Exploring the promising potential of induced pluripotent stem cells in cancer research and therapy

Rowe RG, Daley GQ. Induced pluripotent stem cells in disease modelling and drug discovery. Nat Rev Genet. 2019;20:377–88.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li L, Papadopoulos V. Advances in stem cell research for the treatment of primary hypogonadism. Nat Rev Urol. 2021;18:487–507.

Article  CAS  PubMed  Google Scholar 

Lawrence M, Evans A, Moreau T, Bagnati M, Smart M, Hassan E, et al. Process analysis of pluripotent stem cell differentiation to megakaryocytes to make platelets applying European GMP. NPJ Regen Med. 2021;6:27.

Article  PubMed  PubMed Central  Google Scholar 

Chandrasekaran V, Carta G, da Costa PD, Gupta R, Murphy C, Feifel E, et al. Generation and characterization of iPSC-derived renal proximal tubule-like cells with extended stability. Sci Rep. 2021;11:11575.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shi Y, Inoue H, Wu JC, Yamanaka S. Induced pluripotent stem cell technology: a decade of progress. Nat Rev Drug Discov. 2017;16:115–30.

Article  CAS  PubMed  Google Scholar 

Duff C, Baruteau J. Modelling urea cycle disorders using iPSCs. NPJ Regen Med. 2022;7:56.

Article  CAS  PubMed  PubMed Central  Google Scholar 

de Rus JA, Denis HL, Cicchetti F, Alpaugh M. Current and future applications of induced pluripotent stem cell-based models to study pathological proteins in neurodegenerative disorders. Mol Psychiatry. 2021;26:2685–706.

Article  Google Scholar 

Hiratsuka K, Monkawa T, Akiyama T, Nakatake Y, Oda M, Goparaju SK, et al. Induction of human pluripotent stem cells into kidney tissues by synthetic mRNAs encoding transcription factors. Sci Rep. 2019;9:913.

Article  PubMed  PubMed Central  Google Scholar 

Zhang W, Ross PJ, Ellis J, Salter MW. Targeting NMDA receptors in neuropsychiatric disorders by drug screening on human neurons derived from pluripotent stem cells. Transl Psychiatry. 2022;12:243.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ji S, Xiong M, Chen H, Liu Y, Zhou L, Hong Y, et al. Cellular rejuvenation: molecular mechanisms and potential therapeutic interventions for diseases. Signal Transduct Target Ther. 2023;8:116.

Article  PubMed  PubMed Central  Google Scholar 

Araki R, Hoki Y, Suga T, Obara C, Sunayama M, Imadome K, et al. Genetic aberrations in iPSCs are introduced by a transient G1/S cell cycle checkpoint deficiency. Nat Commun. 2020;11:197.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Taguchi J, Shibata H, Kabata M, Kato M, Fukuda K, Tanaka A, et al. DMRT1-mediated reprogramming drives development of cancer resembling human germ cell tumors with features of totipotency. Nat Commun. 2021;12:5041.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Supharattanasitthi W, Carlsson E, Sharif U, Paraoan L. CRISPR/Cas9-mediated one step bi-allelic change of genomic DNA in iPSCs and human RPE cells in vitro with dual antibiotic selection. Sci Rep. 2019;9:174.

Article  PubMed  PubMed Central  Google Scholar 

Maruoka S, Ojima T, Iwamoto H, Kitadani J, Tabata H, Tominaga S, et al. Tumor RNA transfected DCs derived from iPS cells elicit cytotoxicity against cancer cells induced from colorectal cancer patients in vitro. Sci Rep. 2022;12:3295.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Marin Navarro A, Susanto E, Falk A, Wilhelm M. Modeling cancer using patient-derived induced pluripotent stem cells to understand development of childhood malignancies. Cell death Discov. 2018;4:7.

Article  PubMed  PubMed Central  Google Scholar 

Ueda T, Shiina S, Iriguchi S, Terakura S, Kawai Y, Kabai R, et al. Optimization of the proliferation and persistency of CAR T cells derived from human induced pluripotent stem cells. Nat Biomed Eng. 2023;7:24–37.

Article  CAS  PubMed  Google Scholar 

Ghosh S, Nehme R, Barrett LE. Greater genetic diversity is needed in human pluripotent stem cell models. Nat Commun. 2022;13(1):7301.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wiegand C, Banerjee I. Recent advances in the applications of iPSC technology. Curr Opin Biotechnol. 2019;60:250–8.

Article  CAS  PubMed  Google Scholar 

Aboul-Soud MAM, Alzahrani AJ, Mahmoud A. Induced pluripotent stem cells (iPSCs)—roles in regenerative therapies, disease modelling and drug screening. Cells. 2021;10(9):2319.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Peñalosa-Ruiz G, Bright AR, Mulder KW, Veenstra GJC. The interplay of chromatin and transcription factors during cell fate transitions in development and reprogramming. Biochim Biophys Acta - Gene Regul Mech. 2019;1862: 194407.

