Xie CD, Lee ZJ, Ye SJ, Barrow CJ, Dunshea FR, Suleria HAR. A review on seaweeds and seaweed-derived polysaccharides: Nutrition, chemistry, bioactivities, and applications. Food Rev Int. 2023. https://doi.org/10.1080/87559129.2023.2212055.

Xie ZY, Jiang NH, Lin MQ, He XLS, Li B, Dong YJ, et al. The mechanisms of polysaccharides from tonic chinese herbal medicine on the enhancement immune function: a review. Molecules. 2023;28:7355. https://doi.org/10.3390/molecules28217355.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu Y, Guo QW, Zhang SM, Bao YL, Chen ML, Gao L, et al. Polysaccharides from discarded stems of Trollius chinensis bunge elicit promising potential in cosmetic industry: characterization, moisture retention and antioxidant activity. Molecules. 2023;28:3114. https://doi.org/10.3390/molecules28073114.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang YN, Zeng TT, Li H, Wang YD, Wang JH, Yuan HB. Structural characterization and hypoglycemic function of polysaccharides from Cordyceps cicadae. Molecules. 2023;28:526. https://doi.org/10.3390/molecules28020526.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang XL, Li N, Li Y, Zhao YN, Zhang L, Sun YJ, et al. A novel polysaccharide from Paeonia lactiflora exerts anti-tumor activity via immunoregulation. Arabian J Chem. 2022;15. https://doi.org/10.1016/j.arabjc.2022.104132.

Yan XL, Miao J, Zhang B, Liu H, Ma HF, Sun YF, et al. Study on semi-bionic extraction of Astragalus polysaccharide and its anti-aging activity in vivo. Front Nutr. 2023;10. https://doi.org/10.3389/fnut.2023.1201919.

Zhang RX, Li MX, Jia ZP. Rehmannia glutinosa: review of botany, chemistry and pharmacology. J Ethnopharmacol. 2008;117:199–214. https://doi.org/10.1016/j.jep.2008.02.018

Article  CAS  PubMed  Google Scholar 

Tang FF, Wang XQ, Lian YJ, Liu HX, Feng TY, Xu WX, et al. Textual research on processing methods and nomenclature of Dihuang (Radix Rehmannia). China J Tradit Chin Med Pharm. 2021;36:1966–8.

Google Scholar 

Wang J, Cheng ME, Zhan ZL, Zhang W, Yang HJ, Peng HS. Variety evolution and herbal textual research on “Dihuang” in Chinese classical prescriptions. Chin J Med Hist. 2020;50:275–82. https://doi.org/10.3760/cma.j.cn112155-20191028-00093.

Article  CAS  Google Scholar 

Guo H, Miao Y, Miao M. Analysis on the application and characteristics of Chinese patent medicines containing dried Rehmanniae Radix. IOP Conf Ser Earth Environ Sci. 2018;111. https://doi.org/10.1088/1755-1315/111/1/012033.

National Pharmacopoeia Committee. Pharmacopoeia of the People’s Republic of China. Beijing: China Medical Science and Technology Press; 2020.

Zhou J, Shi GR, Liu YF, Chen RY, Yu DQ. Five new iridoids from the whole plants of Rehmannia henryi. J Asian Nat Prod Res. 2019;21:727–34. https://doi.org/10.1080/10286020.2019.1621853.

Article  CAS  PubMed  Google Scholar 

Tong S, Chen L, Zhang Q, Liu J, Yan J, Ito Y. Separation of catalpol from Rehmannia glutinosa Libosch. by high-speed countercurrent chromatography. J Chromatogr Sci. 2015;53:725–9. https://doi.org/10.1093/chromsci/bmu114.

Article  CAS  PubMed  Google Scholar 

Thu VK, Dung NT, Seo Y, Namkung W, Kim SH, Kiem PV, et al. Two new iridoid-sesquiterpene conjugates from Rehmannia glutinosa. Phytochem Lett. 2021;43:208–11. https://doi.org/10.1016/j.phytol.2021.04.008.

