Seroprevalence of SARS-CoV-2 antibodies among healthcare workers in Dutch hospitals after the 2020 first wave: a multicentre cross-sectional study with prospective follow-up

Chou R, Dana T, Buckley DI, Selph S, Fu R, Totten AM. Epidemiology of and risk factors for Coronavirus infection in health care workers—a living rapid review. Ann Intern Med. 2020;173:120–36.

Article  PubMed  Google Scholar 

Mutambudzi M, Niedwiedz C, Macdonald EB, Leyland A, Mair F, Anderson J, et al. Occupation and risk of severe COVID-19: prospective cohort study of 120 075 UK Biobank participants. Occup Environ Med. 2021;78:307–14.

Article  Google Scholar 

Iversen K, Bundgaard H, Hasselbalch RB, Kristensen JH, Nielsen PB, Pries-Heje M, et al. Risk of COVID-19 in health-care workers in Denmark: an observational cohort study. Lancet Infect Dis. 2020;20:1401–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gómez-Ochoa S, Franco OH, Rojas L, Raguindin PF, Roa-Diaz ZM, Minder B, et al. COVID-19 in healthcare workers: a living systematic review and meta-analysis of prevalence, risk factors, clinical characteristics, and outcomes. Am J Epidemiol. 2020;190:161–75.

Article  Google Scholar 

Government of Canada. COVID-19 infections among healthcare workers and other people working in healthcare settings. Updated: March 4, 2022. https://www.canada.ca/en/public-health/services/diseases/coronavirus-disease-covid-19/epidemiological-economic-research-data/infections-healthcare-workers-other-people-working-healthcare-settings.html. Accessed 27 May 2022.

Ranney ML, Griffeth V, Jha AK. Critical supply shortages—the need for ventilators and personal protective equipment during the COVID-19 pandemic. N Engl J Med. 2020;6:510–2.

Google Scholar 

Tabah A, Ramanan M, Laupland KB, Buetti N, Cortegiani A, Mellinghoff J, et al. Personal protective equipment and intensive care unit healthcare worker safety in the COVID-19 era (PPE-SAFE): an international survey. J Crit Care. 2020;59:70–5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Papoutsi E, Giannakoulis VG, Ntella V, Katsaounou P. Global burden of COVID-19 pandemic on healthcare workers. ERJ Open Res. 2020;6:00195–2020.

Article  PubMed  PubMed Central  Google Scholar 

Nguyen LH, Drew DA, Graham MS, Joshi AD, Guo CG, Ma W, et al. Risk of COVID-19 among front-line health-care workers and the general community: a prospective cohort study. Lancet Public Health. 2020;5:e475–83.

Article  PubMed  PubMed Central  Google Scholar 

Okba NMA, Müller MA, Li W, Wang C, Geurtsvankessel CH, Corman VM, et al. Severe acute respiratory syndrome Coronavirus 2-specific antibody responses in Coronavirus disease patients. Emerg Infect Dis. 2020;26:1478–88.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kayi İ, Madran B, Keske Ş, Karanfil Ö, Arribas JR, Pshenichnaya N, et al. The seroprevalence of SARS-CoV-2 antibodies among health care workers before the era of vaccination: a systematic review and meta-analysis. Clin Microbiol Infect. 2021;27:1242–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Galanis P, Vraka I, Fragkou D, Bilali A, Kaitelidou D. Seroprevalence of SARS-CoV-2 antibodies and associated factors in healthcare workers: a systematic review and meta-analysis. J Hosp Infect. 2021;108:120–34.

Article  CAS  PubMed  Google Scholar 

Vos ERA, Van Boven M, Den Hartog G, Backer JA, Klinkenberg D, Van Hagen CCE, et al. Associations between measures of social distancing and severe acute respiratory syndrome Coronavirus 2 seropositivity: a nationwide population-based study in the Netherlands. Clin Infect Dis. 2021;73:2318–21.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vos ERA, Den Hartog G, Schepp RM, Kaaijk P, Van Vliet J, Helm K, et al. Nationwide seroprevalence of SARS-CoV-2 and identification of risk factors in the general population of the Netherlands during the first epidemic wave. J Epidemiol Community Health. 2021;75:489–95.