Article  PubMed  Google Scholar 

Lange L, Esteban MA, Schambach A. Back to pluripotency: fully chemically induced reboot of human somatic cells. Signal Transduct Target Ther. 2022;7:244.

Article  PubMed  PubMed Central  Google Scholar 

Fathi M, Riazi SS, Pourdamghan N. Triple-negative Breast Cancer Therapy Using RNA Nanoparticles Targeting Stem Cell Markers with Anti-miRNA: A Systematic Review and Meta-Analysis. Int J Sci Res Dent Med Sci. 2023;5(2):96–101.

CAS  Google Scholar 

Chakrabarty K, Shetty R, Argulwar S, Das D, Ghosh A. Induced pluripotent stem cell-based disease modeling and prospective immune therapy for coronavirus disease 2019. Cytotherapy. 2022;24:235–48.

Article  CAS  PubMed  Google Scholar 

Papapetrou EP. Patient-derived induced pluripotent stem cells in cancer research and precision oncology. Nat Med. 2016;22:1392–401.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhou Y, Li M, Zhou K, Brown J, Tsao T, Cen X, et al. Engineering induced pluripotent stem cells for cancer immunotherapy. Cancers (Basel). 2022;14(9):2266.

Article  CAS  PubMed  Google Scholar 

Sayed N, Liu C, Wu JC. Translation of Human-Induced Pluripotent Stem Cells: From Clinical Trial in a Dish to Precision Medicine. J Am Coll Cardiol. 2016;67:2161–76.

Article  PubMed  PubMed Central  Google Scholar 

Sharkis SJ, Jones RJ, Civin C, Jang Y-Y. Pluripotent stem cell-based cancer therapy: promise and challenges. Sci Transl Med. 2012;4:127ps9.

Article  PubMed  PubMed Central  Google Scholar 

Griscelli F, Féraud O, Oudrhiri N, Gobbo E, Casal I, Chomel J-C, et al. Malignant germ cell-like tumors, expressing Ki-1 antigen (CD30), are revealed during in vivo differentiation of partially reprogrammed human-induced pluripotent stem cells. Am J Pathol. 2012;180:2084–96.

Article  CAS  PubMed  Google Scholar 

Câmara DAD, Mambelli LI, Porcacchia AS, Kerkis I. Advances and challenges on cancer cells reprogramming using induced pluripotent stem cells technologies. J Cancer. 2016;7:2296–303.

Article  PubMed  PubMed Central  Google Scholar 

Moquin-Beaudry G, Benabdallah B, Maggiorani D, Le O, Li Y, Colas C, et al. Autologous humanized mouse models of iPSC-derived tumors enable characterization and modulation of cancer-immune cell interactions. Cell Rep Methods. 2022;2: 100153.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Steeg R, Mueller SC, Mah N, Holst B, Cabrera-Socorro A, Stacey GN, et al. EBiSC best practice: How to ensure optimal generation, qualification, and distribution of iPSC lines. Stem Cell Rep. 2021;16:1853–67.

Article  Google Scholar 

Daley GQ, Hyun I, Apperley JF, Barker RA, Benvenisty N, Bredenoord AL, et al. Setting global standards for stem cell research and clinical translation: the 2016 ISSCR guidelines. Stem Cell Rep. 2016;6:787–97.

Article  Google Scholar 

Watanabe N, Santostefano KE, Yachnis AT, Terada N. A pathologist’s perspective on induced pluripotent stem cells. Lab Investig. 2017;97:1126–32.

Article  PubMed  Google Scholar 

Biglari N, Mehdizadeh A, Mastanabad MV, Gharaeikhezri MH, Afrakoti LG, Pourbala H, et al. Application of mesenchymal stem cells (MSCs) in neurodegenerative disorders: history, findings, and prospective challenges. Pathol Res Pract. 2023:154541.

Wuputra K, Ku C-C, Wu D-C, Lin Y-C, Saito S, Yokoyama KK. Prevention of tumor risk associated with the reprogramming of human pluripotent stem cells. J Exp Clin Cancer Res. 2020;39:1–24.

Article  Google Scholar 

Krog RT, de Miranda NFCC, Vahrmeijer AL, Kooreman NG. The potential of induced pluripotent stem cells to advance the treatment of pancreatic ductal adenocarcinoma. Cancers (Basel). 2021;13(22):5789.

Article  CAS  PubMed  Google Scholar 

Shamsian A, Sahebnasagh R, Norouzy A, Hussein SH, Ghahremani MH, Azizi Z. Cancer cells as a new source of induced pluripotent stem cells. Stem Cell Res Ther. 2022;13:459.

Article  PubMed  PubMed Central 

Comments (0)

No login
gif