Article  CAS  Google Scholar 

Wang Y, Kwak M, Lee PC, Jin JO. Rehmannia glutinosa polysaccharide promoted activation of human dendritic cells. Int J Biol Macromol. 2018;116:232–8. https://doi.org/10.1016/j.ijbiomac.2018.04.144.

Article  CAS  PubMed  Google Scholar 

Zhang Z, Meng Y, Guo Y, He X, Liu Q, Wang X, et al. Rehmannia glutinosa polysaccharide induces maturation of murine bone marrow derived Dendritic cells (BMDCs). Int J Biol Macromol. 2013;54:136–43. https://doi.org/10.1016/j.ijbiomac.2012.12.005.

Article  CAS  PubMed  Google Scholar 

Thu VK, Thoa NT, Hien NTT, Hang DTT, Kiem PV. Iridoid glycosides link with phenylpropanoids from Rehmannia glutinosa. Nat Prod Res. 2022;36:5370–5. https://doi.org/10.1080/14786419.2021.1931189.

Article  CAS  PubMed  Google Scholar 

Zhou J, Shi G, Zhang W, Li L, Chen R, Liu Y, et al. Cyclopentanoid monoterpenes from the whole plant of Rehmannia piasezkii maxim. Phytochemistry. 2022;203:113316 https://doi.org/10.1016/j.phytochem.2022.113316.

Article  CAS  PubMed  Google Scholar 

Feng W, Li M, Zheng X, Zhang N, Song K, Wang J, et al. Two new ionone glycosides from the roots of Rehmannia glutinosa Libosch. Nat Prod Res. 2015;29:59–63. https://doi.org/10.1080/14786419.2014.958735.

Article  CAS  PubMed  Google Scholar 

Chen X, Cao Y, Ren Y, Liu Y, Fan X, He C, et al. Ionones and lignans from the fresh roots of Rehmannia glutinosa. Phytochemistry. 2022;203:113423 https://doi.org/10.1016/j.phytochem.2022.113423.

Article  CAS  PubMed  Google Scholar 

Li M, Wang X, Zheng X, Wang J, Zhao W, Song K, et al. A new ionone glycoside and three new rhemaneolignans from the roots of Rehmannia glutinosa. Molecules. 2015;20:15192–201. https://doi.org/10.3390/molecules200815192.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhou J, Shi GR, Liu YF, Chen RY, Yu DQ. Nine new compounds from the whole plants of Rehmannia henryi. J Asian Nat Prod Res. 2019;21:399–408. https://doi.org/10.1080/10286020.2018.1541892.

Article  CAS  PubMed  Google Scholar 

Shi GR, Zhou J, Wang X, Chen RY, Liu YF, Yu DQ. Three new pyridine alkaloids and one new iridoid analogue from the leaves of Rehmannia glutinosa. J Asian Nat Prod Res. 2022;24:945–54. https://doi.org/10.1080/10286020.2022.2102974.

Article  CAS  PubMed  Google Scholar 

Liu YL, Cao YG, Kan YX, Ren YJ, Wang MN, Fan XL, et al. Renoprotective activity of a new amide and a new hydroxycinnamic acid derivative from the fresh roots of Rehmannia glutinosa. J Asian Nat Prod Res. 2022;24:163–9. https://doi.org/10.1080/10286020.2021.1912027.

Article  CAS  PubMed  Google Scholar 

Liu C, Zhou N, Cui T, Li J, Pu D, Wang G, et al. Optimization of purification process of polysaccharides from Rehmannia glutinosa Libosch. with macroporous adsorption resins by response surface methodology. Sci Technol Food Ind. 2021;42:202–7+32. https://doi.org/10.13386/j.issn1002-0306.2020050280.

Article  CAS  Google Scholar 

Liu C, Pu D, Ren J, Li J, Zhang L, Zhao P. Purification and antioxidant activity of polysaccharides from Rehmannia glutinosa libosch. in shaanxi province. Chem Bioeng. 2020;37:15–21.

