cardiovascular disease: a population-based study. BMC Med. 2020;18(1):361.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang L, Cong HL, Zhang JX, Hu YC, Wei A, Zhang YY, Yang H, Ren LB, Qi W, Li WY, et al. Triglyceride-glucose index predicts adverse cardiovascular events in patients with diabetes and acute coronary syndrome. Cardiovasc Diabetol. 2020;19(1):80.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang X, Xu W, Song Q, Zhao Z, Meng X, Xia C, Xie Y, Yang C, Jin P, Wang F. Association between the triglyceride-glucose index and severity of coronary artery disease. Cardiovasc Diabetol. 2022;21(1):168.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Grant PJ, Cosentino F, Marx N. Diabetes and coronary artery disease: not just a risk factor. Heart. 2020;106(17):1357–64.

Article  CAS  PubMed  Google Scholar 

Tai S, Fu L, Zhang N, Yang R, Zhou Y, Xing Z, Wang Y, Zhou S. Association of the cumulative triglyceride-glucose index with major adverse cardiovascular events in patients with type 2 diabetes. Cardiovasc Diabetol. 2022;21(1):161.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li T, Wang P, Wang X, Liu Z, Zhang Z, Zhang Y, Wang Z, Feng Y, Wang Q, Guo X et al. Inflammation and Insulin Resistance in Diabetic Chronic Coronary Syndrome patients. Nutrients 2023, 15(12).

Lee SE, Sung JM, Andreini D, Al-Mallah MH, Budoff MJ, Cademartiri F, Chinnaiyan K, Choi JH, Chun EJ, Conte E, et al. Association between Changes in Perivascular Adipose Tissue Density and plaque progression. JACC Cardiovasc Imaging. 2022;15(10):1760–7.

Article  PubMed  Google Scholar 

Antonopoulos AS, Sanna F, Sabharwal N, Thomas S, Oikonomou EK, Herdman L, Margaritis M, Shirodaria C, Kampoli AM, Akoumianakis I et al. Detecting human coronary inflammation by imaging perivascular fat. Sci Transl Med 2017, 9(398).

Oikonomou EK, Marwan M, Desai MY, Mancio J, Alashi A, Hutt Centeno E, Thomas S, Herdman L, Kotanidis CP, Thomas KE, et al. Non-invasive detection of coronary inflammation using computed tomography and prediction of residual cardiovascular risk (the CRISP CT study): a post-hoc analysis of prospective outcome data. Lancet. 2018;392(10151):929–39.

Article  PubMed  PubMed Central  Google Scholar 

Lin A, Nerlekar N, Yuvaraj J, Fernandes K, Jiang C, Nicholls SJ, Dey D, Wong DTL. Pericoronary adipose tissue computed tomography attenuation distinguishes different stages of coronary artery disease: a cross-sectional study. Eur Heart J Cardiovasc Imaging. 2021;22(3):298–306.

Article  CAS  PubMed  Google Scholar 

Goeller M, Achenbach S, Cadet S, Kwan AC, Commandeur F, Slomka PJ, Gransar H, Albrecht MH, Tamarappoo BK, Berman DS, et al. Pericoronary Adipose tissue computed tomography attenuation and high-risk plaque characteristics in Acute Coronary Syndrome compared with stable coronary artery disease. JAMA Cardiol. 2018;3(9):858–63.

Article  PubMed  PubMed Central  Google Scholar 

Jin A, Wang S, Li J, Wang M, Lin J, Li H, Meng X, Wang Y, Pan Y. Mediation of systemic inflammation on insulin resistance and prognosis of nondiabetic patients with ischemic stroke. Stroke. 2023;54(3):759–69.

Article  CAS  PubMed  Google Scholar 

Tan N, Dey D, Marwick TH, Nerlekar N. Pericoronary Adipose tissue as a marker of Cardiovascular Risk: JACC Review topic of the Week. J Am Coll Cardiol. 2023;81(9):913–23.

Article  CAS  PubMed  Google Scholar 

American Diabetes A. 2. Classification and diagnosis of diabetes: standards of Medical Care in Diabetes-2021. Diabetes Care. 2021;44(Suppl 1):15–S33.

Article  Google Scholar 

Imai K, Keele L, Tingley D. A general approach to causal mediation analysis. Psychol Methods. 2010;15(4):309–34.

