Targeting of oncogenic AAA-ATPase TRIP13 reduces progression of pancreatic ductal adenocarcinoma

Keywords

Pancreatic ductal adenocarcinoma

TRIP13

Tumor progression

Metastasis

Immune response

AbbreviationsEMT

epithelial-mesenchymal transition

FGFR4

Fibroblast growth factor receptor 4

LEF1

Lymphoid enhancer factor 1

NSG

NOD/SCID/IL2γ receptor-null

PD-1

Programmed cell death protein 1

PDAC

Pancreatic ductal adenocarcinoma

PD-L1

Programmed death-ligand 1

STAT3

Signal transducer and activator of transcription 3

TME

Tumor microenvironment

TRIP13

Thyroid hormone receptor-interacting protein 13

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