Camal RI, Cicero AM, Issa J, Feldman S. Bone fracture healing: perspectives according to molecular basis. J Bone Miner Metab. 2021;39(3):311–31.
Liu Y, Jia Z, Akhter MP, Gao X, Wang X, Wang X, et al. Bone-targeting liposome formulation of Salvianic acid A accelerates the healing of delayed fracture Union in Mice. Nanomed Nanotechnol Biol Med. 2018;14(7):2271–82.
Nicholson JA, Makaram N, Simpson A, Keating JF. Fracture nonunion in long bones: a literature review of risk factors and surgical management. Injury. 2021;52:S3-11.
Jo H, Brito S, Kwak BM, Park S, Lee M, Bin B. Applications of mesenchymal stem cells in skin regeneration and rejuvenation. Int J Mol Sci. 2021;22(5):2410.
Article CAS PubMed PubMed Central Google Scholar
Almalki SG, Agrawal DK. Key transcription factors in the differentiation of mesenchymal stem cells. Differentiation. 2016;92(1):41–51.
Article CAS PubMed PubMed Central Google Scholar
Pajarinen J, Lin T, Gibon E, Kohno Y, Maruyama M, Nathan K, et al. Mesenchymal stem cell-macrophage crosstalk and bone healing. Biomaterials. 2019;196:80–9.
Article CAS PubMed Google Scholar
Wang Y, Yao J, Cai L, Liu T, Wang X, Zhang Y, et al. Bone-targeted extracellular vesicles from mesenchymal stem cells for osteoporosis therapy. Int J Nanomed. 2020;15:7967–77.
Du GQ, Gong ZH, Liang B, Li P, Yang SY, Jia L, et al. Concentration changes of peripheral blood mesenchymal stem cells of Sprague Dawley rats during distraction osteogenesis. Orthop Surg. 2021;13(2):623–31.
Article PubMed PubMed Central Google Scholar
Zhang D, Wu Y, Li Z, Chen H, Huang S, Jian C, et al. MiR-144-5p, an exosomal miRNA from bone marrow-derived macrophage in type 2 diabetes, impairs bone fracture healing via targeting Smad1. J Nanobiotechnol. 2021;19(1):226.
Ransohoff JD, Wei Y, Khavari PA. The functions and unique features of long intergenic non-coding RNA. Nat Rev Mol Cell Biol. 2018;19(3):143–57.
Article CAS PubMed Google Scholar
Fu Y, Hu X, Gao Y, Li K, Fu Q, Liu Q, et al. LncRNA ROR/miR-145-5p axis modulates the osteoblasts proliferation and apoptosis in osteoporosis. Bioengineered. 2021;12(1):7714–23.
Article CAS PubMed PubMed Central Google Scholar
Wang Y, Li T, Yang Q, Feng B, Xiang Y, Lv Z, et al. LncRNA THUMPD3-AS1 enhances the proliferation and inflammatory response of chondrocytes in osteoarthritis. Int Immunopharmacol. 2021;100:108138.
Article CAS PubMed Google Scholar
Shi C, Zheng W, Wang J. lncRNA-CRNDE regulates BMSC chondrogenic differentiation and promotes cartilage repair in osteoarthritis through SIRT1/SOX9. Mol Cell Biochem. 2021;476(4):1881–90.
Article CAS PubMed Google Scholar
Xia F, Wang Y, Xue M, Zhu L, Jia D, Shi Y, et al. LncRNA KCNQ1OT1: molecular mechanisms and pathogenic roles in human diseases. Genes Dis. 2022;9(6):1556–65.
Article CAS PubMed Google Scholar
Li Y, Li C, Li D, Yang L, Jin J, Zhang B. lncRNA KCNQ1OT1 enhances the chemoresistance of oxaliplatin in colon cancer by targeting the miR-34a/ATG4B pathway. Oncotargets Ther. 2019;12:2649–60.
Zheng L, Zhang F, Wang L, Hu H, Lian Y. LncRNA KCNQ1OT1 is overexpressed in non-small cell lung cancer and its expression level is related to clinicopathology. Eur Rev Med Pharmacol. 2019;23(16):6944.
Yu S, Yu M, He X, Wen L, Bu Z, Feng J. KCNQ1OT1 promotes autophagy by regulating miR-200a/FOXO3/ATG7 pathway in cerebral ischemic stroke. Aging Cell. 2019;18(3):e12940.
Article PubMed PubMed Central Google Scholar
Gao X, Ge J, Li W, Zhou W, Xu L. LncRNA KCNQ1OT1 promotes osteogenic differentiation to relieve osteolysis via Wnt/β-catenin activation. Cell Biosci. 2018;8(1):19.
Article PubMed PubMed Central Google Scholar
Wang C, Liao Z, Xiao H, Liu H, Hu Y, Liao Q, et al. LncRNA KCNQ1OT1 promoted BMP2 expression to regulate osteogenic differentiation by sponging miRNA-214. Exp Mol Pathol. 2019;107:77–84.
Article CAS PubMed Google Scholar
Yu Y, Chen Y, Zhang X, Lu X, Hong J, Guo X, et al. Knockdown of lncRNA KCNQ1OT1 suppresses the adipogenic and osteogenic differentiation of tendon stem cell via downregulating miR-138 target genes PPARγ and RUNX2. Cell cycle (Georgetown, Tex). 2018;17(19–20):2374–85.
