Feigin VL, Roth GA, Naghavi M, Parmar P, Krishnamurthi R, Chugh S, Mensah GA, Norrving B, Shiue I, Ng M. Global burden of Stroke and risk factors in 188 countries, during 1990–2013: a systematic analysis for the global burden of Disease Study 2013. Lancet Neurol. 2016;15:913–24.

Article  PubMed  Google Scholar 

Feigin VL, Forouzanfar MH, Krishnamurthi R, Mensah GA, Connor M, Bennett DA, Moran AE, Sacco RL, Anderson L, Truelsen T. Global and regional burden of Stroke during 1990–2010: findings from the global burden of Disease Study 2010. The Lancet. 2014;383:245–55.

Article  Google Scholar 

Straus SE, Majumdar SR, McAlister FA. New evidence for Stroke prevention: scientific review. JAMA. 2002;288:1388–95.

Article  PubMed  Google Scholar 

Di Carlo A. Human and economic burden of Stroke. Age Ageing. 2009;38:4–5.

Article  PubMed  Google Scholar 

Feigin VL, Lawes CM, Bennett DA, Barker-Collo SL, Parag V. Worldwide Stroke incidence and early case fatality reported in 56 population-based studies: a systematic review. Lancet Neurol. 2009;8:355–69.

Article  PubMed  Google Scholar 

MAZDEH M, SEYF RM. Study of the relative frequency of mortality and morbidity in stroke with hypertension, and normal blood pressure. 2008.

Warner DS, Sheng H, Batinić-Haberle I. Oxidants, antioxidants and the ischemic brain. J Exp Biol. 2004;207:3221–31.

Article  CAS  PubMed  Google Scholar 

Lakhan SE, Kirchgessner A, Hofer M. Inflammatory mechanisms in ischemic Stroke: therapeutic approaches. J Translational Med. 2009;7:1–11.

Article  Google Scholar 

Alavian F. Hypothermia and Stroke: pros and cons. Shefaye Khatam. 2019;7:83–98.

Article  Google Scholar 

Pan JH, Song XY, Lee SY, Kwok T. Longitudinal analysis of quality of life for Stroke survivors using latent curve models. Stroke. 2008;39:2795–802.

Article  PubMed  Google Scholar 

Sainsbury A, Heatley R. Psychosocial factors in the quality of life of patients with inflammatory bowel Disease. Aliment Pharmacol Ther. 2005;21:499–508.

Article  CAS  PubMed  Google Scholar 

Wu X, Min L, Cong L, Jia Y, Liu C, Zhao H, Liu P, Luo Y. Sex differences in health-related quality of life among adult Stroke patients in Northeastern China. J Clin Neurosci. 2014;21:957–61.

Article  PubMed  Google Scholar 

Carod-Artal FJ, Egido JA. Quality of life after Stroke: the importance of a good recovery. Cerebrovasc Dis. 2009;27:204–14.

Article  PubMed  Google Scholar 

Calixto JB. Twenty-five years of research on medicinal plants in Latin America: a personal view. J Ethnopharmacol. 2005;100:131–4.

Article  PubMed  Google Scholar 

Aggarwal BB, Surh Y-J, Shishodia S. The molecular targets and therapeutic uses of curcumin in health and Disease. Springer Science & Business Media; 2007.

Chattopadhyay I, Biswas K, Bandyopadhyay U, Banerjee RK. Turmeric and curcumin: Biological actions and medicinal applications. Curr Sci 2004:44–53.

Liu Z, Ran Y, Huang S, Wen S, Zhang W, Liu X, Ji Z, Geng X, Ji X, Du H. Curcumin protects against ischemic Stroke by titrating microglia/macrophage polarization. Front Aging Neurosci. 2017;9:233.

Article  PubMed  PubMed Central  Google Scholar 

Eke-Okoro U, Raffa R, Pergolizzi J Jr, Breve F, Taylor R Jr, Group NR. Curcumin in turmeric: Basic and clinical evidence for a potential role in analgesia. J Clin Pharm Ther. 2018;43:460–6.

Article  CAS  PubMed  Google Scholar 

Mohseni M, Sahebkar A, Askari G, Johnston TP, Alikiaii B, Bagherniya M. The clinical use of curcumin on neurological disorders: an updated systematic review of clinical trials. Phytother Res. 2021;35:6862–82.

Article  CAS  PubMed  Google Scholar 

Ovbiagele B. Potential role of curcumin in Stroke prevention. Expert Rev Neurother. 2008;8:1175–6.

Article  PubMed  Google Scholar 

Bavarsad K, Barreto GE, Hadjzadeh MAR, Sahebkar A. Protective effects of Curcumin Against Ischemia-Reperfusion Injury in the nervous system. Mol Neurobiol. 2019;56:1391–404.

Article  CAS  PubMed  Google Scholar 

Sharifi ZN, Movassaghi S, Mohamadzadeh F, Asl SS, Pourheydar B, Mehdizadeh M. Reduction in ischemic brain injury following the administration of pentoxifylline after transient global ischemia/reperfusion in a rat model. Med J Islamic Repub Iran. 2015;29:193.

Google Scholar 

Xie C-J, Gu A-P, Cai J, Wu Y, Chen R-C. Curcumin protects neural cells against ischemic injury in N2a cells and mouse brain with ischemic Stroke. Brain and Behavior. 2018;8:e00921.

