The role of N-methyladenosine modification in acute and chronic kidney diseases

Anders HJ, Saxena R, Zhao MH, Parodis I, Salmon JE, Mohan C. Lupus nephritis. Nat Rev Dis Primers. 2020;6(1):7. https://doi.org/10.1038/s41572-019-0141-9.

Article  PubMed  Google Scholar 

Bagshaw SM, Laupland KB, Doig CJ, Mortis G, Fick GH, Mucenski M, et al. Prognosis for long-term survival and renal recovery in critically ill patients with severe acute renal failure: a population-based study. Crit Care. 2005;9(6):R700–9. https://doi.org/10.1186/cc3879.

Article  PubMed  PubMed Central  Google Scholar 

Bonventre JV, Yang L. Cellular pathophysiology of ischemic acute kidney injury. J Clin Invest. 2011;121(11):4210–21. https://doi.org/10.1172/JCI45161.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bonventre JV, Vaidya VS, Schmouder R, Feig P, Dieterle F. Next-generation biomarkers for detecting kidney toxicity. Nat Biotechnol. 2010;28(5):436–40. https://doi.org/10.1038/nbt0510-436.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen J, Ning Y, Zhang H, Song N, Gu Y, Shi Y, et al. METTL14-dependent m6A regulates vascular calcification induced by indoxyl sulfate. Life Sci. 2019a;239: 117034. https://doi.org/10.1016/j.lfs.2019.117034.

Article  CAS  PubMed  Google Scholar 

Chen XY, Zhang J, Zhu JS. The role of m(6)A RNA methylation in human cancer. Mol Cancer. 2019b;18(1):103. https://doi.org/10.1186/s12943-019-1033-z.

Article  PubMed  PubMed Central  Google Scholar 

Chen J, Xu C, Yang K, Gao R, Cao Y, Liang L, et al. Inhibition of ALKBH5 attenuates I/R-induced renal injury in male mice by promoting Ccl28 m6A modification and increasing Treg recruitment. Nat Commun. 2023;14(1):1161. https://doi.org/10.1038/s41467-023-36747-y.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Choudhury D, Tuncel M, Levi M. Diabetic nephropathy—a multifaceted target of new therapies. Discov Med. 2010;10(54):406–15.

PubMed  Google Scholar 

Cui YH, Yang S, Wei J, Shea CR, Zhong W, Wang F, et al. Autophagy of the m6A mRNA demethylase FTO is impaired by low-level arsenic exposure to promote tumorigenesis. Nat Commun. 2021;12(1):2183. https://doi.org/10.1038/s41467-021-22469-6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Desrosiers R, Friderici K, Rottman F. Identification of methylated nucleosides in messenger RNA from Novikoff hepatoma cells. Proc Natl Acad Sci U S A. 1974;71(10):3971–5. https://doi.org/10.1073/pnas.71.10.3971.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dominissini D, Moshitch-Moshkovitz S, Schwartz S, Salmon-Divon M, Ungar L, Osenberg S, et al. Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq. Nature. 2012;485(7397):201–6. https://doi.org/10.1038/nature11112.

Article  CAS  PubMed  Google Scholar 

Feng C, Wang Z, Liu C, Liu S, Wang Y, Zeng Y, et al. Integrated bioinformatical analysis, machine learning and in vitro experiment-identified m6A subtype, and predictive drug target signatures for diagnosing renal fibrosis. Front Pharmacol. 2022;13: 909784. https://doi.org/10.3389/fphar.2022.909784.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gu HF. Genetic and epigenetic studies in diabetic kidney disease. Front Genet. 2019;10:507. https://doi.org/10.3389/fgene.2019.00507.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hammad FT. The long-term renal effects of short periods of unilateral ureteral obstruction. Int J Physiol Pathophysiol Pharmacol. 2022;14(2):60–72.