Article  Google Scholar 

van den Hurk K, Merz EM, Prinsze FJ, Spekman MLC, Quee FA, Ramondt S, et al. Low awareness of past SARS-CoV-2 infection in healthy plasma donors. Cell Rep Med. 2021;2:100222.

Article  PubMed  PubMed Central  Google Scholar 

Slot E, Hogema BM, Reusken CBEM, Reimerink JH, Molier M, Karregat JHM, et al. Low SARS-CoV-2 seroprevalence in blood donors in the early COVID-19 epidemic in the Netherlands. Nat Commun. 2020;11:1–7.

Article  Google Scholar 

Bouwman M, Van Osch F, Crijns F, Trienekens T, Mehagnoul-Schipper J, Van Den Bergh JP, et al. SARS-CoV-2 seroprevalence in healthcare workers of a teaching hospital in a highly endemic region in the Netherlands after the first wave: a cross-sectional study. BMJ Open. 2021;11:1–12.

Article  Google Scholar 

Sikkens JJ, Buis DTP, Peters EJG, Dekker M, Schinkel M, Reijnders TDY, et al. Serologic surveillance and phylogenetic analysis of SARS-CoV-2 infection among hospital health care workers. JAMA Netw Open. 2021;4:1–13.

Article  Google Scholar 

Chou R, Dana T, Buckley DI, Selph S, Fu R, Totten AM. Update alert 10: epidemiology of and risk factors for coronavirus infection in health care workers—a living rapid review. Ann Intern Med. 2022;175:W8-9.

Article  PubMed  Google Scholar 

Dzinamarira T, Nkambule SJ, Hlongwa M, Mhango M, Iradukunda PG, Chitungo I, et al. Risk factors for COVID-19 infection among healthcare workers. A first report from a living systematic review and meta-analysis. Saf Health Work. 2022;13:263–8.

Article  PubMed  PubMed Central  Google Scholar 

Jacob JT, Baker JM, Fridkin SK, Lopman BA, Steinberg JP, Christenson RH, et al. Risk factors associated with SARS-CoV-2 seropositivity among US health care personnel. JAMA Netw Open. 2021;4:e211283.

Article  PubMed  PubMed Central  Google Scholar 

Steensels D, Oris E, Coninx L, Nuyens D, Delforge ML, Vermeersch P, et al. Hospital-wide SARS-CoV-2 antibody screening in 3056 staff in a tertiary center in Belgium. JAMA. 2020;324:195–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Baker JM, Nelson KN, Overton E, Lopman BA, Lash TL, Photakis M, et al. Quantification of occupational and community risk factors for SARS-CoV-2 seropositivity among health care workers in a large U.S. health care system. Ann Intern Med. 2021;174:649–54.

Article  PubMed  Google Scholar 

GeurtsvanKessel CH, Okba NMA, Igloi Z, Bogers S, Embregts CWE, Laksono BM, et al. An evaluation of COVID-19 serological assays informs future diagnostics and exposure assessment. Nat Commun. 2020;11:3436.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Geers D, Shamier MC, Bogers S, den Hartog G, Gommers L, Nieuwkoop NN, et al. SARS-CoV-2 variants of concern partially escape humoral but not T-cell responses in COVID-19 convalescent donors and vaccinees. Sci Immunol. 2021;6:eabj1750.

Article  PubMed  PubMed Central  Google Scholar 

RIVM Archive Corona updates April 3, 2020, Oversterfte. https://www.rivm.nl/en/novel-coronavirus-covid-19/archive-covid-19-updates. Accessed 18 June 2022.

Daniel WW. Biostatistics: a foundation for analysis in the health sciences. 7th ed. New York: Wiley; 1999.

