Zamfirescu MB, Ghilencea LN, Popescu MR, Bejan GC, Ghiordanescu IM, Popescu AC, Myerson SG, Dorobanțu M (2021) A practical risk score for prediction of early readmission after a first episode of Acute Heart Failure with preserved ejection fraction. Diagnostics (Basel) 11. https://doi.org/10.3390/diagnostics11020198

McDonagh TA, Metra M, Adamo M et al (2021) 2021 ESC guidelines for the diagnosis and treatment of acute and chronic Heart Failure. Eur Heart J 42:3599–3726. https://doi.org/10.1093/eurheartj/ehab368

Article  CAS  PubMed  Google Scholar 

Ponikowski P, Voors AA, Anker SD et al (2016) 2016 ESC guidelines for the diagnosis and treatment of acute and chronic Heart Failure: the Task Force for the diagnosis and treatment of acute and chronic Heart Failure of the European Society of Cardiology (ESC). Developed with the special contribution of the Heart Failure Association (HFA) of the ESC. Eur J Heart Fail 18:891–975. https://doi.org/10.1002/ejhf.592

Article  PubMed  Google Scholar 

Pieske B, Tschöpe C, de Boer RA et al (2020) How to diagnose Heart Failure with preserved ejection fraction: the HFA-PEFF diagnostic algorithm: a consensus recommendation from the Heart Failure Association (HFA) of the European Society of Cardiology (ESC). Eur J Heart Fail 22:391–412. https://doi.org/10.1002/ejhf.1741

Article  PubMed  Google Scholar 

Harada T, Obokata M (2020) Obesity-related Heart Failure with preserved ejection fraction: pathophysiology, diagnosis, and potential therapies. Heart Fail Clin 16:357–368. https://doi.org/10.1016/j.hfc.2020.02.004

Article  PubMed  Google Scholar 

Dzhioeva O, Belyavskiy E (2020) Diagnosis and management of patients with Heart Failure with preserved ejection fraction (HFpEF): current perspectives and recommendations. Ther Clin Risk Manag 16:769–785. https://doi.org/10.2147/tcrm.s207117

Article  CAS  PubMed  PubMed Central  Google Scholar 

Borlaug BA (2020) Evaluation and management of Heart Failure with preserved ejection fraction. Nat Rev Cardiol 17:559–573. https://doi.org/10.1038/s41569-020-0363-2

Article  CAS  PubMed  Google Scholar 

Rahman M, Kerut EK (2021) Update of clinical echocardiographic assessment of Heart Failure with preserved ejection fraction. Curr Opin Cardiol 36:198–204. https://doi.org/10.1097/hco.0000000000000835

Article  PubMed  Google Scholar 

Gehlken C, Screever EM, Suthahar N, van der Meer P, Westenbrink BD, Coster JE, Van Veldhuisen DJ, de Boer RA, Meijers WC (2021) Left atrial volume and left ventricular mass indices in Heart Failure with preserved and reduced ejection fraction. ESC Heart Fail 8:2458–2466. https://doi.org/10.1002/ehf2.13366

Article  PubMed  PubMed Central  Google Scholar 

Beitzke D, Gremmel F, Senn D, Laggner R, Kammerlander A, Wielandner A, Nolz R, Hülsmann M, Loewe C (2021) Effects of Levosimendan on cardiac function, size and strain in Heart Failure patients. Int J Cardiovasc Imaging 37:1063–1071. https://doi.org/10.1007/s10554-020-02077-z

Article  CAS  PubMed  Google Scholar 

Sakane K, Kanzaki Y, Tsuda K, Maeda D, Sohmiya K, Hoshiga M (2021) Disproportionately low BNP levels in patients of acute Heart Failure with preserved vs. reduced ejection fraction. Int J Cardiol 327:105–110. https://doi.org/10.1016/j.ijcard.2020.11.066

Article  PubMed  Google Scholar 

Volpato V, Mor-Avi V, Narang A, Prater D, Gonçalves A, Tamborini G, Fusini L, Pepi M, Patel AR, Lang RM (2019) Automated, machine learning-based, 3D echocardiographic quantification of left ventricular mass. Echocardiography 36:312–319. https://doi.org/10.1111/echo.14234

