Bai T, Lei P, Zhou H et al (2019) Sigma-1 receptor protects against ferroptosis in hepatocellular carcinoma cells. J Cell Mol Med 23(11):7349–7359

Article  PubMed  PubMed Central  CAS  Google Scholar 

Bai T, Wang S, Zhao Y, Zhu R, Wang W, Sun Y (2017) Haloperidol, a sigma receptor 1 antagonist, promotes ferroptosis in hepatocellular carcinoma cells. Biochem Biophys Res Commun 491(4):919–925

Article  PubMed  CAS  Google Scholar 

Barayuga SM, Pang X, Andres MA, Panee J, Bellinger FP (2013) Methamphetamine decreases levels of glutathione peroxidases 1 and 4 in SH-SY5Y neuronal cells: protective effects of selenium. Neurotoxicology. 37:240–246

Article  PubMed  PubMed Central  CAS  Google Scholar 

Chen X, Li W, Ren J et al (2014) Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death. Cell Res 24(1):105–121

Article  PubMed  CAS  Google Scholar 

Chen X, Xu S, Zhao C, Liu B (2019b) Role of TLR4/NADPH oxidase 4 pathway in promoting cell death through autophagy and ferroptosis during heart failure. Biochem Biophys Res Commun 516(1):37–43

Article  PubMed  CAS  Google Scholar 

Chen X, Zhang B, Liu T et al (2019a) Liproxstatin-1 attenuates morphine tolerance through inhibiting spinal ferroptosis-like cell death. ACS Chem Nerosci 10(12):4824–4833

Article  Google Scholar 

Del Re DP, Amgalan D, Linkermann A, Liu Q, Kitsis RN (2019) Fundamental mechanisms of regulated cell death and implications for heart disease. Physiol Rev 99(4):1765–1817

Article  PubMed  PubMed Central  Google Scholar 

Dixon SJ, Lemberg KM, Lamprecht MR et al (2012) Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell. 149(5):1060–1072

Article  PubMed  PubMed Central  CAS  Google Scholar 

Dodson M, Castro-Portuguez R, Zhang DD (2019) NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis. Redox Biol 23:101107

Article  PubMed  PubMed Central  CAS  Google Scholar 

Dolma S, Lessnick SL, Hahn WC, Stockwell BR (2003) Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells. Cancer Cell 3(3):285–296

Article  PubMed  CAS  Google Scholar 

Dong H, Qiang Z, Chai D et al (2020) Nrf2 inhibits ferroptosis and protects against acute lung injury due to intestinal ischemia reperfusion via regulating SLC7A11 and HO-1. Aging (Albany NY) 12(13):12943–12959

Article  PubMed  CAS  Google Scholar 

Fan BY, Pang YL, Li WX et al (2021a) Liproxstatin-1 is an effective inhibitor of oligodendrocyte ferroptosis induced by inhibition of glutathione peroxidase 4. Neural Regen Res 16(3):561–566

Article  PubMed  CAS  Google Scholar 

Fan RF, Tang KK, Wang ZY, Wang L (2021b) Persistent activation of Nrf2 promotes a vicious cycle of oxidative stress and autophagy inhibition in cadmium-induced kidney injury. Toxicology. 464:152999

Article  PubMed  CAS  Google Scholar 

Fang X, Wang H, Han D et al (2019) Ferroptosis as a target for protection against cardiomyopathy. Proc Natl Acad Sci U S A 116(7):2672–2680

Article  PubMed  PubMed Central  CAS  Google Scholar 

Ferreira-Chamorro P, Redondo A, Riego G, Leánez S, Pol O (2018) Sulforaphane inhibited the nociceptive responses, anxiety- and depressive-like behaviors associated with neuropathic pain and improved the anti-allodynic effects of morphine in mice. Front Pharmacol 9:1332

Article  PubMed  PubMed Central  CAS  Google Scholar 

Friedmann Angeli JP, Schneider M, Proneth B et al (2014) Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice. Nat Cell Biol 16(12):1180–1191

Article  PubMed  CAS  Google Scholar 

Friesen C, Roscher M, Hormann I et al (2013) Cell death sensitization of leukemia cells by opioid receptor activation. Oncotarget 4(5):677–690

Article  PubMed  PubMed Central  Google Scholar 

Fu J, Xu M, Xu L et al (2021) Sulforaphane alleviates hyperalgesia and enhances analgesic potency of morphine in rats with cancer-induced bone pain. Eur J Pharmacol 909:174412

Article  PubMed  CAS  Google Scholar 

Galluzzi L, Vitale I, Aaronson SA et al (2018) Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death Differ 25(3):486–541

