Abu-Alghayth M, Vanhatalo A, Wylie LJ, McDonagh STJ, Thompson C, Kadach S, Kerr P, Smallwood MJ, Jones AM, Winyard PG (2021) S-nitrosothiols, and other products of nitrate metabolism, are increased in multiple human blood compartments following ingestion of beetroot juice. Redox Biol 43:101974. https://doi.org/10.1016/j.redox.2021.101974

Article  PubMed  PubMed Central  CAS  Google Scholar 

Baehr EK, Revelle W, Eastman CI (2000) Individual differences in the phase and amplitude of the human circadian temperature rhythm: with an emphasis on morningness-eveningness. J Sleep Res 9:117–127. https://doi.org/10.1046/j.1365-2869.2000.00196.x

Article  PubMed  CAS  Google Scholar 

Bahadoran Z, Mirmiran P, Kabir A, Azizi F, Ghasemi A (2017) The nitrate-independent blood pressure-lowering effect of beetroot juice: a systematic review and meta-analysis. Adv Nutr: Int Rev J 8:830–838. https://doi.org/10.3945/an.117.016717

Article  CAS  Google Scholar 

Bahrami LS, Arabi SM, Feizy Z, Rezvani R (2021) The effect of beetroot inorganic nitrate supplementation on cardiovascular risk factors: a systematic review and meta-regression of randomized controlled trials. Nitric Oxide 115:8–22. https://doi.org/10.1016/j.niox.2021.06.002

Article  PubMed  CAS  Google Scholar 

Bailey SL, Heitkemper MM (2001) Circadian rhythmicity of cortisol and body temperature: Morningness-eveningness effects. Chronobiol Int 18:249–261. https://doi.org/10.1081/CBI-100103189

Article  PubMed  CAS  Google Scholar 

Bailey SJ, Fulford J, Vanhatalo A, Winyard PG, Blackwell JR, DiMenna FJ, Wilkerson DP, Benjamin N, Jones AM (2010) Dietary nitrate supplementation enhances muscle contractile efficiency during knee-extensor exercise in humans. J Appl Physiol 109:135–148. https://doi.org/10.1152/japplphysiol.00046.2010

Article  PubMed  CAS  Google Scholar 

Bailey SJ, Blackwell JR, Wylie LJ, Holland T, Winyard PG, Jones AM (2016) Improvement in blood pressure after short-term inorganic nitrate supplementation is attenuated in cigarette smokers compared to non-smoking controls. Nitric Oxide 61:29–37. https://doi.org/10.1016/j.niox.2016.10.002

Article  PubMed  CAS  Google Scholar 

Benjamin N, O’Driscoll F, Dougall H, Duncan C, Smith L, Golden M, McKenzie H (1994) Stomach NO synthesis. Nature 368:502–502. https://doi.org/10.1038/368502a0

Article  PubMed  CAS  Google Scholar 

Boggia J, Luzardo L, Lujambio I, Sottolano M, Robaina S, Thijs L, Olascoaga A, Noboa A, Struijker-Boudier HA, Safar ME, Staessen JA (2016) The diurnal profile of central hemodynamics in a general Uruguayan population. Am J Hypertens 6:737–746. https://doi.org/10.1093/ajh/hpv169

Article  Google Scholar 

Brunstrom J, Tribbeck P, MacRae AW (2000) The role of mouth state in the termination of drinking behavior in humans. Physiol Behav 68:579–583. https://doi.org/10.1016/S0031-9384(99)00210-3

Article  PubMed  CAS  Google Scholar 

Bryan NS, Fernandez BO, Bauer SM, Garcia-Saura MF, Milsom AB, Rassaf T, Maloney RE, Bharti A, Rodriguez J, Feelisch M (2005) Nitrite is a signaling molecule and regulator of gene expression in mammalian tissues. Nat Chem Biol 1:290–297. https://doi.org/10.1038/nchembio734

Article  PubMed  CAS  Google Scholar 

Burleigh MC, Liddle L, Monaghan C, Muggeridge DJ, Sculthorpe N, Butcher JP, Henriquez FL, Allen JD, Easton C (2018) Salivary nitrite production is elevated in individuals with a higher abundance of oral nitrate-reducing bacteria. Free Radic Biol Med 120:80–88. https://doi.org/10.1016/j.freeradbiomed.2018.03.023

Article  PubMed  CAS  Google Scholar 

Carlström M, Lundberg JO, Weitzberg E (2018) Mechanisms underlying blood pressure reduction by dietary inorganic nitrate. Acta Physiol 224:13080. https://doi.org/10.1111/apha.13080

Article  CAS  Google Scholar 

Cermak NM, Gibala MJ, Van Loon LJC (2012) Nitrate supplementation’s improvement of 10-km time-trial performance in trained cyclists. Int J Sport Nutr Exerc Metab 1:64–71. https://doi.org/10.1123/ijsnem.22.1.64

Article  Google Scholar 

Chen CH, Nevo E, Fetics B, Pak PH, Yin FCP, Maughan WL, Kass DA (1997) Estimation of central aortic pressure waveform by mathematical transformation of radial tonometry pressure. Circulation 95:1827–1836. https://doi.org/10.1161/01.CIR.95.7.1827

Article  PubMed  CAS  Google Scholar 

Choi JE, Lyons KM, Kieser JA, Waddell NJ (2017) Diurnal variation of intraoral pH and temperature. BDJ Open 3:170015. https://doi.org/10.1038/bdjopen.2017.15

Article  Google Scholar 

Chtourou H, Zarrouk N, Chaouachi A, Dogui M, Behm DG, Chamari K, Hug F, Souissi N (2011) Diurnal variation in Wingate-test performance and associated electromyographic parameters. Chronobiol Int 8:706–713. https://doi.org/10.3109/07420528.2011.596295