CAS  Google Scholar 

Liu C, Chen Z, Wang R, Li J, Chen Y, Zhang L, et al. Deproteinization of polysaccharides from Rehmannia glutinosa Libosch. Chem Bioeng. 2020;37:46–50.

Google Scholar 

Lu MK, Chang CC, Chao CH, Hsu YC. Structural changes, and anti-inflammatory, anti-cancer potential of polysaccharides from multiple processing of Rehmannia glutinosa. Int J Biol Macromol. 2022;206:621–32. https://doi.org/10.1016/j.ijbiomac.2022.02.112.

Article  CAS  PubMed  Google Scholar 

Xue S, Wang L, Chen S, Cheng Y. Simultaneous analysis of saccharides between fresh and processed Radix Rehmanniae by HPLC and UHPLC-LTQ-Orbitrap-MS with multivariate statistical analysis. Molecules. 2018;23:541. https://doi.org/10.3390/molecules23030541.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tomoda M, Miyamoto H, Shimizu N, Gonda R, Ohara N. Characterization of two polysaccharides having activity on the reticuloendothelial system from the root of Rehmannia glutinosa. Chem Pharm Bull. 1994;42:625–9. https://doi.org/10.1248/cpb.42.625.

Article  CAS  Google Scholar 

Tomoda M, Miyamoto H, Shimizu N, Gonda R, Ohara N. Two acidic polysaccharides having reticuloendothelial system-potentiating activity from the raw root of Rehmannia glutinosa. Biol Pharm Bull. 1994;17:1456–9. https://doi.org/10.1248/bpb.17.1456.

Article  CAS  PubMed  Google Scholar 

Zhou Y, Wang S, Feng W, Zhang Z, Li H. Structural characterization and immunomodulatory activities of two polysaccharides from Rehmanniae Radix Praeparata. Int J Biol Macromol. 2021;186:385–95. https://doi.org/10.1016/j.ijbiomac.2021.06.100.

Article  CAS  PubMed  Google Scholar 

Zeng M, Xu H, Yu J. Characterization and immunity activity of polysaccharides from the leaves of Rehmannia glutinosa Libosch. Res Pract Chin Med. 2017;31:27–30. https://doi.org/10.13728/j.1673-6427.2017.02.007.

Article  Google Scholar 

Zhang H, Yue Y, Zhang Q, Liang L, Li C, Chen Y, et al. Structural characterization and anti-inflammatory effects of an arabinan isolated from Rehmannia glutinosa Libosch. Carbohydr Polym. 2023;303:120441 https://doi.org/10.1016/j.carbpol.2022.120441.

Article  CAS  PubMed  Google Scholar 

Song L, Xue S, Wang L, Zhang F, Chen S. Analysis of chemical constituents from Rehmannia glutinosa with different storage years. Chin Tradit Patent Med. 2020;42:2661–9.

Google Scholar 

Liu W, Yin DX, Zhang T, Qiao Q, Yang YQ, Wang WL. Phytochemical profiles and antioxidant activity of Rehmannia glutinosa from different production locations. Chem Biodivers. 2020;17:e2000341 https://doi.org/10.1002/cbdv.202000341.

Article  CAS  PubMed  Google Scholar 

Zhang W, He J, Guo Z, Shi S. Ingredients changes in Rehmanniae Radix processing based by HPLC-ELSD specific chromatogram. China J Chin Mater Med. 2020;45:3877–82. https://doi.org/10.19540/j.cnki.cjcmm.20200523.303.

Article  CAS  Google Scholar 

Zhao P, Liu X. Extraction and purifction of Rehmannia glutinosa polysaccharide and its effect on blood glucose in diabetic mice. Strait Pharm J. 2010;22:29–32.

Google Scholar 

Ren H, Li Z, Gao R, Zhao T, Luo D, Yu Z, et al. Structural characteristics of Rehmannia glutinosa polysaccharides treated using different decolorization processes and their antioxidant effects in intestinal epithelial cells. Foods. 2022;11:3449. https://doi.org/10.3390/foods11213449.