Rigaill J, Gavid M, Fayolle M, Morgene MF, Lelonge Y, Grattard F, Pozzetto B, Crepin A, Prades JM, Laurent F, et al. Staphylococcus aureus nasal colonization level and intracellular reservoir: a prospective cohort study. Eur J Clin Microbiol Infect Dis. 2023;42(5):621–9.

Liang B, Liang X, Gao F, Long Y, Mai J, Ai X, Wang J, Gao X, Xiong Z, Liang Z, et al. Active surveillance, drug resistance, and genotypic profiling of staphylococcus aureus among school-age children in China. Front Med Lausanne. 2021;8:701494.

Article  PubMed  PubMed Central  Google Scholar 

Krismer B, Weidenmaier C, Zipperer A, Peschel A. The commensal lifestyle of Staphylococcus aureus and its interactions with the nasal microbiota. Nat Rev Microbiol. 2017;15(11):675–87.

Article  CAS  PubMed  Google Scholar 

de Benedictis FM, Kerem E, Chang AB, Colin AA, Zar HJ, Bush A. Complicated pneumonia in children. Lancet. 2020;396(10253):786–98.

Article  PubMed  Google Scholar 

Nurjadi D, Last K, Klein S, Boutin S, Schmack B, Mueller F, Heeg K, Ruhparwar A, Heininger A, Zanger P. Nasal colonization with Staphylococcus aureus is a risk factor for ventricular assist device infection in the first year after implantation: a prospective, single-centre, cohort study. J Infect. 2020;80(5):511–8.

Article  CAS  PubMed  Google Scholar 

Zhen X, Lundborg CS, Zhang M, Sun X, Li Y, Hu X, Gu S, Gu Y, Wei J, Dong H. Clinical and economic impact of methicillin-resistant Staphylococcus aureus: a multicentre study in China. Sci Rep. 2020;10(1):3900.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pang R, Wu S, Zhang F, Huang J, Wu H, Zhang J, Li Y, Ding Y, Zhang J, Chen M, et al. The genomic context for the evolution and transmission of community-associated staphylococcus aureus ST59 through the food chain. Front Microbiol. 2020;11:422.

Article  PubMed  PubMed Central  Google Scholar 

Liang B, Mai J, Liu Y, Huang Y, Zhong H, Xie Y, Deng Q, Huang L, Yao S, He Y, et al. Prevalence and Characterization of Staphylococcus aureus Isolated From Women and Children in Guangzhou China. Front Microbiol. 2018;9:2790.

Article  PubMed  PubMed Central  Google Scholar 

Nakamura Y, Takahashi H, Takaya A, Inoue Y, Katayama Y, Kusuya Y, Shoji T, Takada S, Nakagawa S, Oguma R, et al. Staphylococcus Agr virulence is critical for epidermal colonization and associates with atopic dermatitis development. Sci Transl Med. 2020;12(551):eaay4068.

Jenul C, Horswill AR. Regulation of Staphylococcus aureus Virulence. Microbiol Spectr. 2019;7(2). https://doi.org/10.1128/microbiolspec.GPP3-0031-2018.

Tan L, Huang Y, Shang W, Yang Y, Peng H, Hu Z, Wang Y, Rao Y, Hu Q, Rao X, et al. Accessory Gene Regulator (agr) Allelic variants in cognate staphylococcus aureus strain display similar phenotypes. Front Microbiol. 2022;13:700894.

Article  PubMed  PubMed Central  Google Scholar 

Gor V, Takemura AJ, Nishitani M, Higashide M, Medrano RV, Ohniwa RL, Morikawa K. Finding of Agr Phase Variants in Staphylococcus aureus. Mbio. 2019;10(4):e00796–19.

Tam K, Torres VJ. Staphylococcus aureus secreted toxins and extracellular enzymes. Microbiol Spectr. 2019;7(2). https://doi.org/10.1128/microbiolspec.GPP3-0039-2018.

Tong SY, Davis JS, Eichenberger E, Holland TL, Fowler VJ. Staphylococcus aureus infections: epidemiology, pathophysiology, clinical manifestations, and management. Clin Microbiol Rev. 2015;28(3):603–61.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang J, Wang J, Jin J, Li X, Zhang H, Shi X, Zhao C. Prevalence, antibiotic resistance, and enterotoxin genes of Staphylococcus aureus isolated from milk and dairy products worldwide: a systematic review and meta-analysis. Food Res Int. 2022;162(Pt A):111969.

Article  CAS  PubMed  Google Scholar 

Benkerroum N. Staphylococcal enterotoxins and enterotoxin-like toxins with special reference to dairy products: An overview. Crit Rev Food Sci. 2018;58(12):1943–70.

Article  CAS  Google Scholar 

Sadat A, Shata RR, Farag A, Ramadan H, Alkhedaide A, Soliman MM, et al. Prevalence and characterization of PVL-positive staphylococcus aureus isolated from raw cow's milk. Toxins. 2022;14(2):97.

