Bhasin S, Brito JP, Cunningham GR, Hayes FJ, Hodis HN, Matsumoto AM, et al. Testosterone therapy in men with hypogonadism: an endocrine society* clinical practice guideline. J Clin Endocrinol Metab. 2018;103:1715–44.

Article  PubMed  Google Scholar 

Yeap BB, Wu FCW. Clinical practice update on testosterone therapy for male hypogonadism: contrasting perspectives to optimize care. Clin Endocrinol. 2019;90:56–65.

Article  CAS  Google Scholar 

Salonia A, Bettocchi C, Boeri L, Capogrosso P, Carvalho J, Cilesiz NC, et al. European Association of Urology guidelines on sexual and reproductive health-2021 update: male sexual dysfunction. Eur Urol. 2021;80:333–57.

Article  PubMed  Google Scholar 

Tajar A, Forti G, O’Neill TW, Lee DM, Silman AJ, Finn JD, et al. Characteristics of secondary, primary, and compensated hypogonadism in aging men: evidence from the European Male Ageing Study. J Clin Endocrinol Metab. 2010;95:1810–8.

Article  CAS  PubMed  Google Scholar 

Corona G, Goulis DG, Huhtaniemi I, Zitzmann M, Toppari J, Forti G, et al. European Academy of Andrology (EAA) guidelines* on investigation, treatment and monitoring of functional hypogonadism in males. Andrology. 2020;8:970–87.

Article  PubMed  Google Scholar 

Basaria S. Male hypogonadism. Lancet. 2014;383:1250–63.

Article  CAS  PubMed  Google Scholar 

Wallin JA. Bibliometric methods: pitfalls and possibilities. Basic Clin Pharm Toxicol. 2005;97:261–75.

Article  CAS  Google Scholar 

van Eck NJ, Waltman L. Software survey: VOSviewer, a computer program for bibliometric mapping. Scientometrics. 2010;84:523–38.

Article  PubMed  Google Scholar 

Ellegaard O, Wallin JA. The bibliometric analysis of scholarly production: how great is the impact? Scientometrics. 2015;105:1809–31.

Article  PubMed  PubMed Central  Google Scholar 

Rondanelli M, Perna S, Peroni G, Guido D. A bibliometric study of scientific literature in scopus on botanicals for treatment of androgenetic alopecia. J Cosmet Dermatol. 2016;15:120–30.

Article  PubMed  Google Scholar 

Corona G, Vignozzi L, Sforza A, Mannucci E, Maggi M. Obesity and late-onset hypogonadism. Mol Cell Endocrinol. 2015;418:120–33.

Article  CAS  PubMed  Google Scholar 

Corona G, Rastrelli G, Monami M, Saad F, Luconi M, Lucchese M, et al. Body weight loss reverts obesity-associated hypogonadotropic hypogonadism: a systematic review and meta-analysis. Eur J Endocrinol. 2013;168:829–43.

Article  CAS  PubMed  Google Scholar 

Corona G, Rastrelli G, Monami M, Guay A, Buvat J, Sforza A, et al. Hypogonadism as a risk factor for cardiovascular mortality in men: a meta-analytic study. Eur J Endocrinol. 2011;165:687–701.

Article  CAS  PubMed  Google Scholar 

Chan YM, Broder-Fingert S, Wong KM, Seminara SB. Kisspeptin/Gpr54-independent gonadotrophin-releasing hormone activity in Kiss1 and Gpr54 mutant mice. J Neuroendocrinol. 2009;21:1015–23.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lapatto R, Pallais JC, Zhang D, Chan Y-M, Mahan A, Cerrato F, et al. Kiss1(-/-) mice exhibit more variable hypogonadism than Gpr54(-/-) mice. Endocrinology. 2007;148:4927–36.

Article  CAS  PubMed  Google Scholar 

Berthon A, Settas N, Delaney A, Giannakou A, Demidowich A, Faucz FR, et al. Kisspeptin deficiency leads to abnormal adrenal glands and excess steroid hormone secretion. Hum Mol Genet. 2020;29:3443–50.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Seminara SB, Messager S, Chatzidaki EE, Thresher RR, Acierno JS, Shagoury JK, et al. The GPR54 gene as a regulator of puberty. N Engl J Med. 2003;349:1614–U8.

Article  CAS  PubMed  Google Scholar 

Wu FCW, Tajar A, Beynon JM, Pye SR, Silman AJ, Finn JD, et al. Identification of late-onset hypogonadism in middle-aged and elderly men. N Engl J Med. 2010;363:123–35.

Article  CAS  PubMed  Google Scholar 

Bhasin S, Cunningham GR, Hayes FJ, Matsumoto AM, Snyder PJ, Swerdloff RS, et al. Testosterone Therapy in Men with Androgen Deficiency Syndromes: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2010;95:2536–59.

