Long non-coding RNA KCNQ10T1/miR-19a-3p/SMAD5 axis promotes osteogenic differentiation of mouse bone mesenchymal stem cells

Camal RI, Cicero AM, Issa J, Feldman S. Bone fracture healing: perspectives according to molecular basis. J Bone Miner Metab. 2021;39(3):311–31.

Article  Google Scholar 

Liu Y, Jia Z, Akhter MP, Gao X, Wang X, Wang X, et al. Bone-targeting liposome formulation of Salvianic acid A accelerates the healing of delayed fracture Union in Mice. Nanomed Nanotechnol Biol Med. 2018;14(7):2271–82.

Article  CAS  Google Scholar 

Nicholson JA, Makaram N, Simpson A, Keating JF. Fracture nonunion in long bones: a literature review of risk factors and surgical management. Injury. 2021;52:S3-11.

Article  PubMed  Google Scholar 

Jo H, Brito S, Kwak BM, Park S, Lee M, Bin B. Applications of mesenchymal stem cells in skin regeneration and rejuvenation. Int J Mol Sci. 2021;22(5):2410.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Almalki SG, Agrawal DK. Key transcription factors in the differentiation of mesenchymal stem cells. Differentiation. 2016;92(1):41–51.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pajarinen J, Lin T, Gibon E, Kohno Y, Maruyama M, Nathan K, et al. Mesenchymal stem cell-macrophage crosstalk and bone healing. Biomaterials. 2019;196:80–9.

Article  CAS  PubMed  Google Scholar 

Wang Y, Yao J, Cai L, Liu T, Wang X, Zhang Y, et al. Bone-targeted extracellular vesicles from mesenchymal stem cells for osteoporosis therapy. Int J Nanomed. 2020;15:7967–77.

Article  CAS  Google Scholar 

Du GQ, Gong ZH, Liang B, Li P, Yang SY, Jia L, et al. Concentration changes of peripheral blood mesenchymal stem cells of Sprague Dawley rats during distraction osteogenesis. Orthop Surg. 2021;13(2):623–31.

Article  PubMed  PubMed Central  Google Scholar 

Zhang D, Wu Y, Li Z, Chen H, Huang S, Jian C, et al. MiR-144-5p, an exosomal miRNA from bone marrow-derived macrophage in type 2 diabetes, impairs bone fracture healing via targeting Smad1. J Nanobiotechnol. 2021;19(1):226.

Article  CAS  Google Scholar 

Ransohoff JD, Wei Y, Khavari PA. The functions and unique features of long intergenic non-coding RNA. Nat Rev Mol Cell Biol. 2018;19(3):143–57.

Article  CAS  PubMed  Google Scholar 

Fu Y, Hu X, Gao Y, Li K, Fu Q, Liu Q, et al. LncRNA ROR/miR-145-5p axis modulates the osteoblasts proliferation and apoptosis in osteoporosis. Bioengineered. 2021;12(1):7714–23.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang Y, Li T, Yang Q, Feng B, Xiang Y, Lv Z, et al. LncRNA THUMPD3-AS1 enhances the proliferation and inflammatory response of chondrocytes in osteoarthritis. Int Immunopharmacol. 2021;100:108138.

Article  CAS  PubMed  Google Scholar 

Shi C, Zheng W, Wang J. lncRNA-CRNDE regulates BMSC chondrogenic differentiation and promotes cartilage repair in osteoarthritis through SIRT1/SOX9. Mol Cell Biochem. 2021;476(4):1881–90.

Article  CAS  PubMed  Google Scholar 

Xia F, Wang Y, Xue M, Zhu L, Jia D, Shi Y, et al. LncRNA KCNQ1OT1: molecular mechanisms and pathogenic roles in human diseases. Genes Dis. 2022;9(6):1556–65.

Article  CAS  PubMed  Google Scholar 

Li Y, Li C, Li D, Yang L, Jin J, Zhang B. lncRNA KCNQ1OT1 enhances the chemoresistance of oxaliplatin in colon cancer by targeting the miR-34a/ATG4B pathway. Oncotargets Ther. 2019;12:2649–60.

Article  CAS  Google Scholar 

Zheng L, Zhang F, Wang L, Hu H, Lian Y. LncRNA KCNQ1OT1 is overexpressed in non-small cell lung cancer and its expression level is related to clinicopathology. Eur Rev Med Pharmacol. 2019;23(16):6944.

CAS  Google Scholar 

Yu S, Yu M, He X, Wen L, Bu Z, Feng J. KCNQ1OT1 promotes autophagy by regulating miR-200a/FOXO3/ATG7 pathway in cerebral ischemic stroke. Aging Cell. 2019;18(3):e12940.

Article  PubMed  PubMed Central  Google Scholar 

Gao X, Ge J, Li W, Zhou W, Xu L. LncRNA KCNQ1OT1 promotes osteogenic differentiation to relieve osteolysis via Wnt/β-catenin activation. Cell Biosci. 2018;8(1):19.

Article  PubMed  PubMed Central  Google Scholar 

Wang C, Liao Z, Xiao H, Liu H, Hu Y, Liao Q, et al. LncRNA KCNQ1OT1 promoted BMP2 expression to regulate osteogenic differentiation by sponging miRNA-214. Exp Mol Pathol. 2019;107:77–84.

Article  CAS  PubMed  Google Scholar 

Yu Y, Chen Y, Zhang X, Lu X, Hong J, Guo X, et al. Knockdown of lncRNA KCNQ1OT1 suppresses the adipogenic and osteogenic differentiation of tendon stem cell via downregulating miR-138 target genes PPARγ and RUNX2. Cell cycle (Georgetown, Tex). 2018;17(19–20):2374–85.

