Positive single-center randomized trials and subsequent multicenter randomized trials in critically ill patients: a systematic review

A Medical Research Council Investigation. Streptomycin treatment of pulmonary tuberculosis. Br Med J. 1948;2:769–82.

Article  Google Scholar 

Bellomo R, Warrillow SJ, Reade MC. Why we should be wary of single-center trials. Crit Care Med. 2009;37:3114–9.

Article  PubMed  Google Scholar 

Landoni G, Pieri M, Young PJ, Bellomo R. Why do multicenter randomized controlled trials not confirm the positive findings of single center randomized controlled trials in acute care? Minerva Anestesiol. 2019;85:194–200. https://doi.org/10.23736/s0375-9393.18.13070-7.

Article  PubMed  Google Scholar 

Ridgeon EE, Young PJ, Bellomo R, Mucchetti M, Lembo R, Landoni G. The fragility index in multicenter randomized controlled critical care trials. Crit Care Med. 2016;44:1278–84. https://doi.org/10.1097/ccm.0000000000001670.

Article  PubMed  Google Scholar 

Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;372:n71.

Article  PubMed  PubMed Central  Google Scholar 

Sterne JAC, Savović J, Page MJ, Elbers RG, Blencowe NS, Boutron I, et al. RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ. 2019;366:l4898.

Article  PubMed  Google Scholar 

Antonelli M, Conti G, Bufi M, Costa MG, Lappa A, Rocco M, et al. Noninvasive ventilation for treatment of acute respiratory failure in patients undergoing solid organ transplantation: a randomized trial. JAMA. 2000;283:235–41. https://doi.org/10.1001/jama.283.2.235.

Article  CAS  PubMed  Google Scholar 

Boyd O, Grounds RM, Bennett ED. A randomized clinical trial of the effect of deliberate perioperative increase of oxygen delivery on mortality in high-risk surgical patients. JAMA. 1993;270:2699–707.

Article  CAS  PubMed  Google Scholar 

de Jonge E, Schultz MJ, Spanjaard L, Bossuyt PM, Vroom MB, Dankert J, et al. Effects of selective decontamination of digestive tract on mortality and acquisition of resistant bacteria in intensive care: a randomised controlled trial. Lancet. 2003;362:1011–6. https://doi.org/10.1016/s0140-6736(03)14409-1.

Article  PubMed  Google Scholar 

de Silva HA, Fonseka MM, Pathmeswaran A, Alahakone DG, Ratnatilake GA, Gunatilake SB, et al. Multiple-dose activated charcoal for treatment of yellow oleander poisoning: a single-blind, randomised, placebo-controlled trial. Lancet. 2003;361:1935–8. https://doi.org/10.1016/s0140-6736(03)13581-7.

Article  PubMed  Google Scholar 

Dorian P, Cass D, Schwartz B, Cooper R, Gelaznikas R, Barr A. Amiodarone as compared with lidocaine for shock-resistant ventricular fibrillation. N Engl J Med. 2002;346:884–90. https://doi.org/10.1056/NEJMoa013029.

Article  CAS  PubMed  Google Scholar 

Girardis M, Busani S, Damiani E, Donati A, Rinaldi L, Marudi A, et al. Effect of conservative vs conventional oxygen therapy on mortality among patients in an intensive care unit: the oxygen-ICU randomized clinical trial. JAMA. 2016;316:1583–9. https://doi.org/10.1001/jama.2016.11993.

Article  CAS  PubMed  Google Scholar 

Hilbert G, Gruson D, Vargas F, Valentino R, Gbikpi-Benissan G, Dupon M, et al. Noninvasive ventilation in immunosuppressed patients with pulmonary infiltrates, fever, and acute respiratory failure. N Engl J Med. 2001;344:481–7. https://doi.org/10.1056/nejm200102153440703.

Article  CAS  PubMed  Google Scholar 

Lachman E, Pitsoe SB, Gaffin SL. Anti-lipopolysaccharide immunotherapy in management of septic shock of obstetric and gynaecological origin. Lancet. 1984;1:981–3. https://doi.org/10.1016/s0140-6736(84)92324-9.

Article  CAS  PubMed  Google Scholar 

Levacher S, Letoumelin P, Pateron D, Blaise M, Lapandry C, Pourriat JL. Early administration of terlipressin plus glyceryl trinitrate to control active upper gastrointestinal bleeding in cirrhotic patients. Lancet. 1995;346:865–8. https://doi.org/10.1016/s0140-6736(95)92708-5.

Article  CAS  PubMed  Google Scholar 

Morelli A, Ertmer C, Westphal M, Rehberg S, Kampmeier T, Ligges S, et al. Effect of heart rate control with esmolol on hemodynamic and clinical outcomes in patients with septic shock: a randomized clinical trial. JAMA. 2013;310:1683–91. https://doi.org/10.1001/jama.2013.278477.

Article  CAS  PubMed  Google Scholar 

Olasveengen TM, Sunde K, Brunborg C, Thowsen J, Steen PA, Wik L. Intravenous drug administration during out-of-hospital cardiac arrest: a randomized trial. JAMA. 2009;302:2222–9. https://doi.org/10.1001/jama.2009.1729.

Article  PubMed  Google Scholar 

Phu NH, Hien TT, Mai NT, Chau TT, Chuong LV, Loc PP, et al. Hemofiltration and peritoneal dialysis in infection-associated acute renal failure in Vietnam. N Engl J Med. 2002;347:895–902. https://doi.org/10.1056/NEJMoa020074.

