Finch CE, Holmes DJ. Ovarian aging in developmental and evolutionary contexts. Ann N Y Acad Sci. 2010;1204:82–94.

Article  PubMed  Google Scholar 

Giorgi C, Marchi S, Simoes ICM, Ren Z, Morciano G, Perrone M, Patalas-Krawczyk P, Borchard S, Jedrak P, Pierzynowska K, Szymanski J, Wang DQ, Portincasa P, Wegrzyn G, Zischka H, Dobrzyn P, Bonora M, Duszynski J, Rimessi A, Karkucinska-Wieckowska A, Dobrzyn A, Szabadkai G, Zavan B, Oliveira PJ, Sardao VA, Pinton P, Wieckowski MR. Mitochondria and reactive oxygen species in aging and age-related diseases. Int Rev Cell Mol Biol. 2018;340:209–344.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li CJ, Lin LT, Tsai HW, Chern CU, Wen ZH, Wang PH, Tsui KH. The molecular regulation in the pathophysiology in ovarian aging. Aging Dis. 2021;12(3):934–49.

Article  PubMed  PubMed Central  Google Scholar 

de Vet A, Laven JS, de Jong FH, Themmen AP, Fauser BC. Antimullerian hormone serum levels: a putative marker for ovarian aging. Fertil Steril. 2002;77(2):357–62.

Article  PubMed  Google Scholar 

Chen X, Yu C, Kang R, Tang D. Iron metabolism in ferroptosis. Front Cell Dev Biol. 2020;8:590226.

Article  PubMed  PubMed Central  Google Scholar 

Jiang X, Stockwell BR, Conrad M. Ferroptosis: mechanisms, biology and role in disease. Nat Rev Mol Cell Biol. 2021;22(4):266–82.

Article  PubMed  PubMed Central  Google Scholar 

Koppula P, Zhuang L, Gan B. Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy. Protein Cell. 2021;12(8):599–620.

Article  CAS  PubMed  Google Scholar 

Ju J, Song YN, Wang K. Mechanism of ferroptosis: a potential target for cardiovascular diseases treatment. Aging Dis. 2021;12(1):261–76.

Article  PubMed  PubMed Central  Google Scholar 

Gao H, Bai Y, Jia Y, Zhao Y, Kang R, Tang D, Dai E. Ferroptosis is a lysosomal cell death process. Biochem Biophys Res Commun. 2018;503(3):1550–6.

Article  CAS  PubMed  Google Scholar 

Shin D, Kim EH, Lee J, Roh JL. Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer. Free Radic Biol Med. 2018;129:454–62.

Article  CAS  PubMed  Google Scholar 

Feng H, Schorpp K, Jin J, Yozwiak CE, Hoffstrom BG, Decker AM, Rajbhandari P, Stokes ME, Bender HG, Csuka JM, Upadhyayula PS, Canoll P, Uchida K, Soni RK, Hadian K, Stockwell BR. Transferrin receptor is a specific ferroptosis marker. Cell Rep. 2020;30(10):3411-3423 e7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Maiorino M, Conrad M, Ursini F. GPx4, lipid peroxidation, and cell death: discoveries, rediscoveries, and open issues. Antioxid Redox Signal. 2018;29(1):61–74.

Article  CAS  PubMed  Google Scholar 

Sun L, Dong H, Zhang W, Wang N, Ni N, Bai X, Liu N. Lipid peroxidation, GSH depletion, and SLC7A11 inhibition are common causes of EMT and ferroptosis in A549 cells, but different in specific mechanisms. DNA Cell Biol. 2021;40(2):172–83.

Article  CAS  PubMed  Google Scholar 

Bannai S, Kitamura E. Transport interaction of L-cystine and L-glutamate in human diploid fibroblasts in culture. J Biol Chem. 1980;255(6):2372–6.

Article  CAS  PubMed  Google Scholar 

Xu X, Zhang X, Wei C, Zheng D, Lu X, Yang Y, Luo A, Zhang K, Duan X, Wang Y. Targeting SLC7A11 specifically suppresses the progression of colorectal cancer stem cells via inducing ferroptosis. Eur J Pharm Sci. 2020;152:105450.