Article  PubMed  Google Scholar 

Cho YR, Ann SH, Won KB, Park GM, Kim YG, Yang DH, Kang JW, Lim TH, Kim HK, Choe J, et al. Association between insulin resistance, hyperglycemia, and coronary artery disease according to the presence of diabetes. Sci Rep. 2019;9(1):6129.

Article  ADS  PubMed  PubMed Central  Google Scholar 

Zhang Y, Wang R, Fu X, Song H. Non-insulin-based insulin resistance indexes in predicting severity for coronary artery disease. Diabetol Metab Syndr. 2022;14(1):191.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Su J, Li Z, Huang M, Wang Y, Yang T, Ma M, Ni T, Pan G, Lai Z, Li C, et al. Triglyceride glucose index for the detection of the severity of coronary artery disease in different glucose metabolic states in patients with coronary heart disease: a RCSCD-TCM study in China. Cardiovasc Diabetol. 2022;21(1):96.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ghosh A, Gao L, Thakur A, Siu PM, Lai CWK. Role of free fatty acids in endothelial dysfunction. J Biomed Sci. 2017;24(1):50.

Article  PubMed  PubMed Central  Google Scholar 

Bai B, Yang Y, Wang Q, Li M, Tian C, Liu Y, Aung LHH, Li PF, Yu T, Chu XM. NLRP3 inflammasome in endothelial dysfunction. Cell Death Dis. 2020;11(9):776.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yaribeygi H, Farrokhi FR, Butler AE, Sahebkar A. Insulin resistance: review of the underlying molecular mechanisms. J Cell Physiol. 2019;234(6):8152–61.

Article  CAS  PubMed  Google Scholar 

Kong P, Cui ZY, Huang XF, Zhang DD, Guo RJ, Han M. Inflammation and atherosclerosis: signaling pathways and therapeutic intervention. Signal Transduct Target Ther. 2022;7(1):131.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Inoguchi T, Li P, Umeda F, Yu HY, Kakimoto M, Imamura M, Aoki T, Etoh T, Hashimoto T, Naruse M, et al. High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C–dependent activation of NAD(P)H oxidase in cultured vascular cells. Diabetes. 2000;49(11):1939–45.

Article  CAS  PubMed  Google Scholar 

Bian K, Doursout MF, Murad F. Vascular system: role of nitric oxide in cardiovascular diseases. J Clin Hypertens (Greenwich). 2008;10(4):304–10.

Article  CAS  PubMed  Google Scholar 

Laakso M, Kuusisto J. Insulin resistance and hyperglycaemia in cardiovascular disease development. Nat Rev Endocrinol. 2014;10(5):293–302.

Article  CAS  PubMed  Google Scholar 

Puschel GP, Klauder J, Henkel J. Macrophages, low-Grade inflammation, Insulin Resistance and hyperinsulinemia: a mutual ambiguous relationship in the development of metabolic diseases. J Clin Med 2022, 11(15).

Libby P. Inflammation during the life cycle of the atherosclerotic plaque. Cardiovasc Res. 2021;117(13):2525–36.

CAS  PubMed  PubMed Central  Google Scholar 

Ridker PM, Everett BM, Thuren T, MacFadyen JG, Chang WH, Ballantyne C, Fonseca F, Nicolau J, Koenig W, Anker SD, et al. Antiinflammatory therapy with Canakinumab for atherosclerotic disease. N Engl J Med. 2017;377(12):1119–31.

Article  CAS  PubMed  Google Scholar 

Tardif JC, Kouz S, Waters DD, Bertrand OF, Diaz R, Maggioni AP, Pinto FJ, Ibrahim R, Gamra H, Kiwan GS, et al. Efficacy and safety of low-dose colchicine after myocardial infarction. N Engl J Med. 2019;381(26):2497–505.

Article  CAS  PubMed  Google Scholar 

Tong DC, Quinn S, Nasis A, Hiew C, Roberts-Thomson P, Adams H, Sriamareswaran R, Htun NM, Wilson W, Stub D, et al. Colchicine in patients with Acute Coronary Syndrome: the Australian COPS randomized clinical trial. Circulation. 2020;142(20):1890–900.

Article  PubMed  Google Scholar 

Ma R, Ties D, van Assen M, Pelgrim GJ, Sidorenkov G, van Ooijen PMA, van der Harst P, van Dijk R, Vliegenthart R. Towards reference values of pericoronary adipose tissue attenuation: impact of coronary artery and tube voltage in coronary computed tomography angiography. Eur Radiol. 2020;30(12):6838–46.

Article  PubMed  PubMed Central  Google Scholar