Article  CAS  PubMed  Google Scholar 

Giordano L, Porta GD, Peretti GM, Maffulli N. Therapeutic potential of microRNA in tendon injuries. Brit Med Bull. 2020;133(1):79–94.

Article  CAS  PubMed  Google Scholar 

Oliviero APGG. MicroRNA in osteoarthritis: physiopathology, diagnosis and therapeutic challenge. Brit Med Bull. 2019;130:137–47.

Article  CAS  PubMed  Google Scholar 

Gargano G, Oliviero A, Oliva F, Maffulli N. Small interfering RNAs in tendon homeostasis. Brit Med Bull. 2021;138(1):58–67.

Article  CAS  PubMed  Google Scholar 

Gargano G, Oliva F, Oliviero A, Maffulli N. Small interfering RNAs in the management of human rheumatoid arthritis. Brit Med Bull. 2022;142(1):34–43.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gargano G, Asparago G, Spiezia F, Oliva F, Maffulli N. Small interfering RNAs in the management of human osteoporosis. Br Med Bull. 2023:ldad023. https://doi.org/10.1093/bmb/ldad023.

Guo Q, Chen Y, Guo L, Jiang T, Lin Z. miR-23a/b regulates the balance between osteoblast and adipocyte differentiation in bone marrow mesenchymal stem cells. Bone Res. 2016;4(2):110–8.

Google Scholar 

Chen H, Li X, Liu S, Gu L, Zhou X. MircroRNA-19a promotes vascular inflammation and foam cell formation by targeting HBP-1 in atherogenesis. Sci Rep-UK. 2017;7(1):12010–89.

Google Scholar 

Wang N, Li R, Xue M. Potential regulatory network in the PSG10P/miR-19a-3p/IL1RAP pathway is possibly involved in preeclampsia pathogenesis. J Cell Mol Med. 2019;23(2):852–64.

Article  CAS  PubMed  Google Scholar 

Qiao F, Gong P, Song Y, Shen X, Su X, Li Y, et al. Downregulated PITX1 modulated by MiR-19a-3p promotes cell malignancy and predicts a poor prognosis of gastric cancer by affecting transcriptionally activated PDCD5. Cell Physiol Biochem. 2018;46(6):2215–31.

Article  CAS  PubMed  Google Scholar 

Zhang B, Liu Y, Zhang J. Silencing of miR-19a-3p enhances osteosarcoma cells chemosensitivity by elevating the expression of tumor suppressor PTEN. Oncol Lett. 2019;17(1):414–21.

CAS  PubMed  Google Scholar 

Wang Z, Shi Z, Zhang L, Zhang H, Zhang Y. Profilin 1, negatively regulated by microRNA-19a-3p, serves as a tumor suppressor in human hepatocellular carcinoma. Pathol Res Pract. 2019;215(3):499–505.

Article  CAS  PubMed  Google Scholar 

Gu Y, Liu S, Zhang X, Chen G, Liang H, Yu M, et al. Oncogenic miR-19a and miR-19b co-regulate tumor suppressor MTUS1 to promote cell proliferation and migration in lung cancer. Protein Cell. 2017;8(6):455–66.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ye Y, Ke Y, Liu L, Xiao T, Yu J, Christian M, et al. CircRNA FAT1 Regulates osteoblastic differentiation of periodontal ligament stem cells via miR-4781-3p/SMAD5 pathway. Stem Cells Int. 2021;2021:5177416–88.

Article  Google Scholar 

Zhang X, Li H, Chen F, Chen Y, Chai Y, Liao J, et al. Icariin regulates miR-23a-3p-mediated osteogenic differentiation of BMSCs via BMP-2/Smad5/Runx2 and WNT/β-catenin pathways in osteonecrosis of the femoral head. Saudi Pharm J. 2021;29(12):1405–15.

Article  PubMed  PubMed Central  Google Scholar 

Wu Y, Lu X, Shen B, Zeng Y. The therapeutic potential and role of miRNA, lncRNA, and circRNA in osteoarthritis. Curr Gene Ther. 2019;19(4):255–63.

Article  CAS  PubMed  Google Scholar 

Zhang H, Xu R, Li B, Xin Z, Ling Z, Zhu W, et al. LncRNA NEAT1 controls the lineage fates of BMSCs during skeletal aging by impairing mitochondrial function and pluripotency maintenance. Cell Death Differ. 2022;29(2):351–65.

Article  CAS  PubMed  Google Scholar 

Yin J, Zheng Z, Zeng X, Zhao Y, Ai Z, Yu M, et al. lncRNA MALAT1 mediates osteogenic differentiation of bone mesenchymal stem cells by sponging miR-129-5p. PeerJ. 2022;10:e13355.

Article  PubMed  PubMed Central  Google Scholar 

Yu X, Song MS, Rong PZ, Chen XJ, Shi L, Wang CH, et al. LncRNA SNHG1 modulates adipogenic differentiation of BMSCs by promoting DNMT1 mediated Opg hypermethylation via interacting with PTBP1. J Cell Mol Med. 2022;26(1):60–74.

Article  CAS  PubMed  Google Scholar 

Shen Y, Xu J, Pan X, Zhang Y, Weng Y, Zhou D, et al. LncRNA KCNQ1OT1 sponges miR-34c-5p to promote osteosarcoma growth via ALDOA enhanced aerobic glycolysis. Cell Death Dis. 2020;11(4):278.

Comments (0)

No login
gif