Article  CAS  PubMed  Google Scholar 

Snyder P. Testosterone treatment of late-onset hypogonadism - benefits and risks. Rev Endocr Metab Disord. 2022;23:1151–7.

Article  PubMed  Google Scholar 

Snyder PJ, Bhasin S, Cunningham GR, Matsumoto AM, Stephens-Shields AJ, Cauley JA, et al. Lessons From the Testosterone Trials. Endocr Rev. 2018;39:369–86.

Article  PubMed  PubMed Central  Google Scholar 

Kondoh N, Kaizuka Y, Nagasawa S, Togo Y, Yamamoto S. Predictive factors for efficacy of testosterone replacement therapy for late-onset hypogonadism in Japanese men: a preliminary report. Asian J Androl. 2023;25:587–90.

Article  PubMed  PubMed Central  Google Scholar 

Aribarg A, Zhang GY, Cao J, Li GZ, Anderson RA, Swerdloff RS, et al. Contraceptive efficacy of testosterone-induced azoospermia and oligozoospermia in normal men. Fertil Steril. 1996;65:821–9.

Article  Google Scholar 

Shah R, Patil V, Sarathi V, Lila AR, Zacharin M, Krishnappa B, et al. Prior testosterone replacement therapy may impact spermatogenic response to combined gonadotropin therapy in severe congenital hypogonadotropic hypogonadism. Pituitary. 2021;24:326–33.

Article  CAS  PubMed  Google Scholar 

Rastrelli G, Filippi S, Sforza A, Maggi M, Corona G. Metabolic Syndrome in Male Hypogonadism. Front Horm Res. 2018;49:131–55.

Article  CAS  PubMed  Google Scholar 

Garcia-Cruz E, Piqueras M, Huguet J, Perez-Marquez M, Gosalbez D, Peri L, et al. Hypertension, dyslipidemia and overweight are related to lower testosterone levels in a cohort of men undergoing prostate biopsy. Int J Impot Res. 2012;24:110–3.

Article  CAS  PubMed  Google Scholar 

Dimopoulou C, Goulis DG, Corona G, Maggi M. The complex association between metabolic syndrome and male hypogonadism. Metabolism. 2018;86:61–8.

Article  CAS  PubMed  Google Scholar 

Taskin HE, Al M. Testosterone Changes in Men With Obesity and Type 2 Diabetes 6 Months After Sleeve Gastrectomy With Transit Bipartition. Surg Laparosc Endosc Percutan Tech. 2022;32:188–96.

Article  PubMed  Google Scholar 

Dhindsa S, Ghanim H, Jenkins T, Inge TH, Harmon CM, Ghoshal A, et al. High prevalence of subnormal testosterone in obese adolescent males: reversal with bariatric surgery. Eur J Endocrinol. 2022;186:319–27.

Article  CAS  PubMed  Google Scholar 

Genchi VA, Rossi E, Lauriola C, D’Oria R, Palma G, Borrelli A, et al. Adipose tissue dysfunction and obesity-related male hypogonadism. Int J Mol Sci. 2022;23:8194.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Finkelstein JS, Lee H, Burnett-Bowie S-AM, Pallais JC, Yu EW, Borges LF, et al. Gonadal steroids and body composition, strength, and sexual function in men. N. Engl J Med. 2013;369:1011–22.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wake DJ, Strand M, Rask E, Westerbacka J, Livingstone DEW, Soderberg S, et al. Intra-adipose sex steroid metabolism and body fat distribution in idiopathic human obesity. Clin Endocrinol. 2007;66:440–6.

Article  CAS  Google Scholar 

Xu X, Sun M, Ye J, Luo D, Su X, Zheng D, et al. The effect of aromatase on the reproductive function of obese males. Horm Metab Res. 2017;49:572–9.

Article  CAS  PubMed  Google Scholar 

Wang S-K, Lee M-C, Hung C-L, Chen H-H, Liao C-C, Chiu Y-L. Association between hypertriglyceridemic waist phenotype and hypogonadism in Taiwanese adult men. PLoS ONE. 2022;17:e0265629.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Davidson LM, Millar K, Jones C, Fatum M, Coward K. Deleterious effects of obesity upon the hormonal and molecular mechanisms controlling spermatogenesis and male fertility. Hum Fertil. 2015;18:184–93.

Article  CAS  Google Scholar 

Bellastella G, Menafra D, Puliani G, Colao A, Savastano S, Obesity Programs of nutrition ER. How much does obesity affect the male reproductive function? Int J Obes Suppl. 2019;9:50–64.

Article  PubMed  PubMed Central  Google Scholar 

Salim S. Oxidative stress and the central nervous system. J Pharm Exp Ther. 2017;360:201–5.

Article  CAS  Google Scholar 

Bisht S, Faiq M, Tolahunase M, Dada R. Oxidative stress and male infertility. Nat Rev Urol. 2017;14:470–85.

Article  CAS