Article CAS PubMed Google Scholar
Giordano L, Porta GD, Peretti GM, Maffulli N. Therapeutic potential of microRNA in tendon injuries. Brit Med Bull. 2020;133(1):79–94.
Article CAS PubMed Google Scholar
Oliviero APGG. MicroRNA in osteoarthritis: physiopathology, diagnosis and therapeutic challenge. Brit Med Bull. 2019;130:137–47.
Article CAS PubMed Google Scholar
Gargano G, Oliviero A, Oliva F, Maffulli N. Small interfering RNAs in tendon homeostasis. Brit Med Bull. 2021;138(1):58–67.
Article CAS PubMed Google Scholar
Gargano G, Oliva F, Oliviero A, Maffulli N. Small interfering RNAs in the management of human rheumatoid arthritis. Brit Med Bull. 2022;142(1):34–43.
Article CAS PubMed PubMed Central Google Scholar
Gargano G, Asparago G, Spiezia F, Oliva F, Maffulli N. Small interfering RNAs in the management of human osteoporosis. Br Med Bull. 2023:ldad023. https://doi.org/10.1093/bmb/ldad023.
Guo Q, Chen Y, Guo L, Jiang T, Lin Z. miR-23a/b regulates the balance between osteoblast and adipocyte differentiation in bone marrow mesenchymal stem cells. Bone Res. 2016;4(2):110–8.
Chen H, Li X, Liu S, Gu L, Zhou X. MircroRNA-19a promotes vascular inflammation and foam cell formation by targeting HBP-1 in atherogenesis. Sci Rep-UK. 2017;7(1):12010–89.
Wang N, Li R, Xue M. Potential regulatory network in the PSG10P/miR-19a-3p/IL1RAP pathway is possibly involved in preeclampsia pathogenesis. J Cell Mol Med. 2019;23(2):852–64.
Article CAS PubMed Google Scholar
Qiao F, Gong P, Song Y, Shen X, Su X, Li Y, et al. Downregulated PITX1 modulated by MiR-19a-3p promotes cell malignancy and predicts a poor prognosis of gastric cancer by affecting transcriptionally activated PDCD5. Cell Physiol Biochem. 2018;46(6):2215–31.
Article CAS PubMed Google Scholar
Zhang B, Liu Y, Zhang J. Silencing of miR-19a-3p enhances osteosarcoma cells chemosensitivity by elevating the expression of tumor suppressor PTEN. Oncol Lett. 2019;17(1):414–21.
Wang Z, Shi Z, Zhang L, Zhang H, Zhang Y. Profilin 1, negatively regulated by microRNA-19a-3p, serves as a tumor suppressor in human hepatocellular carcinoma. Pathol Res Pract. 2019;215(3):499–505.
Article CAS PubMed Google Scholar
Gu Y, Liu S, Zhang X, Chen G, Liang H, Yu M, et al. Oncogenic miR-19a and miR-19b co-regulate tumor suppressor MTUS1 to promote cell proliferation and migration in lung cancer. Protein Cell. 2017;8(6):455–66.
Article CAS PubMed PubMed Central Google Scholar
Ye Y, Ke Y, Liu L, Xiao T, Yu J, Christian M, et al. CircRNA FAT1 Regulates osteoblastic differentiation of periodontal ligament stem cells via miR-4781-3p/SMAD5 pathway. Stem Cells Int. 2021;2021:5177416–88.
Zhang X, Li H, Chen F, Chen Y, Chai Y, Liao J, et al. Icariin regulates miR-23a-3p-mediated osteogenic differentiation of BMSCs via BMP-2/Smad5/Runx2 and WNT/β-catenin pathways in osteonecrosis of the femoral head. Saudi Pharm J. 2021;29(12):1405–15.
Article PubMed PubMed Central Google Scholar
Wu Y, Lu X, Shen B, Zeng Y. The therapeutic potential and role of miRNA, lncRNA, and circRNA in osteoarthritis. Curr Gene Ther. 2019;19(4):255–63.
Article CAS PubMed Google Scholar
Zhang H, Xu R, Li B, Xin Z, Ling Z, Zhu W, et al. LncRNA NEAT1 controls the lineage fates of BMSCs during skeletal aging by impairing mitochondrial function and pluripotency maintenance. Cell Death Differ. 2022;29(2):351–65.
Article CAS PubMed Google Scholar
Yin J, Zheng Z, Zeng X, Zhao Y, Ai Z, Yu M, et al. lncRNA MALAT1 mediates osteogenic differentiation of bone mesenchymal stem cells by sponging miR-129-5p. PeerJ. 2022;10:e13355.
Article PubMed PubMed Central Google Scholar
Yu X, Song MS, Rong PZ, Chen XJ, Shi L, Wang CH, et al. LncRNA SNHG1 modulates adipogenic differentiation of BMSCs by promoting DNMT1 mediated Opg hypermethylation via interacting with PTBP1. J Cell Mol Med. 2022;26(1):60–74.
Article CAS PubMed Google Scholar
Shen Y, Xu J, Pan X, Zhang Y, Weng Y, Zhou D, et al. LncRNA KCNQ1OT1 sponges miR-34c-5p to promote osteosarcoma growth via ALDOA enhanced aerobic glycolysis. Cell Death Dis. 2020;11(4):278.
Comments (0)