Article  CAS  PubMed  Google Scholar 

Mancias JD, Wang X, Gygi SP, Harper JW, Kimmelman AC. Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy. Nature. 2014;509(7498):105–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Santana-Codina N, Gikandi A, Mancias JD. The role of NCOA4-mediated ferritinophagy in ferroptosis. Adv Exp Med Biol. 2021;1301:41–57.

Article  CAS  PubMed  Google Scholar 

Gao M, Monian P, Pan Q, Zhang W, Xiang J, Jiang X. Ferroptosis is an autophagic cell death process. Cell Res. 2016;26(9):1021–32.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li CJ, Chang CH, Tsang YL, Fang SH, Chen SN, Chiang AJ. Prognostic significance of ferroptosis pathway gene signature and correlation with macrophage infiltration in cervical squamous cell carcinoma. Int Immunopharmacol. 2022;112:109273.

Article  CAS  PubMed  Google Scholar 

Han X, Wang R, Zhou Y, Fei L, Sun H, Lai S, Saadatpour A, Zhou Z, Chen H, Ye F, Huang D, Xu Y, Huang W, Jiang M, Jiang X, Mao J, Chen Y, Lu C, Xie J, Fang Q, Wang Y, Yue R, Li T, Huang H, Orkin SH, Yuan GC, Chen M, Guo G. Mapping the mouse cell atlas by microwell-seq. Cell. 2018;173(5):1307.

Article  CAS  PubMed  Google Scholar 

Russ JE, Haywood ME, Lane SL, Schoolcraft WB, Katz-Jaffe MG. Spatially resolved transcriptomic profiling of ovarian aging in mice. iScience. 2022;25(8):104819.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li CJ, Lin LT, Tsai HW, Wen ZH, Tsui KH. Phosphoglycerate mutase family member 5 maintains oocyte quality via mitochondrial dynamic rearrangement during aging. Aging Cell. 2022;21(2):e13546.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hansen KR, Knowlton NS, Thyer AC, Charleston JS, Soules MR, Klein NA. A new model of reproductive aging: the decline in ovarian non-growing follicle number from birth to menopause. Hum Reprod. 2008;23(3):699–708.

Article  PubMed  Google Scholar 

Tsang YL, Kao CL, Lin SA, Li CJ. Mitochondrial dysfunction and oxidative stress in aging and disease. Biomedicines. 2022;10(11):2872.

Article  PubMed  PubMed Central  Google Scholar 

Goldman KN. The quest for biomarkers linking ovarian aging and longevity. Fertil Steril. 2022;118(1):134–5.

Article  PubMed  Google Scholar 

Mazhar M, Din AU, Ali H, Yang G, Ren W, Wang L, Fan X, Yang S. Implication of ferroptosis in aging. Cell Death Discov. 2021;7(1):149.

Article  PubMed  PubMed Central  Google Scholar 

Cao JY, Dixon SJ. Mechanisms of ferroptosis. Cell Mol Life Sci. 2016;73(11–12):2195–209.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Friedmann Angeli JP, Schneider M, Proneth B, Tyurina YY, Tyurin VA, Hammond VJ, Herbach N, Aichler M, Walch A, Eggenhofer E, Basavarajappa D, Radmark O, Kobayashi S, Seibt T, Beck H, Neff F, Esposito I, Wanke R, Forster H, Yefremova O, Heinrichmeyer M, Bornkamm GW, Geissler EK, Thomas SB, Stockwell BR, O’Donnell VB, Kagan VE, Schick JA, Conrad M. Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice. Nat Cell Biol. 2014;16(12):1180–91.

Article  CAS  PubMed  Google Scholar 

Ng SW, Norwitz SG, Norwitz ER. The impact of iron overload and ferroptosis on reproductive disorders in humans: implications for preeclampsia. Int J Mol Sci. 2019;20(13):3283.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yureneva S, Averkova V, Silachev D, Donnikov A, Gavisova A, Serov V, Sukhikh G. Searching for female reproductive aging and longevity biomarkers. Aging (Albany NY). 2021;13(12):16873–94.

Article  CAS  PubMed  Google Scholar 

Ng SW, Norwitz SG, Taylor HS, Norwitz ER. Endometriosis: the role of iron overload and ferroptosis. Reprod Sci. 2020;27(7):1383–90.

Article  CAS  PubMed  Google Scholar 

Kelsey T. Models and biomarkers for ovarian ageing. Subcell Biochem. 2023;103:185–99.

Article  PubMed  Google Scholar