Peng L, Jiang J, Chen T, Xu D, Hou F, Huang Q, et al. Toxic shock syndrome toxin 1 induces immune response via the activation of NLRP3 inflammasome. Toxins. 2021;13(1):68.

Najafi OZ, Najar-Peerayeh S, Yadegar A, Bakhshi B. Clonal diversity and genomic characterization of Panton-valentine Leukocidin (PVL)-positive Staphylococcus aureus in Tehran, Iran. BMC Infect Dis. 2021;21(1):372.

Article  Google Scholar 

De Backer S, Xavier BB, Vanjari L, Coppens J, Lammens C, Vemu L, Carevic B, Hryniewicz W, Jorens P, Kumar-Singh S, et al. Remarkable geographical variations between India and Europe in carriage of the staphylococcal surface protein-encoding sasX/sesI and in the population structure of methicillin-resistant Staphylococcus aureus belonging to clonal complex 8. Clin Microbiol Infec. 2019;25(5):621–8.

Article  Google Scholar 

Li M, Du X, Villaruz AE, Diep BA, Wang D, Song Y, Tian Y, Hu J, Yu F, Lu Y, et al. MRSA epidemic linked to a quickly spreading colonization and virulence determinant. Nat Med. 2012;18(5):816–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xu Y, Qian SY, Yao KH, Dong F, Song WQ, Sun C, Yang X, Zhen JH, Liu XQ, Lv Z, et al. Clinical and molecular characteristics of Staphylococcus aureus isolated from Chinese children: association among the agr groups and genotypes, virulence genes and disease types. World J Pediatr. 2021;17(2):180–8.

Article  CAS  PubMed  Google Scholar 

Raghuram V, Alexander AM, Loo HQ, Petit RR, Goldberg JB, Read TD. Species-Wide Phylogenomics of the Staphylococcus aureus Agr Operon Revealed Convergent Evolution of Frameshift Mutations. Microbiol Spectr. 2022;10(1):e0133421.

Article  Google Scholar 

He W, Chen H, Zhao C, Zhang F, Li H, Wang Q, Wang X, Wang H. Population structure and characterisation of Staphylococcus aureus from bacteraemia at multiple hospitals in China: association between antimicrobial resistance, toxin genes and genotypes. Int J Antimicrob Ag. 2013;42(3):211–9.

Article  CAS  Google Scholar 

Papadimitriou-Olivgeris M, Drougka E, Fligou F, Dodou V, Kolonitsiou F, Filos KS, et al. Spread of Tst-Positive staphylococcus aureus strains belonging to ST30 clone among patients and healthcare workers in two intensive care units. Toxins. 2017;9(9):270.

Zhao H, Wu X, Wang B, Shen L, Rao L, Wang X, Zhang J, Xiao Y, Xu Y, Yu J, et al. Phenotypic and genomic analysis of the hypervirulent ST22 methicillin-resistant Staphylococcus aureus in China. Msystems. 2023;8(3):e01242–22.

Kaneko H, Yanagi Y, Otake S, Sato M, Saito T, Nakaminami H. The emerging threat of methicillin-resistant Staphylococcus aureus (MRSA) clone ST22-PT, carrying both Panton-Valentine leucocidin and toxic shock syndrome toxin 1 genes. J Antimicrob Chemoth. 2023;78(4):1023–7.

Article  CAS  Google Scholar 

Yang X, Yu S, Wu Q, Zhang J, Wu S, Rong D. Multilocus sequence typing and virulence-associated gene profile analysis of staphylococcus aureus isolates from retail ready-to-eat food in China. Front Microbiol. 2018;9:197.

Article  PubMed  PubMed Central  Google Scholar 

Hong X, Zhou S, Dai X, Xie D, Cai Y, Zhao G, Li B. Molecular typing and characterization of Staphylococcus aureus isolates from burn wound infections in Fujian, China. Front Microbiol. 2023;14:1236497.

Article  PubMed  PubMed Central  Google Scholar 

Shopsin B, Mathema B, Alcabes P, Said-Salim B, Lina G, Matsuka A, Martinez J, Kreiswirth BN. Prevalence of agr specificity groups among Staphylococcus aureus strains colonizing children and their guardians. J Clin Microbiol. 2003;41(1):456–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang WY, Chiu CF, Lee YT, Hsueh PR, Tsao SM. Molecular epidemiology and phenotypes of invasive methicillin-resistant vancomycin-intermediate Staphylococcus aureus in Taiwan. J Microbiol Immunol. 2022;55(6 Pt 2):1203–10.

CAS  Google Scholar 

Silva V, Hermenegildo S, Ferreira C, Manaia CM, Capita R, Alonso-Calleja C, Carvalho I, Pereira JE, Maltez L, Capelo JL, et al. Genetic characterization of methicillin-resistant staphylococcus aureus isolates from human bloodstream infections: detection of MLS(B) resistance. Antibiotics (Basel). 2020;9(7):375.