Article  Google Scholar 

Chtourou H, Chaouachi A, Driss T, Dogui M, Behm DG, Chamari K, Souissi N (2012) The effect of training at the same time of day and tapering period on the diurnal variation of short exercise performances. J Strength Cond Res 3:697–708. https://doi.org/10.1519/JSC.0b013e3182281c87

Article  Google Scholar 

Cocksedge SP, Breese BC, Morgan PT, Nogueira L, Thompson C, Wylie LJ, Jones AM, Bailey SJ (2020) Influence of muscle oxygenation and nitrate-rich beetroot juice supplementation on O2 uptake kinetics and exercise tolerance. Nitric Oxide 99:25–33. https://doi.org/10.1016/j.niox.2020.03.007

Article  PubMed  CAS  Google Scholar 

Cocksedge SP, Causer AJ, Winyard PJ, Jones AM, Bailey SJ (2023) Oral temperature and pH influence dietary nitrate metabolism in healthy adults. Nutrients 15:784. https://doi.org/10.3390/nu15030784

Article  PubMed  PubMed Central  CAS  Google Scholar 

Cohen MC, Rohtla KM, Lavery CE, Muller JE, Mittleman MA (1997) Meta-analysis of the morning excess of acute myocardial infarction and sudden cardiac death. Am J Cardiol 11:1512–1516. https://doi.org/10.1016/S0002-9149(97)00181-1

Article  Google Scholar 

Dawes C (1972) Circadian rhythms in human salivary flow rate and composition. J Physiol 220:529–545. https://doi.org/10.1113/jphysiol.1972.sp009721

Article  PubMed  PubMed Central  CAS  Google Scholar 

Dawes C (1975) Circadian rhythms in the flow rate and composition of unstimulated and stimulated human submandibular saliva. J Physiol 244:535–548. https://doi.org/10.1113/jphysiol.1975.sp010811

Article  PubMed  PubMed Central  CAS  Google Scholar 

Dewhurst-Trigg R, Yeates T, Blackwell JR, Thompson C, Linoby A, Morgan PT, Clarke I, Connolly LJ, Wylie LJ, Winyard PG, Jones AM, Bailey SJ (2018) Lowering of blood pressure after nitrate-rich vegetable consumption is abolished with the co-ingestion of thiocyanate-rich vegetables in healthy normotensive males. Nitric Oxide 74:39–46. https://doi.org/10.1016/j.niox.2018.01.009

Article  PubMed  CAS  Google Scholar 

Doel JJ, Benjamin N, Hector MP, Rogers M, Allaker RP (2005) Evaluation of bacterial nitrate reduction in the human oral cavity. Eur J Oral Sci 113:14–19. https://doi.org/10.1111/j.1600-0722.2004.00184.x

Article  PubMed  CAS  Google Scholar 

Douma LG, Gumz ML (2018) Circadian clock-mediated regulation of blood pressure. Free Radic Biol Med 119:108–114. https://doi.org/10.1016/j.freeradbiomed.2017.11.024

Article  PubMed  CAS  Google Scholar 

Dumar AM, Huntington AF, Rogers RR, Kopec TJ, Williams TD, Ballmann CG (2021) Acute beetroot juice supplementation attenuates morning-associated decrements in supramaximal exercise performance in trained sprinters. Int J Environ Res Public Health 18:412. https://doi.org/10.3390/ijerph18020412

Article  PubMed  PubMed Central  CAS  Google Scholar 

Duncan C, Dougall H, Johnston P, Green S, Brogan R, Leifert C, Smith L, Golden M, Benjamin N (1995) Chemical generation of nitric oxide in the mouth from the enterosalivary circulation of dietary nitrate. Nat Med 1:546–551. https://doi.org/10.1038/nm0695-546

Article  PubMed  CAS  Google Scholar 

Elliott WJ (1998) Circadian variation in the timing of stroke onset: a meta-analysis. Stroke 29:992–996. https://doi.org/10.1161/01.STR.29.5.992

Article  PubMed  CAS  Google Scholar 

Fabbian F, Bhatia S, de Giorgi A, Maietti E, Bhatia S, Shanbhag A, Deshmukh A (2017) Circadian periodicity of ischemic heart disease: a systematic review of the literature. Heart Fail Clin 4:673–680. https://doi.org/10.1016/j.hfc.2017.05.003

Article  Google Scholar 

Faconti L, Mills CE, Govoni V, Gu H, Morant S, Jiang B, Cruickshank JK, Webb AJ (2019) Cardiac effects of 6 months’ dietary nitrate and spironolactone in patients with hypertension and with/at risk of type 2 diabetes, in the factorial design, double-blind, randomized controlled VaSera trial. Br J Clin Pharmacol 85:169–180. https://doi.org/10.1111/bcp.13783

Article  PubMed  CAS  Google Scholar 

Feelisch M, Akaike T, Griffiths K, Ida T, Prysyazhna O, Goodwin JJ, Gollop ND, Fernandez BO, Minnion M, Cortese-Krott MM, Borgognone A, Hayes RM, Eaton P, Frenneaux MP, Madhani M (2020) Long-lasting blood pressure lowering effects of nitrite are NO-independent and mediated by hydrogen peroxide, persulfides, and oxidation of protein kinase G1α redox signalling. Cardiovasc Res 116:51–62. https://doi.org/10.1093/cvr/cvz202

Article  PubMed  CAS  Google Scholar 

Ferguson DB, Fort A (1974) Circadian variations in human resting submandibular saliva flow rate and composition. Arch Oral Biol 19:47–55. https://doi.org/10.1016/0003-9969(74)90224-6

Article  PubMed  CAS  Google Scholar