PubMed  PubMed Central  Google Scholar 

Han D, Liu J, Chen C, Dong L, Liu Y, Chang R, et al. Anti-tumour immunity controlled through mRNA m6A methylation and YTHDF1 in dendritic cells. Nature. 2019;566(7743):270–4. https://doi.org/10.1038/s41586-019-0916-x.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hu J, Lieb JD, Sancar A, Adar S. Cisplatin DNA damage and repair maps of the human genome at single-nucleotide resolution. Proc Natl Acad Sci U S A. 2016;113(41):11507–12. https://doi.org/10.1073/pnas.1614430113.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hu J, Qiu D, Yu A, Hu J, Deng H, Li H, et al. YTHDF1 is a potential pan-cancer biomarker for prognosis and immunotherapy. Front Oncol. 2021;11: 607224. https://doi.org/10.3389/fonc.2021.607224.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hu J, Wang Q, Fan X, Zhen J, Wang C, Chen H, et al. Long noncoding RNA ENST00000436340 promotes podocyte injury in diabetic kidney disease by facilitating the association of PTBP1 with RAB3B. Cell Death Dis. 2023;14(2):130. https://doi.org/10.1038/s41419-023-05658-7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jiang L, Li X, Wang S, Yuan Z, Cheng J. The role and regulatory mechanism of m6A methylation in the nervous system. Front Genet. 2022a;13: 962774. https://doi.org/10.3389/fgene.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jiang L, Liu X, Hu X, Gao L, Zeng H, Wang X, et al. METTL3-mediated m6A modification of TIMP2 mRNA promotes podocyte injury in diabetic nephropathy. Mol Ther. 2022b;30(4):1721–40. https://doi.org/10.1016/j.ymthe.2022.01.002.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kaur R, Singh R. Mechanistic insights into CKD-MBD-related vascular calcification and its clinical implications. Life Sci. 2022;311(Pt B): 121148. https://doi.org/10.1016/j.lfs.2022.121148.

Article  CAS  PubMed  Google Scholar 

Kopp JB, Anders HJ, Susztak K, Podestà MA, Remuzzi G, Hildebrandt F, et al. Podocytopathies. Nat Rev Dis Primers. 2020;6(1):68. https://doi.org/10.1038/s41572-020-0196-7.

Article  PubMed  PubMed Central  Google Scholar 

Kumari R, Ranjan P, Suleiman ZG, Goswami SK, Li J, Prasad R, et al. mRNA modifications in cardiovascular biology and disease: with a focus on m6A modification. Cardiovasc Res. 2022;118(7):1680–92. https://doi.org/10.1093/cvr/cvab160.

Article  CAS  PubMed  Google Scholar 

Kurbegovic A, Trudel M. The master regulators Myc and p53 cellular signaling and functions in polycystic kidney disease. Cell Signal. 2020;71: 109594. https://doi.org/10.1016/j.cellsig.2020.109594.

Article  CAS  PubMed  Google Scholar 

Li X, Fan X, Yin X, Liu H, Yang Y. Alteration of N6-methyladenosine epitranscriptome profile in unilateral ureteral obstructive nephropathy. Epigenomics. 2020;12(14):1157–73. https://doi.org/10.2217/epi-2020-0126.

Article  CAS  PubMed  Google Scholar 

Li C, Jiang Z, Hao J, Liu D, Hu H, Gao Y, et al. Role of N6-methyl-adenosine modification in mammalian embryonic development. Genet Mol Biol. 2021a;44(2): e20200253. https://doi.org/10.1590/1678-4685-GMB-2020-0253.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li CM, Li M, Zhao WB, Ye ZC, Peng H. Alteration of N6-methyladenosine RNA profiles in cisplatin-induced acute kidney injury in mice. Front Mol Biosci. 2021b;8: 654465. https://doi.org/10.3389/fmolb.2021.654465.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li M, Deng L, Xu G. METTL14 promotes glomerular endothelial cell injury and diabetic nephropathy via m6A modification of α-klotho. Mol Med. 2021c;27(1):106. https://doi.org/10.1186/s10020-021-00365-5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li N, Tang H, Wu L, Ge H, Wang Y, Yu H, et al. Chemical constituents, clinical efficacy and molecular mechanisms of the ethanol extract of Abelmoschus manihot flowers in treatment of kidney diseases. Phytother Res. 2021d;35(1):198–206. https://doi.org/10.1002/ptr.6818.

Article  CAS  PubMed  Google Scholar 

Li X, Jiang Y, Sun X, Wu Y, Chen Z. METTL3 is required for maintaining β-cell function. Metabolism. 2021e;116: 154702. https://doi.org/10.1016/j.metabol.2021.154702.

Article  CAS  PubMed  Google Scholar 

Li X, Li Y, Wang Y, He X. The m6A demethylase FTO promotes renal epithelial-mesenchymal transition by reducing the m6A modification of lncRNA GAS5. Cytokine. 2022;159: 156000. https://doi.org/10.1016/j.cyto.2022.156000.

Article  CAS  PubMed  Google Scholar 

Liu J, Yue Y, Han D, Wang X, Fu Y, Zhang L, et al. A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation. Nat Chem Biol. 2014;10(2):93–5. https://doi.org/10.1038/nchembio.1432.

Article  CAS  PubMed  Google Scholar 

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