Article  PubMed  Google Scholar 

Rivers E, Nguyen B, Havstad S, Ressler J, Muzzin A, Knoblich B, et al. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med. 2001;345:1368–77. https://doi.org/10.1056/NEJMoa010307.

Article  CAS  PubMed  Google Scholar 

Ronco C, Bellomo R, Homel P, Brendolan A, Dan M, Piccinni P, et al. Effects of different doses in continuous veno-venous haemofiltration on outcomes of acute renal failure: a prospective randomised trial. Lancet. 2000;356:26–30. https://doi.org/10.1016/s0140-6736(00)02430-2.

Article  CAS  PubMed  Google Scholar 

Sack JB, Kesselbrenner MB, Bregman D. Survival from in-hospital cardiac arrest with interposed abdominal counterpulsation during cardiopulmonary resuscitation. JAMA. 1992;267:379–85.

Article  CAS  PubMed  Google Scholar 

Schiffl H, Lang SM, Fischer R. Daily hemodialysis and the outcome of acute renal failure. N Engl J Med. 2002;346:305–10. https://doi.org/10.1056/NEJMoa010877.

Article  PubMed  Google Scholar 

van den Berghe G, Wouters P, Weekers F, Verwaest C, Bruyninckx F, Schetz M, et al. Intensive insulin therapy in critically ill patients. N Engl J Med. 2001;345:1359–67. https://doi.org/10.1056/NEJMoa011300.

Article  PubMed  Google Scholar 

Villanueva C, Colomo A, Bosch A, Concepción M, Hernandez-Gea V, Aracil C, et al. Transfusion strategies for acute upper gastrointestinal bleeding. N Engl J Med. 2013;368:11–21. https://doi.org/10.1056/NEJMoa1211801.

Article  CAS  PubMed  Google Scholar 

Zarbock A, Kellum JA, Schmidt C, Van Aken H, Wempe C, Pavenstädt H, et al. Effect of early vs delayed initiation of renal replacement therapy on mortality in critically ill patients with acute kidney injury: the ELAIN randomized clinical trial. JAMA. 2016;315:2190–9. https://doi.org/10.1001/jama.2016.5828.

Article  CAS  PubMed  Google Scholar 

Angus DC, Birmingham MC, Balk RA, Scannon PJ, Collins D, Kruse JA, et al. E5 murine monoclonal antiendotoxin antibody in gram-negative sepsis: a randomized controlled trial. E5 Study Investigators. JAMA. 2000;283:1723–30. https://doi.org/10.1001/jama.283.13.1723.

Article  CAS  PubMed  Google Scholar 

The STARRT-AKI Investigators, & for the Canadian Critical Care Trials Group, the Australian and New Zealand Intensive Care Society Clinical Trials Group, the United Kingdom Critical Care Research Group, the Canadian Nephrology Trials Network, and the Irish Critical Care Trials Group. Timing of initiation of renal-replacement therapy in acute kidney injury. N Engl J Med. 2020;383:240–51. https://doi.org/10.1056/NEJMoa2000741.

Article  Google Scholar 

Barbar SD, Clere-Jehl R, Bourredjem A, Hernu R, Montini F, Bruyère R, et al. Timing of renal-replacement therapy in patients with acute kidney injury and sepsis. N Engl J Med. 2018;379:1431–42. https://doi.org/10.1056/NEJMoa1803213.

Article  CAS  PubMed  Google Scholar 

Bellomo R, Cass A, Cole L, Finfer S, Gallagher M, Lo S, et al. Intensity of continuous renal-replacement therapy in critically ill patients. N Engl J Med. 2009;361:1627–38. https://doi.org/10.1056/NEJMoa0902413.

Article  PubMed  Google Scholar 

de Smet AM, Kluytmans JA, Cooper BS, Mascini EM, Benus RF, van der Werf TS, et al. Decontamination of the digestive tract and oropharynx in ICU patients. N Engl J Med. 2009;360:20–31. https://doi.org/10.1056/NEJMoa0800394.

Article  PubMed  Google Scholar 

Eddleston M, Juszczak E, Buckley NA, Senarathna L, Mohamed F, Dissanayake W, et al. Multiple-dose activated charcoal in acute self-poisoning: a randomised controlled trial. Lancet. 2008;371:579–87. https://doi.org/10.1016/s0140-6736(08)60270-6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Escorsell A, Ruiz del Arbol L, Planas R, Albillos A, Bañares R, Calès P, et al. Multicenter randomized controlled trial of terlipressin versus sclerotherapy in the treatment of acute variceal bleeding: the TEST study. Hepatology. 2000;32:471–6. https://doi.org/10.1053/jhep.2000.16601.

Article  CAS  PubMed  Google Scholar 

Feu F, Ruiz del Arbol L, Bañares R, Planas R, Bosch J. Double-blind randomized controlled trial comparing terlipressin and somatostatin for acute variceal hemorrhage. Variceal Bleeding Study Group. Gastroenterology. 1996;111:1291–9. https://doi.org/10.1053/gast.1996.v111.pm8898643.

Article  CAS  PubMed  Google Scholar 

Finfer S, Chittock DR, Su SY, Blair D, Foster D, Dhingra V, et al. Intensive versus conventional glucose control in critically ill patients. N Engl J Med. 2009;360:1283–97. https://doi.org/10.1056/NEJMoa0810625.

Article  PubMed  Google Scholar 

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