Google Scholar 

PIENTER Corona Study. https://www.rivm.nl/en/pienter-corona-study/results. Accessed 7 Jun 2022.

Lau EHY, Tsang OTY, Hui DSC, Kwan MYW, Chan WH, Chiu SS, et al. Neutralizing antibody titres in SARS-CoV-2 infections. Nat Commun. 2021;12:1–7.

Article  Google Scholar 

GeurtsvanKessel CH, Okba NMA, Igloi Z, Bogers S, Embregts CWE, Laksono BM, et al. An evaluation of COVID-19 serological assays informs future diagnostics and exposure assessment. Nat Commun. 2020;11:1–5.

Article  Google Scholar 

Aziz NA, Corman VM, Echterhoff AKC, Müller MA, Richter A, Schmandke A, et al. Seroprevalence and correlates of SARS-CoV-2 neutralizing antibodies from a population-based study in Bonn, Germany. Nat Commun. 2021;12:1–10.

Article  Google Scholar 

Wajnberg A, Amanat F, Firpo A, Altman DR, Bailey MJ, Mansour M, et al. Robust neutralizing antibodies to SARS-CoV-2 infection persist for months. Science. 2020;370:1227–30.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Poletti P, Tirani M, Cereda D, Guzzetta G, Trentini F, Marziano V, et al. Seroprevalence of and risk factors associated with SARS-CoV-2 infection in health care workers during the early COVID-19 pandemic in Italy. JAMA Netw Open. 2021;4:e2115699.

Article  PubMed  PubMed Central  Google Scholar 

Jespersen S, Mikkelsen S, Greve T, Kaspersen KA, Tolstrup M, Boldsen JK, et al. Severe acute respiratory syndrome Coronavirus 2 seroprevalence survey among 17 971 healthcare and administrative personnel at hospitals, prehospital services, and specialist practitioners in the Central Denmark Region. Clin Infect Dis. 2021;73:E2853–60.

Article  CAS  PubMed  Google Scholar 

Kluytmans van den Bergh MFQ, Buiting AGM, Pas SD, Bentvelsen RG, van den Bijllaardt W, van Oudheusden AJG, et al. Prevalence and clinical presentation of health care workers with symptoms of Coronavirus Disease 2019 in 2 Dutch Hospitals during an Early Phase of the Pandemic. JAMA Netw Open. 2020;3:1–7.

Article  Google Scholar 

Jeremias A, Nguyen J, Levine J, Pollack S, Engellenner W, Thakore A, et al. Prevalence of SARS-CoV-2 infection among health care workers in a tertiary community hospital. JAMA Intern Med. 2020;180:1707–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Colton H, Hodgson D, Hornsby H, Brown R, Mckenzie J, Bradley KL, et al. Risk factors for SARS-CoV-2 seroprevalence following the first pandemic wave in UK healthcare workers in a large NHS Foundation Trust. Wellcome Open Res. 2022;6:220.

Article  PubMed  PubMed Central  Google Scholar 

Lentz RJ, Colt H, Chen H, Cordovilla R, Popevic S, Tahura S, et al. Assessing coronavirus disease 2019 (COVID-19) transmission to healthcare personnel: the global ACT-HCP case-control study. Infect Control Hosp Epidemiol. 2021;42:381–7.

Article  PubMed  Google Scholar 

Muhsen K, Schwaber MJ, Bishara J, Kassem E, Atamna A, Na’amnih W, et al. Sero-Prevalence and Sero-Incidence of antibodies to SARS-CoV-2 in health care workers in Israel, prior to mass COVID-19 vaccination. Front Med (Lausanne). 2021;8:1–9.

Google Scholar 

Hughes MM, Groenewold MR, Lessem SE, Xu K, Ussery EN, Wiegand RE, et al. Update: characteristics of health care personnel with COVID-19—United States, February 12–July 16, 2020. MMWR Morb Mortal Wkly Rep. 2020;69:1364–8.

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