Article  PubMed  PubMed Central  Google Scholar 

Gaschler MM, Andia AA, Liu H et al (2018) FINO(2) initiates ferroptosis through GPX4 inactivation and iron oxidation. Nat Chem Biol 14(5):507–515

Article  PubMed  PubMed Central  CAS  Google Scholar 

Guo Y, Li D, Cen XF et al (2022) Diosmetin protects against cardiac hypertrophy via p62/Keap1/Nrf2 signaling pathway. Oxid Med Cell Longev 2022:8367997

Article  PubMed  PubMed Central  Google Scholar 

Hassanzadeh K, Habibi-asl B, Farajnia S, Roshangar L (2011) Minocycline prevents morphine-induced apoptosis in rat cerebral cortex and lumbar spinal cord: a possible mechanism for attenuating morphine tolerance. Neurotox Res 19(4):649–659

Article  PubMed  CAS  Google Scholar 

Iglesias M, Segura MF, Comella JX, Olmos G (2003) Mu-opioid receptor activation prevents apoptosis following serum withdrawal in differentiated SH-SY5Y cells and cortical neurons via phosphatidylinositol 3-kinase. Neuropharmacology. 44(4):482–492

Article  PubMed  CAS  Google Scholar 

Jiang L, Kon N, Li T et al (2015) Ferroptosis as a p53-mediated activity during tumour suppression. Nature. 520(7545):57–62

Article  PubMed  PubMed Central  CAS  Google Scholar 

Kang R, Kroemer G, Tang D (2019) The tumor suppressor protein p53 and the ferroptosis network. Free Radic Biol Med 133:162–168

Article  PubMed  CAS  Google Scholar 

Khakpai F, Nedaei F, Shahini F, Zarrindast MR (2021) Synergistic analgesic effect of morphine and tramadol in non-sensitized and morphine-sensitized mice: an isobolographic study. Acta Neurobiol Exp (Wars) 81(4):350–361

PubMed  Google Scholar 

Khot M, Sood A, Tryphena KP et al (2023) Dimethyl fumarate ameliorates parkinsonian pathology by modulating autophagy and apoptosis via Nrf2-TIGAR-LAMP2/Cathepsin D axis. Brain Res 1815:148462

Article  PubMed  CAS  Google Scholar 

Khurdayan VK, Buch S, El-Hage N et al (2004) Preferential vulnerability of astroglia and glial precursors to combined opioid and HIV-1 Tat exposure in vitro. Eur J Neurosci 19(12):3171–3182

Article  PubMed  PubMed Central  Google Scholar 

Komatsu M, Waguri S, Koike M et al (2007) Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice. Cell. 131(6):1149–1163

Article  PubMed  CAS  Google Scholar 

Koppula P, Zhang Y, Zhuang L, Gan B (2018) Amino acid transporter SLC7A11/xCT at the crossroads of regulating redox homeostasis and nutrient dependency of cancer. Cancer communications (London, England) 38(1):12

PubMed  Google Scholar 

Kruiswijk F, Labuschagne CF, Vousden KH (2015) p53 in survival, death and metabolic health: a lifeguard with a licence to kill. Nat Rev Mol Cell Biol 16(7):393–405

Article  PubMed  CAS  Google Scholar 

Lamark T, Kirkin V, Dikic I, Johansen T (2009) NBR1 and p62 as cargo receptors for selective autophagy of ubiquitinated targets. Cell Cycle 8(13):1986–1990

Article  PubMed  CAS  Google Scholar 

Listos J, Łupina M, Talarek S, Mazur A, Orzelska-Górka J, Kotlińska J (2019) The Mechanisms Involved in Morphine Addiction: An Overview. Int J Mol Sci 20(17):4302

Article  PubMed  PubMed Central  CAS  Google Scholar 

Liu J, Wang C, Li J et al (2021) Autophagy blockage promotes the pyroptosis of ox-LDL-treated macrophages by modulating the p62/Nrf2/ARE axis. J Physiol Biochem 77(3):419–429

Article  PubMed  PubMed Central  CAS  Google Scholar 

Liu LT, Song YQ, Chen XS et al (2020) Morphine-induced RACK1-dependent autophagy in immortalized neuronal cell lines. Br J Pharmacol 177(7):1609–1621

Article  PubMed  PubMed Central  CAS  Google Scholar 

Ma Q (2013) Role of nrf2 in oxidative stress and toxicity. Annu Rev Pharmacol Toxicol 53:401–426

Article  PubMed  PubMed Central  CAS