Article  PubMed  PubMed Central  Google Scholar 

Attari F, Nadia Sharifi Z, Movassaghi S, Aligholi H, Alizamir T, Hassanzadeh G. Neuroprotective effects of Curcumin against Transient Global Ischemia are dose and area dependent. Arch Neurosci. 2016;3:e32600.

Article  Google Scholar 

Alloubani A, Nimer R, Samara R. Relationship between Hyperlipidemia, Cardiovascular Disease and Stroke: a systematic review. Curr Cardiol Rev. 2021;17:e051121189015.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Buonacera A, Stancanelli B, Malatino L. Stroke and Hypertension: an Appraisal from Pathophysiology to Clinical Practice. Curr Vasc Pharmacol. 2019;17:72–84.

Article  CAS  PubMed  Google Scholar 

Przykaza Ł. Understanding the connection between common Stroke comorbidities, their Associated inflammation, and the course of the cerebral Ischemia/Reperfusion Cascade. Front Immunol. 2021;12:782569.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang Y, Xing Z, Zhou K, Jiang S. The predictive role of systemic inflammation response index (SIRI) in the prognosis of Stroke patients. Clin Interv Aging. 2021;16:1997–2007.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Su X, Li K, Yang L, Yang Y, Gao Y, Gao Y, Guo J, Lin J, Chen K, Han J, Liu L. Associations between abdominal obesity and the risk of Stroke in Chinese older patients with obstructive sleep apnea: is there an obesity paradox? Front Aging Neurosci. 2022;14:957396.

Article  PubMed  PubMed Central  Google Scholar 

Winter Y, Pieper L, Klotsche J, Riedel O, Wittchen HU. Obesity and abdominal fat markers in patients with a history of Stroke and transient ischemic Attacks. J Stroke Cerebrovasc Dis. 2016;25:1141–7.

Article  PubMed  Google Scholar 

Baziar N, Parohan M. The effects of curcumin supplementation on body mass index, body weight, and waist circumference in patients with nonalcoholic fatty Liver Disease: a systematic review and dose-response meta-analysis of randomized controlled trials. Phytother Res. 2020;34:464–74.

Article  CAS  PubMed  Google Scholar 

Hadi A, Pourmasoumi M, Ghaedi E, Sahebkar A. The effect of Curcumin/Turmeric on blood pressure modulation: a systematic review and meta-analysis. Pharmacol Res. 2019;150:104505.

Article  CAS  PubMed  Google Scholar 

Rafiee S, Bagherniya M, Askari G, Sathyapalan T, Jamialahmadi T, Sahebkar A. The Effect of Curcumin in improving lipid Profile in patients with Cardiovascular Risk factors: a systematic review of clinical trials. Adv Exp Med Biol. 2021;1291:165–77.

Article  CAS  PubMed  Google Scholar 

Safari Z, Bagherniya M, Askari G, Sathyapalan T, Sahebkar A. The Effect of Curcumin Supplemsentation on Anthropometric indices in overweight and obese individuals: a systematic review of Randomized controlled trials. Adv Exp Med Biol. 2021;1291:121–37.

Article  CAS  PubMed  Google Scholar 

Tabrizi R, Vakili S, Akbari M, Mirhosseini N, Lankarani KB, Rahimi M, Mobini M, Jafarnejad S, Vahedpoor Z, Asemi Z. The effects of curcumin-containing supplements on biomarkers of inflammation and oxidative stress: a systematic review and meta-analysis of randomized controlled trials. Phytother Res. 2019;33:253–62.

Article  CAS  PubMed  Google Scholar 

Qin S, Huang L, Gong J, Shen S, Huang J, Tang Y, Ren H, Hu H. Meta-analysis of randomized controlled trials of 4 weeks or longer suggest that curcumin may afford some protection against oxidative stress. Nutr Res. 2018;60:1–12.

Article  CAS  PubMed  Google Scholar 

Itokawa H, Shi Q, Akiyama T, Morris-Natschke SL, Lee K-H. Recent advances in the investigation of curcuminoids. Chin Med. 2008;3:1–13.

Article  Google Scholar 

Modaresi M, HarfBol M, Ahmadi F. A review on pharmacological effects and therapeutic properties of curcumin. J Med Plants. 2017;16:1–17.

Google Scholar 

Pulido-Moran M, Moreno-Fernandez J, Ramirez-Tortosa C, Ramirez-Tortosa M. Curcumin and health. Molecules. 2016;21:264.

Article  PubMed  PubMed Central  Google Scholar 

Trujillo J, Molina-Jijón E, Medina-Campos ON, Rodríguez-Muñoz R, Reyes JL, Loredo ML, Barrera-Oviedo D, Pinzón E, Rodríguez-Rangel DS, Pedraza-Chaverri J. Curcumin prevents cisplatin-induced decrease in the tight and adherens junctions: relation to oxidative stress. Food Funct. 2016;7:279–93.

Article  CAS  PubMed  Google Scholar 

Babu PS, Srinivasan K. Hypolipidemic action of curcumin, the active principle of turmeric (Curcuma longa) in streptozotocin induced diabetic rats. Mol Cell Biochem. 1997;166:169–75.

Article  CAS  PubMed  Google Scholar 

Chao J, Li H, Cheng K-W, Yu M-S, Chang RC-C, Wang M. Protective effects