Article  PubMed  Google Scholar 

Tamborini G, Piazzese C, Lang RM et al (2017) Feasibility and accuracy of Automated Software for Transthoracic three-Dimensional Left Ventricular volume and function analysis: comparisons with two-Dimensional Echocardiography, three-Dimensional Transthoracic Manual Method, and Cardiac magnetic resonance imaging. J Am Soc Echocardiogr 30:1049–1058. https://doi.org/10.1016/j.echo.2017.06.026

Article  PubMed  Google Scholar 

Medvedofsky D, Mor-Avi V, Amzulescu M et al (2018) Three-dimensional echocardiographic quantification of the left-heart chambers using an automated adaptive analytics algorithm: multicentre validation study. Eur Heart J Cardiovasc Imaging 19:47–58. https://doi.org/10.1093/ehjci/jew328

Article  PubMed  Google Scholar 

Sun L, Feng H, Ni L, Wang H, Gao D (2018) Realization of fully automated quantification of left ventricular volumes and systolic function using transthoracic 3D echocardiography. Cardiovasc Ultrasound 16:2. https://doi.org/10.1186/s12947-017-0121-8

Article  PubMed  PubMed Central  Google Scholar 

Reddy YNV, Lewis GD, Shah SJ et al (2017) INDIE-HFpEF (Inorganic Nitrite Delivery to Improve Exercise Capacity in Heart Failure with preserved ejection fraction): Rationale and Design. Circ Heart Fail. https://doi.org/10.1161/circheartfailure.117.003862

Article  PubMed  PubMed Central  Google Scholar 

Frisk M, Le C, Shen X et al (2021) Etiology-dependent impairment of Diastolic Cardiomyocyte Calcium Homeostasis in Heart Failure with preserved ejection fraction. J Am Coll Cardiol 77:405–419. https://doi.org/10.1016/j.jacc.2020.11.044

Article  CAS  PubMed  PubMed Central  Google Scholar 

Baral R, Loudon B, Frenneaux MP, Vassiliou VS (2021) Ventricular-vascular coupling in Heart Failure with preserved ejection fraction: a systematic review and meta-analysis. Heart Lung 50:121–128. https://doi.org/10.1016/j.hrtlng.2020.07.002

Article  PubMed  Google Scholar 

Nagueh SF, Smiseth OA, Appleton CP et al (2016) Recommendations for the evaluation of left ventricular diastolic function by Echocardiography: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. Eur Heart J Cardiovasc Imaging 17:1321–1360. https://doi.org/10.1093/ehjci/jew082

Article  PubMed  Google Scholar 

Zhang Y, Li SY, Xie JJ, Wu Y (2020) Twist/untwist parameters are promising evaluators of myocardial mechanic changes in Heart Failure patients with preserved ejection fraction. Clin Cardiol 43:587–593. https://doi.org/10.1002/clc.23353

Article  PubMed  PubMed Central  Google Scholar 

Rethy L, Borlaug BA, Redfield MM, Oh JK, Shah SJ, Patel RB (2021) Application of Guideline-based echocardiographic Assessment of Left Atrial pressure to Heart Failure with preserved ejection fraction. J Am Soc Echocardiogr 34:455–464. https://doi.org/10.1016/j.echo.2020.12.008

Article  PubMed  PubMed Central  Google Scholar 

Reddy YNV, Obokata M, Egbe A, Yang JH, Pislaru S, Lin G, Carter R, Borlaug BA (2019) Left atrial strain and compliance in the diagnostic evaluation of Heart Failure with preserved ejection fraction. Eur J Heart Fail 21:891–900. https://doi.org/10.1002/ejhf.1464

Article  PubMed  Google Scholar 

Narang A, Mor-Avi V, Prado A et al (2019) Machine learning based automated dynamic quantification of left heart chamber volumes. Eur Heart J Cardiovasc Imaging 20:541–549. https://doi.org/10.1093/ehjci/jey137

Article  PubMed  Google Scholar